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| Title : Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms - Tweedie_2016_PLoS.One_11_e0156493 |
| Author(s) : Tweedie D , Fukui K , Li Y , Yu QS , Barak S , Tamargo IA , Rubovitch V , Holloway HW , Lehrmann E , Wood WH, 3rd , Zhang Y , Becker KG , Perez E , Van Praag H , Luo Y , Hoffer BJ , Becker RE , Pick CG , Greig NH |
| Ref : PLoS ONE , 11 :e0156493 , 2016 |
| Abstract : Tweedie_2016_PLoS.One_11_e0156493 |
| ESTHER : Tweedie_2016_PLoS.One_11_e0156493 |
| PubMedSearch : Tweedie_2016_PLoS.One_11_e0156493 |
| PubMedID: 27254111 |
| Title : Synthesis of the Alzheimer Drug Posiphen into its Primary Metabolic Products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their Inhibition of Amyloid Precursor Protein, alpha -Synuclein Synthesis, Interleukin-1beta Release, and Cholinergic Action - Yu_2013_Antiinflamm.Antiallergy.Agents.Med.Chem_12_117 |
| Author(s) : Yu QS , Reale M , Kamal MA , Holloway HW , Luo W , Sambamurti K , Ray B , Lahiri DK , Rogers JT , Greig NH |
| Ref : Antiinflamm Antiallergy Agents Med Chem , 12 :117 , 2013 |
| Abstract : Yu_2013_Antiinflamm.Antiallergy.Agents.Med.Chem_12_117 |
| ESTHER : Yu_2013_Antiinflamm.Antiallergy.Agents.Med.Chem_12_117 |
| PubMedSearch : Yu_2013_Antiinflamm.Antiallergy.Agents.Med.Chem_12_117 |
| PubMedID: 23360256 |
| Title : Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine - Yu_2010_Bioorg.Med.Chem_18_4687 |
| Author(s) : Yu QS , Holloway HW , Luo W , Lahiri DK , Brossi A , Greig NH |
| Ref : Bioorganic & Medicinal Chemistry , 18 :4687 , 2010 |
| Abstract : Yu_2010_Bioorg.Med.Chem_18_4687 |
| ESTHER : Yu_2010_Bioorg.Med.Chem_18_4687 |
| PubMedSearch : Yu_2010_Bioorg.Med.Chem_18_4687 |
| PubMedID: 20627738 |
| Title : Tetrahydrofurobenzofuran cymserine, a potent butyrylcholinesterase inhibitor and experimental Alzheimer drug candidate, enzyme kinetic analysis - Kamal_2008_J.Neural.Transm.(Vienna)_115_889 |
| Author(s) : Kamal MA , Qu X , Yu QS , Tweedie D , Holloway HW , Li Y , Tan Y , Greig NH |
| Ref : J Neural Transm (Vienna) , 115 :889 , 2008 |
| Abstract : Kamal_2008_J.Neural.Transm.(Vienna)_115_889 |
| ESTHER : Kamal_2008_J.Neural.Transm.(Vienna)_115_889 |
| PubMedSearch : Kamal_2008_J.Neural.Transm.(Vienna)_115_889 |
| PubMedID: 18235987 |
| Title : Kinetics of human serum butyrylcholinesterase inhibition by a novel experimental Alzheimer therapeutic, dihydrobenzodioxepine cymserine - Kamal_2008_Neurochem.Res_33_745 |
| Author(s) : Kamal MA , Klein P , Luo W , Li Y , Holloway HW , Tweedie D , Greig NH |
| Ref : Neurochem Res , 33 :745 , 2008 |
| Abstract : Kamal_2008_Neurochem.Res_33_745 |
| ESTHER : Kamal_2008_Neurochem.Res_33_745 |
| PubMedSearch : Kamal_2008_Neurochem.Res_33_745 |
| PubMedID: 17985237 |
| Title : Preclinical investigation of the topical administration of phenserine: transdermal flux, cholinesterase inhibition, and cognitive efficacy - Utsuki_2007_J.Pharmacol.Exp.Ther_321_353 |
| Author(s) : Utsuki T , Uchimura N , Irikura M , Moriuchi H , Holloway HW , Yu QS , Spangler EL , Mamczarz J , Ingram DK , Irie T , Greig NH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 321 :353 , 2007 |
