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| Title : Endocannabinoid biosynthetic enzymes regulate pain response via LKB1-AMPK signaling - Chen_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2304900120 |
| Author(s) : Chen M , Shin M , Ware TB , Donvito G , Muchhala KH , Mischel R , Mustafa MA , Serbulea V , Upchurch CM , Leitinger N , Akbarali HI , Lichtman AH , Hsu KL |
| Ref : Proc Natl Acad Sci U S A , 120 :e2304900120 , 2023 |
| Abstract : Chen_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2304900120 |
| ESTHER : Chen_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2304900120 |
| PubMedSearch : Chen_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2304900120 |
| PubMedID: 38109529 |
| Title : Diacylglycerol Lipase-beta Is Required for TNF-alpha Response but Not CD8(+) T Cell Priming Capacity of Dendritic Cells - Shin_2019_Cell.Chem.Biol_26_1036 |
| Author(s) : Shin M , Buckner A , Prince J , Bullock TNJ , Hsu KL |
| Ref : Cell Chemical Biology , 26 :1036 , 2019 |
| Abstract : Shin_2019_Cell.Chem.Biol_26_1036 |
| ESTHER : Shin_2019_Cell.Chem.Biol_26_1036 |
| PubMedSearch : Shin_2019_Cell.Chem.Biol_26_1036 |
| PubMedID: 31105063 |
| Title : Lipid-metabolizing serine hydrolases in the mammalian central nervous system: endocannabinoids and beyond - Shin_2019_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1864_907 |
| Author(s) : Shin M , Ware TB , Lee HC , Hsu KL |
| Ref : Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids , 1864 :907 , 2019 |
| Abstract : Shin_2019_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1864_907 |
| ESTHER : Shin_2019_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1864_907 |
| PubMedSearch : Shin_2019_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1864_907 |
| PubMedID: 30905349 |
| Title : Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis - Manterola_2018_Neuropharmacol_141_181 |
| Author(s) : Manterola A , Bernal-Chico A , Cipriani R , Ruiz A , Perez-Samartin A , Moreno-Rodriguez M , Hsu KL , Cravatt BF , Brown JM , Rodriguez-Puertas R , Matute C , Mato S |
| Ref : Neuropharmacology , 141 :181 , 2018 |
| Abstract : Manterola_2018_Neuropharmacol_141_181 |
| ESTHER : Manterola_2018_Neuropharmacol_141_181 |
| PubMedSearch : Manterola_2018_Neuropharmacol_141_181 |
| PubMedID: 30171986 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination - Manterola_2018_Biochem.Pharmacol_157_189 |
| Author(s) : Manterola A , Bernal-Chico A , Cipriani R , Canedo-Antelo M , Moreno-Garcia A , Martin-Fontecha M , Perez-Cerda F , Sanchez-Gomez MV , Ortega-Gutierrez S , Brown JM , Hsu KL , Cravatt B , Matute C , Mato S |
| Ref : Biochemical Pharmacology , 157 :189 , 2018 |
| Abstract : Manterola_2018_Biochem.Pharmacol_157_189 |
| ESTHER : Manterola_2018_Biochem.Pharmacol_157_189 |
| PubMedSearch : Manterola_2018_Biochem.Pharmacol_157_189 |
| PubMedID: 30075103 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo - Shin_2018_Mol.Pharm_15_721 |
| Author(s) : Shin M , Snyder HW , Donvito G , Schurman LD , Fox TE , Lichtman AH , Kester M , Hsu KL |
| Ref : Mol Pharm , 15 :721 , 2018 |
| Abstract : Shin_2018_Mol.Pharm_15_721 |
| ESTHER : Shin_2018_Mol.Pharm_15_721 |
| PubMedSearch : Shin_2018_Mol.Pharm_15_721 |
| PubMedID: 28901776 |
| Title : Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy - Curry_2018_J.Pharmacol.Exp.Ther_366_169 |
