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| Title : The tertiary oxime monoisonitrosoacetone penetrates the brain, reactivates inhibited acetylcholinesterase, and reduces mortality and morbidity following lethal sarin intoxication in guinea pigs - Shih_2021_Toxicol.Appl.Pharmacol__115443 |
| Author(s) : Shih TM , Oyler BL , Capacio BR , Koplovitz I |
| Ref : Toxicol Appl Pharmacol , :115443 , 2021 |
| Abstract : Shih_2021_Toxicol.Appl.Pharmacol__115443 |
| ESTHER : Shih_2021_Toxicol.Appl.Pharmacol__115443 |
| PubMedSearch : Shih_2021_Toxicol.Appl.Pharmacol__115443 |
| PubMedID: 33548273 |
| Title : Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX - Saxena_2011_Biochem.Pharmacol_81_164 |
| Author(s) : Saxena A , Sun W , Fedorko JM , Koplovitz I , Doctor BP |
| Ref : Biochemical Pharmacology , 81 :164 , 2011 |
| Abstract : Saxena_2011_Biochem.Pharmacol_81_164 |
| ESTHER : Saxena_2011_Biochem.Pharmacol_81_164 |
| PubMedSearch : Saxena_2011_Biochem.Pharmacol_81_164 |
| PubMedID: 20846507 |
| Title : Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure - Haigh_2010_Chem.Biol.Interact_187_416 |
| Author(s) : Haigh JR , Adler M , Apland JP , Deshpande SS , Barham CB , Desmond P , Koplovitz I , Lenz DE , Gordon RK |
| Ref : Chemico-Biological Interactions , 187 :416 , 2010 |
| Abstract : Haigh_2010_Chem.Biol.Interact_187_416 |
| ESTHER : Haigh_2010_Chem.Biol.Interact_187_416 |
| PubMedSearch : Haigh_2010_Chem.Biol.Interact_187_416 |
| PubMedID: 20144889 |
| Title : Reactivation of brain acetylcholinesterase by monoisonitrosoacetone increases the therapeutic efficacy against nerve agents in guinea pigs - Skovira_2010_Chem.Biol.Interact_187_318 |
| Author(s) : Skovira JW , O'Donnell JC , Koplovitz I , Kan RK , McDonough JH , Shih TM |
| Ref : Chemico-Biological Interactions , 187 :318 , 2010 |
| Abstract : Skovira_2010_Chem.Biol.Interact_187_318 |
| ESTHER : Skovira_2010_Chem.Biol.Interact_187_318 |
| PubMedSearch : Skovira_2010_Chem.Biol.Interact_187_318 |
| PubMedID: 20230808 |
| Title : A structure-activity analysis of the variation in oxime efficacy against nerve agents - Maxwell_2008_Toxicol.Appl.Pharmacol_231_157 |
| Author(s) : Maxwell DM , Koplovitz I , Worek F , Sweeney RE |
| Ref : Toxicol Appl Pharmacol , 231 :157 , 2008 |
| Abstract : Maxwell_2008_Toxicol.Appl.Pharmacol_231_157 |
| ESTHER : Maxwell_2008_Toxicol.Appl.Pharmacol_231_157 |
| PubMedSearch : Maxwell_2008_Toxicol.Appl.Pharmacol_231_157 |
| PubMedID: 18508103 |
| Title : Acetylcholinesterase inhibition: does it explain the toxicity of organophosphorus compounds? - Maxwell_2006_Arch.Toxicol_80_756 |
| Author(s) : Maxwell DM , Brecht KM , Koplovitz I , Sweeney RE |
| Ref : Archives of Toxicology , 80 :756 , 2006 |
| Abstract : Maxwell_2006_Arch.Toxicol_80_756 |
| ESTHER : Maxwell_2006_Arch.Toxicol_80_756 |
| PubMedSearch : Maxwell_2006_Arch.Toxicol_80_756 |
| PubMedID: 16770629 |
| Title : Toxicodynamic modeling of highly toxic organophosphorus compounds - Maxwell_2006_J.Mol.Neurosci_30_129 |
| Author(s) : Maxwell DM , Brecht KM , Chang FC , Koplovitz I , Shih TM , Sweeney RE |
| Ref : Journal of Molecular Neuroscience , 30 :129 , 2006 |
| Abstract : Maxwell_2006_J.Mol.Neurosci_30_129 |
| ESTHER : Maxwell_2006_J.Mol.Neurosci_30_129 |
| PubMedSearch : Maxwell_2006_J.Mol.Neurosci_30_129 |