| Abstract : Utsuki_2007_J.Pharmacol.Exp.Ther_321_353 |
| ESTHER : Utsuki_2007_J.Pharmacol.Exp.Ther_321_353 |
| PubMedSearch : Utsuki_2007_J.Pharmacol.Exp.Ther_321_353 |
| PubMedID: 17255466 |
| Title : The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice - Lahiri_2007_J.Pharmacol.Exp.Ther_320_386 |
| Author(s) : Lahiri DK , Chen D , Maloney B , Holloway HW , Yu QS , Utsuki T , Giordano T , Sambamurti K , Greig NH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 320 :386 , 2007 |
| Abstract : Lahiri_2007_J.Pharmacol.Exp.Ther_320_386 |
| ESTHER : Lahiri_2007_J.Pharmacol.Exp.Ther_320_386 |
| PubMedSearch : Lahiri_2007_J.Pharmacol.Exp.Ther_320_386 |
| PubMedID: 17003227 |
| Title : Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic, bisnorcymserine - Kamal_2006_J.Alzheimers.Dis_10_43 |
| Author(s) : Kamal MA , Klein P , Yu QS , Tweedie D , Li Y , Holloway HW , Greig NH |
| Ref : J Alzheimers Dis , 10 :43 , 2006 |
| Abstract : Kamal_2006_J.Alzheimers.Dis_10_43 |
| ESTHER : Kamal_2006_J.Alzheimers.Dis_10_43 |
| PubMedSearch : Kamal_2006_J.Alzheimers.Dis_10_43 |
| PubMedID: 16988481 |
| Title : Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide - Utsuki_2006_J.Pharmacol.Exp.Ther_318_855 |
| Author(s) : Utsuki T , Yu QS , Davidson D , Chen D , Holloway HW , Brossi A , Sambamurti K , Lahiri DK , Greig NH , Giordano T |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 318 :855 , 2006 |
| Abstract : Utsuki_2006_J.Pharmacol.Exp.Ther_318_855 |
| ESTHER : Utsuki_2006_J.Pharmacol.Exp.Ther_318_855 |
| PubMedSearch : Utsuki_2006_J.Pharmacol.Exp.Ther_318_855 |
| PubMedID: 16690718 |
| Title : Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine - Luo_2006_J.Med.Chem_49_2174 |
| Author(s) : Luo W , Yu QS , Kulkarni SS , Parrish DA , Holloway HW , Tweedie D , Shafferman A , Lahiri DK , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 49 :2174 , 2006 |
| Abstract : Luo_2006_J.Med.Chem_49_2174 |
| ESTHER : Luo_2006_J.Med.Chem_49_2174 |
| PubMedSearch : Luo_2006_J.Med.Chem_49_2174 |
| PubMedID: 16570913 |
| Title : Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent - Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| Author(s) : Greig NH , Utsuki T , Ingram DK , Wang Y , Pepeu G , Scali C , Yu QS , Mamczarz J , Holloway HW , Giordano T , Chen D , Furukawa K , Sambamurti K , Brossi A , Lahiri DK |
| Ref : Proc Natl Acad Sci U S A , 102 :17213 , 2005 |
| Abstract : Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| ESTHER : Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| PubMedSearch : Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| PubMedID: 16275899 |
| Title : Intravenous butyrylcholinesterase administration and plasma and brain levels of cocaine and metabolites in rats - Carmona_2005_Eur.J.Pharmacol_517_186 |
| Author(s) : Carmona GN , Schindler CW , Greig NH , Holloway HW , Jufer RA , Cone EJ , Gorelick DA |
| Ref : European Journal of Pharmacology , 517 :186 , 2005 |
| Abstract : Carmona_2005_Eur.J.Pharmacol_517_186 |
| ESTHER : Carmona_2005_Eur.J.Pharmacol_517_186 |
| PubMedSearch : Carmona_2005_Eur.J.Pharmacol_517_186 |
| PubMedID: 15967428 |