| Author(s) : Curry ZA , Wilkerson JL , Bagdas D , Kyte SL , Patel N , Donvito G , Mustafa MA , Poklis JL , Niphakis MJ , Hsu KL , Cravatt BF , Gewirtz DA , Damaj MI , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 366 :169 , 2018 |
| Abstract : Curry_2018_J.Pharmacol.Exp.Ther_366_169 |
| ESTHER : Curry_2018_J.Pharmacol.Exp.Ther_366_169 |
| PubMedSearch : Curry_2018_J.Pharmacol.Exp.Ther_366_169 |
| PubMedID: 29540562 |
| Title : Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2 - Yun_2017_Biochem.Biophys.Res.Commun_490_1226 |
| Author(s) : Yun B , Lee H , Powell R , Reisdorph N , Ewing H , Gelb MH , Hsu KL , Cravatt BF , Leslie CC |
| Ref : Biochemical & Biophysical Research Communications , 490 :1226 , 2017 |
| Abstract : Yun_2017_Biochem.Biophys.Res.Commun_490_1226 |
| ESTHER : Yun_2017_Biochem.Biophys.Res.Commun_490_1226 |
| PubMedSearch : Yun_2017_Biochem.Biophys.Res.Commun_490_1226 |
| PubMedID: 28684316 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Diacylglycerol lipase beta inhibition reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain - Wilkerson_2016_Br.J.Pharmacol_173_1678 |
| Author(s) : Wilkerson JL , Ghosh S , Bagdas D , Mason BL , Crowe MS , Hsu KL , Wise LE , Kinsey SG , Damaj MI , Cravatt BF , Lichtman AH |
| Ref : British Journal of Pharmacology , 173 :1678 , 2016 |
| Abstract : Wilkerson_2016_Br.J.Pharmacol_173_1678 |
| ESTHER : Wilkerson_2016_Br.J.Pharmacol_173_1678 |
| PubMedSearch : Wilkerson_2016_Br.J.Pharmacol_173_1678 |
| PubMedID: 26915789 |
| Title : Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure - Buczynski_2016_Proc.Natl.Acad.Sci.U.S.A_113_1086 |
| Author(s) : Buczynski MW , Herman MA , Hsu KL , Natividad LA , Irimia C , Polis IY , Pugh H , Chang JW , Niphakis MJ , Cravatt BF , Roberto M , Parsons LH |
| Ref : Proc Natl Acad Sci U S A , 113 :1086 , 2016 |
| Abstract : Buczynski_2016_Proc.Natl.Acad.Sci.U.S.A_113_1086 |
| ESTHER : Buczynski_2016_Proc.Natl.Acad.Sci.U.S.A_113_1086 |
| PubMedSearch : Buczynski_2016_Proc.Natl.Acad.Sci.U.S.A_113_1086 |
| PubMedID: 26755579 |
| Title : Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons - Baggelaar_2015_J.Am.Chem.Soc_137_8851 |
| Author(s) : Baggelaar MP , Chameau PJ , Kantae V , Hummel J , Hsu KL , Janssen F , van der Wel T , Soethoudt M , Deng H , den Dulk H , Allara M , Florea BI , Di Marzo V , Wadman WJ , Kruse CG , Overkleeft HS , Hankemeier T , Werkman TR , Cravatt BF , van der Stelt M |
| Ref : Journal of the American Chemical Society , 137 :8851 , 2015 |
| Abstract : Baggelaar_2015_J.Am.Chem.Soc_137_8851 |
| ESTHER : Baggelaar_2015_J.Am.Chem.Soc_137_8851 |
| PubMedSearch : Baggelaar_2015_J.Am.Chem.Soc_137_8851 |
| PubMedID: 26083464 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6\/2 Mice - Naydenov_2014_Neuron_83_361 |
| Author(s) : Naydenov AV , Horne EA , Cheah CS , Swinney K , Hsu KL , Cao JK , Marrs WR , Blankman JL , Tu S , Cherry AE , Fung S , Wen A , Li W , Saporito MS , Selley DE , Cravatt BF , Oakley JC , Stella N |
| Ref : Neuron , 83 :361 , 2014 |
| Abstract : Naydenov_2014_Neuron_83_361 |
| ESTHER : Naydenov_2014_Neuron_83_361 |
| PubMedSearch : Naydenov_2014_Neuron_83_361 |
| PubMedID: 25033180 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes - Dominguez_2014_Nat.Chem.Biol_10_113 |
| Author(s) : Dominguez E , Galmozzi A , Chang JW , Hsu KL , Pawlak J , Li W , Godio C , Thomas J , Partida D , Niessen S , O'Brien PE , Russell AP , Watt MJ , Nomura DK , Cravatt BF , Saez E |
| Ref : Nat Chemical Biology , 10 :113 , 2014 |
| Abstract : Dominguez_2014_Nat.Chem.Biol_10_113 |
| ESTHER : Dominguez_2014_Nat.Chem.Biol_10_113 |
