Full name : Hepnarova Vendula
First name : Vendula
Mail : Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01\; Biomedical Research Centre, University Hospital, Sokolska 581, 500 05, Hradec Kralove
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Country : Czech Republic
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| Title : A-series agent A-234: initial in vitro and in vivo characterization - Hrabinova_2024_Arch.Toxicol__ |
| Author(s) : Hrabinova M , Pejchal J , Hepnarova V , Muckova L , Junova L , Opravil J , Zdarova Karasova J , Rozsypal T , Dlabkova A , Rehulkova H , Kucera T , Vecera Z , Caisberger F , Schmidt M , Soukup O , Jun D |
| Ref : Archives of Toxicology , : , 2024 |
| Abstract : Hrabinova_2024_Arch.Toxicol__ |
| ESTHER : Hrabinova_2024_Arch.Toxicol__ |
| PubMedSearch : Hrabinova_2024_Arch.Toxicol__ |
| PubMedID: 38446233 |
| Title : Uncharged mono- and bisoximes: In search of a zwitterion to countermeasure organophosphorus intoxication - Gorecki_2024_Chem.Biol.Interact__110941 |
| Author(s) : Gorecki L , Markova A , Hepnarova V , Zivna N , Junova L , Hrabinova M , Janousek J , Kobrlova T , Prchal L , Jun D , Soukup O , Horn G , Worek F , Marek J , Korabecny J |
| Ref : Chemico-Biological Interactions , :110941 , 2024 |
| Abstract : Gorecki_2024_Chem.Biol.Interact__110941 |
| ESTHER : Gorecki_2024_Chem.Biol.Interact__110941 |
| PubMedSearch : Gorecki_2024_Chem.Biol.Interact__110941 |
| PubMedID: 38493910 |
| Title : Structure-Guided Design of N-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease - Svobodova_2023_Int.J.Mol.Sci_24_ |
| Author(s) : Svobodova B , Pulkrabkova L , Panek D , Misiachna A , Kolcheva M , Andrys R , Handl J , Capek J , Nyvltova P , Rousar T , Prchal L , Hepnarova V , Hrabinova M , Muckova L , Tosnerova D , Karabanovich G , Finger V , Soukup O , Horak M , Korabecny J |
| Ref : Int J Mol Sci , 24 : , 2023 |
| Abstract : Svobodova_2023_Int.J.Mol.Sci_24_ |
| ESTHER : Svobodova_2023_Int.J.Mol.Sci_24_ |
| PubMedSearch : Svobodova_2023_Int.J.Mol.Sci_24_ |
| PubMedID: 37298087 |
| Title : A-agents, misleadingly known as Novichoks: a narrative review - Opravil_2023_Arch.Toxicol__ |
| Author(s) : Opravil J , Pejchal J , Finger V , Korabecny J , Rozsypal T , Hrabinova M , Muckova L , Hepnarova V , Konecny J , Soukup O , Jun D |
| Ref : Archives of Toxicology , : , 2023 |
| Abstract : Opravil_2023_Arch.Toxicol__ |
| ESTHER : Opravil_2023_Arch.Toxicol__ |
| PubMedSearch : Opravil_2023_Arch.Toxicol__ |
| PubMedID: 37612377 |
| Title : Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870 - Karasova_2022_Food.Chem.Toxicol__113236 |
| Author(s) : Karasova JZ , Kassa J , Hepnarova V , Pejchal J , Junova L , Andrys R , Malinak D , Bzonek P , Kohoutova Z , Musilek K |
| Ref : Food & Chemical Toxicology , :113236 , 2022 |
| Abstract : Karasova_2022_Food.Chem.Toxicol__113236 |
| ESTHER : Karasova_2022_Food.Chem.Toxicol__113236 |
| PubMedSearch : Karasova_2022_Food.Chem.Toxicol__113236 |
| PubMedID: 35738326 |
| Title : Non-covalent acetylcholinesterase inhibitors: In vitro screening and molecular modeling for novel selective insecticides - Hepnarova_2022_Toxicol.In.Vitro__105463 |
