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| Title : Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors - Di Stefano_2023_Eur.J.Med.Chem_263_115916 |
| Author(s) : Di Stefano M , Masoni S , Bononi G , Poli G , Galati S , Gado F , Manzi S , Vagaggini C , Brai A , Caligiuri I , Asif K , Rizzolio F , Macchia M , Chicca A , Sodi A , Di Bussolo V , Minutolo F , Meier P , Gertsch J , Granchi C , Dreassi E , Tuccinardi T |
| Ref : Eur Journal of Medicinal Chemistry , 263 :115916 , 2023 |
| Abstract : Di Stefano_2023_Eur.J.Med.Chem_263_115916 |
| ESTHER : Di Stefano_2023_Eur.J.Med.Chem_263_115916 |
| PubMedSearch : Di Stefano_2023_Eur.J.Med.Chem_263_115916 |
| PubMedID: 37976705 |
| Title : Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives - Bononi_2022_J.Med.Chem__ |
| Author(s) : Bononi G , Di Stefano M , Poli G , Ortore G , Meier P , Masetto F , Caligiuri I , Rizzolio F , Macchia M , Chicca A , Avan A , Giovannetti E , Vagaggini C , Brai A , Dreassi E , Valoti M , Minutolo F , Granchi C , Gertsch J , Tuccinardi T |
| Ref : Journal of Medicinal Chemistry , : , 2022 |
| Abstract : Bononi_2022_J.Med.Chem__ |
| ESTHER : Bononi_2022_J.Med.Chem__ |
| PubMedSearch : Bononi_2022_J.Med.Chem__ |
| PubMedID: 35522977 |
| Title : Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold - Bononi_2021_Eur.J.Med.Chem_223_113679 |
| Author(s) : Bononi G , Tonarini G , Poli G , Barravecchia I , Caligiuri I , Macchia M , Rizzolio F , Demontis GC , Minutolo F , Granchi C , Tuccinardi T |
| Ref : Eur Journal of Medicinal Chemistry , 223 :113679 , 2021 |
| Abstract : Bononi_2021_Eur.J.Med.Chem_223_113679 |
| ESTHER : Bononi_2021_Eur.J.Med.Chem_223_113679 |
| PubMedSearch : Bononi_2021_Eur.J.Med.Chem_223_113679 |
| PubMedID: 34218085 |
| Title : An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present) - Bononi_2021_Expert.Opin.Ther.Pat_31_153 |
| Author(s) : Bononi G , Poli G , Rizzolio F , Tuccinardi T , Macchia M , Minutolo F , Granchi C |
| Ref : Expert Opin Ther Pat , 31 :153 , 2021 |
| Abstract : Bononi_2021_Expert.Opin.Ther.Pat_31_153 |
| ESTHER : Bononi_2021_Expert.Opin.Ther.Pat_31_153 |
| PubMedSearch : Bononi_2021_Expert.Opin.Ther.Pat_31_153 |
| PubMedID: 33085920 |
| Title : Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors - Granchi_2020_Eur.J.Med.Chem_209_112857 |
| Author(s) : Granchi C , Bononi G , Ferrisi R , Gori E , Mantini G , Glasmacher S , Poli G , Palazzolo S , Caligiuri I , Rizzolio F , Canzonieri V , Perin T , Gertsch J , Sodi A , Giovannetti E , Macchia M , Minutolo F , Tuccinardi T , Chicca A |
| Ref : Eur Journal of Medicinal Chemistry , 209 :112857 , 2020 |
| Abstract : Granchi_2020_Eur.J.Med.Chem_209_112857 |
| ESTHER : Granchi_2020_Eur.J.Med.Chem_209_112857 |
| PubMedSearch : Granchi_2020_Eur.J.Med.Chem_209_112857 |
| PubMedID: 33045662 |
| Gene_locus related to this paper: human-MGLL |
| Title : Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study - Jha_2020_Molecules_26_ |
