Full name : Hulme Edward C
First name : Edward C
Mail : The National institute of Mental Research, The Ridgeway, NW71AA London
Zip Code :
City :
Country : United Kingdom
Email : ehulme@nimr.mrc.ac.uk
Phone :
Fax :
Website : \/\/www.researchgate.net\/profile\/Edward_Hulme
Directory :
| Title : GPCR activation: a mutagenic spotlight on crystal structures - Hulme_2013_Trends.Pharmacol.Sci_34_67 |
| Author(s) : Hulme EC |
| Ref : Trends in Pharmacological Sciences , 34 :67 , 2013 |
| Abstract : Hulme_2013_Trends.Pharmacol.Sci_34_67 |
| ESTHER : Hulme_2013_Trends.Pharmacol.Sci_34_67 |
| PubMedSearch : Hulme_2013_Trends.Pharmacol.Sci_34_67 |
| PubMedID: 23245528 |
| Title : Helix 8 of the M1 muscarinic acetylcholine receptor: scanning mutagenesis delineates a G protein recognition site - Kaye_2011_Mol.Pharmacol_79_701 |
| Author(s) : Kaye RG , Saldanha JW , Lu ZL , Hulme EC |
| Ref : Molecular Pharmacology , 79 :701 , 2011 |
| Abstract : Kaye_2011_Mol.Pharmacol_79_701 |
| ESTHER : Kaye_2011_Mol.Pharmacol_79_701 |
| PubMedSearch : Kaye_2011_Mol.Pharmacol_79_701 |
| PubMedID: 21247934 |
| Title : Ligand binding assays at equilibrium: validation and interpretation - Hulme_2010_Br.J.Pharmacol_161_1219 |
| Author(s) : Hulme EC , Trevethick MA |
| Ref : British Journal of Pharmacology , 161 :1219 , 2010 |
| Abstract : Hulme_2010_Br.J.Pharmacol_161_1219 |
| ESTHER : Hulme_2010_Br.J.Pharmacol_161_1219 |
| PubMedSearch : Hulme_2010_Br.J.Pharmacol_161_1219 |
| PubMedID: 20132208 |
| Title : Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptors - Lebon_2009_Mol.Pharmacol_75_331 |
| Author(s) : Lebon G , Langmead CJ , Tehan BG , Hulme EC |
| Ref : Molecular Pharmacology , 75 :331 , 2009 |
| Abstract : Lebon_2009_Mol.Pharmacol_75_331 |
| ESTHER : Lebon_2009_Mol.Pharmacol_75_331 |
| PubMedSearch : Lebon_2009_Mol.Pharmacol_75_331 |
| PubMedID: 19001633 |
| Title : Roof and floor of the muscarinic binding pocket: variations in the binding modes of orthosteric ligands - Goodwin_2007_Mol.Pharmacol_72_1484 |
| Author(s) : Goodwin JA , Hulme EC , Langmead CJ , Tehan BG |
| Ref : Molecular Pharmacology , 72 :1484 , 2007 |
| Abstract : Goodwin_2007_Mol.Pharmacol_72_1484 |
| ESTHER : Goodwin_2007_Mol.Pharmacol_72_1484 |
| PubMedSearch : Goodwin_2007_Mol.Pharmacol_72_1484 |
| PubMedID: 17848601 |
| Title : Functional analysis of transmembrane domain 2 of the M1 muscarinic acetylcholine receptor - Bee_2007_J.Biol.Chem_282_32471 |
| Author(s) : Bee MS , Hulme EC |
| Ref : Journal of Biological Chemistry , 282 :32471 , 2007 |
| Abstract : Bee_2007_J.Biol.Chem_282_32471 |
| ESTHER : Bee_2007_J.Biol.Chem_282_32471 |
| PubMedSearch : Bee_2007_J.Biol.Chem_282_32471 |
| PubMedID: 17823120 |
| Title : Phenotypic classification of mutants: a tool for understanding ligand binding and activation of muscarinic acetylcholine receptors - Hulme_2007_Biochem.Soc.Trans_35_742 |
| Author(s) : Hulme EC , Bee MS , Goodwin JA |
| Ref : Biochemical Society Transactions , 35 :742 , 2007 |
| Abstract : Hulme_2007_Biochem.Soc.Trans_35_742 |
| ESTHER : Hulme_2007_Biochem.Soc.Trans_35_742 |
| PubMedSearch : Hulme_2007_Biochem.Soc.Trans_35_742 |
| PubMedID: 17635138 |
| Title : The hydration of the neurotransmitter acetylcholine in aqueous solution - Hulme_2006_Biophys.J_91_2371 |
| Author(s) : Hulme EC , Soper AK , McLain SE , Finney JL |
| Ref : Biophysical Journal , 91 :2371 , 2006 |
| Abstract : Hulme_2006_Biophys.J_91_2371 |
| ESTHER : Hulme_2006_Biophys.J_91_2371 |
| PubMedSearch : Hulme_2006_Biophys.J_91_2371 |
| PubMedID: 16798812 |
| Title : Structure and activation of muscarinic acetylcholine receptors. - |
| Author(s) : Hulme EC , Lu ZL , Saldanha JW , Bee MS |
| Ref : Cholinergic Mechanisms, CRC Press :55 , 2004 |
| PubMedID: |
| Title : Scanning mutagenesis studies of the M1 muscarinic acetylcholine receptor - Hulme_2003_Receptors.Channels_9_215 |
| Author(s) : Hulme EC , Lu ZL , Bee MS |
| Ref : Receptors Channels , 9 :215 , 2003 |
| Abstract : Hulme_2003_Receptors.Channels_9_215 |
| ESTHER : Hulme_2003_Receptors.Channels_9_215 |
| PubMedSearch : Hulme_2003_Receptors.Channels_9_215 |
| PubMedID: 12893535 |
| Title : Structure and activation of muscarinic acetylcholine receptors - Hulme_2003_Biochem.Soc.Trans_31_29 |
| Author(s) : Hulme EC , Lu ZL , Saldanha JW , Bee MS |
| Ref : Biochemical Society Transactions , 31 :29 , 2003 |
| Abstract : Hulme_2003_Biochem.Soc.Trans_31_29 |
| ESTHER : Hulme_2003_Biochem.Soc.Trans_31_29 |
| PubMedSearch : Hulme_2003_Biochem.Soc.Trans_31_29 |
| PubMedID: 12546648 |
| Title : Seven-transmembrane receptors: crystals clarify - Lu_2002_Trends.Pharmacol.Sci_23_140 |
