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Author Report for: Kozikowski AP

Contact information:

Kozikowski Alan P
89 Headquarters Plaza. North Tower, 14th Floor, Morristown NJ 07960
USA
Phone : 201-984-1777
Fax : 201-993-1685





    Title: Synthesis and biological evaluation of novel hybrids of highly potent and selective alpha4beta2-Nicotinic acetylcholine receptor (nAChR) partial agonists
    Zhang HK, Eaton JB, Fedolak A, Gunosewoyo H, Onajole OK, Brunner D, Lukas RJ, Yu LF, Kozikowski AP
    Ref: Eur Journal of Medicinal Chemistry, 124:689, 2016 : PubMed

            

    Title: Structural analogs of huperzine A improve survival in guinea pigs exposed to soman
    Gunosewoyo H, Tipparaju SK, Pieroni M, Wang Y, Doctor BP, Nambiar MP, Kozikowski AP
    Ref: Bioorganic & Medicinal Chemistry Lett, 23:1544, 2013 : PubMed

            

    Title: Chemistry and behavioral studies identify chiral cyclopropanes as selective alpha4beta2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile
    Zhang H, Tuckmantel W, Eaton JB, Yuen PW, Yu LF, Bajjuri KM, Fedolak A, Wang D, Ghavami A and Kozikowski AP <5 more author(s)>
    Ref: Journal of Medicinal Chemistry, 55:717, 2012 : PubMed

            

    Title: Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380
    Caldarone BJ, Wang D, Paterson NE, Manzano M, Fedolak A, Cavino K, Kwan M, Hanania T, Chellappan SK and Ghavami A <3 more author(s)>
    Ref: Psychopharmacology (Berl), 217:199, 2011 : PubMed

            

    Title: Discovery of isoxazole analogues of sazetidine-A as selective alpha4beta2-nicotinic acetylcholine receptor partial agonists for the treatment of depression
    Liu J, Yu LF, Eaton JB, Caldarone B, Cavino K, Ruiz C, Terry M, Fedolak A, Wang D and Kozikowski AP <4 more author(s)>
    Ref: Journal of Medicinal Chemistry, 54:7280, 2011 : PubMed

            

    Title: The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques
    Malkova L, Kozikowski AP, Gale K
    Ref: Neuropharmacology, 60:1262, 2011 : PubMed

            

    Title: Poster: The nAChR agonist AMOP-H-OH (sazetidine-A) exhibits reinforcing, but not withdrawal-alleviating, properties in rats
    Hackett A, Caldarone B, Kozikowski AP, Ghavami A, Olivier B, Hanania T, Paterson NE
    Ref: Biochemical Pharmacology, 78:919, 2009 : PubMed

            

    Title: 18F-ZW-104: a new radioligand for imaging neuronal nicotinic acetylcholine receptors--in vitro binding properties and PET studies in baboons
    Valette H, Xiao Y, Peyronneau MA, Damont A, Kozikowski AP, Wei ZL, Kassiou M, Kellar KJ, Dolle F, Bottlaender M
    Ref: J Nucl Med, 50:1349, 2009 : PubMed

            

    Title: The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice
    Pibiri F, Kozikowski AP, Pinna G, Auta J, Kadriu B, Costa E, Guidotti A
    Ref: Proc Natl Acad Sci U S A, 105:14169, 2008 : PubMed

            

    Title: Acetylenic pyridines for use in PET imaging of nicotinic receptors
    Kozikowski AP, Chellappan SK, Henderson D, Fulton R, Giboureau N, Xiao Y, Wei ZL, Guilloteau D, Emond P and Kassiou M <2 more author(s)>
    Ref: ChemMedChem, 2:54, 2007 : PubMed

            

    Title: Chemical medicine: novel 10-substituted cytisine derivatives with increased selectivity for alpha4beta2 nicotinic acetylcholine receptors
    Kozikowski AP, Chellappan SK, Xiao Y, Bajjuri KM, Yuan H, Kellar KJ, Petukhov PA
    Ref: ChemMedChem, 2:1157, 2007 : PubMed

