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Author Report for: Hadad CM

Contact information:

Hadad Christopher M
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio, 43210
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    Title: A Novel, Modified Human Butyrylcholinesterase Catalytically Degrades the Chemical Warfare Nerve Agent, Sarin
    McGarry KG, Lalisse RF, Moyer RA, Johnson KM, Tallan AM, Winters TP, Taris JE, McElroy CA, Lemmon EE and Wood DW <6 more author(s)>
    Ref: Toxicol Sci, 174:133, 2020 : PubMed


    Title: Resurrection and Reactivation of Acetylcholinesterase and Butyrylcholinesterase
    Franjesevic AJ, Sillart SB, Beck JM, Vyas S, Callam CS, Hadad CM
    Ref: Chemistry, 25:5337, 2019 : PubMed


    Title: Demonstration of In Vitro Resurrection of Aged Acetylcholinesterase after Exposure to Organophosphorus Chemical Nerve Agents
    Zhuang Q, Franjesevic AJ, Corrigan TS, Coldren WH, Dicken R, Sillart S, DeYong A, Yoshino N, Smith J and Hadad CM <8 more author(s)>
    Ref: Journal of Medicinal Chemistry, 61:7034, 2018 : PubMed


    Title: Study of para-Quinone Methide Precursors toward the Realkylation of Aged Acetylcholinesterase
    Yoder RJ, Zhuang Q, Beck JM, Franjesevic AJ, Blanton TG, Sillart S, Secor T, Guerra L, Brown JD and Hadad CM <4 more author(s)>
    Ref: ACS Med Chem Lett, 8:622, 2017 : PubMed


    Title: Efforts toward treatments against aging of organophosphorus-inhibited acetylcholinesterase
    Zhuang Q, Young A, Callam CS, McElroy CA, Ekici OD, Yoder RJ, Hadad CM
    Ref: Annals of the New York Academy of Sciences, 1374:94, 2016 : PubMed


    Title: Mechanistic Insights into the Hydrolysis of Organophosphorus Compounds by Paraoxonase-1: Exploring the Limits of Substrate Tolerance in a Promiscuous Enzyme
    Muthukrishnan S, Shete VS, Sanan TT, Vyas S, Oottikkal S, Porter LM, Magliery TJ, Hadad CM
    Ref: J Phys Org Chem, 25:1247, 2012 : PubMed


    Title: Reaction profiles of the interaction between sarin and acetylcholinesterase and the S203C mutant: model nucleophiles and QM/MM potential energy surfaces
    Beck JM, Hadad CM
    Ref: Chemico-Biological Interactions, 187:220, 2010 : PubMed


    Title: Gated molecular recognition and dynamic discrimination of guests
    Rieth S, Bao X, Wang BY, Hadad CM, Badjic JD
    Ref: Journal of the American Chemical Society, 132:773, 2010 : PubMed


    Title: Computational Modeling of Human Paraoxonase 1: Preparation of Protein Models, Binding Studies, and Mechanistic Insights
    Sanan TT, Muthukrishnan S, Beck JM, Tao P, Hayes CJ, Otto TC, Cerasoli DM, Lenz DE, Hadad CM
    Ref: J Phys Org Chem, 23:357, 2010 : PubMed


    Title: Butyrylcholinesterase and G116H, G116S, G117H, G117N, E197Q and G117H/E197Q mutants: a molecular dynamics study
    Vyas S, Beck JM, Xia S, Zhang J, Hadad CM
    Ref: Chemico-Biological Interactions, 187:241, 2010 : PubMed


    Title: Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase
    Barakat NH, Zheng X, Gilley CB, MacDonald M, Okolotowicz K, Cashman JR, Vyas S, Beck JM, Hadad CM, Zhang J
    Ref: Chemical Research in Toxicology, 22:1669, 2009 : PubMed


    Title: Hydrolysis of nerve agents by model nucleophiles: a computational study
    Beck JM, Hadad CM
    Ref: Chemico-Biological Interactions, 175:200, 2008 : PubMed


    Title: Reactivation of model cholinesterases by oximes and intermediate phosphyloximes: a computational study
    Vyas S, Hadad CM
    Ref: Chemico-Biological Interactions, 175:187, 2008 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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