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| Title : Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes - Biftu_2014_J.Med.Chem_57_3205 |
| Author(s) : Biftu T , Sinha-Roy R , Chen P , Qian X , Feng D , Kuethe JT , Scapin G , Gao YD , Yan Y , Krueger D , Bak A , Eiermann G , He J , Cox J , Hicks J , Lyons K , He H , Salituro G , Tong S , Patel S , Doss G , Petrov A , Wu J , Xu SS , Sewall C , Zhang X , Zhang B , Thornberry NA , Weber AE |
| Ref : Journal of Medicinal Chemistry , 57 :3205 , 2014 |
| Abstract : Biftu_2014_J.Med.Chem_57_3205 |
| ESTHER : Biftu_2014_J.Med.Chem_57_3205 |
| PubMedSearch : Biftu_2014_J.Med.Chem_57_3205 |
| PubMedID: 24660890 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines - Kim_2008_J.Med.Chem_51_589 |
| Author(s) : Kim D , Kowalchick JE , Brockunier LL , Parmee ER , Eiermann GJ , Fisher MH , He H , Leiting B , Lyons K , Scapin G , Patel SB , Petrov A , Pryor KD , Roy RS , Wu JK , Zhang X , Wyvratt MJ , Zhang BB , Zhu L , Thornberry NA , Weber AE |
| Ref : Journal of Medicinal Chemistry , 51 :589 , 2008 |
| Abstract : Kim_2008_J.Med.Chem_51_589 |
| ESTHER : Kim_2008_J.Med.Chem_51_589 |
| PubMedSearch : Kim_2008_J.Med.Chem_51_589 |
| PubMedID: 18201067 |
| Title : Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes - Liang_2007_Bioorg.Med.Chem.Lett_17_1903 |
| Author(s) : Liang GB , Qian X , Feng D , Biftu T , Eiermann G , He H , Leiting B , Lyons K , Petrov A , Sinha-Roy R , Zhang B , Wu J , Zhang X , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :1903 , 2007 |
| Abstract : Liang_2007_Bioorg.Med.Chem.Lett_17_1903 |
| ESTHER : Liang_2007_Bioorg.Med.Chem.Lett_17_1903 |
| PubMedSearch : Liang_2007_Bioorg.Med.Chem.Lett_17_1903 |
| PubMedID: 17291750 |
| Title : (3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)- 1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Biftu_2007_Bioorg.Med.Chem.Lett_17_49 |
| Author(s) : Biftu T , Feng D , Qian X , Liang GB , Kieczykowski G , Eiermann G , He H , Leiting B , Lyons K , Petrov A , Sinha-Roy R , Zhang B , Scapin G , Patel S , Gao YD , Singh S , Wu J , Zhang X , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :49 , 2007 |
| Abstract : Biftu_2007_Bioorg.Med.Chem.Lett_17_49 |
| ESTHER : Biftu_2007_Bioorg.Med.Chem.Lett_17_49 |
| PubMedSearch : Biftu_2007_Bioorg.Med.Chem.Lett_17_49 |
| PubMedID: 17055272 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin - Biftu_2007_Bioorg.Med.Chem.Lett_17_3384 |
| Author(s) : Biftu T , Scapin G , Singh S , Feng D , Becker JW , Eiermann G , He H , Lyons K , Patel S , Petrov A , Sinha-Roy R , Zhang B , Wu J , Zhang X , Doss GA , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :3384 , 2007 |
| Abstract : Biftu_2007_Bioorg.Med.Chem.Lett_17_3384 |
| ESTHER : Biftu_2007_Bioorg.Med.Chem.Lett_17_3384 |
| PubMedSearch : Biftu_2007_Bioorg.Med.Chem.Lett_17_3384 |
| PubMedID: 17433672 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Inhibition of dipeptidyl-peptidase IV does not increase circulating IGF-1 concentrations in growing pigs - Faidley_2006_Exp.Biol.Med.(Maywood)_231_1373 |
| Author(s) : Faidley TD , Leiting B , Pryor KD , Lyons K , Hickey GJ , Thompson DR |
| Ref : Exp Biol Med (Maywood) , 231 :1373 , 2006 |
| Abstract : Faidley_2006_Exp.Biol.Med.(Maywood)_231_1373 |
| ESTHER : Faidley_2006_Exp.Biol.Med.(Maywood)_231_1373 |
| PubMedSearch : Faidley_2006_Exp.Biol.Med.(Maywood)_231_1373 |
| PubMedID: 16946406 |
| Title : (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]tr iazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Edmondson_2006_J.Med.Chem_49_3614 |
| Author(s) : Edmondson SD , Mastracchio A , Mathvink RJ , He J , Harper B , Park YJ , Beconi M , Di Salvo J , Eiermann GJ , He H , Leiting B , Leone JF , Levorse DA , Lyons K , Patel RA , Patel SB , Petrov A , Scapin G , Shang J , Roy RS , Smith A , Wu JK , Xu S , Zhu B , Thornberry NA , Weber AE |
| Ref : Journal of Medicinal Chemistry , 49 :3614 , 2006 |
| Abstract : Edmondson_2006_J.Med.Chem_49_3614 |
| ESTHER : Edmondson_2006_J.Med.Chem_49_3614 |
| PubMedSearch : Edmondson_2006_J.Med.Chem_49_3614 |
| PubMedID: 16759103 |
| Gene_locus related to this paper: human-DPP4 |
| Title : (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)- yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Kim_2005_J.Med.Chem_48_141 |
| Author(s) : Kim D , Wang L , Beconi M , Eiermann GJ , Fisher MH , He H , Hickey GJ , Kowalchick JE , Leiting B , Lyons K , Marsilio F , McCann ME , Patel RA , Petrov A , Scapin G , Patel SB , Roy RS , Wu JK , Wyvratt MJ , Zhang BB , Zhu L , Thornberry NA , Weber AE |
| Ref : Journal of Medicinal Chemistry , 48 :141 , 2005 |
| Abstract : Kim_2005_J.Med.Chem_48_141 |
| ESTHER : Kim_2005_J.Med.Chem_48_141 |
| PubMedSearch : Kim_2005_J.Med.Chem_48_141 |
| PubMedID: 15634008 |
| Gene_locus related to this paper: human-DPP4 |
| Title : 4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors - Parmee_2004_Bioorg.Med.Chem.Lett_14_43 |
| Author(s) : Parmee ER , He J , Mastracchio A , Edmondson SD , Colwell L , Eiermann G , Feeney WP , Habulihaz B , He H , Kilburn R , Leiting B , Lyons K , Marsilio F , Patel RA , Petrov A , Di Salvo J , Wu JK , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :43 , 2004 |
| Abstract : Parmee_2004_Bioorg.Med.Chem.Lett_14_43 |
| ESTHER : Parmee_2004_Bioorg.Med.Chem.Lett_14_43 |
| PubMedSearch : Parmee_2004_Bioorg.Med.Chem.Lett_14_43 |
| PubMedID: 14684294 |