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Author Report for: Kuca K

Contact information:

Kuca Kamil
Faculty of Military Health Sciences; Center of Advanced Studies; Trebesska 1575; Hradec Kralove; 500
Czech Republic
Phone : +420973253028
Fax :
Send E-Mail to Kuca Kamil
Visit the web site of Kuca K at : http://www.unob.cz/en/fmhs/structure/k311/Pages/Kuca.aspx





    Title: Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups
    Bibi S, Habib R, Shafiq S, Abbas SS, Khan S, Eqani S, Nepovimova E, Khan MS, Kuca K, Nurulain SM
    Ref: Sci Total Environ, :163359, 2023 : PubMed

            

    Title: Applications of the Near Attack Conformation (NAC) approach in the search for Acetylcholinesterase reactivators
    Franca TCC, Valle da Silva JA, Dos Santos MC, Cavalcante SFA, Kuca K
    Ref: Chemico-Biological Interactions, 382:110619, 2023 : PubMed

            

    Title: Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes
    Jacevic V, Dumanovic J, Grujic-Milanovic J, Milovanovic Z, Amidzic L, Vojinovic N, Nezic L, Markovic B, Dobricic V and Kuca K <2 more author(s)>
    Ref: Chemico-Biological Interactions, :110658, 2023 : PubMed

            

    Title: Sustainable ionic liquids-based molecular platforms for designing acetylcholinesterase reactivators
    Kapitanov IV, Spulak M, Pour M, Soukup O, Marek J, Jun D, Novak M, Diz de Almeida JSF, Costa Franca TC and Karpichev Y <2 more author(s)>
    Ref: Chemico-Biological Interactions, :110735, 2023 : PubMed

            

    Title: In vitro comparison of the acetylcholinesterase inhibition caused by V- and A-series nerve agents' surrogates
    Kitagawa DAS, Dos Santos MC, Kuca K, Franca TCC, Cavalcante SFA
    Ref: Chemico-Biological Interactions, 383:110678, 2023 : PubMed

            

    Title: Pralidoxime-like reactivator with increased lipophilicity - Molecular modeling and in vitro study
    Kuca K, Valle da Silva JA, Nepovimova E, Pham NL, Wu W, Valis M, Wu Q, Franca TCC
    Ref: Chemico-Biological Interactions, :110734, 2023 : PubMed

            

    Title: The measured CSF/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24h after donepezil treatment in patients with Alzheimer's disease
    Valis M, Dlabkova A, Hort J, Angelucci F, Pejchal J, Kuca K, Pavelek Z, Karasova JZ, Novotny M
    Ref: Biomed Pharmacother, 159:114223, 2023 : PubMed

            

    Title: N-substituted arylhydroxamic acids as acetylcholinesterase reactivators
    Bondar D, Kapitanov I, Pulkrabkova L, Soukup O, Jun D, Diniz FB, Franca TCC, Kuca K, Karpichev Y
    Ref: Chemico-Biological Interactions, :110078, 2022 : PubMed

            

    Title: Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities
    Chrienova Z, Nepovimova E, Andrys R, Dolezal R, Janockova J, Muckova L, Fabova L, Soukup O, Oleksak P and Kuca K <3 more author(s)>
    Ref: J Enzyme Inhib Med Chem, 37:2605, 2022 : PubMed

            

    Title: Multiple Neurological Effects Associated with Exposure to Organophosphorus Pesticides in Man
    Jokanovic M, Oleksak P, Kuca K
    Ref: Toxicology, :153407, 2022 : PubMed

            

    Title: Dysregulation of butyrylcholinesterase, BCHE gene SNP rs1803274, and pro-inflammatory cytokines in occupational workers
    Khan SA, Leonel Javeres MN, Abbas Shah ST, Bibi N, Muneer Z, Hussain S, Nepovimova E, Kuca K, Nurulain SM
    Ref: Environ Research, :115195, 2022 : PubMed

            

    Title: Assessing the therapeutic and toxicological profile of novel acetylcholinesterase reactivators: value of in silico and in vitro data
    Ramalho TC, de Castro AA, Leal DHS, Teixeira JP, de Cunha EFF, Kuca K
    Ref: Curr Med Chem, :, 2022 : PubMed

            

    Title: Theoretical assessment of the performances of commercial oximes on the reactivation of acetylcholinesterase inhibited by the nerve agent A-242 (novichok)
    Santos MC, Botelho FD, Goncalves AS, Kuca K, Nepovimova E, Cavalcante SFA, Lima ALS, Franca TCC
    Ref: Food & Chemical Toxicology, :113084, 2022 : PubMed

            

    Title: Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series?
    Santos MC, Botelho FD, Goncalves AS, Kitagawa DAS, Borges CVN, Carvalho-Silva T, Bernardo LB, Ferreira CN, Rodrigues RB and Cavalcante SFA <6 more author(s)>
    Ref: Archives of Toxicology, :, 2022 : PubMed

            

    Title: Design and synthesis of novel tacrine-indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease
    Hamulakova S, Kudlickova Z, Janovec L, Mezencev R, Deckner ZJ, Chernoff YO, Janockova J, Ihnatova V, Bzonek P and Kuca K <6 more author(s)>
    Ref: Future Med Chem, :, 2021 : PubMed

            

    Title: Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells
    Hudacova M, Hamuakova S, Konkoova E, Jendzelovsky R, Vargova J, Sevc J, Fedorocko P, Soukup O, Janockova J and Kozurkova M <8 more author(s)>
    Ref: Int J Mol Sci, 22:, 2021 : PubMed

            

    Title: Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators
    Kitagawa DAS, Rodrigues RB, Silva TN, Dos Santos WV, da Rocha VCV, de Almeida JSFD, Bernardo LB, Carvalho-Silva T, Ferreira CN and Cavalcante SFA <5 more author(s)>
    Ref: J Enzyme Inhib Med Chem, 36:1370, 2021 : PubMed

            

    Title: Experimental and Established Oximes as Pretreatment before Acute Exposure to Azinphos-Methyl
    Lorke DE, Nurulain SM, Hasan MY, Kuca K, Petroianu GA
    Ref: Int J Mol Sci, 22:, 2021 : PubMed

            

    Title: Ligand-Based Virtual Screening, Molecular Docking, Molecular Dynamics, and MM-PBSA Calculations towards the Identification of Potential Novel Ricin Inhibitors
    Botelho FD, Dos Santos MC, Goncalves ADS, Kuca K, Valis M, LaPlante SR, Franca TCC, de Almeida J
    Ref: Toxins (Basel), 12:, 2020 : PubMed

            

    Title: Acetylcholinesterase: The Hub for Neurodegenerative Diseases and Chemical Weapons Convention
    Cavalcante SFA, Simas ABC, Barcellos MC, de Oliveira VGM, Sousa RB, Cabral PAM, Kuca K, Franca TCC
    Ref: Biomolecules, 10:, 2020 : PubMed

            

    Title: Review about structure and evaluation of reactivators of Acetylcholinesterase inhibited with neurotoxic organophosphorus compounds
    Figueroa-Villar JD, Petronilho EC, Kuca K, Franca TCC
    Ref: Curr Med Chem, :, 2020 : PubMed

            

    Title: Cannabis Constituents and Acetylcholinesterase Interaction: Molecular Docking, In Vitro Studies and Association with CNR1 rs806368 and ACHE rs17228602
    Furqan T, Batool S, Habib R, Shah M, Kalasz H, Darvas F, Kuca K, Nepovimova E, Nurulain SM
    Ref: Biomolecules, 10:, 2020 : PubMed

            

    Title: Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors
    Gorecki L, Andrys R, Schmidt M, Kucera T, Psotka M, Svobodova B, Hrabcova V, Hepnarova V, Bzonek P and Musilek K <3 more author(s)>
    Ref: ACS Med Chem Lett, 11:65, 2020 : PubMed

            

    Title: Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness
    Karasova JZ, Hepnarova V, Andrys R, Lisa M, Jost P, Muckova L, Pejchal J, Herman D, Jun D and Kuca K <1 more author(s)>
    Ref: Toxicol Lett, 320:64, 2020 : PubMed

            

    Title: Donepezil and Rivastigmine: Pharmacokinetic Profile and Brain-targeting After Intramuscular Administration in Rats
    Karasova JZ, Hrabinova M, Krejciova M, Jun D, Kuca K
    Ref: Iran J Pharm Res, 19:95, 2020 : PubMed

            

    Title: Analysis of PON1 gene polymorphisms (rs662 and rs854560) and inflammatory markers in organophosphate pesticides exposed cohorts from two distinct populations
    Leonel Javeres MN, Habib R, Judith N, Iqbal M, Nepovimova E, Kuca K, Batool S, Nurulain SM
    Ref: Environ Research, :110210, 2020 : PubMed

            

    Title: Combined Pre- and Posttreatment of Paraoxon Exposure
    Lorke DE, Nurulain SM, Hasan MY, Kuca K, Petroianu GA
    Ref: Molecules, 25:, 2020 : PubMed

            

    Title: Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators
    Malinak D, Dolezal R, Hepnarova V, Hozova M, Andrys R, Bzonek P, Racakova V, Korabecny J, Gorecki L and Musilek K <4 more author(s)>
    Ref: J Enzyme Inhib Med Chem, 35:478, 2020 : PubMed

            

    Title: Oxidative Stress and Analysis of Selected SNPs of ACHE (rs 2571598), BCHE (rs 3495), CAT (rs 7943316), SIRT1 (rs 10823108), GSTP1 (rs 1695), and Gene GSTM1, GSTT1 in Chronic Organophosphates Exposed Groups from Cameroon and Pakistan
    Mbah Ntepe LJ, Habib R, Judith Laure N, Raza S, Nepovimova E, Kuca K, Batool S, Muhammad Nurulain S
    Ref: Int J Mol Sci, 21:, 2020 : PubMed

            

    Title: Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimes drugs dealing with cholinergic, amyloid and mitochondrial systems
    Nepovimova E, Svobodova L, Dolezal R, Hepnarova V, Junova L, Jun D, Korabecny J, Kucera T, Gazova Z and Kuca K <20 more author(s)>
    Ref: Bioorg Chem, 107:104596, 2020 : PubMed

            

    Title: Interaction of Synthesized Nitrogen enriched Graphene Quantum Dots with Novel Anti-Alzheimer's Drugs: Spectroscopic Insights
    Sharma S, Singh N, Nepovimova E, Korabecny J, Kuca K, Satnami ML, Ghosh KK
    Ref: J Biomol Struct Dyn, 38:1822, 2020 : PubMed

            

    Title: Glycosylated-Imidazole Aldoximes as Reactivators of Pesticides Inhibited AChE: Synthesis and In-vitro Reactivation Study
    Sharma R, Upadhyaya K, Gupta B, Ghosh KK, Tripathi RP, Musilek K, Kuca K
    Ref: Environ Toxicol Pharmacol, :103454, 2020 : PubMed

            

    Title: An update on T-2 toxin and its modified forms: metabolism, immunotoxicity mechanism, and human exposure assessment
    Wu Q, Qin Z, Kuca K, You L, Zhao Y, Liu A, Musilek K, Chrienova Z, Nepovimova E and Wang X <2 more author(s)>
    Ref: Archives of Toxicology, 94:3645, 2020 : PubMed

