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| Title : Preclinical metabolism and disposition of TP0473292, a novel oral prodrug of the potent metabotropic glutamate 2\/3 receptor antagonist TP0178894 for the treatment of depression - Inatani_2023_Drug.Metab.Dispos__ |
| Author(s) : Inatani S , Ochi M , Kinoshita K , Yamaguchi JI , Endo H |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2023 |
| Abstract : Inatani_2023_Drug.Metab.Dispos__ |
| ESTHER : Inatani_2023_Drug.Metab.Dispos__ |
| PubMedSearch : Inatani_2023_Drug.Metab.Dispos__ |
| PubMedID: 36754836 |
| Title : Bottom-up physiologically based pharmacokinetic modeling for predicting the human pharmacokinetic profiles of the ester prodrug MGS0274 and its active metabolite MGS0008, a metabotropic glutamate 2\/3 receptor agonist - Ochi_2022_Xenobiotica__1 |
| Author(s) : Ochi M , Kinoshita K , Yamaguchi JI , Endo H |
| Ref : Xenobiotica , :1 , 2022 |
| Abstract : Ochi_2022_Xenobiotica__1 |
| ESTHER : Ochi_2022_Xenobiotica__1 |
| PubMedSearch : Ochi_2022_Xenobiotica__1 |
| PubMedID: 35296225 |
| Title : Discovery of MGS0274, an ester prodrug of a metabotropic glutamate receptor 2\/3 agonist with improved oral bioavailability - Urabe_2020_Eur.J.Med.Chem_203_112521 |
| Author(s) : Urabe H , Miyakoshi N , Ohtake N , Nozoe A , Ochi M , Fukasawa M , Kinoshita K , Yamaguchi JI , Marumo T , Hikichi H , Chaki S , Hashihayata T |
| Ref : Eur Journal of Medicinal Chemistry , 203 :112521 , 2020 |
| Abstract : Urabe_2020_Eur.J.Med.Chem_203_112521 |
| ESTHER : Urabe_2020_Eur.J.Med.Chem_203_112521 |
| PubMedSearch : Urabe_2020_Eur.J.Med.Chem_203_112521 |
| PubMedID: 32698110 |
| Title : Safety and pharmacokinetic profiles of MGS0274 besylate (TS-134), a novel metabotropic glutamate 2\/3 receptor agonist prodrug, in healthy subjects - Watanabe_2020_Br.J.Clin.Pharmacol_86_2286 |
| Author(s) : Watanabe M , Marcy B , Kinoshita K , Fukasawa M , Hikichi H , Chaki S , Okuyama S , Gevorkyan H , Yoshida S |
| Ref : British Journal of Clinical Pharmacology , 86 :2286 , 2020 |
| Abstract : Watanabe_2020_Br.J.Clin.Pharmacol_86_2286 |
| ESTHER : Watanabe_2020_Br.J.Clin.Pharmacol_86_2286 |
| PubMedSearch : Watanabe_2020_Br.J.Clin.Pharmacol_86_2286 |
| PubMedID: 32353162 |
| Title : Possible role of inter-domain salt bridges in oligopeptidase B from Trypanosoma brucei: critical role of Glu172 of non-catalytic beta-propeller domain in catalytic activity and Glu490 of catalytic domain in stability of OPB - Fukumoto_2013_J.Biochem_154_465 |
| Author(s) : Fukumoto J , Ismail NI , Kubo M , Kinoshita K , Inoue M , Yuasa K , Nishimoto M , Matsuki H , Tsuji A |
| Ref : J Biochem , 154 :465 , 2013 |
| Abstract : Fukumoto_2013_J.Biochem_154_465 |
| ESTHER : Fukumoto_2013_J.Biochem_154_465 |
| PubMedSearch : Fukumoto_2013_J.Biochem_154_465 |
| PubMedID: 23946505 |
| Title : A novel alkaline esterase from Sporosarcina sp. nov. strain eSP04 catalyzing the hydrolysis of a wide variety of aryl-carboxylic acid esters - Takehara_2012_Biosci.Biotechnol.Biochem_76_1721 |
| Author(s) : Takehara M , Kinoshita K , Miyamoto M , Hirohara H |
| Ref : Biosci Biotechnol Biochem , 76 :1721 , 2012 |
| Abstract : Takehara_2012_Biosci.Biotechnol.Biochem_76_1721 |
| ESTHER : Takehara_2012_Biosci.Biotechnol.Biochem_76_1721 |
| PubMedSearch : Takehara_2012_Biosci.Biotechnol.Biochem_76_1721 |
| PubMedID: 22972336 |
| Title : Synthesis and Structure-Activity Relationships of Dinotefuran Derivatives: Modification in the Nitroguanidine Part - Wakita_2004_J.Pestic.Sci_29_348 |
| Author(s) : Wakita T , Kinoshita K , Yasui N , Yamada E , Kawahara yN , Kodaka K |
| Ref : Journal of Pesticide Science , 29 :348 , 2004 |
| Abstract : Wakita_2004_J.Pestic.Sci_29_348 |
| ESTHER : Wakita_2004_J.Pestic.Sci_29_348 |
| PubMedSearch : Wakita_2004_J.Pestic.Sci_29_348 |
| PubMedID: |
| Title : Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida - Anzai_2003_FEMS.Microbiol.Lett_218_135 |
| Author(s) : Anzai Y , Saito N , Tanaka M , Kinoshita K , Koyama Y , Kato F |
| Ref : FEMS Microbiology Letters , 218 :135 , 2003 |
| Abstract : Anzai_2003_FEMS.Microbiol.Lett_218_135 |
| ESTHER : Anzai_2003_FEMS.Microbiol.Lett_218_135 |
| PubMedSearch : Anzai_2003_FEMS.Microbiol.Lett_218_135 |
| PubMedID: 12583909 |
| Gene_locus related to this paper: micgr-MYCAV |
| Title : Effect of TA-0910, a novel thyrotropin-releasing hormone analog, on in vivo acetylcholine release and turnover in rat brain - Kinoshita_1996_Jpn.J.Pharmacol_71_139 |
| Author(s) : Kinoshita K , Kawashima K , Kawashima Y , Fukuchi I , Yamamura M , Matsuoka Y |
| Ref : Japanese Journal of Pharmacology , 71 :139 , 1996 |
| Abstract : Kinoshita_1996_Jpn.J.Pharmacol_71_139 |
| ESTHER : Kinoshita_1996_Jpn.J.Pharmacol_71_139 |
| PubMedSearch : Kinoshita_1996_Jpn.J.Pharmacol_71_139 |
| PubMedID: 8835640 |