Full name : Greig Nigel H
First name : Nigel H
Mail : Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224
Zip Code :
City :
Country : USA
Email : Greign@grc.nia.nih.gov
Phone :
Fax :
Website :
Directory :
| Title : Sitagliptin elevates plasma and CSF incretin levels following oral administration to nonhuman primates: relevance for neurodegenerative disorders - Li_2024_Geroscience__ |
| Author(s) : Li Y , Vaughan KL , Wang Y , Yu SJ , Bae EK , Tamargo IA , Kopp KO , Tweedie D , Chiang CC , Schmidt KT , Lahiri DK , Tones MA , Zaleska MM , Hoffer BJ , Mattison JA , Greig NH |
| Ref : Geroscience , : , 2024 |
| Abstract : Li_2024_Geroscience__ |
| ESTHER : Li_2024_Geroscience__ |
| PubMedSearch : Li_2024_Geroscience__ |
| PubMedID: 38532069 |
| Title : DPP-4 inhibitors sitagliptin and PF-00734,200 mitigate dopaminergic neurodegeneration, neuroinflammation and behavioral impairment in the rat 6-OHDA model of Parkinson's disease - Yu_2024_Geroscience__ |
| Author(s) : Yu SJ , Wang Y , Shen H , Bae EK , Li Y , Sambamurti K , Tones MA , Zaleska MM , Hoffer BJ , Greig NH |
| Ref : Geroscience , : , 2024 |
| Abstract : Yu_2024_Geroscience__ |
| ESTHER : Yu_2024_Geroscience__ |
| PubMedSearch : Yu_2024_Geroscience__ |
| PubMedID: 38563864 |
| Title : In Silico and Ex Vivo Analyses of the Inhibitory Action of the Alzheimer Drug Posiphen and Primary Metabolites with Human Acetyl- and Butyrylcholinesterase Enzymes - Batool_2022_ACS.Pharmacol.Transl.Sci_5_70 |
| Author(s) : Batool S , Furqan T , Hasan Mahmood MS , Tweedie D , Kamal MA , Greig NH |
| Ref : ACS Pharmacol Transl Sci , 5 :70 , 2022 |
| Abstract : Batool_2022_ACS.Pharmacol.Transl.Sci_5_70 |
| ESTHER : Batool_2022_ACS.Pharmacol.Transl.Sci_5_70 |
| PubMedSearch : Batool_2022_ACS.Pharmacol.Transl.Sci_5_70 |
| PubMedID: 35178511 |
| Title : Post-treatment with Posiphen Reduces Endoplasmic Reticulum Stress and Neurodegeneration in Stroke Brain - Yu_2020_iScience_23_100866 |
| Author(s) : Yu SJ , Wu KJ , Bae E , Wang YS , Chiang CW , Kuo LW , Harvey BK , Greig NH , Wang Y |
| Ref : iScience , 23 :100866 , 2020 |
| Abstract : Yu_2020_iScience_23_100866 |
| ESTHER : Yu_2020_iScience_23_100866 |
| PubMedSearch : Yu_2020_iScience_23_100866 |
| PubMedID: 32058974 |
| Title : Rivastigmine modifies the alpha-secretase pathway and potentially early Alzheimer's disease - Ray_2020_Transl.Psychiatry_10_47 |
| Author(s) : Ray B , Maloney B , Sambamurti K , Karnati HK , Nelson PT , Greig NH , Lahiri DK |
| Ref : Transl Psychiatry , 10 :47 , 2020 |
| Abstract : Ray_2020_Transl.Psychiatry_10_47 |
| ESTHER : Ray_2020_Transl.Psychiatry_10_47 |
| PubMedSearch : Ray_2020_Transl.Psychiatry_10_47 |
| PubMedID: 32066688 |
| Title : (-)-Phenserine Ameliorates Contusion Volume, Neuroinflammation, and Behavioral Impairments Induced by Traumatic Brain Injury in Mice - Hsueh_2019_Cell.Transplant__963689719854693 |
| Author(s) : Hsueh SC , Lecca D , Greig NH , Wang JY , Selman W , Hoffer BJ , Miller JP , Chiang YH |
| Ref : Cell Transplantation , :963689719854693 , 2019 |
| Abstract : Hsueh_2019_Cell.Transplant__963689719854693 |