| PubMedSearch : Dominguez_2014_Nat.Chem.Biol_10_113 |
| PubMedID: 24362705 |
| Gene_locus related to this paper: human-CES3 , mouse-Ces1d |
| Title : Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation - Yun_2014_J.Biol.Chem_289_1491 |
| Author(s) : Yun B , Lee H , Ghosh M , Cravatt BF , Hsu KL , Bonventre JV , Ewing H , Gelb MH , Leslie CC |
| Ref : Journal of Biological Chemistry , 289 :1491 , 2014 |
| Abstract : Yun_2014_J.Biol.Chem_289_1491 |
| ESTHER : Yun_2014_J.Biol.Chem_289_1491 |
| PubMedSearch : Yun_2014_J.Biol.Chem_289_1491 |
| PubMedID: 24297180 |
| Title : Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells - Manna_2014_J.Biol.Chem_289_33741 |
| Author(s) : Manna JD , Wepy JA , Hsu KL , Chang JW , Cravatt BF , Marnett LJ |
| Ref : Journal of Biological Chemistry , 289 :33741 , 2014 |
| Abstract : Manna_2014_J.Biol.Chem_289_33741 |
| ESTHER : Manna_2014_J.Biol.Chem_289_33741 |
| PubMedSearch : Manna_2014_J.Biol.Chem_289_33741 |
| PubMedID: 25301951 |
| Gene_locus related to this paper: human-LYPLA2 |
| Title : Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis - Hsu_2013_J.Med.Chem_56_8257 |
| Author(s) : Hsu KL , Tsuboi K , Whitby LR , Speers AE , Pugh H , Inloes J , Cravatt BF |
| Ref : Journal of Medicinal Chemistry , 56 :8257 , 2013 |
| Abstract : Hsu_2013_J.Med.Chem_56_8257 |
| ESTHER : Hsu_2013_J.Med.Chem_56_8257 |
| PubMedSearch : Hsu_2013_J.Med.Chem_56_8257 |
| PubMedID: 24152245 |
| Gene_locus related to this paper: human-DAGLB |
| Title : Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2) - Adibekian_2013_Probe.Report__4 |
| Author(s) : Adibekian A , Martin BR , Chang JW , Hsu KL , Tsuboi K , Bachovchin DA , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Cravatt BF , Hodder P , Rosen H |
| Ref : Probe Report , : , 2013 |
| Abstract : Adibekian_2013_Probe.Report__4 |
| ESTHER : Adibekian_2013_Probe.Report__4 |
| PubMedSearch : Adibekian_2013_Probe.Report__4 |
| PubMedID: 24624468 |
| Title : Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1) - Adibekian_2013_Probe.Report__3 |
| Author(s) : Adibekian A , Martin BR , Chang JW , Hsu KL , Tsuboi K , Bachovchin DA , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Cravatt BF , Hodder P , Rosen H |
| Ref : Probe Report , : , 2013 |
| Abstract : Adibekian_2013_Probe.Report__3 |
| ESTHER : Adibekian_2013_Probe.Report__3 |
| PubMedSearch : Adibekian_2013_Probe.Report__3 |
| PubMedID: 24624465 |
| Title : Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of alpha\/beta-hydrolase domain containing 6 (ABHD6) - Hsu_2013_J.Med.Chem_56_8270 |
| Author(s) : Hsu KL , Tsuboi K , Chang JW , Whitby LR , Speers AE , Pugh H , Cravatt BF |
| Ref : Journal of Medicinal Chemistry , 56 :8270 , 2013 |
| Abstract : Hsu_2013_J.Med.Chem_56_8270 |
| ESTHER : Hsu_2013_J.Med.Chem_56_8270 |
| PubMedSearch : Hsu_2013_J.Med.Chem_56_8270 |
| PubMedID: 24152295 |
| Title : Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2) - Nagano_2013_Bioorg.Med.Chem.Lett_23_839 |
| Author(s) : Nagano JM , Hsu KL , Whitby LR , Niphakis MJ , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Hodder P , Srinivasan P , Gonzalez TD , Rosen H , Bahnson BJ , Cravatt BF |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :839 , 2013 |
| Abstract : Nagano_2013_Bioorg.Med.Chem.Lett_23_839 |
| ESTHER : Nagano_2013_Bioorg.Med.Chem.Lett_23_839 |
| PubMedSearch : Nagano_2013_Bioorg.Med.Chem.Lett_23_839 |
| PubMedID: 23260346 |