| PubMedID: 17192658 |
| Title : Bioscavenger for protection from toxicity of organophosphorus compounds - Saxena_2006_J.Mol.Neurosci_30_145 |
| Author(s) : Saxena A , Sun W , Luo C , Myers TM , Koplovitz I , Lenz DE , Doctor BP |
| Ref : Journal of Molecular Neuroscience , 30 :145 , 2006 |
| Abstract : Saxena_2006_J.Mol.Neurosci_30_145 |
| ESTHER : Saxena_2006_J.Mol.Neurosci_30_145 |
| PubMedSearch : Saxena_2006_J.Mol.Neurosci_30_145 |
| PubMedID: 17192662 |
| Title : In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger - Cerasoli_2005_Chem.Biol.Interact_157-158_363 |
| Author(s) : Cerasoli DM , Griffiths EM , Doctor BP , Saxena A , Fedorko JM , Greig NH , Yu QS , Huang Y , Wilgus H , Karatzas CN , Koplovitz I , Lenz DE |
| Ref : Chemico-Biological Interactions , 157-158 :363 , 2005 |
| Abstract : Cerasoli_2005_Chem.Biol.Interact_157-158_363 |
| ESTHER : Cerasoli_2005_Chem.Biol.Interact_157-158_363 |
| PubMedSearch : Cerasoli_2005_Chem.Biol.Interact_157-158_363 |
| PubMedID: 16429486 |
| Title : Protection against soman or VX poisoning by human butyrylcholinesterase in guinea pigs and cynomolgus monkeys - Lenz_2005_Chem.Biol.Interact_157-158_205 |
| Author(s) : Lenz DE , Maxwell DM , Koplovitz I , Clark CR , Capacio BR , Cerasoli DM , Federko JM , Luo C , Saxena A , Doctor BP , Olson C |
| Ref : Chemico-Biological Interactions , 157-158 :205 , 2005 |
| Abstract : Lenz_2005_Chem.Biol.Interact_157-158_205 |
| ESTHER : Lenz_2005_Chem.Biol.Interact_157-158_205 |
| PubMedSearch : Lenz_2005_Chem.Biol.Interact_157-158_205 |
| PubMedID: 16289064 |
| Title : Combination anticonvulsant treatment of soman-induced seizures - Koplovitz_2001_J.Appl.Toxicol_21 Suppl 1_S53 |
| Author(s) : Koplovitz I , Schulz S , Shutz M , Railer R , Macalalag R , Schons M , McDonough J |
| Ref : J Appl Toxicol , 21 Suppl 1 :S53 , 2001 |
| Abstract : Koplovitz_2001_J.Appl.Toxicol_21 Suppl 1_S53 |
| ESTHER : Koplovitz_2001_J.Appl.Toxicol_21 Suppl 1_S53 |
| PubMedSearch : Koplovitz_2001_J.Appl.Toxicol_21 Suppl 1_S53 |
| PubMedID: 11920921 |
| Title : Electrocorticographic changes during generalized convulsive status epilepticus in soman intoxicated rats - Koplovitz_1998_Epilepsy.Res_30_159 |
| Author(s) : Koplovitz I , Skvorak JP |
| Ref : Epilepsy Research , 30 :159 , 1998 |
| Abstract : Koplovitz_1998_Epilepsy.Res_30_159 |
| ESTHER : Koplovitz_1998_Epilepsy.Res_30_159 |
| PubMedSearch : Koplovitz_1998_Epilepsy.Res_30_159 |
| PubMedID: 9600547 |
| Title : Acute toxicity of cyclohexylmethylphosphonofluoridate (CMPF) in rhesus monkeys: serum biochemical and hematologic changes - Young_1995_Arch.Toxicol_69_379 |
| Author(s) : Young GD , Koplovitz I |
| Ref : Archives of Toxicology , 69 :379 , 1995 |
| Abstract : Young_1995_Arch.Toxicol_69_379 |
| ESTHER : Young_1995_Arch.Toxicol_69_379 |
| PubMedSearch : Young_1995_Arch.Toxicol_69_379 |
| PubMedID: 7495375 |
| Title : Dose-response effects of atropine and HI-6 treatment of organophosphorus poisoning in guinea pigs - Koplovitz_1995_Drug.Chem.Toxicol_18_119 |
| Author(s) : Koplovitz I , Menton R , Matthews C , Shutz M , Nalls C , Kelly S |
| Ref : Drug & Chemical Toxicology , 18 :119 , 1995 |
| Abstract : Koplovitz_1995_Drug.Chem.Toxicol_18_119 |
| ESTHER : Koplovitz_1995_Drug.Chem.Toxicol_18_119 |
| PubMedSearch : Koplovitz_1995_Drug.Chem.Toxicol_18_119 |