| Title : Syntheses of tetrahydrofurobenzofurans and dihydromethanobenzodioxepines from 5-hydroxy-3-methyl-3H-benzofuran-2-one. Rearrangement and ring expansion under reductive conditions on treatment with hydrides - Luo_2005_J.Org.Chem_70_6171 |
| Author(s) : Luo W , Yu QS , Holloway HW , Parrish D , Greig NH , Brossi A |
| Ref : J Org Chem , 70 :6171 , 2005 |
| Abstract : Luo_2005_J.Org.Chem_70_6171 |
| ESTHER : Luo_2005_J.Org.Chem_70_6171 |
| PubMedSearch : Luo_2005_J.Org.Chem_70_6171 |
| PubMedID: 16050674 |
| Title : Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine - Luo_2005_J.Med.Chem_48_986 |
| Author(s) : Luo W , Yu QS , Zhan M , Parrish D , Deschamps JR , Kulkarni SS , Holloway HW , Alley GM , Lahiri DK , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 48 :986 , 2005 |
| Abstract : Luo_2005_J.Med.Chem_48_986 |
| ESTHER : Luo_2005_J.Med.Chem_48_986 |
| PubMedSearch : Luo_2005_J.Med.Chem_48_986 |
| PubMedID: 15715468 |
| Title : Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors - Campiani_2005_J.Med.Chem_48_1919 |
| Author(s) : Campiani G , Fattorusso C , Butini S , Gaeta A , Agnusdei M , Gemma S , Persico M , Catalanotti B , Savini L , Nacci V , Novellino E , Holloway HW , Greig NH , Belinskaya T , Fedorko JM , Saxena A |
| Ref : Journal of Medicinal Chemistry , 48 :1919 , 2005 |
| Abstract : Campiani_2005_J.Med.Chem_48_1919 |
| ESTHER : Campiani_2005_J.Med.Chem_48_1919 |
| PubMedSearch : Campiani_2005_J.Med.Chem_48_1919 |
| PubMedID: 15771436 |
| Title : Anticholinesterase and pharmacokinetic profile of phenserine in healthy elderly human subjects - Greig_2005_Curr.Alzheimer.Res_2_483 |
| Author(s) : Greig NH , Ruckle J , Comer P , Brownell L , Holloway HW , Flanagan DR, Jr. , Canfield CJ , Burford RG |
| Ref : Curr Alzheimer Res , 2 :483 , 2005 |
| Abstract : Greig_2005_Curr.Alzheimer.Res_2_483 |
| ESTHER : Greig_2005_Curr.Alzheimer.Res_2_483 |
| PubMedSearch : Greig_2005_Curr.Alzheimer.Res_2_483 |
| PubMedID: 16248851 |
| Title : The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats - Janas_2005_Life.Sci_76_1073 |
| Author(s) : Janas AM , Cunningham SC , Duffy KB , Devan BD , Greig NH , Holloway HW , Yu QS , Markowska AL , Ingram DK , Spangler EL |
| Ref : Life Sciences , 76 :1073 , 2005 |
| Abstract : Janas_2005_Life.Sci_76_1073 |
| ESTHER : Janas_2005_Life.Sci_76_1073 |
| PubMedSearch : Janas_2005_Life.Sci_76_1073 |
| PubMedID: 15620572 |
| Title : Poster (43) BChE inhibition as a treatment strategy for alzheimer's disease. - |
| Author(s) : Greig NH , Ingram DK , Yu QS , Holloway HW , Utsuki T , Brossi A , Sambamurti K , Lahiri DK |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :343 , 2004 |
| PubMedID: |
| Title : Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines - Yu_2002_J.Med.Chem_45_3684 |
| Author(s) : Yu QS , Zhu X , Holloway HW , Whittaker NF , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 45 :3684 , 2002 |
| Abstract : Yu_2002_J.Med.Chem_45_3684 |
| ESTHER : Yu_2002_J.Med.Chem_45_3684 |
| PubMedSearch : Yu_2002_J.Med.Chem_45_3684 |
| PubMedID: 12166941 |
| Title : A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase - Greig_2001_Curr.Med.Res.Opin_17_159 |