| Author(s) : Lu ZL , Saldanha JW , Hulme EC |
| Ref : Trends in Pharmacological Sciences , 23 :140 , 2002 |
| Abstract : Lu_2002_Trends.Pharmacol.Sci_23_140 |
| ESTHER : Lu_2002_Trends.Pharmacol.Sci_23_140 |
| PubMedSearch : Lu_2002_Trends.Pharmacol.Sci_23_140 |
| PubMedID: 11879682 |
| Title : Transmembrane domains 4 and 7 of the M(1) muscarinic acetylcholine receptor are critical for ligand binding and the receptor activation switch - Lu_2001_J.Biol.Chem_276_34098 |
| Author(s) : Lu ZL , Saldanha JW , Hulme EC |
| Ref : Journal of Biological Chemistry , 276 :34098 , 2001 |
| Abstract : Lu_2001_J.Biol.Chem_276_34098 |
| ESTHER : Lu_2001_J.Biol.Chem_276_34098 |
| PubMedSearch : Lu_2001_J.Biol.Chem_276_34098 |
| PubMedID: 11441014 |
| Title : The conformational switch in muscarinic acetylcholine receptors - Hulme_2001_Life.Sci_68(22-23)_2495 |
| Author(s) : Hulme EC , Lu ZL , Bee M , Curtis CA , Saldanha J |
| Ref : Life Sciences , 68 :2495 , 2001 |
| Abstract : Hulme_2001_Life.Sci_68(22-23)_2495 |
| ESTHER : Hulme_2001_Life.Sci_68(22-23)_2495 |
| PubMedSearch : Hulme_2001_Life.Sci_68(22-23)_2495 |
| PubMedID: 11392618 |
| Title : ERKI\/II regulation by the muscarinic acetylcholine receptors in neurons - Rosenblum_2000_J.Neurosci_20_977 |
| Author(s) : Rosenblum K , Futter M , Jones M , Hulme EC , Bliss TV |
| Ref : Journal of Neuroscience , 20 :977 , 2000 |
| Abstract : Rosenblum_2000_J.Neurosci_20_977 |
| ESTHER : Rosenblum_2000_J.Neurosci_20_977 |
| PubMedSearch : Rosenblum_2000_J.Neurosci_20_977 |
| PubMedID: 10648702 |
| Title : Scanning mutagenesis identifies amino acid side chains in transmembrane domain 5 of the M(1) muscarinic receptor that participate in binding the acetyl methyl group of acetylcholine - Allman_2000_Mol.Pharmacol_58_175 |
| Author(s) : Allman K , Page KM , Curtis CA , Hulme EC |
| Ref : Molecular Pharmacology , 58 :175 , 2000 |
| Abstract : Allman_2000_Mol.Pharmacol_58_175 |
| ESTHER : Allman_2000_Mol.Pharmacol_58_175 |
| PubMedSearch : Allman_2000_Mol.Pharmacol_58_175 |
| PubMedID: 10860940 |
| Title : A network of conserved intramolecular contacts defines the off-state of the transmembrane switch mechanism in a seven-transmembrane receptor - Lu_2000_J.Biol.Chem_275_5682 |
| Author(s) : Lu ZL , Hulme EC |
| Ref : Journal of Biological Chemistry , 275 :5682 , 2000 |
| Abstract : Lu_2000_J.Biol.Chem_275_5682 |
| ESTHER : Lu_2000_J.Biol.Chem_275_5682 |
| PubMedSearch : Lu_2000_J.Biol.Chem_275_5682 |
| PubMedID: 10681552 |
| Title : The functional topography of transmembrane domain 3 of the M1 muscarinic acetylcholine receptor, revealed by scanning mutagenesis - Lu_1999_J.Biol.Chem_274_7309 |
| Author(s) : Lu ZL , Hulme EC |
| Ref : Journal of Biological Chemistry , 274 :7309 , 1999 |
| Abstract : Lu_1999_J.Biol.Chem_274_7309 |
| ESTHER : Lu_1999_J.Biol.Chem_274_7309 |
| PubMedSearch : Lu_1999_J.Biol.Chem_274_7309 |
| PubMedID: 10066794 |
| Title : Alanine-scanning mutagenesis of transmembrane domain 6 of the M(1) muscarinic acetylcholine receptor suggests that Tyr381 plays key roles in receptor function - Ward_1999_Mol.Pharmacol_56_1031 |
| Author(s) : Ward SD , Curtis CA , Hulme EC |
| Ref : Molecular Pharmacology , 56 :1031 , 1999 |
| Abstract : Ward_1999_Mol.Pharmacol_56_1031 |
| ESTHER : Ward_1999_Mol.Pharmacol_56_1031 |
| PubMedSearch : Ward_1999_Mol.Pharmacol_56_1031 |
| PubMedID: 10531410 |
| Title : The conformational switch in 7-transmembrane receptors: the muscarinic receptor paradigm - Hulme_1999_Eur.J.Pharmacol_375_247 |
| Author(s) : Hulme EC , Lu ZL , Ward SD , Allman K , Curtis CA |
| Ref : European Journal of Pharmacology , 375 :247 , 1999 |
| Abstract : Hulme_1999_Eur.J.Pharmacol_375_247 |
| ESTHER : Hulme_1999_Eur.J.Pharmacol_375_247 |
| PubMedSearch : Hulme_1999_Eur.J.Pharmacol_375_247 |
| PubMedID: 10443581 |
| Title : Scanning mutagenesis of transmembrane domain 3 of the M1 muscarinic acetylcholine receptor - Hulme_1998_J.Physiol.Paris_92_269 |
| Author(s) : Hulme EC , Lu ZL |
| Ref : Journal de Physiologie (Paris) , 92 :269 , 1998 |
| Abstract : Hulme_1998_J.Physiol.Paris_92_269 |
| ESTHER : Hulme_1998_J.Physiol.Paris_92_269 |
| PubMedSearch : Hulme_1998_J.Physiol.Paris_92_269 |
| PubMedID: 9789821 |
| Title : The role of the aspartate-arginine-tyrosine triad in the m1 muscarinic receptor: mutations of aspartate 122 and tyrosine 124 decrease receptor expression but do not abolish signaling - Lu_1997_Mol.Pharmacol_51_234 |
| Author(s) : Lu ZL , Curtis CA , Jones PG , Pavia J , Hulme EC |
| Ref : Molecular Pharmacology , 51 :234 , 1997 |
| Abstract : Lu_1997_Mol.Pharmacol_51_234 |
