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| Title : Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations - |
| Author(s) : Jensen AA , Frolund B , Liljefors T , Krogsgaard-Larsen P |
| Ref : Journal of Medicinal Chemistry , 48 :4705 , 2005 |
| PubMedID: 16033252 |
| Title : First demonstration of a functional role for central nervous system betaine\/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2 - White_2005_J.Pharmacol.Exp.Ther_312_866 |
| Author(s) : White HS , Watson WP , Hansen SL , Slough S , Perregaard J , Sarup A , Bolvig T , Petersen G , Larsson OM , Clausen RP , Frolund B , Falch E , Krogsgaard-Larsen P , Schousboe A |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 312 :866 , 2005 |
| Abstract : White_2005_J.Pharmacol.Exp.Ther_312_866 |
| ESTHER : White_2005_J.Pharmacol.Exp.Ther_312_866 |
| PubMedSearch : White_2005_J.Pharmacol.Exp.Ther_312_866 |
| PubMedID: 15550575 |
| Title : Carbamoylcholine homologs: synthesis and pharmacology at nicotinic acetylcholine receptors - Jensen_2004_Eur.J.Pharmacol_497_125 |
| Author(s) : Jensen AA , Mikkelsen I , Frolund B , Frydenvang K , Brehm L , Jaroszewski JW , Brauner-Osborne H , Falch E , Krogsgaard-Larsen P |
| Ref : European Journal of Pharmacology , 497 :125 , 2004 |
| Abstract : Jensen_2004_Eur.J.Pharmacol_497_125 |
| ESTHER : Jensen_2004_Eur.J.Pharmacol_497_125 |
| PubMedSearch : Jensen_2004_Eur.J.Pharmacol_497_125 |
| PubMedID: 15306197 |
| Title : Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors - Mellor_2003_Neuropharmacol_44_70 |
| Author(s) : Mellor IR , Brier TJ , Pluteanu F , Stromgaard K , Saghyan A , Eldursi N , Brierley MJ , Andersen K , Jaroszewski JW , Krogsgaard-Larsen P , Usherwood PN |
| Ref : Neuropharmacology , 44 :70 , 2003 |
| Abstract : Mellor_2003_Neuropharmacol_44_70 |
| ESTHER : Mellor_2003_Neuropharmacol_44_70 |
| PubMedSearch : Mellor_2003_Neuropharmacol_44_70 |
| PubMedID: 12559123 |
| Title : Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors - Jensen_2003_Mol.Pharmacol_64_865 |
| Author(s) : Jensen AA , Mikkelsen I , Frolund B , Brauner-Osborne H , Falch E , Krogsgaard-Larsen P |
| Ref : Molecular Pharmacology , 64 :865 , 2003 |
| Abstract : Jensen_2003_Mol.Pharmacol_64_865 |
| ESTHER : Jensen_2003_Mol.Pharmacol_64_865 |
| PubMedSearch : Jensen_2003_Mol.Pharmacol_64_865 |
| PubMedID: 14500743 |
| Title : Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist - Stromgaard_2002_Bioorg.Med.Chem.Lett_12_1159 |
| Author(s) : Stromgaard K , Mellor IR , Andersen K , Neagoe I , Pluteanu F , Usherwood PN , Krogsgaard-Larsen P , Jaroszewski JW |
| Ref : Bioorganic & Medicinal Chemistry Lett , 12 :1159 , 2002 |
| Abstract : Stromgaard_2002_Bioorg.Med.Chem.Lett_12_1159 |
| ESTHER : Stromgaard_2002_Bioorg.Med.Chem.Lett_12_1159 |
| PubMedSearch : Stromgaard_2002_Bioorg.Med.Chem.Lett_12_1159 |
| PubMedID: 11934578 |
| Title : Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues - Stromgaard_2000_J.Med.Chem_43_4526 |
| Author(s) : Stromgaard K , Brier TJ , Andersen K , Mellor IR , Saghyan A , Tikhonov D , Usherwood PN , Krogsgaard-Larsen P , Jaroszewski JW |
| Ref : Journal of Medicinal Chemistry , 43 :4526 , 2000 |
| Abstract : Stromgaard_2000_J.Med.Chem_43_4526 |
| ESTHER : Stromgaard_2000_J.Med.Chem_43_4526 |
| PubMedSearch : Stromgaard_2000_J.Med.Chem_43_4526 |
| PubMedID: 11087577 |
| Title : Synthesis and pharmacology of the baclofen homologues 5-amino-4-(4-chlorophenyl)pentanoic acid and the R- and S-enantiomers of 5-amino-3-(4-chlorophenyl)pentanoic acid - Karla_1999_J.Med.Chem_42_2053 |