| Author(s) : Jha V , Biagi M , Spinelli V , Di Stefano M , Macchia M , Minutolo F , Granchi C , Poli G , Tuccinardi T |
| Ref : Molecules , 26 : , 2020 |
| Abstract : Jha_2020_Molecules_26_ |
| ESTHER : Jha_2020_Molecules_26_ |
| PubMedSearch : Jha_2020_Molecules_26_ |
| PubMedID: 33375358 |
| Title : Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors - Poli_2019_J.Enzyme.Inhib.Med.Chem_34_589 |
| Author(s) : Poli G , Lapillo M , Jha V , Mouawad N , Caligiuri I , Macchia M , Minutolo F , Rizzolio F , Tuccinardi T , Granchi C |
| Ref : J Enzyme Inhib Med Chem , 34 :589 , 2019 |
| Abstract : Poli_2019_J.Enzyme.Inhib.Med.Chem_34_589 |
| ESTHER : Poli_2019_J.Enzyme.Inhib.Med.Chem_34_589 |
| PubMedSearch : Poli_2019_J.Enzyme.Inhib.Med.Chem_34_589 |
| PubMedID: 30696302 |
| Gene_locus related to this paper: human-MGLL |
| Title : Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system - Gado_2019_Bioorg.Chem__103353 |
| Author(s) : Gado F , Arena C , Fauci C , Reynoso-Moreno I , Bertini S , Digiacomo M , Meini S , Poli G , Macchia M , Tuccinardi T , Gertsch J , Chicca A , Manera C |
| Ref : Bioorg Chem , :103353 , 2019 |
| Abstract : Gado_2019_Bioorg.Chem__103353 |
| ESTHER : Gado_2019_Bioorg.Chem__103353 |
| PubMedSearch : Gado_2019_Bioorg.Chem__103353 |
| PubMedID: 31668465 |
| Title : Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors - Bononi_2018_Eur.J.Med.Chem_157_817 |
| Author(s) : Bononi G , Granchi C , Lapillo M , Giannotti M , Nieri D , Fortunato S , Boustani ME , Caligiuri I , Poli G , Carlson KE , Kim SH , Macchia M , Martinelli A , Rizzolio F , Chicca A , Katzenellenbogen JA , Minutolo F , Tuccinardi T |
| Ref : Eur Journal of Medicinal Chemistry , 157 :817 , 2018 |
| Abstract : Bononi_2018_Eur.J.Med.Chem_157_817 |
| ESTHER : Bononi_2018_Eur.J.Med.Chem_157_817 |
| PubMedSearch : Bononi_2018_Eur.J.Med.Chem_157_817 |
| PubMedID: 30144699 |
| Title : Rational Development of MAGL Inhibitors - Granchi_2018_Methods.Mol.Biol_1824_335 |
| Author(s) : Granchi C , Rizzolio F , Caligiuri I , Macchia M , Martinelli A , Minutolo F , Tuccinardi T |
| Ref : Methods Mol Biol , 1824 :335 , 2018 |
| Abstract : Granchi_2018_Methods.Mol.Biol_1824_335 |
| ESTHER : Granchi_2018_Methods.Mol.Biol_1824_335 |
| PubMedSearch : Granchi_2018_Methods.Mol.Biol_1824_335 |
| PubMedID: 30039417 |
| Title : Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system - Chicca_2018_Eur.J.Med.Chem_154_155 |
| Author(s) : Chicca A , Arena C , Bertini S , Gado F , Ciaglia E , Abate M , Digiacomo M , Lapillo M , Poli G , Bifulco M , Macchia M , Tuccinardi T , Gertsch J , Manera C |
| Ref : Eur Journal of Medicinal Chemistry , 154 :155 , 2018 |
| Abstract : Chicca_2018_Eur.J.Med.Chem_154_155 |
| ESTHER : Chicca_2018_Eur.J.Med.Chem_154_155 |
| PubMedSearch : Chicca_2018_Eur.J.Med.Chem_154_155 |
| PubMedID: 29793210 |
| Title : Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors - Aghazadeh Tabrizi_2018_J.Med.Chem_61_1340 |