| ESTHER : Lu_1997_Mol.Pharmacol_51_234 |
| PubMedSearch : Lu_1997_Mol.Pharmacol_51_234 |
| PubMedID: 9203628 |
| Title : The role of charge interactions in muscarinic agonist binding, and receptor-response coupling - Hulme_1995_Life.Sci_56(11-12)_891 |
| Author(s) : Hulme EC , Curtis CA , Page KM , Jones PG |
| Ref : Life Sciences , 56(11-12) :891 , 1995 |
| Abstract : Hulme_1995_Life.Sci_56(11-12)_891 |
| ESTHER : Hulme_1995_Life.Sci_56(11-12)_891 |
| PubMedSearch : Hulme_1995_Life.Sci_56(11-12)_891 |
| PubMedID: 10188790 |
| Title : The functional role of the binding site aspartate in muscarinic acetylcholine receptors, probed by site-directed mutagenesis - Page_1995_Eur.J.Pharmacol_289_429 |
| Author(s) : Page KM , Curtis CA , Jones PG , Hulme EC |
| Ref : European Journal of Pharmacology , 289 :429 , 1995 |
| Abstract : Page_1995_Eur.J.Pharmacol_289_429 |
| ESTHER : Page_1995_Eur.J.Pharmacol_289_429 |
| PubMedSearch : Page_1995_Eur.J.Pharmacol_289_429 |
| PubMedID: 7556411 |
| Title : Characterization of the rat m3 muscarinic acetylcholine receptor produced in insect cells infected with recombinant baculovirus - Vasudevan_1995_Eur.J.Biochem_227_466 |
| Author(s) : Vasudevan S , Hulme EC , Bach M , Haase W , Pavia J , Reilander H |
| Ref : European Journal of Biochemistry , 227 :466 , 1995 |
| Abstract : Vasudevan_1995_Eur.J.Biochem_227_466 |
| ESTHER : Vasudevan_1995_Eur.J.Biochem_227_466 |
| PubMedSearch : Vasudevan_1995_Eur.J.Biochem_227_466 |
| PubMedID: 7851424 |
| Title : The function of a highly-conserved arginine residue in activation of the muscarinic M1 receptor - Jones_1995_Eur.J.Pharmacol_288_251 |
| Author(s) : Jones PG , Curtis CA , Hulme EC |
| Ref : European Journal of Pharmacology , 288 :251 , 1995 |
| Abstract : Jones_1995_Eur.J.Pharmacol_288_251 |
| ESTHER : Jones_1995_Eur.J.Pharmacol_288_251 |
| PubMedSearch : Jones_1995_Eur.J.Pharmacol_288_251 |
| PubMedID: 7774669 |
| Title : Acetylcholine mustard labels the binding site aspartate in muscarinic acetylcholine receptors - Spalding_1994_J.Biol.Chem_269_4092 |
| Author(s) : Spalding TA , Birdsall NJ , Curtis CA , Hulme EC |
| Ref : Journal of Biological Chemistry , 269 :4092 , 1994 |
| Abstract : Spalding_1994_J.Biol.Chem_269_4092 |
| ESTHER : Spalding_1994_J.Biol.Chem_269_4092 |
| PubMedSearch : Spalding_1994_J.Biol.Chem_269_4092 |
| PubMedID: 8307968 |
| Title : Poster: Studies on muscarinic receptors using nitrogen mustards - |
| Author(s) : Birdsall NJ , Spalding TA , Corrie JE , Curtis CA , Hulme EC |
| Ref : Life Sciences , 52(5-6) :561 , 1993 |
| PubMedID: |
| Title : Modulation of the structure-binding relationships of antagonists for muscarinic acetylcholine receptor subtypes - Pedder_1991_Br.J.Pharmacol_103_1561 |
| Author(s) : Pedder EK , Eveleigh P , Poyner D , Hulme EC , Birdsall NJ |
| Ref : British Journal of Pharmacology , 103 :1561 , 1991 |
| Abstract : Pedder_1991_Br.J.Pharmacol_103_1561 |
| ESTHER : Pedder_1991_Br.J.Pharmacol_103_1561 |
| PubMedSearch : Pedder_1991_Br.J.Pharmacol_103_1561 |
| PubMedID: 1884110 |
| Title : Muscarinic acetylcholine receptors: structure and function - |
| Author(s) : Hulme EC , Kurtenbach E , Curtis CA |
| Ref : Biochemical Society Transactions , 19 :133 , 1991 |
| PubMedID: 1903735 |
| Title : Use of clonal cell lines in the analysis of neurotransmitter receptor mechanisms and function - |
| Author(s) : Buckley NJ , Hulme EC , Birdsall NJ |
| Ref : Biochimica & Biophysica Acta , 1055 :43 , 1990 |
| PubMedID: 2171675 |
| Title : Muscarinic acetylcholine receptors. Peptide sequencing identifies residues involved in antagonist binding and disulfide bond formation - Kurtenbach_1990_J.Biol.Chem_265_13702 |
| Author(s) : Kurtenbach E , Curtis CA , Pedder EK , Aitken A , Harris AC , Hulme EC |
| Ref : Journal of Biological Chemistry , 265 :13702 , 1990 |
| Abstract : Kurtenbach_1990_J.Biol.Chem_265_13702 |
| ESTHER : Kurtenbach_1990_J.Biol.Chem_265_13702 |
| PubMedSearch : Kurtenbach_1990_J.Biol.Chem_265_13702 |
| PubMedID: 2380182 |
| Title : The putative disulphide bond in muscarinic receptors - |
| Author(s) : Kurtenbach E , Pedder EK , Curtis CA , Hulme EC |
| Ref : Biochemical Society Transactions , 18 :442 , 1990 |
| PubMedID: 2373234 |
| Title : Muscarinic acetylcholine receptors: typical G-coupled receptors - Hulme_1990_Symp.Soc.Exp.Biol_44_39 |
| Author(s) : Hulme EC |
| Ref : Symp Soc Exp Biol , 44 :39 , 1990 |
| Abstract : Hulme_1990_Symp.Soc.Exp.Biol_44_39 |
| ESTHER : Hulme_1990_Symp.Soc.Exp.Biol_44_39 |
| PubMedSearch : Hulme_1990_Symp.Soc.Exp.Biol_44_39 |
| PubMedID: 2130518 |