| Author(s) : Karla R , Ebert B , Thorkildsen C , Herdeis C , Johansen TN , Nielsen B , Krogsgaard-Larsen P |
| Ref : Journal of Medicinal Chemistry , 42 :2053 , 1999 |
| Abstract : Karla_1999_J.Med.Chem_42_2053 |
| ESTHER : Karla_1999_J.Med.Chem_42_2053 |
| PubMedSearch : Karla_1999_J.Med.Chem_42_2053 |
| PubMedID: 10354414 |
| Title : Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor - Stromgaard_1999_J.Med.Chem_42_5224 |
| Author(s) : Stromgaard K , Brierley MJ , Andersen K , Slok FA , Mellor IR , Usherwood PN , Krogsgaard-Larsen P , Jaroszewski JW |
| Ref : Journal of Medicinal Chemistry , 42 :5224 , 1999 |
| Abstract : Stromgaard_1999_J.Med.Chem_42_5224 |
| ESTHER : Stromgaard_1999_J.Med.Chem_42_5224 |
| PubMedSearch : Stromgaard_1999_J.Med.Chem_42_5224 |
| PubMedID: 10602707 |
| Title : Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists - Rosini_1999_J.Med.Chem_42_5212 |
| Author(s) : Rosini M , Budriesi R , Bixel MG , Bolognesi ML , Chiarini A , Hucho F , Krogsgaard-Larsen P , Mellor IR , Minarini A , Tumiatti V , Usherwood PN , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 42 :5212 , 1999 |
| Abstract : Rosini_1999_J.Med.Chem_42_5212 |
| ESTHER : Rosini_1999_J.Med.Chem_42_5212 |
| PubMedSearch : Rosini_1999_J.Med.Chem_42_5212 |
| PubMedID: 10602706 |
| Title : Synthesis and muscarinic receptor pharmacology of a series of 4,5,6,7-tetrahydroisothiazolo[4,5-c]pyridine bioisosteres of arecoline - Pedersen_1999_Bioorg.Med.Chem_7_795 |
| Author(s) : Pedersen H , Brauner-Osborne H , Ball RG , Frydenvang K , Meier E , Bogeso KP , Krogsgaard-Larsen P |
| Ref : Bioorganic & Medicinal Chemistry , 7 :795 , 1999 |
| Abstract : Pedersen_1999_Bioorg.Med.Chem_7_795 |
| ESTHER : Pedersen_1999_Bioorg.Med.Chem_7_795 |
| PubMedSearch : Pedersen_1999_Bioorg.Med.Chem_7_795 |
| PubMedID: 10400332 |
| Title : Functional partial agonism at cloned human muscarinic acetylcholine receptors - Brauner-Osborne_1996_Eur.J.Pharmacol_313_145 |
| Author(s) : Brauner-Osborne H , Ebert B , Brann MR , Falch E , Krogsgaard-Larsen P |
| Ref : European Journal of Pharmacology , 313 :145 , 1996 |
| Abstract : Brauner-Osborne_1996_Eur.J.Pharmacol_313_145 |
| ESTHER : Brauner-Osborne_1996_Eur.J.Pharmacol_313_145 |
| PubMedSearch : Brauner-Osborne_1996_Eur.J.Pharmacol_313_145 |
| PubMedID: 8905341 |
| Title : Analogues of carbacholine: synthesis and relationship between structure and affinity for muscarinic and nicotinic acetylcholine receptors - Sokilde_1996_Arch.Pharm.(Weinheim)_329_95 |
| Author(s) : Sokilde B , Mikkelsen I , Stensbol TB , Andersen B , Ebdrup S , Krogsgaard-Larsen P , Falch E |
| Ref : Arch Pharm (Weinheim) , 329 :95 , 1996 |
| Abstract : Sokilde_1996_Arch.Pharm.(Weinheim)_329_95 |
| ESTHER : Sokilde_1996_Arch.Pharm.(Weinheim)_329_95 |
| PubMedSearch : Sokilde_1996_Arch.Pharm.(Weinheim)_329_95 |
| PubMedID: 8851473 |
| Title : Poster: Molecular pharmacology of O-alkyl-thao compounds using the five cloned muscarinic acetylcholine receptors - |
| Author(s) : Jorgensen HB , Ebert B , Krogsgaard-Larsen P , Brann MR , Falch E |
| Ref : Life Sciences , 56(11-12) :1007 , 1995 |
| PubMedID: |
| Title : Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors - Brauner-Osborne_1995_J.Med.Chem_38_2188 |
| Author(s) : Brauner-Osborne H , Ebert B , Brann MR , Falch E , Krogsgaard-Larsen P |
| Ref : Journal of Medicinal Chemistry , 38 :2188 , 1995 |
| Abstract : Brauner-Osborne_1995_J.Med.Chem_38_2188 |
| ESTHER : Brauner-Osborne_1995_J.Med.Chem_38_2188 |
| PubMedSearch : Brauner-Osborne_1995_J.Med.Chem_38_2188 |