            

    Title: Reactivation of VX-Inhibited Human Acetylcholinesterase by Deprotonated Pralidoxime. A Complementary Quantum Mechanical Study
    da Silva JAV, Pereira AF, LaPlante SR, Kuca K, Ramalho TC, Franca TCC
    Ref: Biomolecules, 10:, 2020 : PubMed

            

    Title: Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016-2019)
    de Castro AA, Assis LC, Soares FV, Kuca K, Polisel DA, da Cunha EFF, Ramalho TC
    Ref: Biomolecules, 10:, 2020 : PubMed

            

    Title: Understanding the Interaction Modes and Reactivity of Trimedoxime toward MmAChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects
    de Castro AA, Polisel DA, Pereira BTL, da Cunha EFF, Kuca K, Nepovimova E, Ramalho TC
    Ref: Int J Mol Sci, 21:, 2020 : PubMed

            

    Title: Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation
    Antonijevic E, Musilek K, Kuca K, Djukic-Cosic D, Andjelkovic M, Djordjevic AB, Antonijevic B
    Ref: Chemico-Biological Interactions, 308:385, 2019 : PubMed

            

    Title: Some Possibilities to Study New Prophylactics against Nerve Agents
    Bajgar J, Kassa J, Kucera T, Musilek K, Jun D, Kuca K
    Ref: Mini Rev Med Chem, 19:970, 2019 : PubMed

            

    Title: Biodegradation of Organophosphorus Compounds Predicted by Enzymatic Process Using Molecular Modelling and Observed in Soil Samples Through Analytical Techniques and Microbiological Analysis: A Comparison
    Cardozo M, de Almeida J, Cavalcante SFA, Salgado JRS, Goncalves AS, Franca TCC, Kuca K, Bizzo HR
    Ref: Molecules, 25:, 2019 : PubMed

            

    Title: Synthesis and in vitro evaluation of neutral aryloximes as reactivators of Electrophorus eel acetylcholinesterase inhibited by NEMP, a VX surrogate
    Cavalcante SFA, Kitagawa DAS, Rodrigues RB, Bernardo LB, da Silva TN, Dos Santos WV, Correa ABA, de Almeida JSFD, Franca TCC and Simas ABC <1 more author(s)>
    Ref: Chemico-Biological Interactions, 309:108682, 2019 : PubMed

            

    Title: Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
    Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ and Kuca K <25 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 168:491, 2019 : PubMed

            

    Title: Molecular dynamics simulation and binding free energy studies of novel leads belonging to the benzofuran class inhibitors of Mycobacterium tuberculosis Polyketide Synthase 13
    Cruz JN, Costa JFS, Khayat AS, Kuca K, Barros CAL, Neto A
    Ref: J Biomol Struct Dyn, 37:1616, 2019 : PubMed

            

    Title: Novichoks: The Dangerous Fourth Generation of Chemical Weapons
    Franca TCC, Kitagawa DAS, Cavalcante SFA, da Silva JAV, Nepovimova E, Kuca K
    Ref: Int J Mol Sci, 20:, 2019 : PubMed

            

    Title: Oxime K203: a drug candidate for the treatment of tabun intoxication
    Gorecki L, Soukup O, Kucera T, Malinak D, Jun D, Kuca K, Musilek K, Korabecny J
    Ref: Archives of Toxicology, 93:673, 2019 : PubMed

            

    Title: Reactivation potency of two novel oximes (K456 and K733) against paraoxon-inhibited acetyl and butyrylcholinesterase: In silico and in vitro models
    Iqbal A, Malik S, Nurulain SM, Musilek K, Kuca K, Kalasz H, Fatmi MQ
    Ref: Chemico-Biological Interactions, 310:108735, 2019 : PubMed

            

    Title: Toxic Injury to Muscle Tissue of Rats Following Acute Oximes Exposure
    Jacevic V, Nepovimova E, Kuca K
    Ref: Sci Rep, 9:1457, 2019 : PubMed

            

    Title: Interspecies and intergender differences in acute toxicity of K-oximes drug candidates
    Jacevic V, Nepovimova E, Kuca K
    Ref: Chemico-Biological Interactions, 308:312, 2019 : PubMed

            

    Title: In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers
    Janockova J, Korabecny J, Plsikova J, Babkova K, Konkolova E, Kucerova D, Vargova J, Koval J, Jendzelovsky R and Kozurkova M <7 more author(s)>
    Ref: J Enzyme Inhib Med Chem, 34:877, 2019 : PubMed

            

    Title: Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats
    Karasova JZ, Soukup O, Korabecny J, Hroch M, Krejciova M, Hrabinova M, Misik J, Novotny L, Hepnarova V, Kuca K
    Ref: Drug & Chemical Toxicology, :1, 2019 : PubMed

            

    Title: In Vitro Evaluation of Neutral Aryloximes as Reactivators for Electrophorus eel Acetylcholinesterase Inhibited by Paraoxon
    Kitagawa DAS, Cavalcante SFA, de Paula RL, Rodrigues RB, Bernardo LB, da Silva MCJ, da Silva TN, Dos Santos WV, Granjeiro JM and Simas ABC <5 more author(s)>
    Ref: Biomolecules, 9:, 2019 : PubMed

            

    Title: Oximes as pretreatment before acute exposure to paraoxon
    Lorke DE, Nurulain SM, Hasan MY, Kuca K, Petroianu GA
    Ref: J Appl Toxicol, 39:1506, 2019 : PubMed

            

    Title: Donepezil Derivatives Targeting Amyloid-beta Cascade in Alzheimer's Disease
    Mezeiova E, Chalupova K, Nepovimova E, Gorecki L, Prchal L, Malinak D, Kuca K, Soukup O, Korabecny J
    Ref: Curr Alzheimer Res, 16:772, 2019 : PubMed

            

    Title: N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy
    Nepovimova E, Korabecny J, Hepnarova V, Jun D, Dolezal R, Muckova L, Jost P, Soukup O, Janockova J and Kuca K <3 more author(s)>
    Ref: Curr Alzheimer Res, 16:333, 2019 : PubMed

            

    Title: Orexin supplementation in narcolepsy treatment: A review
    Nepovimova E, Janockova J, Misik J, Kubik S, Stuchlik A, Vales K, Korabecny J, Mezeiova E, Dolezal R and Kuca K <5 more author(s)>
    Ref: Med Res Rev, 39:961, 2019 : PubMed

            

    Title: Slight difference in the isomeric oximes K206 and K203 makes huge difference for the reactivation of organophosphorus-inhibited AChE: Theoretical and experimental aspects
    Polisel DA, de Castro AA, Mancini DT, da Cunha EFF, Franca TCC, Ramalho TC, Kuca K
    Ref: Chemico-Biological Interactions, 309:108671, 2019 : PubMed

            

    Title: Traditional Ayurvedic and herbal remedies for Alzheimer's disease: from bench to bedside
    Sharma R, Kuca K, Nepovimova E, Kabra A, Rao MM, Prajapati PK
    Ref: Expert Rev Neurother, 19:359, 2019 : PubMed

            

    Title: Pharmacokinetics of K117 and K127, two novel antidote candidates to treat Tabun poisoning
    Tekes K, Karvaly G, Nurulain S, Kuca K, Musilek K, Adeghate E, Jung YS, Kalasz H
    Ref: Chemico-Biological Interactions, 310:108737, 2019 : PubMed

            

    Title: Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes
    Zorbaz T, Malinak D, Kuca K, Musilek K, Kovarik Z
    Ref: Chemico-Biological Interactions, 307:16, 2019 : PubMed

            

    Title: Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach
    da Silva JAV, Nepovimova E, Ramalho TC, Kuca K, Franca TCC
    Ref: J Enzyme Inhib Med Chem, 34:1018, 2019 : PubMed

            

    Title: Molecular modelling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime with VX-inhibited human acetylcholinesterase. A near attack approach to assess different spacer-lengths
    da Silva JAV, Nepovimova E, Ramalho TC, Kuca K, Franca TCC
    Ref: Chemico-Biological Interactions, 307:195, 2019 : PubMed

            

    Title: Surface screening, molecular modeling and in vitro studies on the interactions of aflatoxin M1 and human enzymes acetyl- and butyrylcholinesterase
    de Almeida JSFD, Cavalcante SFA, Dolezal R, Kuca K, Musilek K, Jun D, Franca TCC
    Ref: Chemico-Biological Interactions, 308:113, 2019 : PubMed

            

    Title: Non-conventional compounds with potential therapeutic effects against Alzheimer's disease
    de Castro AA, Soares FV, Pereira AF, Polisel DA, Caetano MS, Leal DHS, da Cunha EFF, Nepovimova E, Kuca K, Ramalho TC
    Ref: Expert Rev Neurother, 19:375, 2019 : PubMed

            

    Title: Synthesis of New Quinoline-Piperonal Hybrids as Potential Drugs against Alzheimer's Disease
    de Oliveira CBJ, Neto DCF, de Almeida JSFD, Lima JA, Kuca K, Franca TCC, Figueroa-Villar JD
    Ref: Int J Mol Sci, 20:, 2019 : PubMed

            

    Title: Quantification through TLC-densitometric analysis, repellency and anticholinesterase activity of the homemade extract of Indian cloves
    Affonso RS, Lima JA, Lessa BM, Caetano JVO, Obara MT, Nobrega AB, Nepovimova E, Musilek K, Kuca K and Franca TCC <1 more author(s)>
    Ref: Biomedical Chromatography, 32:, 2018 : PubMed

            

    Title: Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain
    Antonijevic E, Kotur-Stevuljevic J, Musilek K, Kosvancova A, Kuca K, Djukic-Cosic D, Spasojevic-Kalimanovska V, Antonijevic B
    Ref: Archives of Toxicology, 92:745, 2018 : PubMed

            

    Title: Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes
    Antonijevic E, Musilek K, Kuca K, Djukic-Cosic D, Curcic M, Miladinovic DC, Bulat Z, Antonijevic B
    Ref: Food & Chemical Toxicology, 121:224, 2018 : PubMed

            

    Title: In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication
    Arshad M, Fatmi MQ, Musilek K, Hussain A, Kuca K, Petroianu G, Kalasz H, Nurulain SM
    Ref: Toxicol Mech Methods, 28:62, 2018 : PubMed

            

    Title: Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier
    Hamulakova S, Janovec L, Soukup O, Jun D, Janockova J, Hrabinova M, Sepsova V, Kuca K
    Ref: Curr Alzheimer Res, 15:1096, 2018 : PubMed

            

    Title: The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease
    Hepnarova V, Korabecny J, Matouskova L, Jost P, Muckova L, Hrabinova M, Vykoukalova N, Kerhartova M, Kucera T and Soukup O <9 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 150:292, 2018 : PubMed

            

    Title: Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods
    Janockova J, Dolezal R, Nepovimova E, Kobrlova T, Benkova M, Kuca K, Konecny J, Mezeiova E, Melikova M and Korabecny J <3 more author(s)>
    Ref: Molecules, 23:, 2018 : PubMed

            

    Title: Newly Developed Drugs for Alzheimer's Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission
    Korabecny J, Nepovimova E, Cikankova T, Spilovska K, Vaskova L, Mezeiova E, Kuca K, Hroudova J
    Ref: Neuroscience, 370:191, 2018 : PubMed