| Title : Muscarinic receptor subtypes - |
| Author(s) : Hulme EC , Birdsall NJ , Buckley NJ |
| Ref : Annual Review of Pharmacology & Toxicology , 30 :633 , 1990 |
| PubMedID: 2188581 |
| Title : Blockade of muscarinic receptors by alkylating agonist analogues - |
| Author(s) : Hulme EC , Spalding TA , Curtis CA , Birdsall NJ , Corrie JE |
| Ref : Biochemical Society Transactions , 18 :440 , 1990 |
| PubMedID: 2373233 |
| Title : Poster: Location of sulfydryl groups of the muscarinic acetylcnoline receptors involved in intramolecular disulfide bonds by peptide mapping studies - |
| Author(s) : Kurtenbach E , Pedder EK , Curtis CA , Hulme EC |
| Ref : Trends in Pharmacological Sciences , Suppl :115 , 1989 |
| PubMedID: |
| Title : The existence of stable enantiomers of telenzepine and their stereoselective interaction with muscarinic receptor subtypes - Eveleigh_1989_Mol.Pharmacol_35_477 |
| Author(s) : Eveleigh P , Hulme EC , Schudt C , Birdsall NJ |
| Ref : Molecular Pharmacology , 35 :477 , 1989 |
| Abstract : Eveleigh_1989_Mol.Pharmacol_35_477 |
| ESTHER : Eveleigh_1989_Mol.Pharmacol_35_477 |
| PubMedSearch : Eveleigh_1989_Mol.Pharmacol_35_477 |
| PubMedID: 2704371 |
| Title : Propylbenzilylcholine mustard labels an acidic residue in transmembrane helix 3 of the muscarinic receptor - Curtis_1989_J.Biol.Chem_264_489 |
| Author(s) : Curtis CA , Wheatley M , Bansal S , Birdsall NJ , Eveleigh P , Pedder EK , Poyner D , Hulme EC |
| Ref : Journal of Biological Chemistry , 264 :489 , 1989 |
| Abstract : Curtis_1989_J.Biol.Chem_264_489 |
| ESTHER : Curtis_1989_J.Biol.Chem_264_489 |
| PubMedSearch : Curtis_1989_J.Biol.Chem_264_489 |
| PubMedID: 2909533 |
| Title : Localization and structure of the muscarinic receptor ligand binding site - Hulme_1989_Trends.Pharmacol.Sci_Suppl_22 |
| Author(s) : Hulme EC , Curtis CA , Wheatley M , Aitken A , Harris AC |
| Ref : Trends in Pharmacological Sciences , Suppl :22 , 1989 |
| Abstract : Hulme_1989_Trends.Pharmacol.Sci_Suppl_22 |
| ESTHER : Hulme_1989_Trends.Pharmacol.Sci_Suppl_22 |
| PubMedSearch : Hulme_1989_Trends.Pharmacol.Sci_Suppl_22 |
| PubMedID: 2694518 |
| Title : The modes of binding of ligands to cardiac muscarinic receptors - Birdsall_1989_Trends.Pharmacol.Sci_Suppl_31 |
| Author(s) : Birdsall NJ , Chan SC , Eveleigh P , Hulme EC , Miller KW |
| Ref : Trends in Pharmacological Sciences , Suppl :31 , 1989 |
| Abstract : Birdsall_1989_Trends.Pharmacol.Sci_Suppl_31 |
| ESTHER : Birdsall_1989_Trends.Pharmacol.Sci_Suppl_31 |
| PubMedSearch : Birdsall_1989_Trends.Pharmacol.Sci_Suppl_31 |
| PubMedID: 2694519 |
| Title : Binding and hydrodynamic properties of muscarinic receptor subtypes solubilized in 3-(3-cholamidopropyl)dimethylammonio-2-hydroxy-1-propanesulfonate - Poyner_1989_Mol.Pharmacol_36_420 |
| Author(s) : Poyner DR , Birdsall NJ , Curtis CA , Eveleigh P , Hulme EC , Pedder EK , Wheatley M |
| Ref : Molecular Pharmacology , 36 :420 , 1989 |
| Abstract : Poyner_1989_Mol.Pharmacol_36_420 |
| ESTHER : Poyner_1989_Mol.Pharmacol_36_420 |
| PubMedSearch : Poyner_1989_Mol.Pharmacol_36_420 |
| PubMedID: 2506431 |
| Title : Muscarinic receptor subtypes and the selectivity of agonists and antagonists - Birdsall_1988_Pharmacology_37 Suppl 1_22 |
| Author(s) : Birdsall NJ , Curtis CA , Eveleigh P , Hulme EC , Pedder EK , Poyner D , Wheatley M |
| Ref : Pharmacology , 37 Suppl 1 :22 , 1988 |
| Abstract : Birdsall_1988_Pharmacology_37 Suppl 1_22 |
| ESTHER : Birdsall_1988_Pharmacology_37 Suppl 1_22 |
| PubMedSearch : Birdsall_1988_Pharmacology_37 Suppl 1_22 |
| PubMedID: 2467316 |
| Title : Peptide mapping studies on muscarinic receptors: receptor structure and location of the ligand binding site - |
| Author(s) : Wheatley M , Hulme EC , Birdsall NJ , Curtis CA , Eveleigh P , Pedder EK , Poyner D |
| Ref : Trends in Pharmacological Sciences , Suppl :19 , 1988 |
| PubMedID: 3074531 |
| Title : Muscarinic acetylcholine receptors: structure, function subtypes and therapeutic perspectives - Hulme_1987_Postgrad.Med.J_63 Suppl 1_5 |
| Author(s) : Hulme EC , Birdsall NJ , Wheatley M , Curtis CA , Pedder EK , Poyner D , Stockton JM , Eveleigh P |
| Ref : Postgrad Med J , 63 Suppl 1 :5 , 1987 |
| Abstract : Hulme_1987_Postgrad.Med.J_63 Suppl 1_5 |
| ESTHER : Hulme_1987_Postgrad.Med.J_63 Suppl 1_5 |
| PubMedSearch : Hulme_1987_Postgrad.Med.J_63 Suppl 1_5 |
| PubMedID: 3321013 |
| Title : The structure and properties of the purified muscarinic acetylcholine receptor from rat forebrain - |
| Author(s) : Wheatley M , Birdsall NJ , Curtis CA , Eveleigh P , Pedder EK , Poyner D , Stockton JM , Hulme EC |
