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| Title : Agonists and Antagonists of Nicotinic Acetylcholine Receptors - |
| Author(s) : Arneric SP , Holladay MW |
| Ref : Handbook of Experimental Pharmacology , 144 :419 , 2000 |
| PubMedID: |
| Title : Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors - Holladay_1998_J.Med.Chem_41_407 |
| Author(s) : Holladay MW , Wasicak JT , Lin NH , He Y , Ryther KB , Bannon AW , Buckley MJ , Kim DJ , Decker MW , Anderson DJ , Campbell JE , Kuntzweiler TA , Donnelly-Roberts D , Piattoni-Kaplan M , Briggs CA , Williams M , Arneric SP |
| Ref : Journal of Medicinal Chemistry , 41 :407 , 1998 |
| Abstract : Holladay_1998_J.Med.Chem_41_407 |
| ESTHER : Holladay_1998_J.Med.Chem_41_407 |
| PubMedSearch : Holladay_1998_J.Med.Chem_41_407 |
| PubMedID: 9484491 |
| Title : Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors - Bannon_1998_Science_279_77 |
| Author(s) : Bannon AW , Decker MW , Holladay MW , Curzon P , Donnelly-Roberts D , Puttfarcken PS , Bitner RS , Diaz A , Dickenson AH , Porsolt RD , Williams M , Arneric SP |
| Ref : Science , 279 :77 , 1998 |
| Abstract : Bannon_1998_Science_279_77 |
| ESTHER : Bannon_1998_Science_279_77 |
| PubMedSearch : Bannon_1998_Science_279_77 |
| PubMedID: 9417028 |
| Title : Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist - Lin_1998_Bioorg.Med.Chem.Lett_8_249 |
| Author(s) : Lin NH , Gunn DE , Li Y , He Y , Bai H , Ryther KB , Kuntzweiler T , Donnelly-Roberts D , Anderson DJ , Campbell JE , Sullivan JP , Arneric SP , Holladay MW |
| Ref : Bioorganic & Medicinal Chemistry Lett , 8 :249 , 1998 |
| Abstract : Lin_1998_Bioorg.Med.Chem.Lett_8_249 |
| ESTHER : Lin_1998_Bioorg.Med.Chem.Lett_8_249 |
| PubMedSearch : Lin_1998_Bioorg.Med.Chem.Lett_8_249 |
| PubMedID: 9871663 |
| Title : The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594 - Decker_1998_J.Physiol.Paris_92_221 |
| Author(s) : Decker MW , Curzon P , Holladay MW , Nikkel AL , Bitner RS , Bannon AW , Donnelly-Roberts D , Puttfarcken PS , Kuntzweiler TA , Briggs CA , Williams M , Arneric SP |
| Ref : Journal de Physiologie (Paris) , 92 :221 , 1998 |
| Abstract : Decker_1998_J.Physiol.Paris_92_221 |
| ESTHER : Decker_1998_J.Physiol.Paris_92_221 |
| PubMedSearch : Decker_1998_J.Physiol.Paris_92_221 |
| PubMedID: 9789812 |
| Title : ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization - Donnelly-Roberts_1998_J.Pharmacol.Exp.Ther_285_777 |
| Author(s) : Donnelly-Roberts D , Puttfarcken PS , Kuntzweiler TA , Briggs CA , Anderson DJ , Campbell JE , Piattoni-Kaplan M , McKenna DG , Wasicak JT , Holladay MW , Williams M , Arneric SP |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 285 :777 , 1998 |
| Abstract : Donnelly-Roberts_1998_J.Pharmacol.Exp.Ther_285_777 |
| ESTHER : Donnelly-Roberts_1998_J.Pharmacol.Exp.Ther_285_777 |
| PubMedSearch : Donnelly-Roberts_1998_J.Pharmacol.Exp.Ther_285_777 |
| PubMedID: 9580626 |
| Title : ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization - Bannon_1998_J.Pharmacol.Exp.Ther_285_787 |