            

    Title: A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase
    Kuca K, Musilek K, Jun D, Karasova JZ, Nepovimova E, Soukup O, Hrabinova M, Mikler J, Franca TCC and Ramalho TC <3 more author(s)>
    Ref: BMC Pharmacol Toxicol, 19:8, 2018 : PubMed

            

    Title: Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings
    Kuca K, Karasova JZ, Soukup O, Kassa J, Novotna E, Sepsova V, Horova A, Pejchal J, Hrabinova M and Musilek K <4 more author(s)>
    Ref: Drug Des Devel Ther, 12:505, 2018 : PubMed

            

    Title: Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon
    Kuca K, Jun D, Junova L, Musilek K, Hrabinova M, da Silva JAV, Ramalho TC, Valko M, Wu Q and Franca TCC <1 more author(s)>
    Ref: Molecules, 23:, 2018 : PubMed

            

    Title: Novel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking Study
    Malinak D, Nepovimova E, Jun D, Musilek K, Kuca K
    Ref: Molecules, 23:, 2018 : PubMed

            

    Title: A Review of the Synthesis of Quaternary Acetylcholinesterase Reactivators
    Malinak D, Korabecny J, Soukup O, Gorecki L, Nepovimova E, Psotka M, Dolezal R, Nguyen TD, Mezeiova E and Kuca K <1 more author(s)>
    Ref: Current Organic Chemistry, 22":1619, 2018 : PubMed

            

    Title: Profiling donepezil template into multipotent hybrids with antioxidant properties
    Mezeiova E, Spilovska K, Nepovimova E, Gorecki L, Soukup O, Dolezal R, Malinak D, Janockova J, Jun D and Korabecny J <1 more author(s)>
    Ref: J Enzyme Inhib Med Chem, 33:583, 2018 : PubMed

            

    Title: Chemical warfare agent NOVICHOK - mini-review of available data
    Nepovimova E, Kuca K
    Ref: Food & Chemical Toxicology, 121:343, 2018 : PubMed

            

    Title: Theoretical Studies Applied to the Evaluation of the DFPase Bioremediation Potential against Chemical Warfare Agents Intoxication
    Soares FV, de Castro AA, Pereira AF, Leal DHS, Mancini DT, Krejcar O, Ramalho TC, da Cunha EFF, Kuca K
    Ref: Int J Mol Sci, 19:, 2018 : PubMed

            

    Title: In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
    Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R and Kuca K <12 more author(s)>
    Ref: Med Chem, 14:281, 2018 : PubMed

            

    Title: The New Acetylcholinesterase Inhibitors PC-37 and PC-48 (7-Methoxytacrine-Donepezil-Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics and In Vivo Formation of the Major Metabolites in Rats
    Karasova JZ, Mzik M, Hroch M, Korabecny J, Nepovimova E, Vorisek V, Palicka V, Kuca K
    Ref: Basic Clin Pharmacol Toxicol, 122:373, 2018 : PubMed

            

    Title: Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents
    Zorbaz T, Malinak D, Marakovic N, Macek Hrvat N, Zandona A, Novotny M, Skarka A, Andrys R, Benkova M and Musilek K <4 more author(s)>
    Ref: Journal of Medicinal Chemistry, 61:10753, 2018 : PubMed

            

    Title: Molecular modeling studies on the interactions of aflatoxin B1 and its metabolites with the peripheral anionic site (PAS) of human acetylcholinesterase
    de Almeida JSFD, Cavalcante SFA, Dolezal R, Kuca K, Musilek K, Jun D, Franca TCC
    Ref: J Biomol Struct Dyn, :1, 2018 : PubMed

            

    Title: Molecular Modeling Studies on the Interactions of Aflatoxin B1 and Its Metabolites with Human Acetylcholinesterase. Part II: Interactions with the Catalytic Anionic Site (CAS)
    de Almeida JSFD, Dolezal R, Krejcar O, Kuca K, Musilek K, Jun D, Franca TCC
    Ref: Toxins (Basel), 10:, 2018 : PubMed

            

    Title: Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon
    de Paula RL, de Almeida JSFD, Cavalcante SFA, Goncalves AS, Simas ABC, Franca TCC, Valis M, Kuca K, Nepovimova E, Granjeiro JM
    Ref: Molecules, 23:, 2018 : PubMed

            

    Title: Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors
    Babkova K, Korabecny J, Soukup O, Nepovimova E, Jun D, Kuca K
    Ref: Future Med Chem, 9:1015, 2017 : PubMed

            

    Title: The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: A computational study
    Cuya T, Goncalves ADS, da Silva JAV, Ramalho TC, Kuca K, Franca TCC
    Ref: J Biomol Struct Dyn, :1, 2017 : PubMed

            

    Title: Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment
    Gazova Z, Soukup O, Sepsova V, Siposova K, Drtinova L, Jost P, Spilovska K, Korabecny J, Nepovimova E and Kuca K <5 more author(s)>
    Ref: Biochimica & Biophysica Acta Mol Basis Dis, 1863:607, 2017 : PubMed

            

    Title: Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016)
    Gorecki L, Korabecny J, Musilek K, Nepovimova E, Malinak D, Kucera T, Dolezal R, Jun D, Soukup O, Kuca K
    Ref: Expert Opin Ther Pat, 27:971, 2017 : PubMed

            

    Title: Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids
    Hamulakova S, Janovec L, Soukup O, Jun D, Kuca K
    Ref: Int J Biol Macromol, 104:333, 2017 : PubMed

            

    Title: The pharmacology of tacrine at N-methyl-d-aspartate receptors
    Horak M, Holubova K, Nepovimova E, Krusek J, Kaniakova M, Korabecny J, Vyklicky L, Kuca K, Stuchlik A and Soukup O <2 more author(s)>
    Ref: Prog Neuropsychopharmacol Biological Psychiatry, 75:54, 2017 : PubMed

            

    Title: Pharmacokinetic profile of promising acetylcholinesterase reactivators K027 and K203 in experimental pigs
    Karasova JZ, Kvetina J, Tacheci I, Radochova V, Musilek K, Kuca K, Bures J
    Ref: Toxicol Lett, 273:20, 2017 : PubMed

            

    Title: Activity of cholinesterases in a young and healthy middle-European population: Relevance for toxicology, pharmacology and clinical praxis
    Karasova JZ, Maderycova Z, Tumova M, Jun D, Rehacek V, Kuca K, Misik J
    Ref: Toxicol Lett, 277:24, 2017 : PubMed

            

    Title: Optimal Pre-treatment for Acute Exposure to the Organophosphate Dicrotophos
    Lorke DE, Nurulain SM, Hasan MY, Kuca K, Petroianu GA
    Ref: Curr Pharm Des, 23:3432, 2017 : PubMed

            

    Title: Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy
    Mezeiova E, Korabecny J, Sepsova V, Hrabinova M, Jost P, Muckova L, Kucera T, Dolezal R, Misik J and Kuca K <7 more author(s)>
    Ref: Molecules, 22:, 2017 : PubMed

            

    Title: HLo-7 - A review of acetylcholinesterase reactivator against organophosphorus intoxication
    Psotka M, Malinak D, Gorecki L, Nguyen TD, Soukup O, Jun D, Kuca K, Musilek K, Korabecny J
    Ref: Military Medical Science Letters, 86:70, 2017 : PubMed

            

    Title: Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment
    Soukup O, Winder M, Killi UK, Wsol V, Jun D, Kuca K, Tobin G
    Ref: Curr Neuropharmacol, 15:637, 2017 : PubMed

            

    Title: Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation
    Spilovska K, Korabecny J, Sepsova V, Jun D, Hrabinova M, Jost P, Muckova L, Soukup O, Janockova J and Kuca K <4 more author(s)>
    Ref: Molecules, 22:, 2017 : PubMed

            

    Title: Multitarget Tacrine Hybrids with Neuroprotective Properties to Confront Alzheimer's Disease
    Spilovska K, Korabecny J, Nepovimova E, Dolezal R, Mezeiova E, Soukup O, Kuca K
    Ref: Curr Top Med Chem, 17:1006, 2017 : PubMed

            

    Title: Behavior of uncharged oximes compared to HI6 and 2-PAM in the human AChE-Tabun conjugate: A molecular modeling approach
    de Souza FR, Garcia DR, Guizado TC, Kuca K, de Alencastro RB, Franca TCC
    Ref: J Biomol Struct Dyn, :1, 2017 : PubMed

            

    Title: Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor
    Antonijevic E, Musilek K, Kuca K, Djukic-Cosic D, Vucinic S, Antonijevic B
    Ref: Neurotoxicology, 55:33, 2016 : PubMed

            

    Title: Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease
    Benek O, Soukup O, Pasdiorova M, Hroch L, Sepsova V, Jost P, Hrabinova M, Jun D, Kuca K and Musilek K <3 more author(s)>
    Ref: ChemMedChem, 11:1264, 2016 : PubMed

            

    Title: Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies
    Dolezal R, Soukup O, Malinak D, Savedra RML, Marek J, Dolezalova M, Pasdiorova M, Salajkova S, Korabecny J and Kuca K <2 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 121:699, 2016 : PubMed

            

    Title: SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides
    Gorecki L, Korabecny J, Musilek K, Malinak D, Nepovimova E, Dolezal R, Jun D, Soukup O, Kuca K
    Ref: Archives of Toxicology, 90:2831, 2016 : PubMed

            

    Title: Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules
    Hamulakova S, Poprac P, Jomova K, Brezova V, Lauro P, Drostinova L, Jun D, Sepsova V, Hrabinova M and Valko M <5 more author(s)>
    Ref: J Inorg Biochem, 161:52, 2016 : PubMed

            

    Title: Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity
    Janockova J, Zilecka E, Kasparkova J, Brabec V, Soukup O, Kuca K, Kozurkova M
    Ref: Mol Biosyst, 12:2910, 2016 : PubMed

            

    Title: Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease
    Jerabek J, Uliassi E, Guidotti L, Korabecny J, Soukup O, Sepsova V, Hrabinova M, Kuca K, Bartolini M and Bolognesi ML <4 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 127:250, 2016 : PubMed

            

    Title: Small Quaternary Inhibitors K298 and K524: Cholinesterases Inhibition, Absorption, Brain Distribution, and Toxicity
    Karasova JZ, Hroch M, Musilek K, Kuca K
    Ref: Neurotox Res, 29:267, 2016 : PubMed

            

    Title: Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1
    Kristofikova Z, Ricny J, Soukup O, Korabecny J, Nepovimova E, Kuca K, Ripova D
    Ref: Dementia & Geriatric Cognitive Disorders, 43:45, 2016 : PubMed

            

    Title: Monooxime Bispyridinium Reactivators Bearing Xylene Linker Synthesis and In Vitro Evaluation on Model of Organophosphate-Inhibited Acetylcholinesterase
    Musilek K, Hambalek J, Holas O, Dohnal V, Kuca K
    Ref: Med Chem, 12:362, 2016 : PubMed

            

    Title: An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study
    Mzik M, Korabecny J, Nepovimova E, Vorisek V, Palicka V, Kuca K, Karasova JZ
    Ref: Journal of Chromatography B Analyt Technol Biomed Life Sciences, 1020:85, 2016 : PubMed

            