| ESTHER : Hsueh_2019_Cell.Transplant__963689719854693 |
| PubMedSearch : Hsueh_2019_Cell.Transplant__963689719854693 |
| PubMedID: 31177840 |
| Title : Inhibition of Butyrylcholinesterase with Fluorobenzylcymserine, An Experimental Alzheimer's Drug Candidate: Validation of Enzoinformatics Results by Classical and Innovative Enzyme Kinetic Analyses - Kamal_2017_CNS.Neurol.Disord.Drug.Targets_16_820 |
| Author(s) : Kamal MA , Shakil S , Nawaz MS , Yu QS , Tweedie D , Tan Y , Qu X , Greig NH |
| Ref : CNS Neurol Disord Drug Targets , 16 :820 , 2017 |
| Abstract : Kamal_2017_CNS.Neurol.Disord.Drug.Targets_16_820 |
| ESTHER : Kamal_2017_CNS.Neurol.Disord.Drug.Targets_16_820 |
| PubMedSearch : Kamal_2017_CNS.Neurol.Disord.Drug.Targets_16_820 |
| PubMedID: 28176640 |
| Title : (-)-Phenserine inhibits neuronal apoptosis following ischemia\/reperfusion injury - Chang_2017_Brain.Res_1677_118 |
| Author(s) : Chang CF , Lai JH , Wu JC , Greig NH , Becker RE , Luo Y , Chen YH , Kang SJ , Chiang YH , Chen KY |
| Ref : Brain Research , 1677 :118 , 2017 |
| Abstract : Chang_2017_Brain.Res_1677_118 |
| ESTHER : Chang_2017_Brain.Res_1677_118 |
| PubMedSearch : Chang_2017_Brain.Res_1677_118 |
| PubMedID: 28963051 |
| Title : Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms - Tweedie_2016_PLoS.One_11_e0156493 |
| Author(s) : Tweedie D , Fukui K , Li Y , Yu QS , Barak S , Tamargo IA , Rubovitch V , Holloway HW , Lehrmann E , Wood WH, 3rd , Zhang Y , Becker KG , Perez E , Van Praag H , Luo Y , Hoffer BJ , Becker RE , Pick CG , Greig NH |
| Ref : PLoS ONE , 11 :e0156493 , 2016 |
| Abstract : Tweedie_2016_PLoS.One_11_e0156493 |
| ESTHER : Tweedie_2016_PLoS.One_11_e0156493 |
| PubMedSearch : Tweedie_2016_PLoS.One_11_e0156493 |
| PubMedID: 27254111 |
| Title : (-)-phenserine attenuates soman-induced neuropathology - Chen_2014_PLoS.One_9_e99818 |
| Author(s) : Chen J , Pan H , Chen C , Wu W , Iskandar K , He J , Piermartiri T , Jacobowitz DM , Yu QS , McDonough JH , Greig NH , Marini AM |
| Ref : PLoS ONE , 9 :e99818 , 2014 |
| Abstract : Chen_2014_PLoS.One_9_e99818 |
| ESTHER : Chen_2014_PLoS.One_9_e99818 |
| PubMedSearch : Chen_2014_PLoS.One_9_e99818 |
| PubMedID: 24955574 |
| Title : Status of acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease and type 2 diabetes mellitus - Mushtaq_2014_CNS.Neurol.Disord.Drug.Targets_13_1432 |
| Author(s) : Mushtaq G , Greig NH , Khan JA , Kamal MA |
| Ref : CNS Neurol Disord Drug Targets , 13 :1432 , 2014 |
| Abstract : Mushtaq_2014_CNS.Neurol.Disord.Drug.Targets_13_1432 |
| ESTHER : Mushtaq_2014_CNS.Neurol.Disord.Drug.Targets_13_1432 |
| PubMedSearch : Mushtaq_2014_CNS.Neurol.Disord.Drug.Targets_13_1432 |
| PubMedID: 25345511 |
| Title : Selective Acetyl- and Butyrylcholinesterase Inhibitors Reduce Amyloid-beta Ex Vivo Activation of Peripheral Chemo-cytokines From Alzheimer's Disease Subjects: Exploring the Cholinergic Anti-inflammatory Pathway - Reale_2014_Curr.Alzheimer.Res_11_608 |
| Author(s) : Reale M , Di Nicola M , Velluto L , D'Angelo C , Costantini E , Lahiri DK , Kamal MA , Yu QS , Greig NH |
| Ref : Curr Alzheimer Res , 11 :608 , 2014 |
