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| Title : Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator - Dotsch_2024_J.Med.Chem__ |
| Author(s) : Dotsch L , Davies C , Hennes E , Schonfeld J , Kumar A , Guita C , Ehrler JHM , Hiesinger K , Thavam S , Janning P , Sievers S , Knapp S , Proschak E , Ziegler S , Waldmann H |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : Dotsch_2024_J.Med.Chem__ |
| ESTHER : Dotsch_2024_J.Med.Chem__ |
| PubMedSearch : Dotsch_2024_J.Med.Chem__ |
| PubMedID: 38470246 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Designing a Small Fluorescent Inhibitor to Investigate Soluble Epoxide Hydrolase Engagement in Living Cells - Brunst_2022_ACS.Med.Chem.Lett_13_1062 |
| Author(s) : Brunst S , Schonfeld J , Breunig P , Burgers LD , DeMeglio M , Ehrler JHM , Lillich FF , Weizel L , Hefendehl JK , Furst R , Proschak E , Hiesinger K |
| Ref : ACS Med Chem Lett , 13 :1062 , 2022 |
| Abstract : Brunst_2022_ACS.Med.Chem.Lett_13_1062 |
| ESTHER : Brunst_2022_ACS.Med.Chem.Lett_13_1062 |
| PubMedSearch : Brunst_2022_ACS.Med.Chem.Lett_13_1062 |
| PubMedID: 35859883 |
| Title : Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase - Hiesinger_2020_J.Med.Chem_63_11498 |
| Author(s) : Hiesinger K , Kramer JS , Beyer S , Eckes T , Brunst S , Flauaus C , Wittmann SK , Weizel L , Kaiser A , Kretschmer SBM , George S , Angioni C , Heering J , Geisslinger G , Schubert-Zsilavecz M , Schmidtko A , Pogoryelov D , Pfeilschifter J , Hofmann B , Steinhilber D , Schwalm S , Proschak E |
| Ref : Journal of Medicinal Chemistry , 63 :11498 , 2020 |
| Abstract : Hiesinger_2020_J.Med.Chem_63_11498 |
| ESTHER : Hiesinger_2020_J.Med.Chem_63_11498 |
| PubMedSearch : Hiesinger_2020_J.Med.Chem_63_11498 |
| PubMedID: 33044073 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase - Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| Author(s) : Hiesinger K , Schott A , Kramer JS , Blocher R , Witt F , Wittmann SK , Steinhilber D , Pogoryelov D , Gerstmeier J , Werz O , Proschak E |
| Ref : ACS Med Chem Lett , 11 :298 , 2020 |
| Abstract : Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| ESTHER : Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| PubMedSearch : Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| PubMedID: 32184960 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Computer-Aided Fragment Growing Strategies to Design Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase - Hefke_2020_ACS.Med.Chem.Lett_11_1244 |
| Author(s) : Hefke L , Hiesinger K , Zhu WF , Kramer JS , Proschak E |
| Ref : ACS Med Chem Lett , 11 :1244 , 2020 |
| Abstract : Hefke_2020_ACS.Med.Chem.Lett_11_1244 |
| ESTHER : Hefke_2020_ACS.Med.Chem.Lett_11_1244 |
| PubMedSearch : Hefke_2020_ACS.Med.Chem.Lett_11_1244 |
| PubMedID: 32551007 |
| Title : Computer-Aided Selective Optimization of Side Activities of Talinolol - Hiesinger_2019_ACS.Med.Chem.Lett_10_899 |
| Author(s) : Hiesinger K , Kramer JS , Achenbach J , Moser D , Weber J , Wittmann SK , Morisseau C , Angioni C , Geisslinger G , Kahnt AS , Kaiser A , Proschak A , Steinhilber D , Pogoryelov D , Wagner K , Hammock BD , Proschak E |
| Ref : ACS Med Chem Lett , 10 :899 , 2019 |
| Abstract : Hiesinger_2019_ACS.Med.Chem.Lett_10_899 |
| ESTHER : Hiesinger_2019_ACS.Med.Chem.Lett_10_899 |
| PubMedSearch : Hiesinger_2019_ACS.Med.Chem.Lett_10_899 |
| PubMedID: 31223445 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Development of multitarget agents possessing soluble epoxide hydrolase inhibitory activity - Hiesinger_2019_Prostaglandins.Other.Lipid.Mediat_140_31 |
| Author(s) : Hiesinger K , Wagner KM , Hammock BD , Proschak E , Hwang SH |
| Ref : Prostaglandins Other Lipid Mediat , 140 :31 , 2019 |
| Abstract : Hiesinger_2019_Prostaglandins.Other.Lipid.Mediat_140_31 |
| ESTHER : Hiesinger_2019_Prostaglandins.Other.Lipid.Mediat_140_31 |
| PubMedSearch : Hiesinger_2019_Prostaglandins.Other.Lipid.Mediat_140_31 |
| PubMedID: 30593866 |
| Title : Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain - Kramer_2019_J.Med.Chem_62_8443 |
| Author(s) : Kramer JS , Woltersdorf S , Duflot T , Hiesinger K , Lillich FF , Knoll F , Wittmann SK , Klingler FM , Brunst S , Chaikuad A , Morisseau C , Hammock BD , Buccellati C , Sala A , Rovati GE , Leuillier M , Fraineau S , Rondeaux J , Hernandez-Olmos V , Heering J , Merk D , Pogoryelov D , Steinhilber D , Knapp S , Bellien J , Proschak E |
| Ref : Journal of Medicinal Chemistry , 62 :8443 , 2019 |
| Abstract : Kramer_2019_J.Med.Chem_62_8443 |
| ESTHER : Kramer_2019_J.Med.Chem_62_8443 |
| PubMedSearch : Kramer_2019_J.Med.Chem_62_8443 |
| PubMedID: 31436984 |