| PubMedID: 7497907 |
| Title : A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit - Koplovitz_1994_Toxicol.Lett_70_269 |
| Author(s) : Koplovitz I , Stewart JR |
| Ref : Toxicology Letters , 70 :269 , 1994 |
| Abstract : Koplovitz_1994_Toxicol.Lett_70_269 |
| ESTHER : Koplovitz_1994_Toxicol.Lett_70_269 |
| PubMedSearch : Koplovitz_1994_Toxicol.Lett_70_269 |
| PubMedID: 8284794 |
| Title : Efficacy of tacrine as a nerve agent pretreatment - Fricke_1994_Drug.Chem.Toxicol_17_15 |
| Author(s) : Fricke RF , Koplovitz I , Scharf BA , Rockwood GA , Olson CT , Hobson DW , Blank JA |
| Ref : Drug & Chemical Toxicology , 17 :15 , 1994 |
| Abstract : Fricke_1994_Drug.Chem.Toxicol_17_15 |
| ESTHER : Fricke_1994_Drug.Chem.Toxicol_17_15 |
| PubMedSearch : Fricke_1994_Drug.Chem.Toxicol_17_15 |
| PubMedID: 8168431 |
| Title : Evaluation of the toxicity, pathology, and treatment of cyclohexylmethylphosphonofluoridate (CMPF) poisoning in rhesus monkeys - Koplovitz_1992_Arch.Toxicol_66_622 |
| Author(s) : Koplovitz I , Gresham VC , Dochterman LW , Kaminskis A , Stewart JR |
| Ref : Archives of Toxicology , 66 :622 , 1992 |
| Abstract : Koplovitz_1992_Arch.Toxicol_66_622 |
| ESTHER : Koplovitz_1992_Arch.Toxicol_66_622 |
| PubMedSearch : Koplovitz_1992_Arch.Toxicol_66_622 |
| PubMedID: 1482284 |
| Title : Reduction by pyridostigmine pretreatment of the efficacy of atropine and 2-PAM treatment of sarin and VX poisoning in rodents - Koplovitz_1992_Fundam.Appl.Toxicol_18_102 |
| Author(s) : Koplovitz I , Harris LW , Anderson DR , Lennox WJ , Stewart JR |
| Ref : Fundamental & Applied Toxicology , 18 :102 , 1992 |
| Abstract : Koplovitz_1992_Fundam.Appl.Toxicol_18_102 |
| ESTHER : Koplovitz_1992_Fundam.Appl.Toxicol_18_102 |
| PubMedSearch : Koplovitz_1992_Fundam.Appl.Toxicol_18_102 |
| PubMedID: 160120 |
| Title : Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 5. Structure-activity relationships for side-chain nitro-, sulfone-, amino-, and aminosulfonyl-substituted analogues for therapy against anticholinesterase intoxication - Koolpe_1991_J.Med.Chem_34_1368 |
| Author(s) : Koolpe GA , Lovejoy SM , Goff DA , Lin KY , Leung DS , Bedford CD , Musallam HA , Koplovitz I , Harris RNd |
| Ref : Journal of Medicinal Chemistry , 34 :1368 , 1991 |
| Abstract : Koolpe_1991_J.Med.Chem_34_1368 |
| ESTHER : Koolpe_1991_J.Med.Chem_34_1368 |
| PubMedSearch : Koolpe_1991_J.Med.Chem_34_1368 |
| PubMedID: 2016712 |
| Title : Effect of endogenous carboxylesterase on HI-6 protection against soman toxicity - Maxwell_1990_J.Pharmacol.Exp.Ther_254_440 |
| Author(s) : Maxwell DM , Koplovitz I |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 254 :440 , 1990 |
| Abstract : Maxwell_1990_J.Pharmacol.Exp.Ther_254_440 |
| ESTHER : Maxwell_1990_J.Pharmacol.Exp.Ther_254_440 |
| PubMedSearch : Maxwell_1990_J.Pharmacol.Exp.Ther_254_440 |
| PubMedID: 2384881 |
| Title : Acetylcholinesterase prophylaxis against organophosphate toxicity - Wolfe_1987_Fundam.Appl.Toxicol_9_266 |
| Author(s) : Wolfe AD , Rush RS , Doctor BP , Koplovitz I , Jones D |
| Ref : Fundamental & Applied Toxicology , 9 :266 , 1987 |
| Abstract : Wolfe_1987_Fundam.Appl.Toxicol_9_266 |
| ESTHER : Wolfe_1987_Fundam.Appl.Toxicol_9_266 |
| PubMedSearch : Wolfe_1987_Fundam.Appl.Toxicol_9_266 |
| PubMedID: 3653568 |