| Author(s) : Hepnarova V , Hrabinova M , Muckova L , Kucera T , Schmidt M , Dolezal R , Gorecki L , Hrabcova V , Korabecny J , Mezeiova E , Jun D , Pejchal J |
| Ref : Toxicol In Vitro , :105463 , 2022 |
| Abstract : Hepnarova_2022_Toxicol.In.Vitro__105463 |
| ESTHER : Hepnarova_2022_Toxicol.In.Vitro__105463 |
| PubMedSearch : Hepnarova_2022_Toxicol.In.Vitro__105463 |
| PubMedID: 36041654 |
| Title : Design and synthesis of novel tacrine-indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease - Hamulakova_2021_Future.Med.Chem__ |
| Author(s) : Hamulakova S , Kudlickova Z , Janovec L , Mezencev R , Deckner ZJ , Chernoff YO , Janockova J , Ihnatova V , Bzonek P , Novakova N , Hepnarova V , Hrabinova M , Jun D , Korabecny J , Soukup O , Kuca K |
| Ref : Future Med Chem , : , 2021 |
| Abstract : Hamulakova_2021_Future.Med.Chem__ |
| ESTHER : Hamulakova_2021_Future.Med.Chem__ |
| PubMedSearch : Hamulakova_2021_Future.Med.Chem__ |
| PubMedID: 33829876 |
| Title : Huprine Y - tryptophan heterodimers with potential implication to Alzheimer's disease treatment - Mezeiova_2021_Bioorg.Med.Chem.Lett__128100 |
| Author(s) : Mezeiova E , Hrabinova M , Hepnarova V , Jun D , Janockova J , Muckova L , Prchal L , Kristofikova Z , Kucera T , Gorecki L , Chalupova K , Kunes J , Hroudova J , Soukup O , Korabecny J |
| Ref : Bioorganic & Medicinal Chemistry Lett , :128100 , 2021 |
| Abstract : Mezeiova_2021_Bioorg.Med.Chem.Lett__128100 |
| ESTHER : Mezeiova_2021_Bioorg.Med.Chem.Lett__128100 |
| PubMedSearch : Mezeiova_2021_Bioorg.Med.Chem.Lett__128100 |
| PubMedID: 33984470 |
| Title : Development of versatile and potent monoquaternary reactivators of acetylcholinesterase - Gorecki_2021_Arch.Toxicol__ |
| Author(s) : Gorecki L , Hepnarova V , Karasova JZ , Hrabinova M , Courageux C , Dias J , Kucera T , Kobrlova T , Muckova L , Prchal L , Malinak D , Jun D , Musilek K , Worek F , Nachon F , Soukup O , Korabecny J |
| Ref : Archives of Toxicology , : , 2021 |
| Abstract : Gorecki_2021_Arch.Toxicol__ |
| ESTHER : Gorecki_2021_Arch.Toxicol__ |
| PubMedSearch : Gorecki_2021_Arch.Toxicol__ |
| PubMedID: 33517499 |
| Title : 7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo - Kaniakova_2021_Biochem.Pharmacol__114460 |
| Author(s) : Kaniakova M , Korabecny J , Holubova K , Kleteckova L , Chvojkova M , Hakenova K , Prchal L , Novak M , Dolezal R , Hepnarova V , Svobodova B , Kucera T , Lichnerova K , Krausova B , Horak M , Vales K , Soukup O |
| Ref : Biochemical Pharmacology , :114460 , 2021 |
| Abstract : Kaniakova_2021_Biochem.Pharmacol__114460 |
| ESTHER : Kaniakova_2021_Biochem.Pharmacol__114460 |
| PubMedSearch : Kaniakova_2021_Biochem.Pharmacol__114460 |
| PubMedID: 33571502 |
| Title : Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease - Gorecki_2021_ACS.Chem.Neurosci__ |
| Author(s) : Gorecki L , Uliassi E , Bartolini M , Janockova J , Hrabinova M , Hepnarova V , Prchal L , Muckova L , Pejchal J , Karasova JZ , Mezeiova E , Benkova M , Kobrlova T , Soukup O , Petralla S , Monti B , Korabecny J , Bolognesi ML |
| Ref : ACS Chem Neurosci , : , 2021 |
| Abstract : Gorecki_2021_ACS.Chem.Neurosci__ |
| ESTHER : Gorecki_2021_ACS.Chem.Neurosci__ |