| Ref : Biochemical Society Transactions , 15 :113 , 1987 |
| PubMedID: 3556731 |
| Title : Use of 125I-Tyr27 beta-endorphin for the study of beta-endorphin binding sites in rat cortex - Toogood_1986_Neuroendocrinology_43_629 |
| Author(s) : Toogood CL , McFarthing KG , Hulme EC , Smyth DG |
| Ref : Neuroendocrinology , 43 :629 , 1986 |
| Abstract : Toogood_1986_Neuroendocrinology_43_629 |
| ESTHER : Toogood_1986_Neuroendocrinology_43_629 |
| PubMedSearch : Toogood_1986_Neuroendocrinology_43_629 |
| PubMedID: 3020464 |
| Title : Muscarinic receptor-subclasses: The binding properties of the soluble receptor binding sites - |
| Author(s) : Berrie CP , Birdsall NJ , Hulme EC , Keen M , Stockton JM , Wheatley M |
| Ref : Trends in Pharmacological Sciences , Suppl :8 , 1986 |
| PubMedID: |
| Title : The binding of pirenzepine to digitonin-solubilized muscarinic acetylcholine receptors from the rat myocardium - Birdsall_1986_Br.J.Pharmacol_87_307 |
| Author(s) : Birdsall NJ , Hulme EC , Keen M |
| Ref : British Journal of Pharmacology , 87 :307 , 1986 |
| Abstract : Birdsall_1986_Br.J.Pharmacol_87_307 |
| ESTHER : Birdsall_1986_Br.J.Pharmacol_87_307 |
| PubMedSearch : Birdsall_1986_Br.J.Pharmacol_87_307 |
| PubMedID: 3754173 |
| Title : Soluble and membrane-bound muscarinic acetylcholine receptors - Birdsall_1986_Biochem.Soc.Symp_52_23 |
| Author(s) : Birdsall NJ , Hulme EC , Keen M , Pedder EK , Poyner D , Stockton JM , Wheatley M |
| Ref : Biochemical Society Symposium , 52 :23 , 1986 |
| Abstract : Birdsall_1986_Biochem.Soc.Symp_52_23 |
| ESTHER : Birdsall_1986_Biochem.Soc.Symp_52_23 |
| PubMedSearch : Birdsall_1986_Biochem.Soc.Symp_52_23 |
| PubMedID: 3579968 |
| Title : Purification of the muscarinic acetylcholine receptor from rat forebrain - |
| Author(s) : Berrie CP , Birdsall NJ , Dadi HK , Hulme EC , Morris RJ , Stockton JM , Wheatley M |
| Ref : Biochemical Society Transactions , 13 :1101 , 1985 |
| PubMedID: 4092829 |
| Title : Solubilization and characterization of high and low affinity pirenzepine binding sites from rat cerebral cortex - Berrie_1985_Br.J.Pharmacol_85_697 |
| Author(s) : Berrie CP , Birdsall NJ , Hulme EC , Keen M , Stockton JM |
| Ref : British Journal of Pharmacology , 85 :697 , 1985 |
| Abstract : Berrie_1985_Br.J.Pharmacol_85_697 |
| ESTHER : Berrie_1985_Br.J.Pharmacol_85_697 |
| PubMedSearch : Berrie_1985_Br.J.Pharmacol_85_697 |
| PubMedID: 4027484 |
| Title : Muscarinic receptor heterogeneity - |
| Author(s) : Birdsall NJ , Hulme EC , Stockton JM |
| Ref : Trends in Pharmacological Sciences , Suppl :4 , 1984 |
| PubMedID: |
| Title : [125I] Tyr27 beta-endorphin: a radio-iodinated derivative of beta-endorphin for the study of opiate receptors - Toogood_1984_Neuropeptides_5_121 |
| Author(s) : Toogood CI , McFarthing KG , Hulme EC , Smyth DG |
| Ref : Neuropeptides , 5 :121 , 1984 |
| Abstract : Toogood_1984_Neuropeptides_5_121 |
| ESTHER : Toogood_1984_Neuropeptides_5_121 |
| PubMedSearch : Toogood_1984_Neuropeptides_5_121 |
| PubMedID: 6099478 |
| Title : Hydrodynamic properties of muscarinic acetylcholine receptors solubilized from rat forebrain - Berrie_1984_Br.J.Pharmacol_82_839 |
| Author(s) : Berrie CP , Birdsall NJ , Haga K , Haga T , Hulme EC |
| Ref : British Journal of Pharmacology , 82 :839 , 1984 |
| Abstract : Berrie_1984_Br.J.Pharmacol_82_839 |
| ESTHER : Berrie_1984_Br.J.Pharmacol_82_839 |
| PubMedSearch : Berrie_1984_Br.J.Pharmacol_82_839 |
| PubMedID: 6478114 |
| Title : Solubilization and characterization of guanine nucleotide-sensitive muscarinic agonist binding sites from rat myocardium - Berrie_1984_Br.J.Pharmacol_82_853 |
| Author(s) : Berrie CP , Birdsall NJ , Hulme EC , Keen M , Stockton JM |
| Ref : British Journal of Pharmacology , 82 :853 , 1984 |
| Abstract : Berrie_1984_Br.J.Pharmacol_82_853 |
| ESTHER : Berrie_1984_Br.J.Pharmacol_82_853 |
| PubMedSearch : Berrie_1984_Br.J.Pharmacol_82_853 |
| PubMedID: 6478115 |
| Title : Modification of the binding properties of muscarinic receptors by gallamine - Stockton_1983_Mol.Pharmacol_23_551 |
| Author(s) : Stockton JM , Birdsall NJ , Burgen AS , Hulme EC |
| Ref : Molecular Pharmacology , 23 :551 , 1983 |
| Abstract : Stockton_1983_Mol.Pharmacol_23_551 |
| ESTHER : Stockton_1983_Mol.Pharmacol_23_551 |
| PubMedSearch : Stockton_1983_Mol.Pharmacol_23_551 |
| PubMedID: 6865905 |
| Title : The effects of p-chloromercuribenzoate on muscarinic receptors in the cerebral cortex - Birdsall_1983_Br.J.Pharmacol_80_187 |
| Author(s) : Birdsall NJ , Burgen AS , Hulme EC , Wong EH |
| Ref : British Journal of Pharmacology , 80 :187 , 1983 |
| Abstract : Birdsall_1983_Br.J.Pharmacol_80_187 |
