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| Title : The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors - Cox_2016_Bioorg.Med.Chem.Lett_26_2622 |
| Author(s) : Cox JM , Chu HD , Kuethe JT , Gao YD , Scapin G , Eiermann G , He H , Li X , Lyons KA , Metzger J , Petrov A , Wu JK , Xu S , Sinha-Roy R , Weber AE , Biftu T |
| Ref : Bioorganic & Medicinal Chemistry Lett , 26 :2622 , 2016 |
| Abstract : Cox_2016_Bioorg.Med.Chem.Lett_26_2622 |
| ESTHER : Cox_2016_Bioorg.Med.Chem.Lett_26_2622 |
| PubMedSearch : Cox_2016_Bioorg.Med.Chem.Lett_26_2622 |
| PubMedID: 27106708 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors - Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097 |
| Author(s) : Edmondson SD , Mastracchio A , Cox JM , Eiermann GJ , He H , Lyons KA , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Xu S , Zhu B , Thornberry NA , Roy RS , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 19 :4097 , 2009 |
| Abstract : Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097 |
| ESTHER : Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097 |
| PubMedSearch : Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097 |
| PubMedID: 19539471 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors - Edmondson_2008_Bioorg.Med.Chem.Lett_18_2409 |
| Author(s) : Edmondson SD , Wei L , Xu J , Shang J , Xu S , Pang J , Chaudhary A , Dean DC , He H , Leiting B , Lyons KA , Patel RA , Patel SB , Scapin G , Wu JK , Beconi MG , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :2409 , 2008 |
| Abstract : Edmondson_2008_Bioorg.Med.Chem.Lett_18_2409 |
| ESTHER : Edmondson_2008_Bioorg.Med.Chem.Lett_18_2409 |
| PubMedSearch : Edmondson_2008_Bioorg.Med.Chem.Lett_18_2409 |
| PubMedID: 18331795 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes - Chen_2007_Bioorg.Med.Chem.Lett_17_5853 |
| Author(s) : Chen P , Caldwell CG , Mathvink RJ , Leiting B , Marsilio F , Patel RA , Wu JK , He H , Lyons KA , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :5853 , 2007 |
| Abstract : Chen_2007_Bioorg.Med.Chem.Lett_17_5853 |
| ESTHER : Chen_2007_Bioorg.Med.Chem.Lett_17_5853 |
| PubMedSearch : Chen_2007_Bioorg.Med.Chem.Lett_17_5853 |
| PubMedID: 17869513 |
| Title : Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors - Kowalchick_2007_Bioorg.Med.Chem.Lett_17_5934 |
| Author(s) : Kowalchick JE , Leiting B , Pryor KD , Marsilio F , Wu JK , He H , Lyons KA , Eiermann GJ , Petrov A , Scapin G , Patel RA , Thornberry NA , Weber AE , Kim D |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :5934 , 2007 |
| Abstract : Kowalchick_2007_Bioorg.Med.Chem.Lett_17_5934 |
| ESTHER : Kowalchick_2007_Bioorg.Med.Chem.Lett_17_5934 |
| PubMedSearch : Kowalchick_2007_Bioorg.Med.Chem.Lett_17_5934 |
| PubMedID: 17827003 |
| Gene_locus related to this paper: human-DPP4 |
| Title : 4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV - Kaelin_2007_Bioorg.Med.Chem.Lett_17_5806 |
| Author(s) : Kaelin DE , Smenton AL , Eiermann GJ , He H , Leiting B , Lyons KA , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Thornberry NA , Weber AE , Duffy JL |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :5806 , 2007 |
| Abstract : Kaelin_2007_Bioorg.Med.Chem.Lett_17_5806 |
| ESTHER : Kaelin_2007_Bioorg.Med.Chem.Lett_17_5806 |
| PubMedSearch : Kaelin_2007_Bioorg.Med.Chem.Lett_17_5806 |
| PubMedID: 17851076 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: close analogs of JANUVIA (sitagliptin phosphate) - Kim_2007_Bioorg.Med.Chem.Lett_17_3373 |
| Author(s) : Kim D , Kowalchick JE , Edmondson SD , Mastracchio A , Xu J , Eiermann GJ , Leiting B , Wu JK , Pryor KD , Patel RA , He H , Lyons KA , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :3373 , 2007 |
| Abstract : Kim_2007_Bioorg.Med.Chem.Lett_17_3373 |
| ESTHER : Kim_2007_Bioorg.Med.Chem.Lett_17_3373 |
| PubMedSearch : Kim_2007_Bioorg.Med.Chem.Lett_17_3373 |
| PubMedID: 17434732 |
| Title : 4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV - Duffy_2007_Bioorg.Med.Chem.Lett_17_2879 |
| Author(s) : Duffy JL , Kirk BA , Wang L , Eiermann GJ , He H , Leiting B , Lyons KA , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :2879 , 2007 |
| Abstract : Duffy_2007_Bioorg.Med.Chem.Lett_17_2879 |
| ESTHER : Duffy_2007_Bioorg.Med.Chem.Lett_17_2879 |