| Abstract : Reale_2014_Curr.Alzheimer.Res_11_608 |
| ESTHER : Reale_2014_Curr.Alzheimer.Res_11_608 |
| PubMedSearch : Reale_2014_Curr.Alzheimer.Res_11_608 |
| PubMedID: 24359497 |
| Title : Linking Alzheimer's Disease and Type 2 Diabetes Mellitus via Aberrant Insulin Signaling and Inflammation - Kamal_2014_CNS.Neurol.Disord.Drug.Targets_13_338 |
| Author(s) : Kamal MA , Priyamvada S , Anbazhagan AN , Jabir NR , Tabrez S , Greig NH |
| Ref : CNS Neurol Disord Drug Targets , 13 :338 , 2014 |
| Abstract : Kamal_2014_CNS.Neurol.Disord.Drug.Targets_13_338 |
| ESTHER : Kamal_2014_CNS.Neurol.Disord.Drug.Targets_13_338 |
| PubMedSearch : Kamal_2014_CNS.Neurol.Disord.Drug.Targets_13_338 |
| PubMedID: 24074448 |
| Title : Synthesis of the Alzheimer Drug Posiphen into its Primary Metabolic Products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their Inhibition of Amyloid Precursor Protein, alpha -Synuclein Synthesis, Interleukin-1beta Release, and Cholinergic Action - Yu_2013_Antiinflamm.Antiallergy.Agents.Med.Chem_12_117 |
| Author(s) : Yu QS , Reale M , Kamal MA , Holloway HW , Luo W , Sambamurti K , Ray B , Lahiri DK , Rogers JT , Greig NH |
| Ref : Antiinflamm Antiallergy Agents Med Chem , 12 :117 , 2013 |
| Abstract : Yu_2013_Antiinflamm.Antiallergy.Agents.Med.Chem_12_117 |
| ESTHER : Yu_2013_Antiinflamm.Antiallergy.Agents.Med.Chem_12_117 |
| PubMedSearch : Yu_2013_Antiinflamm.Antiallergy.Agents.Med.Chem_12_117 |
| PubMedID: 23360256 |
| Title : Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group - Bartolucci_2012_Biochem.J_444_269 |
| Author(s) : Bartolucci C , Stojan J , Yu QS , Greig NH , Lamba D |
| Ref : Biochemical Journal , 444 :269 , 2012 |
| Abstract : Bartolucci_2012_Biochem.J_444_269 |
| ESTHER : Bartolucci_2012_Biochem.J_444_269 |
| PubMedSearch : Bartolucci_2012_Biochem.J_444_269 |
| PubMedID: 22390827 |
| Gene_locus related to this paper: torma-ACHE |
| Title : The anticholinesterase phenserine and its enantiomer posiphen as 5'untranslated-region-directed translation blockers of the Parkinson's alpha synuclein expression - Mikkilineni_2012_Parkinsons.Dis_2012_142372 |
| Author(s) : Mikkilineni S , Cantuti-Castelvetri I , Cahill CM , Balliedier A , Greig NH , Rogers JT |
| Ref : Parkinsons Dis , 2012 :142372 , 2012 |
| Abstract : Mikkilineni_2012_Parkinsons.Dis_2012_142372 |
| ESTHER : Mikkilineni_2012_Parkinsons.Dis_2012_142372 |
| PubMedSearch : Mikkilineni_2012_Parkinsons.Dis_2012_142372 |
| PubMedID: 22693681 |
| Title : Acetylcholinesterase inhibition ameliorates deficits in motivational drive - Martinowich_2012_Behav.Brain.Funct_8_15 |
| Author(s) : Martinowich K , Cardinale KM , Schloesser RJ , Hsu M , Greig NH , Manji HK |
| Ref : Behav Brain Funct , 8 :15 , 2012 |
| Abstract : Martinowich_2012_Behav.Brain.Funct_8_15 |
| ESTHER : Martinowich_2012_Behav.Brain.Funct_8_15 |
| PubMedSearch : Martinowich_2012_Behav.Brain.Funct_8_15 |
| PubMedID: 22433906 |
| Title : Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs - Araujo_2011_J.Alzheimers.Dis_26_143 |
| Author(s) : Araujo JA , Greig NH , Ingram DK , Sandin J , de Rivera C , Milgram NW |