| Author(s) : Bannon AW , Decker MW , Curzon P , Buckley MJ , Kim DJ , Radek RJ , Lynch JK , Wasicak JT , Lin NH , Arnold WH , Holladay MW , Williams M , Arneric SP |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 285 :787 , 1998 |
| Abstract : Bannon_1998_J.Pharmacol.Exp.Ther_285_787 |
| ESTHER : Bannon_1998_J.Pharmacol.Exp.Ther_285_787 |
| PubMedSearch : Bannon_1998_J.Pharmacol.Exp.Ther_285_787 |
| PubMedID: 9580627 |
| Title : Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice - Decker_1998_Eur.J.Pharmacol_346_23 |
| Author(s) : Decker MW , Bannon AW , Buckley MJ , Kim DJ , Holladay MW , Ryther KB , Lin NH , Wasicak JT , Williams M , Arneric SP |
| Ref : European Journal of Pharmacology , 346 :23 , 1998 |
| Abstract : Decker_1998_Eur.J.Pharmacol_346_23 |
| ESTHER : Decker_1998_Eur.J.Pharmacol_346_23 |
| PubMedSearch : Decker_1998_Eur.J.Pharmacol_346_23 |
| PubMedID: 9617748 |
| Title : Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice - Holladay_1998_Bioorg.Med.Chem.Lett_8_2797 |
| Author(s) : Holladay MW , Bai H , Li Y , Lin NH , Daanen JF , Ryther KB , Wasicak JT , Kincaid JF , He Y , Hettinger AM , Huang P , Anderson DJ , Bannon AW , Buckley MJ , Campbell JE , Donnelly-Roberts D , Gunther KL , Kim DJ , Kuntzweiler TA , Sullivan JP , Decker MW , Arneric SP |
| Ref : Bioorganic & Medicinal Chemistry Lett , 8 :2797 , 1998 |
| Abstract : Holladay_1998_Bioorg.Med.Chem.Lett_8_2797 |
| ESTHER : Holladay_1998_Bioorg.Med.Chem.Lett_8_2797 |
| PubMedSearch : Holladay_1998_Bioorg.Med.Chem.Lett_8_2797 |
| PubMedID: 9873625 |
| Title : ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties - Sullivan_1997_J.Pharmacol.Exp.Ther_283_235 |
| Author(s) : Sullivan JP , Donnelly-Roberts D , Briggs CA , Anderson DJ , Gopalakrishnan M , Xue IC , Piattoni-Kaplan M , Molinari E , Campbell JE , McKenna DG , Gunn DE , Lin NH , Ryther KB , He Y , Holladay MW , Wonnacott S , Williams M , Arneric SP |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 283 :235 , 1997 |
| Abstract : Sullivan_1997_J.Pharmacol.Exp.Ther_283_235 |
| ESTHER : Sullivan_1997_J.Pharmacol.Exp.Ther_283_235 |
| PubMedSearch : Sullivan_1997_J.Pharmacol.Exp.Ther_283_235 |
| PubMedID: 9336329 |
| Title : Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo - Briggs_1997_Pharmacol.Biochem.Behav_57_231 |
| Author(s) : Briggs CA , Anderson DJ , Brioni JD , Buccafusco JJ , Buckley MJ , Campbell JE , Decker MW , Donnelly-Roberts D , Elliott RL , Gopalakrishnan M , Holladay MW , Hui YH , Jackson WJ , Kim DJ , Marsh KC , O'Neill A , Prendergast MA , Ryther KB , Sullivan JP , Arneric SP |
| Ref : Pharmacol Biochem Behav , 57 :231 , 1997 |
| Abstract : Briggs_1997_Pharmacol.Biochem.Behav_57_231 |
| ESTHER : Briggs_1997_Pharmacol.Biochem.Behav_57_231 |
| PubMedSearch : Briggs_1997_Pharmacol.Biochem.Behav_57_231 |
| PubMedID: 9164577 |
| Title : Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties - Lin_1997_J.Med.Chem_40_385 |