| ESTHER : Birdsall_1983_Br.J.Pharmacol_80_187 |
| PubMedSearch : Birdsall_1983_Br.J.Pharmacol_80_187 |
| PubMedID: 6652369 |
| Title : The effect of p-chloromercuribenzoate on structure-binding relationships of muscarinic receptors in the rat cerebral cortex - Birdsall_1983_Br.J.Pharmacol_80_197 |
| Author(s) : Birdsall NJ , Burgen AS , Hulme EC , Wong EH |
| Ref : British Journal of Pharmacology , 80 :197 , 1983 |
| Abstract : Birdsall_1983_Br.J.Pharmacol_80_197 |
| ESTHER : Birdsall_1983_Br.J.Pharmacol_80_197 |
| PubMedSearch : Birdsall_1983_Br.J.Pharmacol_80_197 |
| PubMedID: 6652370 |
| Title : Regulation of muscarinic agonist binding by cations and guanine nucleotides - Hulme_1983_Eur.J.Pharmacol_94_59 |
| Author(s) : Hulme EC , Berrie CP , Birdsall NJ , Jameson M , Stockton JM |
| Ref : European Journal of Pharmacology , 94 :59 , 1983 |
| Abstract : Hulme_1983_Eur.J.Pharmacol_94_59 |
| ESTHER : Hulme_1983_Eur.J.Pharmacol_94_59 |
| PubMedSearch : Hulme_1983_Eur.J.Pharmacol_94_59 |
| PubMedID: 6418552 |
| Title : Solubilisation and molecular characterisation of muscarinic acetylcholine receptors - Hulme_1983_J.Recept.Res_3_301 |
| Author(s) : Hulme EC , Berrie CP , Haga T , Birdsall NJ , Burgen AS , Stockton J |
| Ref : J Recept Res , 3 :301 , 1983 |
| Abstract : Hulme_1983_J.Recept.Res_3_301 |
| ESTHER : Hulme_1983_J.Recept.Res_3_301 |
| PubMedSearch : Hulme_1983_J.Recept.Res_3_301 |
| PubMedID: 6854547 |
| Title : The effect of McN-A-343 on muscarinic receptors in the cerebral cortex and heart - Birdsall_1983_Br.J.Pharmacol_78_257 |
| Author(s) : Birdsall NJ , Burgen AS , Hulme EC , Stockton JM , Zigmond MJ |
| Ref : British Journal of Pharmacology , 78 :257 , 1983 |
| Abstract : Birdsall_1983_Br.J.Pharmacol_78_257 |
| ESTHER : Birdsall_1983_Br.J.Pharmacol_78_257 |
| PubMedSearch : Birdsall_1983_Br.J.Pharmacol_78_257 |
| PubMedID: 6187403 |
| Title : Muscarinic receptor subclasses: evidence from binding studies - |
| Author(s) : Birdsall NJ , Hulme EC , Stockton J , Burgen AS , Berrie CP , Hammer R , Wong EH , Zigmond MJ |
| Ref : Adv Biochem Psychopharmacol , 37 :323 , 1983 |
| PubMedID: 6688916 |
| Title : Muscarinic receptor subclasses: allosteric interactions - |
| Author(s) : Birdsall NJ , Hulme EC , Stockton JM |
| Ref : Cold Spring Harbor Symposium on Quantitative Biology , 48 Pt 1 :53 , 1983 |
| PubMedID: 6586362 |
| Title : The theory, methods and relevance of muscarinic receptor binding studies - Stockton_1982_Scand.J.Gastroenterol.Suppl_72_43 |
| Author(s) : Stockton J , Birdsall NJ , Burgen AS , Hulme EC |
| Ref : Scand J Gastroenterol Suppl , 72 :43 , 1982 |
| Abstract : Stockton_1982_Scand.J.Gastroenterol.Suppl_72_43 |
| ESTHER : Stockton_1982_Scand.J.Gastroenterol.Suppl_72_43 |
| PubMedSearch : Stockton_1982_Scand.J.Gastroenterol.Suppl_72_43 |
| PubMedID: 6957996 |
| Title : The binding properties of the muscarinic receptors of the cynomolgus monkey ciliary body and the response to the induction of agonist subsensitivity - Barany_1982_Br.J.Pharmacol_77_731 |
| Author(s) : Barany E , Berrie CP , Birdsall NJ , Burgen AS , Hulme EC |
| Ref : British Journal of Pharmacology , 77 :731 , 1982 |
| Abstract : Barany_1982_Br.J.Pharmacol_77_731 |
| ESTHER : Barany_1982_Br.J.Pharmacol_77_731 |
| PubMedSearch : Barany_1982_Br.J.Pharmacol_77_731 |
| PubMedID: 6897523 |
| Title : Presynaptic muscarinic receptors on dopaminergic terminals in the nucleus accumbens - De Belleroche_1982_Brain.Res_234_327 |
| Author(s) : de Belleroche J , Kilpatrick IC , Birdsall NJ , Hulme EC |
| Ref : Brain Research , 234 :327 , 1982 |
| Abstract : De Belleroche_1982_Brain.Res_234_327 |
| ESTHER : De Belleroche_1982_Brain.Res_234_327 |
| PubMedSearch : De Belleroche_1982_Brain.Res_234_327 |
| PubMedID: 7059834 |
| Title : Effect of tityus toxin and sensory stimulation on muscarinic cholinergic receptors in vivo - |
| Author(s) : Abdul-Ghani AS , Boyar MM , Coutinho-Netto J , Bradford HF , Berrie CP , Hulme EC , Birdsall NJ |
| Ref : Biochemical Pharmacology , 30 :2713 , 1981 |
| PubMedID: 7295354 |
| Title : Muscarinic cholinergic receptor localization in brain by electron microscopic autoradiography - Kuhar_1981_Brain.Res_216_1 |
| Author(s) : Kuhar MJ , Taylor N , Wamsley JK , Hulme EC , Birdsall NJ |
| Ref : Brain Research , 216 :1 , 1981 |
| Abstract : Kuhar_1981_Brain.Res_216_1 |
| ESTHER : Kuhar_1981_Brain.Res_216_1 |
| PubMedSearch : Kuhar_1981_Brain.Res_216_1 |
| PubMedID: 7260602 |
| Title : Binding States of Muscarinic Receptors - |
| Author(s) : Birdsall NJ , Berrie CP , Burgen AS , Hammer R , Hulme EC , Stockton J |