| PubMedSearch : Gorecki_2021_ACS.Chem.Neurosci__ |
| PubMedID: 33852284 |
| Title : A Comparison of the Neuroprotective and Reactivating Efficacy of a Novel Bispyridinium Oxime K870 with Commonly Used Pralidoxime and the Oxime HI-6 in Tabun-Poisoned Rats - Kassa_2021_Acta.Medica.(Hradec.Kralove)_64_145 |
| Author(s) : Kassa J , Hatlapatkova J , Karasova JZ , Hepnarova V , Caisberger F , Pejchal J |
| Ref : Acta Medica (Hradec Kralove) , 64 :145 , 2021 |
| Abstract : Kassa_2021_Acta.Medica.(Hradec.Kralove)_64_145 |
| ESTHER : Kassa_2021_Acta.Medica.(Hradec.Kralove)_64_145 |
| PubMedSearch : Kassa_2021_Acta.Medica.(Hradec.Kralove)_64_145 |
| PubMedID: 34779379 |
| Title : (+\/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease - Ismaili_2021_ACS.Chem.Neurosci__ |
| Author(s) : Ismaili L , Monnin J , Etievant A , Arribas RL , Viejo L , Refouvelet B , Soukup O , Janockova J , Hepnarova V , Korabecny J , Kucera T , Jun D , Andrys R , Musilek K , Baguet A , Garcia-Frutos EM , De Simone A , Andrisano V , Bartolini M , de los Rios C , Marco-Contelles J , Haffen E |
| Ref : ACS Chem Neurosci , : , 2021 |
| Abstract : Ismaili_2021_ACS.Chem.Neurosci__ |
| ESTHER : Ismaili_2021_ACS.Chem.Neurosci__ |
| PubMedSearch : Ismaili_2021_ACS.Chem.Neurosci__ |
| PubMedID: 33797877 |
| Title : Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile - Sobolova_2020_Eur.J.Med.Chem_203_112593 |
| Author(s) : Sobolova K , Hrabinova M , Hepnarova V , Kucera T , Kobrlova T , Benkova M , Janockova J , Dolezal R , Prchal L , Benek O , Mezeiova E , Jun D , Soukup O , Korabecny J |
| Ref : Eur Journal of Medicinal Chemistry , 203 :112593 , 2020 |
| Abstract : Sobolova_2020_Eur.J.Med.Chem_203_112593 |
| ESTHER : Sobolova_2020_Eur.J.Med.Chem_203_112593 |
| PubMedSearch : Sobolova_2020_Eur.J.Med.Chem_203_112593 |
| PubMedID: 32688201 |
| Title : Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors - Gorecki_2020_ACS.Med.Chem.Lett_11_65 |
| Author(s) : Gorecki L , Andrys R , Schmidt M , Kucera T , Psotka M , Svobodova B , Hrabcova V , Hepnarova V , Bzonek P , Jun D , Kuca K , Korabecny J , Musilek K |
| Ref : ACS Med Chem Lett , 11 :65 , 2020 |
| Abstract : Gorecki_2020_ACS.Med.Chem.Lett_11_65 |
| ESTHER : Gorecki_2020_ACS.Med.Chem.Lett_11_65 |
| PubMedSearch : Gorecki_2020_ACS.Med.Chem.Lett_11_65 |
| PubMedID: 31938465 |
| Title : Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators - Malinak_2020_J.Enzyme.Inhib.Med.Chem_35_478 |
| Author(s) : Malinak D , Dolezal R , Hepnarova V , Hozova M , Andrys R , Bzonek P , Racakova V , Korabecny J , Gorecki L , Mezeiova E , Psotka M , Jun D , Kuca K , Musilek K |
| Ref : J Enzyme Inhib Med Chem , 35 :478 , 2020 |
| Abstract : Malinak_2020_J.Enzyme.Inhib.Med.Chem_35_478 |
| ESTHER : Malinak_2020_J.Enzyme.Inhib.Med.Chem_35_478 |
| PubMedSearch : Malinak_2020_J.Enzyme.Inhib.Med.Chem_35_478 |
| PubMedID: 31910701 |
| Title : Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness - Karasova_2020_Toxicol.Lett_320_64 |
| Author(s) : Karasova JZ , Hepnarova V , Andrys R , Lisa M , Jost P , Muckova L , Pejchal J , Herman D , Jun D , Kassa J , Kuca K |
| Ref : Toxicol Lett , 320 :64 , 2020 |
| Abstract : Karasova_2020_Toxicol.Lett_320_64 |