    Title: A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication
    Nepovimova E, Korabecny J, Dolezal R, Nguyen TD, Jun D, Soukup O, Pasdiorova M, Jost P, Muckova L and Kuca K <3 more author(s)>
    Ref: Toxicol Res (Camb), 5:1012, 2016 : PubMed

            

    Title: Blood-fetus penetration of pralidoxime
    Ojha S, Nurulain SM, Dhanasekaran S, Shafiullah M, Adem A, Sharma C, Kuca K, Kalasz H
    Ref: Military Medical Science Letters, 85:63, 2016 : PubMed

            

    Title: Computational Enzymology and Organophosphorus Degrading Enzymes: Promising Approaches Toward Remediation Technologies of Warfare Agents and Pesticides
    Ramalho TC, de Castro AA, Silva DR, Silva MC, Franca TCC, Bennion BJ, Kuca K
    Ref: Curr Med Chem, 23:1041, 2016 : PubMed

            

    Title: Oxime-mediated in vitro reactivation kinetic analysis of organophosphates-inhibited human and electric eel acetylcholinesterase
    Sahu AK, Sharma R, Gupta B, Musilek K, Kuca K, Acharya J, Ghosh KK
    Ref: Toxicol Mech Methods, :1, 2016 : PubMed

            

    Title: Evaluation of possible inhibition of human liver drug metabolizing cytochromes P450 by two new acetylcholinesterase oxime-type reactivators
    Spicakova A, Anzenbacher P, Liskova B, Kuca K, Fusek J, Anzenbacherova E
    Ref: Food & Chemical Toxicology, 88:100, 2016 : PubMed

            

    Title: Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase
    Winter M, Wille T, Musilek K, Kuca K, Thiermann H, Worek F
    Ref: Toxicol Lett, 244:136, 2016 : PubMed

            

    Title: Impact of tacrine and 7-methoxytacrine on gastric myoelectrical activity assessed using electrogastrography in experimental pigs
    Bures J, Jun D, Hrabinova M, Tacheci I, Kvetina J, Pavlik M, Rejchrt S, Douda T, Kunes M and Kopacova M <1 more author(s)>
    Ref: Neuro Endocrinol Lett, 36:, 2015 : PubMed

            

    Title: Ligand-based 3D QSAR analysis of reactivation potency of mono- and bis-pyridinium aldoximes toward VX-inhibited rat acetylcholinesterase
    Dolezal R, Korabecny J, Malinak D, Honegr J, Musilek K, Kuca K
    Ref: J Mol Graph Model, 56:113, 2015 : PubMed

            

    Title: Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agents
    Giacoppo JO, Franca TCC, Kuca K, da Cunha EFF, Abagyan R, Mancini DT, Ramalho TC
    Ref: J Biomol Struct Dyn, 33:2048, 2015 : PubMed

            

    Title: Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase
    Horn G, Wille T, Musilek K, Kuca K, Thiermann H, Worek F
    Ref: Archives of Toxicology, 89:405, 2015 : PubMed

            

    Title: 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment
    Korabecny J, Andrs M, Nepovimova E, Dolezal R, Babkova K, Horova A, Malinak D, Mezeiova E, Gorecki L and Kuca K <4 more author(s)>
    Ref: Molecules, 20:22084, 2015 : PubMed

            

    Title: Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE
    Kuca K, Hrabinova M, Jun D, Musilek K, Penhaker M, Krejcar O, Soukup O
    Ref: Med Chem, 11:683, 2015 : PubMed

            

    Title: Development and validation of a FIA/UV-vis method for pK determination of oxime based acetylcholinesterase reactivators
    Musil K, Florianova V, Bucek P, Dohnal V, Kuca K, Musilek K
    Ref: J Pharm Biomed Anal, 117:240, 2015 : PubMed

            

    Title: Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity
    Nepovimova E, Korabecny J, Dolezal R, Babkova K, Ondrejicek A, Jun D, Sepsova V, Horova A, Hrabinova M and Kuca K <7 more author(s)>
    Ref: Journal of Medicinal Chemistry, 58:8985, 2015 : PubMed

            

    Title: Reversible cholinesterase inhibitors as pre-treatment for exposure to organophosphates: assessment using azinphos-methyl
    Petroianu GA, Nurulain SM, Hasan MY, Kuca K, Lorke DE
    Ref: J Appl Toxicol, 35:493, 2015 : PubMed

            

    Title: Cholinergic properties of new 7-methoxytacrine-donepezil derivatives
    Sepsova V, Karasova JZ, Tobin G, Jun D, Korabecny J, Cabelova P, Janska K, Krusek J, Skrenkova K and Soukup O <1 more author(s)>
    Ref: Gen Physiol Biophys, 34:189, 2015 : PubMed

            

    Title: Development and Structural Modifications of Cholinesterase Reactivators against Chemical Warfare Agents in Last Decade: A Review
    Sharma R, Gupta B, Singh N, Acharya JR, Musilek K, Kuca K, Ghosh KK
    Ref: Mini Rev Med Chem, 15:58, 2015 : PubMed

            

    Title: Preparation, in vitro screening and molecular modelling of monoquaternary compounds related to the selective acetylcholinesterase inhibitor BW284c51
    Benek O, Musilek K, Horova A, Dohnal V, Dolezal R, Kuca K
    Ref: Med Chem, 11:21, 2014 : PubMed

            

    Title: Chemical warfare: perspectives on reactivating the enzyme acetylcholinesterase inhibited by organophosphates
    Giacoppo JO, de Lima WE, Kuca K, da Cunha EFF, Franca TCC, Ramalho TC
    Ref: Military Medical Science Letters, 83:165, 2014 : PubMed

            

    Title: In vitro reactivation kinetics of paraoxon- and DFP-inhibited electric eel AChE using mono- and bis-pyridinium oximes
    Gupta B, Sharma R, Singh N, Kuca K, Acharya JR, Ghosh KK
    Ref: Archives of Toxicology, 88:381, 2014 : PubMed

            

    Title: Assessment of antidotal efficacy of cholinesterase reactivators against paraoxon: In vitro reactivation kinetics and physicochemical properties
    Gupta B, Singh N, Sharma R, Foretic B, Musilek K, Kuca K, Acharya J, Satnami ML, Ghosh KK
    Ref: Bioorganic & Medicinal Chemistry Lett, 24:4743, 2014 : PubMed

            

    Title: Novel tacrine/acridine anticholinesterase inhibitors with piperazine and thiourea linkers
    Hamulakova S, Imrich J, Janovec L, Kristian P, Danihel I, Holas O, Pohanka M, Bohm S, Kozurkova M, Kuca K
    Ref: Int J Biol Macromol, 70C:435, 2014 : PubMed

            

    Title: Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors
    Hamulakova S, Janovec L, Hrabinova M, Spilovska K, Korabecny J, Kristian P, Kuca K, Imrich J
    Ref: Journal of Medicinal Chemistry, 57:7073, 2014 : PubMed

            

    Title: In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat
    Killi UK, Wsol V, Soukup O, Kuca K, Winder M, Tobin G
    Ref: Clinical & Experimental Pharmacology & Physiology, 41:139, 2014 : PubMed

            

    Title: 7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies
    Korabecny J, Dolezal R, Cabelova P, Horova A, Hruba E, Ricny J, Sedlacek L, Nepovimova E, Spilovska K and Kuca K <5 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 82C:426, 2014 : PubMed

            

    Title: From Pyridinium-based to Centrally Active Acetylcholinesterase Reactivators
    Korabecny J, Soukup O, Dolezal R, Spilovska K, Nepovimova E, Andrs M, Nguyen TD, Jun D, Musilek K and Kuca K <1 more author(s)>
    Ref: Mini Rev Med Chem, 14:215, 2014 : PubMed

            

    Title: HI-6 oxime (an acetylcholinesterase reactivator): blood plasma pharmacokinetics and organ distribution in experimental pigs
    Kunes M, Kvetina J, Bures J, Karasova JZ, Pavlik M, Tacheci I, Musilek K, Kuca K
    Ref: Neuro Endocrinol Lett, 35:186, 2014 : PubMed

            

    Title: Prophylactic administration of non-organophosphate cholinesterase inhibitors before acute exposure to organophosphates: assessment using terbufos sulfone
    Lorke DE, Nurulain SM, Hasan MY, Kuca K, Petroianu GA
    Ref: J Appl Toxicol, 34:1096, 2014 : PubMed

            

    Title: Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects
    Nepovimova E, Uliassi E, Korabecny J, Pena-Altamira LE, Samez S, Pesaresi A, Garcia GE, Bartolini M, Andrisano V and Bolognesi ML <6 more author(s)>
    Ref: Journal of Medicinal Chemistry, 57:8576, 2014 : PubMed

            

    Title: Structural modifications of dicationic acetylcholinesterase reactivators studied under ion-pairing mechanism in reversed-phase liquid chromatography
    Radulescu M, Kuca K, Musilek K, David V
    Ref: J Sep Sci, 37:3024, 2014 : PubMed

            

    Title: The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor
    Sepsova V, Krusek J, Karasova JZ, Zemek F, Musilek K, Kuca K, Soukup O
    Ref: Physiol Res, 63:771, 2014 : PubMed

            

    Title: Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update
    Wu QH, Wang X, Yang W, Nussler AK, Xiong LY, Kuca K, Dohnal V, Zhang XJ, Yuan ZH
    Ref: Archives of Toxicology, 88:1309, 2014 : PubMed

            

    Title: Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine
    Zemek F, Drtinova L, Nepovimova E, Sepsova V, Korabecny J, Klimes J, Kuca K
    Ref: Expert Opin Drug Safety, 13:759, 2014 : PubMed

            

    Title: In vivo evaluation of cholinesterase activity, oxidative stress markers, cyto- and genotoxicity of K048 oxime-a promising antidote against organophosphate poisoning
    Zunec S, Kopjar N, Zeljezic D, Kuca K, Musilek K, Lucic Vrdoljak A
    Ref: Basic Clin Pharmacol Toxicol, 114:344, 2014 : PubMed

            

    Title: In silico pharmacophore modeling on known pyridinium oxime reactivators of cyclosarin (GF) inhibited AChE to Aid discovery of potential, more efficacious novel non-oxime reactivators
    Bhattacharjee AK, Musilek K, Kuca K
    Ref: Curr Comput Aided Drug Des, 9:402, 2013 : PubMed

            

    Title: Impact of paraoxon followed by acetylcholinesterase reactivator HI-6 on gastric myoelectric activity in experimental pigs
    Bures J, Kvetina J, Pavlik M, Kunes M, Kopacova M, Rejchrt S, Jun D, Hrabinova M, Kuca K, Tacheci I
    Ref: Neuro Endocrinol Lett, 34:79, 2013 : PubMed

            

    Title: Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities
    Cahlikova L, Hrabinova M, Kulhankova A, Benesova N, Chlebek J, Jun D, Novak Z, Macakova K, Kunes J and Opletal L <1 more author(s)>
    Ref: Nat Prod Commun, 8:1541, 2013 : PubMed

            

    Title: selective monitoring of enzymatic activity of acetylcholinesterase by flow injection analysis with mass spectrometric detection
    Dohnal V, Dohnalova L, Jun D, Kuca K
    Ref: Military Medical Science Letters, 82:120, 2013 : PubMed

