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| Title : N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase\/Peroxisome Proliferator-Activated Receptor gamma Modulators - Blocher_2016_J.Med.Chem_59_61 |
| Author(s) : Blocher R , Lamers C , Wittmann SK , Merk D , Hartmann M , Weizel L , Diehl O , Bruggerhoff A , Boss M , Kaiser A , Schader T , Gobel T , Grundmann M , Angioni C , Heering J , Geisslinger G , Wurglics M , Kostenis E , Brune B , Steinhilber D , Schubert-Zsilavecz M , Kahnt AS , Proschak E |
| Ref : Journal of Medicinal Chemistry , 59 :61 , 2016 |
| Abstract : Blocher_2016_J.Med.Chem_59_61 |
| ESTHER : Blocher_2016_J.Med.Chem_59_61 |
| PubMedSearch : Blocher_2016_J.Med.Chem_59_61 |
| PubMedID: 26595749 |
| Title : Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor - Schrage_2013_Br.J.Pharmacol_169_357 |
| Author(s) : Schrage R , Seemann WK , Klockner J , Dallanoce C , Racke K , Kostenis E , De Amici M , Holzgrabe U , Mohr K |
| Ref : British Journal of Pharmacology , 169 :357 , 2013 |
| Abstract : Schrage_2013_Br.J.Pharmacol_169_357 |
| ESTHER : Schrage_2013_Br.J.Pharmacol_169_357 |
| PubMedSearch : Schrage_2013_Br.J.Pharmacol_169_357 |
| PubMedID: 23062057 |
| Title : The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling - Bock_2012_Nat.Commun_3_1044 |
| Author(s) : Bock A , Merten N , Schrage R , Dallanoce C , Batz J , Klockner J , Schmitz J , Matera C , Simon K , Kebig A , Peters L , Muller A , Schrobang-Ley J , Trankle C , Hoffmann C , De Amici M , Holzgrabe U , Kostenis E , Mohr K |
| Ref : Nat Commun , 3 :1044 , 2012 |
| Abstract : Bock_2012_Nat.Commun_3_1044 |
| ESTHER : Bock_2012_Nat.Commun_3_1044 |
| PubMedSearch : Bock_2012_Nat.Commun_3_1044 |
| PubMedID: 22948826 |
| Title : Applying label-free dynamic mass redistribution technology to frame signaling of G protein-coupled receptors noninvasively in living cells - Schroder_2011_Nat.Protoc_6_1748 |
| Author(s) : Schroder R , Schmidt J , Blattermann S , Peters L , Janssen N , Grundmann M , Seemann W , Kaufel D , Merten N , Drewke C , Gomeza J , Milligan G , Mohr K , Kostenis E |
| Ref : Nat Protoc , 6 :1748 , 2011 |
| Abstract : Schroder_2011_Nat.Protoc_6_1748 |
| ESTHER : Schroder_2011_Nat.Protoc_6_1748 |
| PubMedSearch : Schroder_2011_Nat.Protoc_6_1748 |
| PubMedID: 22015845 |
| Title : Rational design of dualsteric GPCR ligands: quests and promise - Mohr_2010_Br.J.Pharmacol_159_997 |
| Author(s) : Mohr K , Trankle C , Kostenis E , Barocelli E , De Amici M , Holzgrabe U |
| Ref : British Journal of Pharmacology , 159 :997 , 2010 |
| Abstract : Mohr_2010_Br.J.Pharmacol_159_997 |
| ESTHER : Mohr_2010_Br.J.Pharmacol_159_997 |
| PubMedSearch : Mohr_2010_Br.J.Pharmacol_159_997 |
| PubMedID: 20136835 |
| Title : Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements - Schroder_2010_Nat.Biotechnol_28_943 |
| Author(s) : Schroder R , Janssen N , Schmidt J , Kebig A , Merten N , Hennen S , Muller A , Blattermann S , Mohr-Andra M , Zahn S , Wenzel J , Smith NJ , Gomeza J , Drewke C , Milligan G , Mohr K , Kostenis E |
| Ref : Nat Biotechnol , 28 :943 , 2010 |
| Abstract : Schroder_2010_Nat.Biotechnol_28_943 |
| ESTHER : Schroder_2010_Nat.Biotechnol_28_943 |
| PubMedSearch : Schroder_2010_Nat.Biotechnol_28_943 |
| PubMedID: 20711173 |
| Title : Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity - Antony_2009_FASEB.J_23_442 |
| Author(s) : Antony J , Kellershohn K , Mohr-Andra M , Kebig A , Prilla S , Muth M , Heller E , Disingrini T , Dallanoce C , Bertoni S , Schrobang J , Trankle C , Kostenis E , Christopoulos A , Holtje HD , Barocelli E , De Amici M , Holzgrabe U , Mohr K |