| ESTHER : Karasova_2020_Toxicol.Lett_320_64 |
| PubMedSearch : Karasova_2020_Toxicol.Lett_320_64 |
| PubMedID: 31794810 |
| Title : Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimes drugs dealing with cholinergic, amyloid and mitochondrial systems - Nepovimova_2020_Bioorg.Chem_107_104596 |
| Author(s) : Nepovimova E , Svobodova L , Dolezal R , Hepnarova V , Junova L , Jun D , Korabecny J , Kucera T , Gazova Z , Motykova K , Kubackova J , Bednarikova Z , Janockova J , Jesus C , Cortes L , Pina J , Rostohar D , Serpa C , Soukup O , Aitken L , Hughes RE , Musilek K , Muckova L , Jost P , Chvojkova M , Vales K , Valis M , Chrienova Z , Chalupova K , Kuca K |
| Ref : Bioorg Chem , 107 :104596 , 2020 |
| Abstract : Nepovimova_2020_Bioorg.Chem_107_104596 |
| ESTHER : Nepovimova_2020_Bioorg.Chem_107_104596 |
| PubMedSearch : Nepovimova_2020_Bioorg.Chem_107_104596 |
| PubMedID: 33421953 |
| Title : Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors - Svobodova_2019_Biomolecules_9_ |
| Author(s) : Svobodova B , Mezeiova E , Hepnarova V , Hrabinova M , Muckova L , Kobrlova T , Jun D , Soukup O , Jimeno ML , Marco-Contelles J , Korabecny J |
| Ref : Biomolecules , 9 : , 2019 |
| Abstract : Svobodova_2019_Biomolecules_9_ |
| ESTHER : Svobodova_2019_Biomolecules_9_ |
| PubMedSearch : Svobodova_2019_Biomolecules_9_ |
| PubMedID: 31430943 |
| Title : N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy - Nepovimova_2019_Curr.Alzheimer.Res_16_333 |
| Author(s) : Nepovimova E , Korabecny J , Hepnarova V , Jun D , Dolezal R , Muckova L , Jost P , Soukup O , Janockova J , Pham NL , Nguyen TD , Valis M , Kuca K |
| Ref : Curr Alzheimer Res , 16 :333 , 2019 |
| Abstract : Nepovimova_2019_Curr.Alzheimer.Res_16_333 |
| ESTHER : Nepovimova_2019_Curr.Alzheimer.Res_16_333 |
| PubMedSearch : Nepovimova_2019_Curr.Alzheimer.Res_16_333 |
| PubMedID: 30873921 |
| Title : Tacroximes: novel unique compounds for the recovery of organophosphorus-inhibited acetylcholinesterase - Gorecki_2019_Future.Med.Chem_11_2625 |
| Author(s) : Gorecki L , Junova L , Kucera T , Hepnarova V , Prchal L , Kobrlova T , Muckova L , Soukup O , Korabecny J |
| Ref : Future Med Chem , 11 :2625 , 2019 |
| Abstract : Gorecki_2019_Future.Med.Chem_11_2625 |
| ESTHER : Gorecki_2019_Future.Med.Chem_11_2625 |
| PubMedSearch : Gorecki_2019_Future.Med.Chem_11_2625 |
| PubMedID: 31556693 |
| Title : Tacrine and its 7-methoxy derivate\; time-change concentration in plasma and brain tissue and basic toxicological profile in rats - Karasova_2019_Drug.Chem.Toxicol__1 |
| Author(s) : Karasova JZ , Soukup O , Korabecny J , Hroch M , Krejciova M , Hrabinova M , Misik J , Novotny L , Hepnarova V , Kuca K |
| Ref : Drug & Chemical Toxicology , :1 , 2019 |
| Abstract : Karasova_2019_Drug.Chem.Toxicol__1 |
| ESTHER : Karasova_2019_Drug.Chem.Toxicol__1 |
| PubMedSearch : Karasova_2019_Drug.Chem.Toxicol__1 |
| PubMedID: 31257938 |
| Title : Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators - Hepnarova_2019_Toxicol.Appl.Pharmacol__114776 |
| Author(s) : Hepnarova V , Muckova L , Ring A , Pejchal J , Herman D , Misik J , Hrabinova M , Jun D , Soukup O |
| Ref : Toxicol Appl Pharmacol , :114776 , 2019 |