            

    Title: Novel cholinesterase modulators and their ability to interact with DNA
    Janockova J, Gulasova Z, Musilek K, Kuca K, Kozurkova M
    Ref: Spectrochim Acta A Mol Biomol Spectrosc, 115C:364, 2013 : PubMed

            

    Title: Interaction of cholinesterase modulators with DNA and their cytotoxic activity
    Janockova J, Gulasova Z, Plsikova J, Musilek K, Kuca K, Mikes J, Culka L, Fedorocko P, Kozurkova M
    Ref: Int J Biol Macromol, 64C:53, 2013 : PubMed

            

    Title: Intravenous application of HI-6 salts (dichloride and dimethansulphonate) in pigs: comparison with pharmacokinetics profile after intramuscular administration
    Karasova JZ, Zemek F, Kunes M, Kvetina J, Chladek J, Jun D, Bures J, Tacheci I, Kuca K
    Ref: Neuro Endocrinol Lett, 34:74, 2013 : PubMed

            

    Title: Pharmacokinetic study of two acetylcholinesterase reactivators, trimedoxime and newly synthesized oxime K027, in rat plasma
    Karasova JZ, Chladek J, Hroch M, Josef F, Hnidkova D, Kuca K
    Ref: J Appl Toxicol, 33:18, 2013 : PubMed

            

    Title: Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors
    Komloova M, Horova A, Hrabinova M, Jun D, Dolezal M, Vinsova J, Kuca K, Musilek K
    Ref: Bioorganic & Medicinal Chemistry Lett, 23:6663, 2013 : PubMed

            

    Title: Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX
    Kuca K, Musilek K, Jun D, Karasova J, Soukup O, Pejchal J, Hrabinova M
    Ref: Med Chem, 9:689, 2013 : PubMed

            

    Title: Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides
    Kuca K, Jun D, Musilek K, Pohanka M, Karasova JZ, Soukup O
    Ref: Mini Rev Med Chem, 13:2102, 2013 : PubMed

            

    Title: Usefulness of administration of non-organophosphate cholinesterase inhibitors before acute exposure to organophosphates: assessment using paraoxon
    Petroianu GA, Nurulain SM, Shafiullah M, Hasan MY, Kuca K, Lorke DE
    Ref: Journal of Applied Toxicology, 33:894, 2013 : PubMed

            

    Title: Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study
    Sepsova V, Karasova JZ, Korabecny J, Dolezal R, Zemek F, Bennion BJ, Kuca K
    Ref: Int J Mol Sci, 14:16882, 2013 : PubMed

            

    Title: Physicochemical properties and supernucleophilicity of oxime-functionalized surfactants: hydrolytic catalysts toward dephosphorylation of di- and triphosphate esters
    Singh N, Karpichev Y, Gupta B, Satnami ML, Marek J, Kuca K, Ghosh KK
    Ref: J Phys Chem B, 117:3806, 2013 : PubMed

            

    Title: The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors
    Soukup O, Jun D, Tobin G, Kuca K
    Ref: Archives of Toxicology, 87:711, 2013 : PubMed

            

    Title: A Resurrection of 7-MEOTA: A Comparison with Tacrine
    Soukup O, Jun D, Karasova JZ, Patocka J, Musilek K, Korabecny J, Krusek J, Kaniakova M, Sepsova V and Kuca K <6 more author(s)>
    Ref: Curr Alzheimer Res, 10:893, 2013 : PubMed

            

    Title: 7-methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in alzheimer's disease treatment, synthesis, biological evaluation and molecular modeling studies
    Spilovska K, Korabecny J, Kral J, Horova A, Musilek K, Soukup O, Drtinova L, Gazova Z, Siposova K, Kuca K
    Ref: Molecules, 18:2397, 2013 : PubMed

            

    Title: An in silico stereo-electronic comparison of conventional pyridinium oximes and K-oximes for organophosphate (OP) poisoning
    Bhattacharjee AK, Kuca K, Musilek K, Gordon RK
    Ref: Med Chem, 8:230, 2012 : PubMed

            

    Title: Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease
    Hamulakova S, Janovec L, Hrabinova M, Kristian P, Kuca K, Banasova M, Imrich J
    Ref: Eur Journal of Medicinal Chemistry, 55:23, 2012 : PubMed

            

    Title: The progress in the cholinesterase quantification methods
    Holas O, Musilek K, Pohanka M, Kuca K
    Ref: Expert Opin Drug Discov, 7:1207, 2012 : PubMed

            

    Title: Two possibilities how to increase the efficacy of antidotal treatment of nerve agent poisonings
    Kassa J, Musilek K, Karasova JZ, Kuca K, Bajgar J
    Ref: Mini Rev Med Chem, 12:24, 2012 : PubMed

            

    Title: [Tacrine and its derivatives in the therapy of Alzheimers disease]
    Korabecny J, Spilovska K, Benek O, Musilek K, Soukup O, Kuca K
    Ref: Ceska a Slovenska Farmacie, 61:210, 2012 : PubMed

            

    Title: Acetylcholinesterase Inhibitors as Pretreatment before Acute Exposure to Organophosphates: Assessment Using Methyl-paraoxon
    Lorke DE, Hasan MY, Nurulain SM, Shafiullah MS, Kuca K, Petroianu GA
    Ref: CNS Neurol Disord Drug Targets, 11:1052, 2012 : PubMed

            

    Title: First principles calculations of thermodynamics and kinetic parameters and molecular dynamics simulations of acetylcholinesterase reactivators: can mouse data provide new insights into humans?
    Matos KS, da Cunha EFF, da Silva Goncalves A, Wilter A, Kuca K, Franca TCC, Ramalho TC
    Ref: J Biomol Struct Dyn, 30:546, 2012 : PubMed

            

    Title: In vivo decontamination of the nerve agent VX using the domestic swine model
    Misik J, Pavlik M, Novotny L, Pavlikova R, Chilcott RP, Cabal J, Kuca K
    Ref: Clinical Toxicology (Phila), 50:807, 2012 : PubMed

            

    Title: The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers
    Soukup O, Kristofikova Z, Jun D, Tambor V, Ripova D, Kuca K
    Ref: Toxicol Lett, 212:315, 2012 : PubMed

            

    Title: Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase
    Worek F, von der Wellen J, Musilek K, Kuca K, Thiermann H
    Ref: Archives of Toxicology, 86:1379, 2012 : PubMed

            

    Title: In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase
    Jun D, Musilova L, Musilek K, Kuca K
    Ref: Int J Mol Sci, 12:2077, 2011 : PubMed

            

    Title: Partition of bispyridinium oximes (trimedoxime and K074) administered in therapeutic doses into different parts of the rat brain
    Karasova JZ, Zemek F, Bajgar J, Vasatova M, Prochazka P, Novotny L, Kuca K
    Ref: J Pharm Biomed Anal, 54:1082, 2011 : PubMed

            

    Title: Human serum butyrylcholinesterase as a prophylaxis against russian VX
    Karasova JZ, Kuca K, Jun D, Bajgar J
    Ref: Military Medical Science Letters, 80:97, 2011 : PubMed

            

    Title: Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment
    Komloova M, Musilek K, Horova A, Holas O, Dohnal V, Gunn-Moore F, Kuca K
    Ref: Bioorganic & Medicinal Chemistry Lett, 21:2505, 2011 : PubMed

            

    Title: Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties
    Korabecny J, Musilek K, Zemek F, Horova A, Holas O, Nepovimova E, Opletalova V, Hroudova J, Fisar Z and Kuca K <1 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 21:6563, 2011 : PubMed

            

    Title: On the universality of oxime Hl-7 - antidote for case of the nerve agent poisoning
    Kuca K, Musilek K, Karasova J, Jun D, Soukup O, Pohanka M, Ghosh KK, Hrabinova M
    Ref: Military Medical Science Letters, 80:80, 2011 : PubMed

            

    Title: Pretreatment for acute exposure to diisopropylfluorophosphate: in vivo efficacy of various acetylcholinesterase inhibitors
    Lorke DE, Hasan MY, Nurulain SM, Shafiullah M, Kuca K, Petroianu GA
    Ref: Journal of Applied Toxicology, 31:515, 2011 : PubMed

            

    Title: Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128
    Musilek K, Roder J, Komloova M, Holas O, Hrabinova M, Pohanka M, Dohnal V, Opletalova V, Kuca K, Jung YS
    Ref: Bioorganic & Medicinal Chemistry Lett, 21:150, 2011 : PubMed

            

    Title: Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking
    Musilek K, Komloova M, Holas O, Horova A, Pohanka M, Gunn-Moore F, Dohnal V, Dolezal M, Kuca K
    Ref: Bioorganic & Medicinal Chemistry, 19:754, 2011 : PubMed

            

    Title: Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment
    Musilek K, Komloova M, Holas O, Hrabinova M, Pohanka M, Dohnal V, Nachon F, Dolezal M, Kuca K
    Ref: Eur Journal of Medicinal Chemistry, 46:811, 2011 : PubMed

            

    Title: The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage
    Musilek K, Pavlikova R, Marek J, Komloova M, Holas O, Hrabinova M, Pohanka M, Dohnal V, Dolezal M and Kuca K <1 more author(s)>
    Ref: J Enzyme Inhib Med Chem, 26:245, 2011 : PubMed

            

    Title: Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides
    Musilek K, Dolezal M, Gunn-Moore F, Kuca K
    Ref: Med Res Rev, 31:548, 2011 : PubMed

            

    Title: Anatoxin-a(s): natural organophosphorus anticholinesterase agent
    Patocka J, Gupta RC, Kuca K
    Ref: Military Medical Science Letters, 80:129, 2011 : PubMed

            

    Title: Assessment of acetylcholinesterase activity using indoxylacetate and comparison with the standard Ellman's method
    Pohanka M, Hrabinova M, Kuca K, Simonato JP
    Ref: Int J Mol Sci, 12:2631, 2011 : PubMed

            

    Title: Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model
    Pohanka M, Pikula J, Kuca K, Kassa J
    Ref: Bratislavske Lekarske Listy, 112:539, 2011 : PubMed

            

    Title: Oximes as inhibitors of acetylholinesterase - a structure-activity relationship (SAR) study
    Sepsova V, Karasova JZ, Zemek F, Bennion BJ, Kuca K
    Ref: Military Medical Science Letters, 80:178, 2011 : PubMed

            

    Title: The effect of oxime reactivators on muscarinic receptors: functional and binding examinations
    Soukup O, Kumar UK, Proska J, Bratova L, Adem A, Jun D, Fusek J, Kuca K, Tobin G
    Ref: Environ Toxicol Pharmacol, 31:364, 2011 : PubMed

            

    Title: Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors
    Soukup O, Krusek J, Kaniakova M, Kumar UK, Oz M, Jun D, Fusek J, Kuca K, Tobin G
    Ref: Physiol Res, 60:679, 2011 : PubMed

            

    Title: Method optimization for acetylcholinesterase modulators-albumin interactions
    Zemek F, Karasova JZ, Musilek K, Kuca K
    Ref: Military Medical Science Letters, 80:58, 2011 : PubMed

            