| Title : DAGLbeta inhibition perturbs a lipid network involved in macrophage inflammatory responses - Hsu_2012_Nat.Chem.Biol_8_999 |
| Author(s) : Hsu KL , Tsuboi K , Adibekian A , Pugh H , Masuda K , Cravatt BF |
| Ref : Nat Chemical Biology , 8 :999 , 2012 |
| Abstract : Hsu_2012_Nat.Chem.Biol_8_999 |
| ESTHER : Hsu_2012_Nat.Chem.Biol_8_999 |
| PubMedSearch : Hsu_2012_Nat.Chem.Biol_8_999 |
| PubMedID: 23103940 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : Optimization and characterization of a triazole urea inhibitor for diacylglycerol lipase beta (DAGL-beta) - Hsu_2012_Probe.Report__ |
| Author(s) : Hsu KL , Tsuboi K , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Cravatt BF , Hodder P , Rosen H |
| Ref : Probe Report , : , 2012 |
| Abstract : Hsu_2012_Probe.Report__ |
| ESTHER : Hsu_2012_Probe.Report__ |
| PubMedSearch : Hsu_2012_Probe.Report__ |
| PubMedID: 23658950 |
| Gene_locus related to this paper: human-ABHD6 |
| Title : Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes - Adibekian_2012_J.Am.Chem.Soc_134_10345 |
| Author(s) : Adibekian A , Martin BR , Chang JW , Hsu KL , Tsuboi K , Bachovchin DA , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Hodder PS , Rosen H , Cravatt BF |
| Ref : J Am Chem Soc , 134 :10345 , 2012 |
| Abstract : Adibekian_2012_J.Am.Chem.Soc_134_10345 |
| ESTHER : Adibekian_2012_J.Am.Chem.Soc_134_10345 |
| PubMedSearch : Adibekian_2012_J.Am.Chem.Soc_134_10345 |
| PubMedID: 22690931 |
| Title : Competitive activity-based protein profiling identifies aza-beta-lactams as a versatile chemotype for serine hydrolase inhibition - Zuhl_2012_J.Am.Chem.Soc_134_5068 |
| Author(s) : Zuhl AM , Mohr JT , Bachovchin DA , Niessen S , Hsu KL , Berlin JM , Dochnahl M , Lopez-Alberca MP , Fu GC , Cravatt BF |
| Ref : J Am Chem Soc , 134 :5068 , 2012 |
| Abstract : Zuhl_2012_J.Am.Chem.Soc_134_5068 |
| ESTHER : Zuhl_2012_J.Am.Chem.Soc_134_5068 |
| PubMedSearch : Zuhl_2012_J.Am.Chem.Soc_134_5068 |
| PubMedID: 22400490 |
| Gene_locus related to this paper: human-ABHD10 |
| Title : Optimization and characterization of a triazole urea inhibitor for alpha\/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1\/LYPLA2 dual inhibitor ML211 - Adibekian_2011_Probe.Report__1 |
| Author(s) : Adibekian A , Hsu KL , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Cravatt BF , Hodder P , Rosen H |
| Ref : Probe Report , : , 2011 |
| Abstract : Adibekian_2011_Probe.Report__1 |
| ESTHER : Adibekian_2011_Probe.Report__1 |
| PubMedSearch : Adibekian_2011_Probe.Report__1 |
| PubMedID: 23658953 |
| Title : Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors - Adibekian_2011_Nat.Chem.Biol_7_469 |
| Author(s) : Adibekian A , Martin BR , Wang C , Hsu KL , Bachovchin DA , Niessen S , Hoover H , Cravatt BF |
| Ref : Nat Chemical Biology , 7 :469 , 2011 |
| Abstract : Adibekian_2011_Nat.Chem.Biol_7_469 |
| ESTHER : Adibekian_2011_Nat.Chem.Biol_7_469 |
| PubMedSearch : Adibekian_2011_Nat.Chem.Biol_7_469 |
| PubMedID: 21572424 |
| Title : Optimization and characterization of a triazole urea inhibitor for platelet-activating factor acetylhydrolase type 2 (PAFAH2) - Adibekian_2011_Probe.Report__2 |
| Author(s) : Adibekian A , Hsu KL , Speers AE , Monillas ES , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Bahnson BJ , Cravatt BF , Hodder P , Rosen H |
| Ref : Probe Report , : , 2011 |
| Abstract : Adibekian_2011_Probe.Report__2 |
| ESTHER : Adibekian_2011_Probe.Report__2 |
| PubMedSearch : Adibekian_2011_Probe.Report__2 |
| PubMedID: 23658960 |