| Abstract : Hepnarova_2019_Toxicol.Appl.Pharmacol__114776 |
| ESTHER : Hepnarova_2019_Toxicol.Appl.Pharmacol__114776 |
| PubMedSearch : Hepnarova_2019_Toxicol.Appl.Pharmacol__114776 |
| PubMedID: 31629733 |
| Title : Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease - Kaniakova_2019_Curr.Alzheimer.Res_16_821 |
| Author(s) : Kaniakova M , Nepovimova E , Kleteckova L , Skrenkova K , Holubova K , Chrienova Z , Hepnarova V , Kucera T , Kobrlova T , Vales K , Korabecny J , Soukup O , Horak M |
| Ref : Curr Alzheimer Res , 16 :821 , 2019 |
| Abstract : Kaniakova_2019_Curr.Alzheimer.Res_16_821 |
| ESTHER : Kaniakova_2019_Curr.Alzheimer.Res_16_821 |
| PubMedSearch : Kaniakova_2019_Curr.Alzheimer.Res_16_821 |
| PubMedID: 30819076 |
| Title : Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease - Chalupova_2019_Eur.J.Med.Chem_168_491 |
| Author(s) : Chalupova K , Korabecny J , Bartolini M , Monti B , Lamba D , Caliandro R , Pesaresi A , Brazzolotto X , Gastellier AJ , Nachon F , Pejchal J , Jarosova M , Hepnarova V , Jun D , Hrabinova M , Dolezal R , Karasova JZ , Mzik M , Kristofikova Z , Misik J , Muckova L , Jost P , Soukup O , Benkova M , Setnicka V , Habartova L , Chvojkova M , Kleteckova L , Vales K , Mezeiova E , Uliassi E , Valis M , Nepovimova E , Bolognesi ML , Kuca K |
| Ref : Eur Journal of Medicinal Chemistry , 168 :491 , 2019 |
| Abstract : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| ESTHER : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| PubMedSearch : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| PubMedID: 30851693 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods - Janockova_2018_Molecules_23_ |
| Author(s) : Janockova J , Dolezal R , Nepovimova E , Kobrlova T , Benkova M , Kuca K , Konecny J , Mezeiova E , Melikova M , Hepnarova V , Ring A , Soukup O , Korabecny J |
| Ref : Molecules , 23 : , 2018 |
| Abstract : Janockova_2018_Molecules_23_ |
| ESTHER : Janockova_2018_Molecules_23_ |
| PubMedSearch : Janockova_2018_Molecules_23_ |
| PubMedID: 30423961 |
| Title : The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease - Hepnarova_2018_Eur.J.Med.Chem_150_292 |
| Author(s) : Hepnarova V , Korabecny J , Matouskova L , Jost P , Muckova L , Hrabinova M , Vykoukalova N , Kerhartova M , Kucera T , Dolezal R , Nepovimova E , Spilovska K , Mezeiova E , Pham NL , Jun D , Staud F , Kaping D , Kuca K , Soukup O |
| Ref : Eur Journal of Medicinal Chemistry , 150 :292 , 2018 |
| Abstract : Hepnarova_2018_Eur.J.Med.Chem_150_292 |
| ESTHER : Hepnarova_2018_Eur.J.Med.Chem_150_292 |
| PubMedSearch : Hepnarova_2018_Eur.J.Med.Chem_150_292 |
| PubMedID: 29533874 |
| Title : In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley? - Soukup_2018_Med.Chem_14_281 |
| Author(s) : Soukup O , Korabecny J , Malinak D , Nepovimova E , Pham NL , Musilek K , Hrabinova M , Hepnarova V , Dolezal R , Pavek P , Jost P , Kobrlova T , Jankockova J , Gorecki L , Psotka M , Nguyen TD , Box K , Outhwaite B , Ceckova M , Sorf A , Jun D , Kuca K |
| Ref : Med Chem , 14 :281 , 2018 |
| Abstract : Soukup_2018_Med.Chem_14_281 |
| ESTHER : Soukup_2018_Med.Chem_14_281 |
| PubMedSearch : Soukup_2018_Med.Chem_14_281 |
| PubMedID: 29332594 |