    Title: Effects of K074 and pralidoxime on antioxidant and acetylcholinesterase response in malathion-poisoned mice
    Dos Santos AA, dos Santos DB, Ribeiro RP, Colle D, Peres KC, Hermes J, Barbosa AM, Dafre AL, de Bem AF and Farina M <1 more author(s)>
    Ref: Neurotoxicology, 32:888, 2011 : PubMed

            

    Title: A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques
    Bajgar J, Hajek P, Karasova JZ, Kassa J, Paseka A, Slizova D, Krs O, Kuca K, Jun D and Capek L <1 more author(s)>
    Ref: J Enzyme Inhib Med Chem, 25:790, 2010 : PubMed

            

    Title: In vivo experimental approach to treatment against tabun poisoning
    Zunec S, Katalinic M, Vrdoljak AL, Kovarik Z, Kuca K, Radic B
    Ref: J Enzyme Inhib Med Chem, 25:531, 2010 : PubMed

            

    Title: The antidotal efficacy of the bispyridinium oximes K027 and TMB-4 against tabun poisoning in mice
    Zunec S, Radic B, Kuca K, Lucic Vrdoljak A
    Ref: Chemico-Biological Interactions, 187:291, 2010 : PubMed

            

    Title: In silico pharmacophore model for tabun-inhibited acetylcholinesterase reactivators: a study of their stereoelectronic properties
    Bhattacharjee AK, Kuca K, Musilek K, Gordon RK
    Ref: Chemical Research in Toxicology, 23:26, 2010 : PubMed

            

    Title: High-performance liquid chromatography analysis of by-products and intermediates arising during the synthesis of the acetylcholinesterase reactivator HI-6
    Jun D, Stodulka P, Kuca K, Dolezal B
    Ref: Journal of Chromatography Sci, 48:694, 2010 : PubMed

            

    Title: Time-dependent changes in concentration of two clinically used acetylcholinesterase reactivators (HI-6 and obidoxime) in rat plasma determined by HPLC techniques after in vivo administration
    Karasova JZ, Novotny L, Antos K, Zivna H, Kuca K
    Ref: Anal Sci, 26:63, 2010 : PubMed

            

    Title: Passive diffusion of acetylcholinesterase oxime reactivators through the blood-brain barrier: influence of molecular structure
    Karasova JZ, Pohanka M, Musilek K, Zemek F, Kuca K
    Ref: Toxicol In Vitro, 24:1838, 2010 : PubMed

            

    Title: Is Oxime Fluorination the Proper Way to Increase Penetration of These Compounds in the Central Nervous System?
    Karasova JZ, Kassa J, Musilek K, Jung Y, Kuca K
    Ref: Military Medical Science Letters, 79:23, 2010 : PubMed

            

    Title: A Comparison of Neuroprotective Efficacy of the Oxime K203 and its Fluorinated Analogue (KR-22836) with Obidoxime in Tabun-Poisoned Rats
    Kassa J, Karasova JZ, Tesarova S, Musilek K, Kuca K, Jung YS
    Ref: Basic Clin Pharmacol Toxicol, 107:861, 2010 : PubMed

            

    Title: A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice
    Kassa J, Karasova JZ, Caisberger F, Musilek K, Kuca K, Jung YS
    Ref: J Enzyme Inhib Med Chem, 25:480, 2010 : PubMed

            

    Title: A comparison of the reactivating and therapeutic efficacy of newly developed oximes (K347, K628) with commonly used oximes (obidoxime, HI-6) against tabun in rats and mice
    Kassa J, Karasova JZ, Kuca K, Musilek K
    Ref: Drug & Chemical Toxicology, 33:227, 2010 : PubMed

            

    Title: Structure-activity relationship of quaternary acetylcholinesterase inhibitors - outlook for early myasthenia gravis treatment
    Komloova M, Musilek K, Dolezal M, Gunn-Moore F, Kuca K
    Ref: Curr Med Chem, 17:1810, 2010 : PubMed

            

    Title: Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease
    Korabecny J, Musilek K, Holas O, Binder J, Zemek F, Marek J, Pohanka M, Opletalova V, Dohnal V, Kuca K
    Ref: Bioorganic & Medicinal Chemistry Lett, 20:6093, 2010 : PubMed

            

    Title: Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment
    Korabecny J, Musilek K, Holas O, Nepovimova E, Jun D, Zemek F, Opletalova V, Patocka J, Dohnal V and Kuca K <3 more author(s)>
    Ref: Molecules, 15:8804, 2010 : PubMed

            

    Title: Pseudo-catalytic scavenging: searching for a suitable reactivator of phosphorylated butyrylcholinesterase
    Kovarik Z, Katalinic M, Sinko G, Binder J, Holas O, Jung YS, Musilova L, Jun D, Kuca K
    Ref: Chemico-Biological Interactions, 187:167, 2010 : PubMed

            

    Title: Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase
    Kuca K, Musilek K, Jun D, Pohanka M, Ghosh KK, Hrabinova M
    Ref: J Enzyme Inhib Med Chem, 25:509, 2010 : PubMed

            

    Title: Pralidoxime--the gold standard of acetylcholinesterase reactivators--reactivation in vitro efficacy
    Kuca K, Hrabinova M, Soukup O, Tobin G, Karasova J, Pohanka M
    Ref: Bratislavske Lekarske Listy, 111:502, 2010 : PubMed

            

    Title: Monooxime-monocarbamoyl Bispyridinium Xylene-Linked Reactivators of Acetylcholinesterase-Synthesis, In vitro and Toxicity Evaluation, and Docking Studies
    Musilek K, Holas O, Misik J, Pohanka M, Novotny L, Dohnal V, Opletalova V, Kuca K
    Ref: ChemMedChem, 5:247, 2010 : PubMed

            

    Title: Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications
    Musilek K, Komloova M, Zavadova V, Holas O, Hrabinova M, Pohanka M, Dohnal V, Nachon F, Dolezal M and Jung YS <1 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 20:1763, 2010 : PubMed

            

    Title: New Bisquaternary Inhibitors of Acetylcholinesterase Used as a Prophylactics in Organophosphorus Poisoning
    Pavlikova R, Marek J, Musilek K, Fusek J, Kuca K, Karasova JZ
    Ref: Military Medical Science Letters, 79:46, 2010 : PubMed

            

    Title: Colorimetric dipstick for assay of organophosphate pesticides and nerve agents represented by paraoxon, sarin and VX
    Pohanka M, Karasova JZ, Kuca K, Pikula J, Holas O, Korabecny J, Cabal J
    Ref: Talanta, 81:621, 2010 : PubMed

            

    Title: Evaluation of aflatoxin B1--acetylcholinesterase dissociation kinetic using the amperometric biosensor technology: prospect for toxicity mechanism
    Pohanka M, Musilek K, Kuca K
    Ref: Protein Pept Lett, 17:340, 2010 : PubMed

            

    Title: Modulation of ionising radiation generated oxidative stress by HI-6 (asoxime) in a laboratory rat model
    Pohanka M, Pejchal J, Horackova S, Kuca K, Bandouchova H, Damkova V, Pikula J
    Ref: Neuro Endocrinol Lett, 31 Suppl 2:62, 2010 : PubMed

            

    Title: Colorimetric Detectors Based on Acetylcholinesterase and Its Construction
    Pohanka M, Vlcek V, Karasova JZ, Kuca K, Cabal J
    Ref: Military Medical Science Letters, 79:9, 2010 : PubMed

            

    Title: Immobilization of Acetylcholinesterase and a Construction of Biochemical Biosensor for Identification of Toxic Organophosphates.
    Pohanka M, Drobik O, Krenkova Z, Karasova JZ, Cabal J, Kuca K
    Ref: Military Medical Science Letters, 79:105, 2010 : PubMed

            

    Title: Testing of a Referential Method Based on Indoxylacetate as a Acetylcholinesterase Substrate for Identification of Reactivation Efficacy.
    Pohanka M, Hrabinova M, Karasova JZ, Holas O, Kuca K, Cabal J
    Ref: Military Medical Science Letters, 79:111, 2010 : PubMed

            

    Title: Development of new acetylcholinesterase reactivators: molecular modeling versus in vitro data
    Ramalho TC, Franca TCC, Renno MN, Guimaraes AP, da Cunha EFF, Kuca K
    Ref: Chemico-Biological Interactions, 185:73, 2010 : PubMed

            

    Title: Novel acetylcholinesterase reactivator K112 and its cholinergic properties
    Soukup O, Kristofikova Z, Proska J, Tobin G, Patocka J, Marek J, Jun D, Fusek J, Ripova D, Kuca K
    Ref: Biomed Pharmacother, 64:541, 2010 : PubMed

            

    Title: Interaction of nerve agent antidotes with cholinergic systems
    Soukup O, Tobin G, Kumar UK, Binder J, Proska J, Jun D, Fusek J, Kuca K
    Ref: Curr Med Chem, 17:1708, 2010 : PubMed

            

    Title: Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder
    Soukup O, Tobin G, Kumar UK, Jun D, Fusek J, Kuca K
    Ref: Toxicol Mech Methods, 20:428, 2010 : PubMed

            

    Title: Why acetylcholinesterase reactivators do not work in butyrylcholinesterase
    Wiesner J, Kriz Z, Kuca K, Jun D, Koca J
    Ref: J Enzyme Inhib Med Chem, 25:318, 2010 : PubMed

            

    Title: Influence of the acetylcholinesterase active site protonation on omega loop and active site dynamics
    Wiesner J, Kriz Z, Kuca K, Jun D, Koca J
    Ref: J Biomol Struct Dyn, 28:393, 2010 : PubMed

            

    Title: In vitro reactivating effects of standard and newly developed oximes on malaoxon-inhibited mouse brain acetylcholinesterase
    Dos Santos AA, dos Santos DB, Dafre AL, de Bem AF, Souza DO, da Rocha JB, Kuca K, Farina M
    Ref: Basic Clin Pharmacol Toxicol, 107:768, 2010 : PubMed

            

    Title: Chemical aspects of pharmacological prophylaxis against nerve agent poisoning
    Bajgar J, Fusek J, Kassa J, Kuca K, Jun D
    Ref: Curr Med Chem, 16:2977, 2009 : PubMed

            

    Title: Different inhibition of acetylcholinesterase in selected parts of the rat brain following intoxication with VX and Russian VX
    Hajek P, Bajgar J, Slizova D, Krs O, Kuca K, Capek L, Fusek J
    Ref: Drug & Chemical Toxicology, 32:1, 2009 : PubMed

            

    Title: Fluorinated pyridinium oximes as potential reactivators for acetylcholinesterases inhibited by paraoxon organophosphorus agent
    Jeong HC, Park NJ, Chae CH, Musilek K, Kassa J, Kuca K, Jung YS
    Ref: Bioorganic & Medicinal Chemistry, 17:6213, 2009 : PubMed

            

    Title: Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX
    Karasova JZ, Bajgar J, Jun D, Pavlikova R, Kuca K
    Ref: Neurotox Res, 16:356, 2009 : PubMed

            

    Title: Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats
    Karasova JZ, Kassa J, Musilek K, Pohanka M, Novotny L, Kuca K
    Ref: Int J Mol Sci, 10:3065, 2009 : PubMed

            

    Title: An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice
    Kassa J, Karasova J, Musilek K, Kuca K, Bajgar J
    Ref: Clinical Toxicology (Phila), 47:72, 2009 : PubMed