| PubMedID: 7783150 |
| Title : Conformational aspects of the muscarinic receptor interactions of bicyclic isoxazole ester bioisosteres of arecoline - Lagersted_1993_Drug.Des.Discov_9_237 |
| Author(s) : Lagersted A , Falch E , Ebert B , Krogsgaard-Larsen P |
| Ref : Drug Des Discov , 9 :237 , 1993 |
| Abstract : Lagersted_1993_Drug.Des.Discov_9_237 |
| ESTHER : Lagersted_1993_Drug.Des.Discov_9_237 |
| PubMedSearch : Lagersted_1993_Drug.Des.Discov_9_237 |
| PubMedID: 8400005 |
| Title : Poster: Heterocyclic muscarinic agonists as experimental tools and potentIal therapeutic agents - |
| Author(s) : Byrholt Hansen A , Falch E , Jorgensen FS , Krogsgaard-Larsen P |
| Ref : Trends in Pharmacological Sciences , Suppl :112 , 1989 |
| PubMedID: |
| Title : Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres - Sauerberg_1988_J.Med.Chem_31_1312 |
| Author(s) : Sauerberg P , Falch E , Meier E , Lembol HL , Krogsgaard-Larsen P |
| Ref : Journal of Medicinal Chemistry , 31 :1312 , 1988 |
| Abstract : Sauerberg_1988_J.Med.Chem_31_1312 |
| ESTHER : Sauerberg_1988_J.Med.Chem_31_1312 |
| PubMedSearch : Sauerberg_1988_J.Med.Chem_31_1312 |
| PubMedID: 3385727 |
| Title : Bioisosteres of arecoline as novel CNS-active muscarinic agonists - |
| Author(s) : Krogsgaard-Larsen P , Falch E , Sauerberg P , Freedman SB , Lembol HL , Meier E |
| Ref : Trends in Pharmacological Sciences , Suppl :69 , 1988 |
| PubMedID: 3074541 |
| Title : GABA uptake inhibitors. Synthesis and effects on audiogenic seizures of ester prodrugs of nipecotic acid, guvacine and cis-4-hydroxynipecotic acid - Falch_1987_Drug.Des.Deliv_2_9 |
| Author(s) : Falch E , Meldrum BS , Krogsgaard-Larsen P |
| Ref : Drug Des Deliv , 2 :9 , 1987 |
| Abstract : Falch_1987_Drug.Des.Deliv_2_9 |
| ESTHER : Falch_1987_Drug.Des.Deliv_2_9 |
| PubMedSearch : Falch_1987_Drug.Des.Deliv_2_9 |
| PubMedID: 3509345 |
| Title : (R)-nipecotic acid ethyl ester: a direct-acting cholinergic agonist that displays greater efficacy at M2 than at M1 muscarinic receptors - Zorn_1987_J.Pharmacol.Exp.Ther_242_173 |
| Author(s) : Zorn SH , Duman RS , Giachetti A , Micheletti R , Giraldo E , Krogsgaard-Larsen P , Enna SJ |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 242 :173 , 1987 |
| Abstract : Zorn_1987_J.Pharmacol.Exp.Ther_242_173 |
| ESTHER : Zorn_1987_J.Pharmacol.Exp.Ther_242_173 |
| PubMedSearch : Zorn_1987_J.Pharmacol.Exp.Ther_242_173 |
| PubMedID: 2886636 |
| Title : Pharmacological profile of a novel class of muscarinic acetylcholine receptor agonists - Sauerberg_1986_Eur.J.Pharmacol_130_125 |
| Author(s) : Sauerberg P , Fjalland B , Larsen JJ , Bach-Lauritsen T , Falch E , Krogsgaard-Larsen P |
| Ref : European Journal of Pharmacology , 130 :125 , 1986 |
| Abstract : Sauerberg_1986_Eur.J.Pharmacol_130_125 |
| ESTHER : Sauerberg_1986_Eur.J.Pharmacol_130_125 |
| PubMedSearch : Sauerberg_1986_Eur.J.Pharmacol_130_125 |
| PubMedID: 3780854 |
| Title : A novel class of conformationally restricted heterocyclic muscarinic agonists - Sauerberg_1986_J.Med.Chem_29_1004 |
| Author(s) : Sauerberg P , Larsen JJ , Falch E , Krogsgaard-Larsen P |
| Ref : Journal of Medicinal Chemistry , 29 :1004 , 1986 |
| Abstract : Sauerberg_1986_J.Med.Chem_29_1004 |
| ESTHER : Sauerberg_1986_J.Med.Chem_29_1004 |
| PubMedSearch : Sauerberg_1986_J.Med.Chem_29_1004 |
| PubMedID: 3712371 |
| Title : Betel nut constituents as inhibitors of gamma-aminobutyric acid uptake - |
| Author(s) : Johnston GA , Krogsgaard-Larsen P , Stephanson A |
| Ref : Nature , 258 :627 , 1975 |
| PubMedID: 1207742 |