| Author(s) : Aghazadeh Tabrizi M , Baraldi PG , Baraldi S , Ruggiero E , De Stefano L , Rizzolio F , Di Cesare Mannelli L , Ghelardini C , Chicca A , Lapillo M , Gertsch J , Manera C , Macchia M , Martinelli A , Granchi C , Minutolo F , Tuccinardi T |
| Ref : Journal of Medicinal Chemistry , 61 :1340 , 2018 |
| Abstract : Aghazadeh Tabrizi_2018_J.Med.Chem_61_1340 |
| ESTHER : Aghazadeh Tabrizi_2018_J.Med.Chem_61_1340 |
| PubMedSearch : Aghazadeh Tabrizi_2018_J.Med.Chem_61_1340 |
| PubMedID: 29309142 |
| Title : Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease - Chen_2017_Eur.J.Med.Chem_125_784 |
| Author(s) : Chen Z , Digiacomo M , Tu Y , Gu Q , Wang S , Yang X , Chu J , Chen Q , Han Y , Chen J , Nesi G , Sestito S , Macchia M , Rapposelli S , Pi R |
| Ref : Eur Journal of Medicinal Chemistry , 125 :784 , 2017 |
| Abstract : Chen_2017_Eur.J.Med.Chem_125_784 |
| ESTHER : Chen_2017_Eur.J.Med.Chem_125_784 |
| PubMedSearch : Chen_2017_Eur.J.Med.Chem_125_784 |
| PubMedID: 27736684 |
| Title : Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors - Granchi_2016_J.Med.Chem_59_10299 |
| Author(s) : Granchi C , Rizzolio F , Palazzolo S , Carmignani S , Macchia M , Saccomanni G , Manera C , Martinelli A , Minutolo F , Tuccinardi T |
| Ref : Journal of Medicinal Chemistry , 59 :10299 , 2016 |
| Abstract : Granchi_2016_J.Med.Chem_59_10299 |
| ESTHER : Granchi_2016_J.Med.Chem_59_10299 |
| PubMedSearch : Granchi_2016_J.Med.Chem_59_10299 |
| PubMedID: 27809504 |
| Title : 4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors - Granchi_2016_J.Enzyme.Inhib.Med.Chem_31_137 |
| Author(s) : Granchi C , Rizzolio F , Bordoni V , Caligiuri I , Manera C , Macchia M , Minutolo F , Martinelli A , Giordano A , Tuccinardi T |
| Ref : J Enzyme Inhib Med Chem , 31 :137 , 2016 |
| Abstract : Granchi_2016_J.Enzyme.Inhib.Med.Chem_31_137 |
| ESTHER : Granchi_2016_J.Enzyme.Inhib.Med.Chem_31_137 |
| PubMedSearch : Granchi_2016_J.Enzyme.Inhib.Med.Chem_31_137 |
| PubMedID: 25669350 |
| Title : Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD - Digiacomo_2015_Bioorg.Med.Chem.Lett_25_807 |
| Author(s) : Digiacomo M , Chen Z , Wang S , Lapucci A , Macchia M , Yang X , Chu J , Han Y , Pi R , Rapposelli S |
| Ref : Bioorganic & Medicinal Chemistry Lett , 25 :807 , 2015 |
| Abstract : Digiacomo_2015_Bioorg.Med.Chem.Lett_25_807 |
| ESTHER : Digiacomo_2015_Bioorg.Med.Chem.Lett_25_807 |
| PubMedSearch : Digiacomo_2015_Bioorg.Med.Chem.Lett_25_807 |
| PubMedID: 25597007 |
| Title : Identification and characterization of a new reversible MAGL inhibitor - Tuccinardi_2014_Bioorg.Med.Chem_22_3285 |
| Author(s) : Tuccinardi T , Granchi C , Rizzolio F , Caligiuri I , Battistello V , Toffoli G , Minutolo F , Macchia M , Martinelli A |
| Ref : Bioorganic & Medicinal Chemistry , 22 :3285 , 2014 |
| Abstract : Tuccinardi_2014_Bioorg.Med.Chem_22_3285 |
| ESTHER : Tuccinardi_2014_Bioorg.Med.Chem_22_3285 |
| PubMedSearch : Tuccinardi_2014_Bioorg.Med.Chem_22_3285 |
| PubMedID: 24853323 |