            

    Title: A comparison of reactivating and therapeutic efficacy of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice
    Kassa J, Karasova JZ, Musilek K, Kuca K
    Ref: Toxicol Mech Methods, 19:346, 2009 : PubMed

            

    Title: A comparison of the neuroprotective efficacy of newly developed oximes (K117, K127) and currently available oxime (obidoxime) in tabun-poisoned rats
    Kassa J, Karasova JZ, Musilek K, Kuca K, Jung AY
    Ref: Toxicol Mech Methods, 19:232, 2009 : PubMed

            

    Title: Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127
    Kuca K, Cabal J, Jung YS, Musilek K, Soukup O, Jun D, Pohanka M, Musilova L, Karasova J and Hrabinova M <1 more author(s)>
    Ref: Basic Clin Pharmacol Toxicol, 105:207, 2009 : PubMed

            

    Title: Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon
    Kuca K, Musilova L, Palecek J, Cirkva V, Paar M, Musilek K, Hrabinova M, Pohanka M, Karasova JZ, Jun D
    Ref: Molecules, 14:4915, 2009 : PubMed

            

    Title: Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6
    Lorke DE, Hasan MY, Nurulain SM, Kuca K, Schmitt A, Petroianu GA
    Ref: Toxicol Mech Methods, 19:327, 2009 : PubMed

            

    Title: Efficacy of eight experimental bispyridinium oximes against paraoxon-induced mortality: comparison with the conventional oximes pralidoxime and obidoxime
    Nurulain SM, Lorke DE, Hasan MY, Shafiullah M, Kuca K, Musilek K, Petroianu GA
    Ref: Neurotox Res, 16:60, 2009 : PubMed

            

    Title: Effect of five acetylcholinesterase reactivators on tabun-intoxicated rats: induction of oxidative stress versus reactivation efficacy
    Pohanka M, Karasova JZ, Musilek K, Kuca K, Kassa J
    Ref: J Appl Toxicol, 29:483, 2009 : PubMed

            

    Title: Progress of biosensors based on cholinesterase inhibition
    Pohanka M, Musilek K, Kuca K
    Ref: Curr Med Chem, 16:1790, 2009 : PubMed

            

    Title: In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048
    Pohanka M, Jun D, Kuca K
    Ref: J Enzyme Inhib Med Chem, 24:680, 2009 : PubMed

            

    Title: Effect of acetylcholinesterase oxime-type reactivators K-48 and HI-6 on human liver microsomal cytochromes P450 in vitro
    Veinlichova A, Jancova P, Siller M, Anzenbacher P, Kuca K, Jun D, Fusek J, Anzenbacherova E
    Ref: Chemico-Biological Interactions, 180:449, 2009 : PubMed

            

    Title: Irinotecan side effects relieved by the use of HI-6 oxime: in vivo experimental approach
    Vrdoljak AL, Zunec S, Zeljezic D, Piljac-Zegarac J, Plestina S, Kuca K, Radic B, Mladinic M, Kopjar N
    Ref: Basic Clin Pharmacol Toxicol, 105:401, 2009 : PubMed

            

    Title: An attempt to assess functionally minimal acetylcholinesterase activity necessary for survival of rats intoxicated with nerve agents
    Bajgar J, Fusek J, Kassa J, Jun D, Kuca K, Hajek P
    Ref: Chemico-Biological Interactions, 175:281, 2008 : PubMed

            

    Title: New bispyridinium oximes: in vitro and in vivo evaluation of their biological efficiency in soman and tabun poisoning
    Zunec S, Vrdoljak AL, Radic B, Kuca K
    Ref: Chemico-Biological Interactions, 175:413, 2008 : PubMed

            

    Title: Interactions of butane, but-2-ene or xylene-like linked bispyridinium para-aldoximes with native and tabun-inhibited human cholinesterases
    Calic M, Bosak A, Kuca K, Kovarik Z
    Ref: Chemico-Biological Interactions, 175:305, 2008 : PubMed

            

    Title: Analysis of pyridinium aldoximes - a chromatographic approach
    Csermely T, Kalasz H, Petroianu GA, Kuca K, Darvas F, Ludanyi K, Mudhafar AA, Tekes K
    Ref: Curr Med Chem, 15:2401, 2008 : PubMed

            

    Title: Potency of novel oximes to reactivate sarin inhibited human cholinesterases
    Jun D, Kuca K, Picha J, Koleckar V, Marek J
    Ref: Drug & Chemical Toxicology, 31:1, 2008 : PubMed

            

    Title: TLC analysis of intermediates arising during the preparation of oxime HI-6 dimethanesulfonate
    Jun D, Stodulka P, Kuca K, Koleckar V, Dolezal B, Simon P, Veverka M
    Ref: Journal of Chromatography Sci, 46:316, 2008 : PubMed

            

    Title: Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro
    Jun D, Musilova L, Kuca K, Kassa J, Bajgar J
    Ref: Chemico-Biological Interactions, 175:421, 2008 : PubMed

            

    Title: Effect of several new and currently available oxime cholinesterase reactivators on tabun-intoxicated rats
    Karasova JZ, Kassa J, Jung YS, Musilek K, Pohanka M, Kuca K
    Ref: Int J Mol Sci, 9:2243, 2008 : PubMed

            

    Title: An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice
    Kassa J, Karasova J, Musilek K, Kuca K
    Ref: Toxicology, 243:311, 2008 : PubMed

            

    Title: A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats
    Kassa J, Jun D, Karasova J, Bajgar J, Kuca K
    Ref: Chemico-Biological Interactions, 175:425, 2008 : PubMed

            

    Title: A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice
    Kassa J, Karasova J, Musilek K, Kuca K, Jung YS
    Ref: Drug & Chemical Toxicology, 31:371, 2008 : PubMed

            

    Title: The development of new oximes and the evaluation of their reactivating, therapeutic and neuroprotective efficacy against tabun
    Kassa J, Kuca K, Karasova J, Musilek K
    Ref: Mini Rev Med Chem, 8:1134, 2008 : PubMed

            

    Title: A comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice
    Kassa J, Karasova J, Bajgar J, Kuca K, Musilek K
    Ref: J Enzyme Inhib Med Chem, 23:776, 2008 : PubMed

            

    Title: In vitro oxime protection of human red blood cell acetylcholinesterase inhibited by diisopropyl-fluorophosphate
    Lorke DE, Hasan MY, Arafat K, Kuca K, Musilek K, Schmitt A, Petroianu GA
    Ref: J Appl Toxicol, 28:422, 2008 : PubMed

            

    Title: Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: in vivo efficacy to protect from diisopropylfluorophosphate toxicity
    Lorke DE, Nurulain SM, Hasan MY, Kuca K, Musilek K, Petroianu GA
    Ref: J Appl Toxicol, 28:920, 2008 : PubMed

            

    Title: Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase
    Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Opletalova V, Dolezal M
    Ref: J Enzyme Inhib Med Chem, 23:70, 2008 : PubMed

            

    Title: RP-HPLC determination of the lipophilicity of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker
    Musilek K, Jampilek J, Dohnal J, Jun D, Gunn-Moore F, Dolezal M, Kuca K
    Ref: Anal Bioanal Chem, 391:367, 2008 : PubMed

            

    Title: Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase
    Musilek K, Kucera J, Jun D, Dohnal V, Opletalova V, Kuca K
    Ref: Bioorganic & Medicinal Chemistry, 16:8218, 2008 : PubMed

            

    Title: Reactivation of DFP- and paraoxon-inhibited acetylcholinesterases by pyridinium oximes
    Oh KA, Park NJ, Park NS, Kuca K, Jun D, Jung YS
    Ref: Chemico-Biological Interactions, 175:365, 2008 : PubMed

            

    Title: Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease
    Patocka J, Jun D, Kuca K
    Ref: Curr Drug Metab, 9:332, 2008 : PubMed

            

    Title: Diagnosis of Intoxication by the Organophosphate VX: Comparison Between an Electrochemical Sensor and Ellman s Photometric Method
    Pohanka M, Hrabinova M, Kuca K
    Ref: Sensors (Basel), 8:5229, 2008 : PubMed

            

    Title: Amperometric Biosensors for Real Time Assays of Organophosphates
    Pohanka M, Jun D, Kuca K
    Ref: Sensors (Basel), 8:5303, 2008 : PubMed

            

    Title: Cholinesterase biosensor construction - a review
    Pohanka M, Jun D, Kalasz H, Kuca K
    Ref: Protein Pept Lett, 15:795, 2008 : PubMed

            

    Title: New performance of biosensor technology for Alzheimer's disease drugs: in vitro comparison of tacrine and 7-methoxytacrine
    Pohanka M, Kuca K, Kassa J
    Ref: Neuro Endocrinol Lett, 29:755, 2008 : PubMed

            

    Title: Photometric microplate assay for estimation of the efficacy of paraoxon-inhibited acetylcholinesterase reactivation
    Pohanka M, Jun D, Kuca K
    Ref: J Enzyme Inhib Med Chem, 23:781, 2008 : PubMed

            

    Title: The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder
    Soukup O, Pohanka M, Tobin G, Jun D, Fusek J, Musilek K, Marek J, Kassa J, Kuca K
    Ref: Neuro Endocrinol Lett, 29:759, 2008 : PubMed

            

    Title: Temporal effects of newly developed oximes (K027, K048) on malathion-induced acetylcholinesterase inhibition and lipid peroxidation in mouse prefrontal cortex
    da Silva AP, Farina M, Franco JL, Dafre AL, Kassa J, Kuca K
    Ref: Neurotoxicology, 29:184, 2008 : PubMed

            

    Title: Changes of acetylcholinesterase activity in different rat brain areas following intoxication with nerve agents: biochemical and histochemical study
    Bajgar J, Hajek P, Slizova D, Krs O, Fusek J, Kuca K, Jun D, Bartosova L, Blaha V
    Ref: Chemico-Biological Interactions, 165:14, 2007 : PubMed

            

    Title: Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase
    Bajgar J, Bartosova L, Kuca K, Jun D, Fusek J
    Ref: Drug & Chemical Toxicology, 30:351, 2007 : PubMed

            

    Title: Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents
    Bajgar J, Kuca K, Jun D, Bartosova L, Fusek J
    Ref: Curr Drug Metab, 8:803, 2007 : PubMed

            

    Title: Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction
    Bajgar J, Fusek J, Kuca K, Bartosova L, Jun D
    Ref: Mini Rev Med Chem, 7:461, 2007 : PubMed

            

    Title: Inhibition of blood cholinesterases following intoxication with VX and its derivatives
    Bajgar J, Kuca K, Fusek J, Karasova J, Kassa J, Cabal J, Jun D, Blaha V
    Ref: J Appl Toxicol, 27:458, 2007 : PubMed

            

    Title: Measurement of K-27, an oxime-type cholinesterase reactivator by high-performance liquid chromatography with electrochemical detection from different biological samples
    Gyenge M, Kalasz H, Petroianu GA, Laufer R, Kuca K, Tekes K
    Ref: Journal of Chromatography A, 1161:146, 2007 : PubMed

            

    Title: Comparison of reactivating and therapeutic efficacy of two salts of the oxime HI-6 against tabun, soman and cyclosarin in rats
    Kassa J, Jun D, Kuca K, Bajgar J
    Ref: Basic Clin Pharmacol Toxicol, 101:328, 2007 : PubMed