| Ref : FASEB Journal , 23 :442 , 2009 |
| Abstract : Antony_2009_FASEB.J_23_442 |
| ESTHER : Antony_2009_FASEB.J_23_442 |
| PubMedSearch : Antony_2009_FASEB.J_23_442 |
| PubMedID: 18842964 |
| Title : An optical dynamic mass redistribution assay reveals biased signaling of dualsteric GPCR activators - Kebig_2009_J.Recept.Signal.Transduct.Res_29_140 |
| Author(s) : Kebig A , Kostenis E , Mohr K , Mohr-Andra M |
| Ref : J Recept Signal Transduct Res , 29 :140 , 2009 |
| Abstract : Kebig_2009_J.Recept.Signal.Transduct.Res_29_140 |
| ESTHER : Kebig_2009_J.Recept.Signal.Transduct.Res_29_140 |
| PubMedSearch : Kebig_2009_J.Recept.Signal.Transduct.Res_29_140 |
| PubMedID: 19586284 |
| Title : Poster: Functional expression of M1 M3, and M5 muscarinic acetylcholine receptors in yeast - |
| Author(s) : Erlenbach I , Kostenis E , Schmidt C , Hamdan F , Pausch MH , Wess J |
| Ref : Life Sciences , 68 :2640 , 2001 |
| PubMedID: |
| Title : Functional expression of M(1), M(3) and M(5) muscarinic acetylcholine receptors in yeast - Erlenbach_2001_J.Neurochem_77_1327 |
| Author(s) : Erlenbach I , Kostenis E , Schmidt C , Hamdan FF , Pausch MH , Wess J |
| Ref : Journal of Neurochemistry , 77 :1327 , 2001 |
| Abstract : Erlenbach_2001_J.Neurochem_77_1327 |
| ESTHER : Erlenbach_2001_J.Neurochem_77_1327 |
| PubMedSearch : Erlenbach_2001_J.Neurochem_77_1327 |
| PubMedID: 11389184 |
| Title : Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice - Gomeza_2001_Life.Sci_68(22-23)_2457 |
| Author(s) : Gomeza J , Zhang L , Kostenis E , Felder CC , Bymaster FP , Brodkin J , Shannon HE , Xia B , Duttaroy A , Deng CX , Wess J |
| Ref : Life Sciences , 68 :2457 , 2001 |
| Abstract : Gomeza_2001_Life.Sci_68(22-23)_2457 |
| ESTHER : Gomeza_2001_Life.Sci_68(22-23)_2457 |
| PubMedSearch : Gomeza_2001_Life.Sci_68(22-23)_2457 |
| PubMedID: 11392613 |
| Title : Muscarinic allosteric modulation: M2\/M3 subtype selectivity of gallamine is independent of G-protein coupling specificity - Trankle_2001_Naunyn.Schmiedebergs.Arch.Pharmacol_364_172 |
| Author(s) : Trankle C , Kostenis E , Mohr K |
| Ref : Naunyn Schmiedebergs Arch Pharmacol , 364 :172 , 2001 |
| Abstract : Trankle_2001_Naunyn.Schmiedebergs.Arch.Pharmacol_364_172 |
| ESTHER : Trankle_2001_Naunyn.Schmiedebergs.Arch.Pharmacol_364_172 |
| PubMedSearch : Trankle_2001_Naunyn.Schmiedebergs.Arch.Pharmacol_364_172 |
| PubMedID: 11534857 |
| Title : Structure-activity relationships in a series of bisquaternary bisphthalimidine derivatives modulating the muscarinic M(2)-receptor allosterically - Botero Cid_2000_J.Med.Chem_43_2155 |
| Author(s) : Botero Cid HM , Trankle C , Baumann K , Pick R , Mies-Klomfass E , Kostenis E , Mohr K , Holzgrabe U |
| Ref : Journal of Medicinal Chemistry , 43 :2155 , 2000 |
| Abstract : Botero Cid_2000_J.Med.Chem_43_2155 |
| ESTHER : Botero Cid_2000_J.Med.Chem_43_2155 |
| PubMedSearch : Botero Cid_2000_J.Med.Chem_43_2155 |
| PubMedID: 10841794 |
| Title : Bisquaternary ligands of the common allosteric site of M2 acetylcholine receptors: search for the minimum essential distances between the pharmacophoric elements - Nassif-Makki_1999_J.Med.Chem_42_849 |
| Author(s) : Nassif-Makki T , Trankle C , Zlotos D , Bejeuhr G , Cambareri A , Pfletschinger C , Kostenis E , Mohr K , Holzgrabe U |
| Ref : Journal of Medicinal Chemistry , 42 :849 , 1999 |
| Abstract : Nassif-Makki_1999_J.Med.Chem_42_849 |
| ESTHER : Nassif-Makki_1999_J.Med.Chem_42_849 |
| PubMedSearch : Nassif-Makki_1999_J.Med.Chem_42_849 |
| PubMedID: 10072682 |