| Author(s) : Lin NH , Gunn DE , Ryther KB , Garvey DS , Donnelly-Roberts D , Decker MW , Brioni JD , Buckley MJ , Rodrigues AD , Marsh KG , Anderson DJ , Buccafusco JJ , Prendergast MA , Sullivan JP , Williams M , Arneric SP , Holladay MW |
| Ref : Journal of Medicinal Chemistry , 40 :385 , 1997 |
| Abstract : Lin_1997_J.Med.Chem_40_385 |
| ESTHER : Lin_1997_J.Med.Chem_40_385 |
| PubMedSearch : Lin_1997_J.Med.Chem_40_385 |
| PubMedID: 9022806 |
| Title : ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys - Decker_1997_J.Pharmacol.Exp.Ther_283_247 |
| Author(s) : Decker MW , Bannon AW , Curzon P , Gunther KL , Brioni JD , Holladay MW , Lin NH , Li Y , Daanen JF , Buccafusco JJ , Prendergast MA , Jackson WJ , Arneric SP |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 283 :247 , 1997 |
| Abstract : Decker_1997_J.Pharmacol.Exp.Ther_283_247 |
| ESTHER : Decker_1997_J.Pharmacol.Exp.Ther_283_247 |
| PubMedSearch : Decker_1997_J.Pharmacol.Exp.Ther_283_247 |
| PubMedID: 9336330 |
| Title : A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand - Sullivan_1996_Neuropharmacol_35_725 |
| Author(s) : Sullivan JP , Donnelly-Roberts D , Briggs CA , Anderson DJ , Gopalakrishnan M , Piattoni-Kaplan M , Campbell JE , McKenna DG , Molinari E , Hettinger AM , Garvey DS , Wasicak JT , Holladay MW , Williams M , Arneric SP |
| Ref : Neuropharmacology , 35 :725 , 1996 |
| Abstract : Sullivan_1996_Neuropharmacol_35_725 |
| ESTHER : Sullivan_1996_Neuropharmacol_35_725 |
| PubMedSearch : Sullivan_1996_Neuropharmacol_35_725 |
| PubMedID: 8887981 |
| Title : Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors - Abreo_1996_J.Med.Chem_39_817 |
| Author(s) : Abreo MA , Lin NH , Garvey DS , Gunn DE , Hettinger AM , Wasicak JT , Pavlik PA , Martin YC , Donnelly-Roberts D , Anderson DJ , Sullivan JP , Williams M , Arneric SP , Holladay MW |
| Ref : Journal of Medicinal Chemistry , 39 :817 , 1996 |
| Abstract : Abreo_1996_J.Med.Chem_39_817 |
| ESTHER : Abreo_1996_J.Med.Chem_39_817 |
| PubMedSearch : Abreo_1996_J.Med.Chem_39_817 |
| PubMedID: 8632405 |
| Title : Cholinergic channel activators: novel opportunities for the treatment of CNS disorders - Sullivan_1995_Proc.West.Pharmacol.Soc_38_127 |
| Author(s) : Sullivan JP , Decker MW , Donnelly-Roberts D , Brioni JD , Bannon AW , Holladay MW , Anderson DJ , Briggs CA , Williams M , Arneric SP |
| Ref : Proc West Pharmacol Soc , 38 :127 , 1995 |
| Abstract : Sullivan_1995_Proc.West.Pharmacol.Soc_38_127 |
| ESTHER : Sullivan_1995_Proc.West.Pharmacol.Soc_38_127 |
| PubMedSearch : Sullivan_1995_Proc.West.Pharmacol.Soc_38_127 |
| PubMedID: 7480004 |
| Title : Novel isoxazoles which interact with brain cholinergic channel receptors have intrinsic cognitive enhancing and anxiolytic activities - |
| Author(s) : Garvey DS , Wasicak JT , Decker MW , Brioni JD , Buckley MJ , Sullivan JP , Carrera GM , Holladay MW , Arneric SP , Williams M |
| Ref : Journal of Medicinal Chemistry , 37 :1055 , 1994 |
| PubMedID: 7909335 |