| Ref : Advances in Behavioral Biology , 25 :595 , 1981 |
| PubMedID: |
| Title : Two populations of binding sites for muscarinic antagonists in the rat heart - Hulme_1981_Eur.J.Pharmacol_73_137 |
| Author(s) : Hulme EC , Berrie CP , Birdsall NJ , Burgen AS |
| Ref : European Journal of Pharmacology , 73 :137 , 1981 |
| Abstract : Hulme_1981_Eur.J.Pharmacol_73_137 |
| ESTHER : Hulme_1981_Eur.J.Pharmacol_73_137 |
| PubMedSearch : Hulme_1981_Eur.J.Pharmacol_73_137 |
| PubMedID: 7308290 |
| Title : Acetylcholine release and muscarinic receptors in cortical synaptosomes from epileptic rats - |
| Author(s) : Coutinho-Netto J , Boyar M , Bradford HF , Birdsall NJ , Hulme EC |
| Ref : Experimental Neurology , 74 :837 , 1981 |
| PubMedID: 7308372 |
| Title : Ontogeny of muscarinic receptors in rat brain - Kuhar_1980_Brain.Res_184_375 |
| Author(s) : Kuhar MJ , Birdsall NJ , Burgen AS , Hulme EC |
| Ref : Brain Research , 184 :375 , 1980 |
| Abstract : Kuhar_1980_Brain.Res_184_375 |
| ESTHER : Kuhar_1980_Brain.Res_184_375 |
| PubMedSearch : Kuhar_1980_Brain.Res_184_375 |
| PubMedID: 7353163 |
| Title : Pirenzepine distinguishes between different subclasses of muscarinic receptors - Hammer_1980_Nature_283_90 |
| Author(s) : Hammer R , Berrie CP , Birdsall NJ , Burgen AS , Hulme EC |
| Ref : Nature , 283 :90 , 1980 |
| Abstract : Hammer_1980_Nature_283_90 |
| ESTHER : Hammer_1980_Nature_283_90 |
| PubMedSearch : Hammer_1980_Nature_283_90 |
| PubMedID: 7350532 |
| Title : Effects of p-chloromercuribenzoate on muscarinic receptor binding in rat brain [proceedings] - |
| Author(s) : Birdsall NJ , Burgen AS , Hulme EC , Wong EH |
| Ref : British Journal of Pharmacology , 68 :142P , 1980 |
| PubMedID: 7357157 |
| Title : Modulation of the binding properties of muscarinic receptors: evidence for receptor-effector coupling - |
| Author(s) : Birdsall NJ , Berrie CP , Burgen AS , Hulme EC |
| Ref : Adv Biochem Psychopharmacol , 21 :107 , 1980 |
| PubMedID: 6246734 |
| Title : Pirenzepine--a ligand with original binding properties to muscarinic receptors - Birdsall_1980_Scand.J.Gastroenterol.Suppl_66_1 |
| Author(s) : Birdsall NJ , Burgen AS , Hammer R , Hulme EC , Stockton J |
| Ref : Scand J Gastroenterol Suppl , 66 :1 , 1980 |
| Abstract : Birdsall_1980_Scand.J.Gastroenterol.Suppl_66_1 |
| ESTHER : Birdsall_1980_Scand.J.Gastroenterol.Suppl_66_1 |
| PubMedSearch : Birdsall_1980_Scand.J.Gastroenterol.Suppl_66_1 |
| PubMedID: 6941372 |
| Title : The binding properties of muscarinic receptors in the brain of the frog (R. temporaria) - Birdsall_1980_Brain.Res_184_385 |
| Author(s) : Birdsall NJ , Burgen AS , Hulme EC |
| Ref : Brain Research , 184 :385 , 1980 |
| Abstract : Birdsall_1980_Brain.Res_184_385 |
| ESTHER : Birdsall_1980_Brain.Res_184_385 |
| PubMedSearch : Birdsall_1980_Brain.Res_184_385 |
| PubMedID: 6965461 |
| Title : Competitive binding studies with multiple sites. Effects arising from depletion of the free radioligand - Wells_1980_Biochim.Biophys.Acta_632_464 |
| Author(s) : Wells JW , Birdsall NJ , Burgen AS , Hulme EC |
| Ref : Biochimica & Biophysica Acta , 632 :464 , 1980 |
| Abstract : Wells_1980_Biochim.Biophys.Acta_632_464 |
| ESTHER : Wells_1980_Biochim.Biophys.Acta_632_464 |
| PubMedSearch : Wells_1980_Biochim.Biophys.Acta_632_464 |
| PubMedID: 7417533 |
| Title : The character of the muscarinic receptors in different regions of the rat brain - Birdsall_1980_Proc.R.Soc.Lond.B.Biol.Sci_207_1 |
| Author(s) : Birdsall NJ , Hulme EC , Burgen AS |
| Ref : Proc R Soc Lond B Biol Sci , 207 :1 , 1980 |
| Abstract : Birdsall_1980_Proc.R.Soc.Lond.B.Biol.Sci_207_1 |
| ESTHER : Birdsall_1980_Proc.R.Soc.Lond.B.Biol.Sci_207_1 |
| PubMedSearch : Birdsall_1980_Proc.R.Soc.Lond.B.Biol.Sci_207_1 |
| PubMedID: 6102394 |
| Title : Muscarinic receptors in the central nervous system of the rat. I. Technique for autoradiographic localization of the binding of [3H]propylbenzilylcholine mustard and its distribution in the forebrain - Rotter_1979_Brain.Res_180_141 |
| Author(s) : Rotter A , Birdsall NJ , Burgen AS , Field PM , Hulme EC , Raisman G |
| Ref : Brain Research , 180 :141 , 1979 |
| Abstract : Rotter_1979_Brain.Res_180_141 |
| ESTHER : Rotter_1979_Brain.Res_180_141 |
| PubMedSearch : Rotter_1979_Brain.Res_180_141 |
| PubMedID: 519514 |
| Title : Temperature coefficients of affinity constants for the binding of antagonists to muscarinic receptors in the rat cerebral cortex - Barlow_1979_Br.J.Pharmacol_66_587 |
| Author(s) : Barlow RB , Birdsall NJ , Hulme EC |
| Ref : British Journal of Pharmacology , 66 :587 , 1979 |
| Abstract : Barlow_1979_Br.J.Pharmacol_66_587 |