            

    Title: A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats
    Kassa J, Jun D, Kuca K
    Ref: J Enzyme Inhib Med Chem, 22:297, 2007 : PubMed

            

    Title: Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications
    Kuca K, Jun D, Bajgar J
    Ref: Curr Pharm Des, 13:3445, 2007 : PubMed

            

    Title: Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide--a new nerve agent reactivator
    Kuca K, Musilek K, Paar M, Jun D, Stodulka P, Hrabinova M, Marek J
    Ref: Molecules, 12:1964, 2007 : PubMed

            

    Title: Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin
    Kuca K, Cabal J, Jun D, Hrabinova M
    Ref: Clinical Toxicology (Phila), 45:512, 2007 : PubMed

            

    Title: In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases
    Kuca K, Cabal J, Jun D, Musilek K
    Ref: Neurotox Res, 11:101, 2007 : PubMed

            

    Title: Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro
    Kuca K, Jun D, Bajgar J
    Ref: Drug & Chemical Toxicology, 30:31, 2007 : PubMed

            

    Title: Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase
    Musilek K, Holas O, Jun D, Dohnal V, Gunn-Moore F, Opletalova V, Dolezal M, Kuca K
    Ref: Bioorganic & Medicinal Chemistry, 15:6733, 2007 : PubMed

            

    Title: Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
    Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Dolezal M
    Ref: J Enzyme Inhib Med Chem, 22:425, 2007 : PubMed

            

    Title: Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203)
    Musilek K, Jun D, Cabal J, Kassa J, Gunn-Moore F, Kuca K
    Ref: Journal of Medicinal Chemistry, 50:5514, 2007 : PubMed

            

    Title: Two step synthesis of a non-symmetric acetylcholinesterase reactivator
    Musilek K, Kuca K, Dohnal V, Jun D, Marek J, Koleckar V
    Ref: Molecules, 12:1755, 2007 : PubMed

            

    Title: Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX)
    Musilek K, Kuca K, Jun D
    Ref: Acta Medica (Hradec Kralove), 50:203, 2007 : PubMed

            

    Title: Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker--synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
    Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Opletalova V, Dolezal M
    Ref: Bioorganic & Medicinal Chemistry Lett, 17:3172, 2007 : PubMed

            

    Title: In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon
    Petroianu GA, Arafat K, Nurulain SM, Kuca K, Kassa J
    Ref: J Appl Toxicol, 27:168, 2007 : PubMed

            

    Title: Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon
    Petroianu GA, Nurulain SM, Nagelkerke N, Shafiullah M, Kassa J, Kuca K
    Ref: J Appl Toxicol, 27:453, 2007 : PubMed

            

    Title: Amperometric biosensor for pesticide methamidophos assay
    Pohanka M, Kuca K, Jun D
    Ref: Acta Medica (Hradec Kralove), 50:239, 2007 : PubMed

            

    Title: Acetylcholinesterases--the structural similarities and differences
    Wiesner J, Kriz Z, Kuca K, Jun D, Koca J
    Ref: J Enzyme Inhib Med Chem, 22:417, 2007 : PubMed

            

    Title: Evaluation of reactivation test in anaesthetized dogs with experimental intoxication with nerve agents
    Bajgar J, Fusek J, Bartosova L, Jun D, Kuca K
    Ref: J Appl Toxicol, 26:439, 2006 : PubMed

            

    Title: Equine butyrylcholinesterase protects rats against inhalation exposure to sublethal sarin concentrations
    Bajgar J, Bartosova L, Fusek J, Jun D, Kuca K
    Ref: Arh Hig Rada Toksikol, 57:391, 2006 : PubMed

            

    Title: The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure
    Bartosova L, Kuca K, Kunesova G, Jun D
    Ref: Neurotox Res, 9:291, 2006 : PubMed

            

    Title: In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity
    Calic M, Vrdoljak AL, Radic B, Jelic D, Jun D, Kuca K, Kovarik Z
    Ref: Toxicology, 219:85, 2006 : PubMed

            

    Title: New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin
    Hrabinova M, Musilek K, Jun D, Kuca K
    Ref: J Enzyme Inhib Med Chem, 21:515, 2006 : PubMed

            

    Title: Effect of some acetylcholinesterase reactivators on human platelet aggregation in vitro
    Jun D, Kuca K, Hronek M, Opletal L
    Ref: J Appl Toxicol, 26:258, 2006 : PubMed

            

    Title: The Reactivating and Therapeutic Efficacy of Oximes to Counteract Russian VX Poisonings
    Kassa J, Jun D, Kuca K
    Ref: Int J Toxicol, 25:397, 2006 : PubMed

            

    Title: A comparison of the efficacy of new asymmetric bispyridinium oximes (K027, K048) with currently available oximes against tabun by in vivo methods
    Kassa J, Kuca K, Cabal J, Paar M
    Ref: J Toxicol Environ Health A, 69:1875, 2006 : PubMed

            

    Title: In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings
    Kuca K, Cabal J, Jun D, Hrabinova M
    Ref: Drug & Chemical Toxicology, 29:443, 2006 : PubMed

            

    Title: Structural requirements of acetylcholinesterase reactivators
    Kuca K, Jun D, Musilek K
    Ref: Mini Rev Med Chem, 6:269, 2006 : PubMed

            

    Title: Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent
    Kuca K, Jun D, Cabal J, Hrabinova M, Bartosova L, Opletalova V
    Ref: Basic Clin Pharmacol Toxicol, 98:389, 2006 : PubMed

            

    Title: In vitro potency of H oximes (HI-6, HLo-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase
    Kuca K, Cabal J, Kassa J, Jun D, Hrabinova M
    Ref: J Toxicol Environ Health A, 69:1431, 2006 : PubMed

            

    Title: Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes
    Kuca K, Jun D
    Ref: J Med Toxicol, 2:141, 2006 : PubMed

            

    Title: Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases
    Kuca K, Cabal J, Jun D, Bajgar J, Hrabinova M
    Ref: J Enzyme Inhib Med Chem, 21:663, 2006 : PubMed

            

    Title: Reactivation potency of new group of acetylcholinesterase reactivators and their comparison with currently available oximes
    Kuca K, Picha J, Jun D
    Ref: Acta Medica (Hradec Kralove), 49:233, 2006 : PubMed

            

    Title: Influence of Length and Shape of the Connecting Chain of Bisquaternary Acetylcholinesterase Reactivators on Their Potency to Reactivate Enzyme Inhibited by Sarin
    Kuca K, Jun D, Musilek K
    Ref: Military Medical Science Letters, 75:37, 2006 : PubMed

            

    Title: Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning
    Lucic Vrdoljak A, Calic M, Radic B, Zunec S, Jun D, Kuca K, Kovarik Z
    Ref: Toxicology, 228:41, 2006 : PubMed

            

    Title: [Synthesis of reactivators of phosphorylated acetylcholinesterase of bis-pyridiniumdialdoxime type with a 3-oxapentane connecting chain and their testing in vitro on a model of the enzyme inhibited by chlorpyrifos and methylchlorpyrifos]
    Musilek K, Kuca K, Jun D, Dohnal V, Kim TH, Jung YS, Dolezal M
    Ref: Ceska a Slovenska Farmacie, 55:115, 2006 : PubMed

            

    Title: Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase
    Musilek K, Kuca K, Jun D, Dohnal V, Dolezal M
    Ref: Bioorganic & Medicinal Chemistry Lett, 16:622, 2006 : PubMed

            

    Title: Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
    Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Dolezal M
    Ref: Bioorganic & Medicinal Chemistry Lett, 16:5673, 2006 : PubMed

            

    Title: Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxon
    Petroianu GA, Arafat K, Kuca K, Kassa J
    Ref: J Appl Toxicol, 26:64, 2006 : PubMed

            

    Title: Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon
    Petroianu GA, Nurulain SM, Nagelkerke N, Al-Sultan MA, Kuca K, Kassa J
    Ref: J Appl Toxicol, 26:262, 2006 : PubMed

            

    Title: Substituted monoquaternary oximes as reactivators of cyclosarin--and chlorpyrifos--inhibited acetylcholinesterase
    Racakova V, Hrabinova M, Jun D, Kuca K
    Ref: Arh Hig Rada Toksikol, 57:387, 2006 : PubMed

            

    Title: High-performance liquid chromatographic determination of the plasma concentration of K-27, a novel oxime-type cholinesterase reactivator
    Tekes K, Hasan MY, Sheen R, Kuca K, Petroianu GA, Ludanyi K, Kalasz H
    Ref: Journal of Chromatography A, 1122:84, 2006 : PubMed

            

    Title: Tests with Daphnia magna: a new approach to prescreen toxicity of newly synthesized acetylcholinesterase reactivators
    Vesela S, Ondruska V, Kuca K, Patocka J
    Ref: J Enzyme Inhib Med Chem, 21:427, 2006 : PubMed

            

    Title: Bispyridinium oximes as antidotal treatment of cyclosarin poisoning-in vitro and in vivo testing
    Bartosova L, Kuca K, Jun D, Kunesova G
    Ref: Int J Toxicol, 24:399, 2005 : PubMed

            

    Title: Effectivity of new acetylcholinesterase reactivators in treatment of cyclosarin poisoning in mice and rats
    Bartosova L, Kuca K, Kunesova G
    Ref: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 149:425, 2005 : PubMed

            

    Title: [A comparison of the efficacy of the reactivators of acetylcholinesterase inhibited with tabun]
    Cabal J, Kuca K, Jun D, Bajgar J, Hrabinova M
    Ref: Ceska a Slovenska Farmacie, 54:192, 2005 : PubMed

            

    Title: Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species
    Jun D, Kuca K, Cabal J, Bartosova L, Kunesova G, Kassa J
    Ref: Chemico-Biological Interactions, 157-158:385, 2005 : PubMed

            

    Title: A comparison of the potency of trimedoxime and other currently available oximes to reactivate tabun-inhibited acetylcholinesterase and eliminate acute toxic effects of tabun
    Kassa J, Kuca K, Cabal J
    Ref: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 149:419, 2005 : PubMed

            

    Title: Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents
    Kim TH, Kuca K, Jun D, Jung YS
    Ref: Bioorganic & Medicinal Chemistry Lett, 15:2914, 2005 : PubMed

            

    Title: Signs of cyclosarin-induced neurotoxicity and its pharmacological treatment with quaternary pyridinium-oximes reactivators
    Krejcova-Kunesova G, Bartosova L, Kuca K
    Ref: Toxicology, 216:32, 2005 : PubMed

            

    Title: A comparison of the potency of newly developed oximes (K005, K027, K033, K048) and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited rat brain acetylcholinesterase by in vitro methods
    Kuca K, Cabal J, Kassa J
    Ref: J Toxicol Environ Health A, 68:677, 2005 : PubMed

            

    Title: In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions
    Kuca K, Cabal J, Jun D, Kassa J, Bartosova L, Kunesova G
    Ref: J Appl Toxicol, 25:296, 2005 : PubMed

            

    Title: Comparison of in vitro potency of oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain
    Kuca K, Cabal J, Kassa J, Jun D, Hrabinova M
    Ref: J Appl Toxicol, 25:271, 2005 : PubMed