| PubMedSearch : Duffy_2007_Bioorg.Med.Chem.Lett_17_2879 |
| PubMedID: 17350841 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors - Cox_2007_Bioorg.Med.Chem.Lett_17_4579 |
| Author(s) : Cox JM , Harper B , Mastracchio A , Leiting B , Sinha Roy R , Patel RA , Wu JK , Lyons KA , He H , Xu S , Zhu B , Thornberry NA , Weber AE , Edmondson SD |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :4579 , 2007 |
| Abstract : Cox_2007_Bioorg.Med.Chem.Lett_17_4579 |
| ESTHER : Cox_2007_Bioorg.Med.Chem.Lett_17_4579 |
| PubMedSearch : Cox_2007_Bioorg.Med.Chem.Lett_17_4579 |
| PubMedID: 17562364 |
| Title : Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors - Xu_2006_Bioorg.Med.Chem.Lett_16_5373 |
| Author(s) : Xu J , Wei L , Mathvink RJ , Edmondson SD , Eiermann GJ , He H , Leone JF , Leiting B , Lyons KA , Marsilio F , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 16 :5373 , 2006 |
| Abstract : Xu_2006_Bioorg.Med.Chem.Lett_16_5373 |
| ESTHER : Xu_2006_Bioorg.Med.Chem.Lett_16_5373 |
| PubMedSearch : Xu_2006_Bioorg.Med.Chem.Lett_16_5373 |
| PubMedID: 16919457 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors - Xu_2006_Bioorg.Med.Chem.Lett_16_1346 |
| Author(s) : Xu J , Wei L , Mathvink R , Edmondson SD , Mastracchio A , Eiermann GJ , He H , Leone JF , Leiting B , Lyons KA , Marsilio F , Patel RA , Petrov A , Wu JK , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 16 :1346 , 2006 |
| Abstract : Xu_2006_Bioorg.Med.Chem.Lett_16_1346 |
| ESTHER : Xu_2006_Bioorg.Med.Chem.Lett_16_1346 |
| PubMedSearch : Xu_2006_Bioorg.Med.Chem.Lett_16_1346 |
| PubMedID: 16332437 |
| Title : Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors - Xu_2005_Bioorg.Med.Chem.Lett_15_2533 |
| Author(s) : Xu J , Wei L , Mathvink R , He J , Park YJ , He H , Leiting B , Lyons KA , Marsilio F , Patel RA , Wu JK , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :2533 , 2005 |
| Abstract : Xu_2005_Bioorg.Med.Chem.Lett_15_2533 |
| ESTHER : Xu_2005_Bioorg.Med.Chem.Lett_15_2533 |
| PubMedSearch : Xu_2005_Bioorg.Med.Chem.Lett_15_2533 |
| PubMedID: 15863311 |
| Title : Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole - Ashton_2005_Bioorg.Med.Chem.Lett_15_2253 |
| Author(s) : Ashton WT , Sisco RM , Dong H , Lyons KA , He H , Doss GA , Leiting B , Patel RA , Wu JK , Marsilio F , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :2253 , 2005 |
| Abstract : Ashton_2005_Bioorg.Med.Chem.Lett_15_2253 |
| ESTHER : Ashton_2005_Bioorg.Med.Chem.Lett_15_2253 |
| PubMedSearch : Ashton_2005_Bioorg.Med.Chem.Lett_15_2253 |
| PubMedID: 15837304 |
| Title : Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9 - Lankas_2005_Diabetes_54_2988 |
| Author(s) : Lankas GR , Leiting B , Roy RS , Eiermann GJ , Beconi MG , Biftu T , Chan CC , Edmondson S , Feeney WP , He H , Ippolito DE , Kim D , Lyons KA , Ok HO , Patel RA , Petrov AN , Pryor KA , Qian X , Reigle L , Woods A , Wu JK , Zaller D , Zhang X , Zhu L , Weber AE , Thornberry NA |
| Ref : Diabetes , 54 :2988 , 2005 |
| Abstract : Lankas_2005_Diabetes_54_2988 |
| ESTHER : Lankas_2005_Diabetes_54_2988 |
| PubMedSearch : Lankas_2005_Diabetes_54_2988 |
| PubMedID: 16186403 |
| Title : Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors - Edmondson_2005_Bioorg.Med.Chem.Lett_15_3048 |
| Author(s) : Edmondson SD , Mastracchio A , Duffy JL , Eiermann GJ , He H , Ita I , Leiting B , Leone JF , Lyons KA , Makarewicz AM , Patel RA , Petrov A , Wu JK , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :3048 , 2005 |
| Abstract : Edmondson_2005_Bioorg.Med.Chem.Lett_15_3048 |
| ESTHER : Edmondson_2005_Bioorg.Med.Chem.Lett_15_3048 |
| PubMedSearch : Edmondson_2005_Bioorg.Med.Chem.Lett_15_3048 |
| PubMedID: 15908206 |
| Title : Potent and selective proline derived dipeptidyl peptidase IV inhibitors - Edmondson_2004_Bioorg.Med.Chem.Lett_14_5151 |
| Author(s) : Edmondson SD , Mastracchio A , Beconi M , Colwell LF, Jr. , Habulihaz B , He H , Kumar S , Leiting B , Lyons KA , Mao A , Marsilio F , Patel RA , Wu JK , Zhu L , Thornberry NA , Weber AE , Parmee ER |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :5151 , 2004 |
| Abstract : Edmondson_2004_Bioorg.Med.Chem.Lett_14_5151 |
| ESTHER : Edmondson_2004_Bioorg.Med.Chem.Lett_14_5151 |
| PubMedSearch : Edmondson_2004_Bioorg.Med.Chem.Lett_14_5151 |
| PubMedID: 15380217 |