| ESTHER : Barlow_1979_Br.J.Pharmacol_66_587 |
| PubMedSearch : Barlow_1979_Br.J.Pharmacol_66_587 |
| PubMedID: 465896 |
| Title : Guanine nucleotides modulate muscarinic receptor binding in the heart - |
| Author(s) : Berrie CP , Birdsall NJ , Burgen AS , Hulme EC |
| Ref : Biochemical & Biophysical Research Communications , 87 :1000 , 1979 |
| PubMedID: 465020 |
| Title : Ionic perturbation of agonist binding to brain muscarinic receptors [proceedings] - |
| Author(s) : Berrie CP , Birdsall NJ , Burgen AS , Hulme EC |
| Ref : British Journal of Pharmacology , 66 :470P , 1979 |
| PubMedID: 526753 |
| Title : Depolarisation-induced changes in muscarinic cholinergic receptors in synaptosomes - |
| Author(s) : Luqmani YA , Bradford HF , Birdsall NJ , Hulme EC |
| Ref : Nature , 277 :481 , 1979 |
| PubMedID: 763331 |
| Title : A study of the muscarinic receptor by gel electrophoresis - Birdsall_1979_Br.J.Pharmacol_66_337 |
| Author(s) : Birdsall NJ , Burgen AS , Hulme EC |
| Ref : British Journal of Pharmacology , 66 :337 , 1979 |
| Abstract : Birdsall_1979_Br.J.Pharmacol_66_337 |
| ESTHER : Birdsall_1979_Br.J.Pharmacol_66_337 |
| PubMedSearch : Birdsall_1979_Br.J.Pharmacol_66_337 |
| PubMedID: 465889 |
| Title : The effects of ions on the binding of agonists and antagonists to muscarinic receptors - Birdsall_1979_Br.J.Pharmacol_67_371 |
| Author(s) : Birdsall NJ , Burgen AS , Hulme EC , Wells JW |
| Ref : British Journal of Pharmacology , 67 :371 , 1979 |
| Abstract : Birdsall_1979_Br.J.Pharmacol_67_371 |
| ESTHER : Birdsall_1979_Br.J.Pharmacol_67_371 |
| PubMedSearch : Birdsall_1979_Br.J.Pharmacol_67_371 |
| PubMedID: 497538 |
| Title : Correlation Between the Binding Properties and Pharmacological Responses of Muscarinic Receptors - |
| Author(s) : Birdsall NJ , Burgen AS , Hulme EC |
| Ref : Advances in Behavioral Biology , 24 :25 , 1978 |
| PubMedID: |
| Title : The binding of antagonists to brain muscarinic receptors - |
| Author(s) : Hulme EC , Birdsall NJ , Burgen AS , Mehta P |
| Ref : Molecular Pharmacology , 14 :737 , 1978 |
| PubMedID: 714022 |
| Title : The binding of agonists to brain muscarinic receptors - |
| Author(s) : Birdsall NJ , Burgen AS , Hulme EC |
| Ref : Molecular Pharmacology , 14 :723 , 1978 |
| PubMedID: 714021 |
| Title : Muscarinic receptors: ionic perturbation of the binding properties [proceedings] - |
| Author(s) : Birdsall NJ , Burgen AS , Hulme EC , Wells JW |
| Ref : British Journal of Pharmacology , 59 :503P , 1977 |
| PubMedID: 843741 |
| Title : Induction of excessive grooming in the rat by fragments of lipotropin - |
| Author(s) : Gispen WH , Wiegant VM , Bradbury AF , Hulme EC , Smyth DG , Snell CR , de Wied D |
| Ref : Nature , 264 :794 , 1976 |
| PubMedID: 189197 |
| Title : Induction of tolerance to the analgesic action of lipotropin in C-fragment - |
| Author(s) : van Ree JM , de Wied D , Bradbury AF , Hulme EC , Smyth DC , Snell CR |
| Ref : Nature , 264 :792 , 1976 |
| PubMedID: 1012322 |
| Title : Interactions of peptides derived from the C-fragment of beta-lipotropin with brain opiate receptors [proceedings] - |
| Author(s) : Birdsall NJ , Bradbury AF , Burgen AS , Hulme EC , Smyth DG , Snell CR |
| Ref : British Journal of Pharmacology , 58 :460P , 1976 |
| PubMedID: 186148 |
| Title : Binding of agonists and antagonists to muscarinic receptors - Birdsall_1976_J.Supramol.Struct_4_367 |
| Author(s) : Birdsall NJ , Burgen AS , Hiley CR , Hulme EC |
| Ref : J Supramol Struct , 4 :367 , 1976 |
| Abstract : Birdsall_1976_J.Supramol.Struct_4_367 |
| ESTHER : Birdsall_1976_J.Supramol.Struct_4_367 |
| PubMedSearch : Birdsall_1976_J.Supramol.Struct_4_367 |
| PubMedID: 1263513 |
| Title : Biochemical studies on muscarinic acetylcholine receptors - |
| Author(s) : Birdsall NJ , Hulme EC |
| Ref : Journal of Neurochemistry , 27 :7 , 1976 |
| PubMedID: 784913 |
| Title : C fragment of lipotropin has a high affinity for brain opiate receptors - |
| Author(s) : Birdsall NJ , Hulme EC |
| Ref : Nature , 260 :793 , 1976 |
| PubMedID: 1264258 |
| Title : The isotope-exchange reactions of ox heart phosphofructokinase - Hulme_1971_Biochem.J_122_181 |
| Author(s) : Hulme EC , Tipton KF |
| Ref : Biochemical Journal , 122 :181 , 1971 |
| Abstract : Hulme_1971_Biochem.J_122_181 |
| ESTHER : Hulme_1971_Biochem.J_122_181 |
| PubMedSearch : Hulme_1971_Biochem.J_122_181 |
| PubMedID: 4256093 |
| Title : Some observations on the surgical treatment of heart block in degenerative heart disease - |
| Author(s) : Nicks R , Stening GF , Hulme EC |
| Ref : Med J Aust , 49(2) :857 , 1962 |
| PubMedID: 13938368 |