| Title : Structure-function analysis of muscarinic receptors and their associated G proteins - Kostenis_1999_Life.Sci_64(6-7)_355 |
| Author(s) : Kostenis E , Zeng FY , Wess J |
| Ref : Life Sciences , 64 :355 , 1999 |
| Abstract : Kostenis_1999_Life.Sci_64(6-7)_355 |
| ESTHER : Kostenis_1999_Life.Sci_64(6-7)_355 |
| PubMedSearch : Kostenis_1999_Life.Sci_64(6-7)_355 |
| PubMedID: 10069496 |
| Title : Molecular basis of receptor\/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits - Kostenis_1997_Biochemistry_36_1487 |
| Author(s) : Kostenis E , Conklin BR , Wess J |
| Ref : Biochemistry , 36 :1487 , 1997 |
| Abstract : Kostenis_1997_Biochemistry_36_1487 |
| ESTHER : Kostenis_1997_Biochemistry_36_1487 |
| PubMedSearch : Kostenis_1997_Biochemistry_36_1487 |
| PubMedID: 9063897 |
| Title : Structural basis of receptor\/G protein coupling selectivity studied with muscarinic receptors as model systems - Wess_1997_Life.Sci_60(13-14)_1007 |
| Author(s) : Wess J , Liu J , Blin N , Yun J , Lerche C , Kostenis E |
| Ref : Life Sciences , 60 :1007 , 1997 |
| Abstract : Wess_1997_Life.Sci_60(13-14)_1007 |
| ESTHER : Wess_1997_Life.Sci_60(13-14)_1007 |
| PubMedSearch : Wess_1997_Life.Sci_60(13-14)_1007 |
| PubMedID: 9121341 |
| Title : Search for lead structures to develop new allosteric modulators of muscarinic receptors - Trankle_1996_J.Pharmacol.Exp.Ther_279_926 |
| Author(s) : Trankle C , Kostenis E , Burgmer U , Mohr K |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 279 :926 , 1996 |
| Abstract : Trankle_1996_J.Pharmacol.Exp.Ther_279_926 |
| ESTHER : Trankle_1996_J.Pharmacol.Exp.Ther_279_926 |
| PubMedSearch : Trankle_1996_J.Pharmacol.Exp.Ther_279_926 |
| PubMedID: 8930201 |
| Title : Evidence for a multiple binding mode of bispyridinium-type allosteric modulators of muscarinic receptors - Kostenis_1996_Eur.J.Pharmacol_314_385 |
| Author(s) : Kostenis E , Botero Cid HM , Holzgrabe U , Mohr K |
| Ref : European Journal of Pharmacology , 314 :385 , 1996 |
| Abstract : Kostenis_1996_Eur.J.Pharmacol_314_385 |
| ESTHER : Kostenis_1996_Eur.J.Pharmacol_314_385 |
| PubMedSearch : Kostenis_1996_Eur.J.Pharmacol_314_385 |
| PubMedID: 8957263 |
| Title : Poster: Potentiation of the action of N-methylscopolamine in guinea pig atria by the allosteric antagonists tetra-W84, W84, and alcuronium - |
| Author(s) : Maass A , Kostenis E , Holzgrabe U , Mohr K |
| Ref : Life Sciences , 56(11-12) :1008 , 1995 |
| PubMedID: |
| Title : Poster: Side chain variations in bispyridinium-type allosteric modulators of M2-cholinoceptors - |
| Author(s) : Kostenis E , Botero Cid HM , Holzgrabe U , Mohr K |
| Ref : Life Sciences , 56(11-12) :1009 , 1995 |
| PubMedID: |
| Title : Potentiation by alcuronium of the antimuscarinic effect of N-methylscopolamine in guinea pig left atria - Maass_1995_Eur.J.Pharmacol_272_103 |
| Author(s) : Maass A , Kostenis E , Mohr K |
| Ref : European Journal of Pharmacology , 272 :103 , 1995 |
| Abstract : Maass_1995_Eur.J.Pharmacol_272_103 |
| ESTHER : Maass_1995_Eur.J.Pharmacol_272_103 |
| PubMedSearch : Maass_1995_Eur.J.Pharmacol_272_103 |
| PubMedID: 7713140 |
| Title : Search for the pharmacophore of bispyridinium-type allosteric modulators of muscarinic receptors - Botero Cid_1994_J.Med.Chem_37_1439 |
| Author(s) : Botero Cid HM , Holzgrabe U , Kostenis E , Mohr K , Trankle C |
| Ref : Journal of Medicinal Chemistry , 37 :1439 , 1994 |
| Abstract : Botero Cid_1994_J.Med.Chem_37_1439 |
| ESTHER : Botero Cid_1994_J.Med.Chem_37_1439 |
| PubMedSearch : Botero Cid_1994_J.Med.Chem_37_1439 |
| PubMedID: 8182702 |