            

    Title: Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity
    Chellappan SK, Xiao Y, Tueckmantel W, Kellar KJ, Kozikowski AP
    Ref: Journal of Medicinal Chemistry, 49:2673, 2006 : PubMed

            

    Title: Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them
    Xiao Y, Fan H, Musachio JL, Wei ZL, Chellappan SK, Kozikowski AP, Kellar KJ
    Ref: Molecular Pharmacology, 70:1454, 2006 : PubMed

            

    Title: Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits
    Wei ZL, Xiao Y, Yuan H, Baydyuk M, Petukhov PA, Musachio JL, Kellar KJ, Kozikowski AP
    Ref: Journal of Medicinal Chemistry, 48:1721, 2005 : PubMed

            

    Title: Synthesis and pharmacological characterization of bivalent ligands of epibatidine at neuronal nicotinic acetylcholine receptors
    Wei ZL, Xiao Y, Kellar KJ, Kozikowski AP
    Ref: Bioorganic & Medicinal Chemistry Lett, 14:1855, 2004 : PubMed

            

    Title: Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues
    Wei ZL, Petukhov PA, Xiao Y, Tuckmantel W, George C, Kellar KJ, Kozikowski AP
    Ref: Journal of Medicinal Chemistry, 46:921, 2003 : PubMed

            

    Title: Functionalization of the alicyclic skeleton of epibatidine: synthesis and nicotinic acetylcholine receptor binding affinities of epibatidine analogues
    Wei ZL, Xiao Y, George C, Kellar KJ, Kozikowski AP
    Ref: Org Biomol Chem, 1:3878, 2003 : PubMed

            

    Title: Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B
    Rajendran V, Saxena A, Doctor BP, Kozikowski AP
    Ref: Bioorganic & Medicinal Chemistry Lett, 12:1521, 2002 : PubMed

            

    Title: Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring
    Campiani G, Kozikowski AP, Wang S, Ming L, Nacci V, Saxena A, Doctor BP
    Ref: Bioorganic & Medicinal Chemistry Lett, 8:1413, 1998 : PubMed

            

    Title: Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A
    Raves ML, Harel M, Pang YP, Silman I, Kozikowski AP, Sussman JL
    Ref: Nat Struct Biol, 4:57, 1997 : PubMed

            

    Title: Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies
    Pang YP, Kozikowski AP
    Ref: J Comput Aided Mol Des, 8:669, 1994 : PubMed

            

    Title: Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program
    Pang YP, Kozikowski AP
    Ref: J Comput Aided Mol Des, 8:683, 1994 : PubMed

            

    Title: Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases
    Saxena A, Qian N, Kovach IM, Kozikowski AP, Pang YP, Vellom DC, Radic Z, Quinn DM, Taylor P, Doctor BP
    Ref: Protein Science, 3:1770, 1994 : PubMed

            

    Title: Comparison of the effects of natural and synthetic huperzine-A on rat brain cholinergic function in vitro and in vivo
    Tang XC, Kindel GH, Kozikowski AP, Hanin I
    Ref: J Ethnopharmacol, 44:147, 1994 : PubMed

            

    Title: Natural and synthetic Huperzine A: effect on cholinergic function in vitro and in vivo
    Hanin I, Tang XC, Kindel GL, Kozikowski AP
    Ref: Annals of the New York Academy of Sciences, 695:304, 1993 : PubMed

            

    Title: Huperzine A--a potent acetylcholinesterase inhibitor of use in the treatment of Alzheimer's disease
    Geib SJ, Tuckmantel W, Kozikowski AP
    Ref: Acta Crystallographica, C47 pt4:824, 1991 : PubMed

            

    Title: Neurochemistry of aging. 2. Design, synthesis, and biological evaluation of halomethyl analogues of choline with high affinity choline transport inhibitory activity
    Mistry JS, Abraham DJ, Kozikowski AP, Hanin I
    Ref: Journal of Medicinal Chemistry, 34:2031, 1991 : PubMed

            


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