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| Title : Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit - Backes_2007_Bioorg.Med.Chem.Lett_17_2005 |
| Author(s) : Backes BJ , Longenecker K , Hamilton GL , Stewart K , Lai C , Kopecka H , von Geldern TW , Madar DJ , Pei Z , Lubben TH , Zinker BA , Tian Z , Ballaron SJ , Stashko MA , Mika AK , Beno DW , Kempf-Grote AJ , Black-Schaefer C , Sham HL , Trevillyan JM |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :2005 , 2007 |
| Abstract : Backes_2007_Bioorg.Med.Chem.Lett_17_2005 |
| ESTHER : Backes_2007_Bioorg.Med.Chem.Lett_17_2005 |
| PubMedSearch : Backes_2007_Bioorg.Med.Chem.Lett_17_2005 |
| PubMedID: 17276063 |
| Gene_locus related to this paper: ratno-dpp4 , human-DPP4 |
| Title : Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes - Madar_2006_J.Med.Chem_49_6416 |
| Author(s) : Madar DJ , Kopecka H , Pireh D , Yong H , Pei Z , Li X , Wiedeman PE , Djuric SW , von Geldern TW , Fickes MG , Bhagavatula L , McDermott T , Wittenberger S , Richards SJ , Longenecker KL , Stewart KD , Lubben TH , Ballaron SJ , Stashko MA , Long MA , Wells H , Zinker BA , Mika AK , Beno DW , Kempf-Grote AJ , Polakowski J , Segreti J , Reinhart GA , Fryer RM , Sham HL , Trevillyan JM |
| Ref : Journal of Medicinal Chemistry , 49 :6416 , 2006 |
| Abstract : Madar_2006_J.Med.Chem_49_6416 |
| ESTHER : Madar_2006_J.Med.Chem_49_6416 |
| PubMedSearch : Madar_2006_J.Med.Chem_49_6416 |
| PubMedID: 17034148 |
| Gene_locus related to this paper: human-DPP4 |