| Author(s) : Greig NH , Utsuki T , Yu Q , Zhu X , Holloway HW , Perry T , Lee B , Ingram DK , Lahiri DK |
| Ref : Curr Med Res Opin , 17 :159 , 2001 |
| Abstract : Greig_2001_Curr.Med.Res.Opin_17_159 |
| ESTHER : Greig_2001_Curr.Med.Res.Opin_17_159 |
| PubMedSearch : Greig_2001_Curr.Med.Res.Opin_17_159 |
| PubMedID: 11900310 |
| Title : Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure\/activity relationships for acetyl- and butyrylcholinesterase inhibitory action - Yu_2001_J.Med.Chem_44_4062 |
| Author(s) : Yu Q , Holloway HW , Flippen-Anderson JL , Hoffman B , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 44 :4062 , 2001 |
| Abstract : Yu_2001_J.Med.Chem_44_4062 |
| ESTHER : Yu_2001_J.Med.Chem_44_4062 |
| PubMedSearch : Yu_2001_J.Med.Chem_44_4062 |
| PubMedID: 11708910 |
| Title : Time course of pharmacodynamic and pharmacokinetic effects of physostigmine assessed by functional brain imaging in humans - Furey_2000_Pharmacol.Biochem.Behav_66_475 |
| Author(s) : Furey ML , Pietrini P , Alexander GE , Mentis MJ , Szczepanik J , Shetty U , Greig NH , Holloway HW , Schapiro MB , Freo U |
| Ref : Pharmacol Biochem Behav , 66 :475 , 2000 |
| Abstract : Furey_2000_Pharmacol.Biochem.Behav_66_475 |
| ESTHER : Furey_2000_Pharmacol.Biochem.Behav_66_475 |
| PubMedSearch : Furey_2000_Pharmacol.Biochem.Behav_66_475 |
| PubMedID: 10899358 |
| Title : The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics - Greig_2000_Acta.Neurol.Scand.Suppl_176_74 |
| Author(s) : Greig NH , De Micheli E , Holloway HW , Yu QS , Utsuki T , Perry TA , Brossi A , Ingram DK , Deutsch J , Lahiri DK , Soncrant TT |
| Ref : Acta Neurologica Scandinavica Supplementum , 176 :74 , 2000 |
| Abstract : Greig_2000_Acta.Neurol.Scand.Suppl_176_74 |
| ESTHER : Greig_2000_Acta.Neurol.Scand.Suppl_176_74 |
| PubMedSearch : Greig_2000_Acta.Neurol.Scand.Suppl_176_74 |
| PubMedID: 11261809 |
| Title : Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease - Yu_1999_J.Med.Chem_42_1855 |
| Author(s) : Yu Q , Holloway HW , Utsuki T , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 42 :1855 , 1999 |
| Abstract : Yu_1999_J.Med.Chem_42_1855 |
| ESTHER : Yu_1999_J.Med.Chem_42_1855 |
| PubMedSearch : Yu_1999_J.Med.Chem_42_1855 |
| PubMedID: 10346939 |
| Title : Syntheses and anticholinesterase activities of (3aS)-N1, N8- bisnorphenserine, (3aS)-N1,N8-bisnorphysostigmine, their antipodal isomers, and other potential metabolites of phenserine - Yu_1998_J.Med.Chem_41_2371 |
| Author(s) : Yu Q , Greig NH , Holloway HW , Brossi A |
| Ref : Journal of Medicinal Chemistry , 41 :2371 , 1998 |
| Abstract : Yu_1998_J.Med.Chem_41_2371 |
| ESTHER : Yu_1998_J.Med.Chem_41_2371 |
| PubMedSearch : Yu_1998_J.Med.Chem_41_2371 |
| PubMedID: 9632370 |
| Title : Total syntheses and anticholinesterase activities of (3aS)-N(8)- norphysostigmine, (3aS)-N(8)-norphenserine, their antipodal isomers, and other N(8)-substituted analogues - Yu_1997_J.Med.Chem_40_2895 |
| Author(s) : Yu QS , Pei XF , Holloway HW , Greig NH , Brossi A |
| Ref : Journal of Medicinal Chemistry , 40 :2895 , 1997 |
| Abstract : Yu_1997_J.Med.Chem_40_2895 |
| ESTHER : Yu_1997_J.Med.Chem_40_2895 |
| PubMedSearch : Yu_1997_J.Med.Chem_40_2895 |
| PubMedID: 9288171 |