| Ref : J Alzheimers Dis , 26 :143 , 2011 |
| Abstract : Araujo_2011_J.Alzheimers.Dis_26_143 |
| ESTHER : Araujo_2011_J.Alzheimers.Dis_26_143 |
| PubMedSearch : Araujo_2011_J.Alzheimers.Dis_26_143 |
| PubMedID: 21593569 |
| Title : Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-beta peptide in mice - Furukawa-Hibi_2011_Behav.Brain.Res_225_222 |
| Author(s) : Furukawa-Hibi Y , Alkam T , Nitta A , Matsuyama A , Mizoguchi H , Suzuki K , Moussaoui S , Yu QS , Greig NH , Nagai T , Yamada K |
| Ref : Behavioural Brain Research , 225 :222 , 2011 |
| Abstract : Furukawa-Hibi_2011_Behav.Brain.Res_225_222 |
| ESTHER : Furukawa-Hibi_2011_Behav.Brain.Res_225_222 |
| PubMedSearch : Furukawa-Hibi_2011_Behav.Brain.Res_225_222 |
| PubMedID: 21820013 |
| Title : Interaction of human brain acetylcholinesterase with cyclophosphamide: a molecular modeling and docking study - Shakil_2011_CNS.Neurol.Disord.Drug.Targets_10_845 |
| Author(s) : Shakil S , Khan R , Tabrez S , Alam Q , Jabir NR , Sulaiman MI , Greig NH , Kamal MA |
| Ref : CNS Neurol Disord Drug Targets , 10 :845 , 2011 |
| Abstract : Shakil_2011_CNS.Neurol.Disord.Drug.Targets_10_845 |
| ESTHER : Shakil_2011_CNS.Neurol.Disord.Drug.Targets_10_845 |
| PubMedSearch : Shakil_2011_CNS.Neurol.Disord.Drug.Targets_10_845 |
| PubMedID: 21999734 |
| Title : Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine - Yu_2010_Bioorg.Med.Chem_18_4687 |
| Author(s) : Yu QS , Holloway HW , Luo W , Lahiri DK , Brossi A , Greig NH |
| Ref : Bioorganic & Medicinal Chemistry , 18 :4687 , 2010 |
| Abstract : Yu_2010_Bioorg.Med.Chem_18_4687 |
| ESTHER : Yu_2010_Bioorg.Med.Chem_18_4687 |
| PubMedSearch : Yu_2010_Bioorg.Med.Chem_18_4687 |
| PubMedID: 20627738 |
| Title : Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions - Barak_2009_Biochem.J_417_213 |
| Author(s) : Barak D , Ordentlich A , Stein D , Yu QS , Greig NH , Shafferman A |
| Ref : Biochemical Journal , 417 :213 , 2009 |
| Abstract : Barak_2009_Biochem.J_417_213 |
| ESTHER : Barak_2009_Biochem.J_417_213 |
| PubMedSearch : Barak_2009_Biochem.J_417_213 |
| PubMedID: 18729824 |
| Title : Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices - Wang_2009_Neurobiol.Aging_30_1061 |
| Author(s) : Wang Y , Greig NH , Yu QS , Mattson MP |
| Ref : Neurobiology of Aging , 30 :1061 , 2009 |
| Abstract : Wang_2009_Neurobiol.Aging_30_1061 |
| ESTHER : Wang_2009_Neurobiol.Aging_30_1061 |
| PubMedSearch : Wang_2009_Neurobiol.Aging_30_1061 |
| PubMedID: 18068871 |
| Title : Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease - Bartolini_2009_J.Chromatogr.A_1216_2730 |
| Author(s) : Bartolini M , Greig NH , Yu QS , Andrisano V |
| Ref : Journal of Chromatography A , 1216 :2730 , 2009 |
| Abstract : Bartolini_2009_J.Chromatogr.A_1216_2730 |
| ESTHER : Bartolini_2009_J.Chromatogr.A_1216_2730 |
| PubMedSearch : Bartolini_2009_J.Chromatogr.A_1216_2730 |
| PubMedID: 18950780 |
| Title : Tetrahydrofurobenzofuran cymserine, a potent butyrylcholinesterase inhibitor and experimental Alzheimer drug candidate, enzyme kinetic analysis - Kamal_2008_J.Neural.Transm.(Vienna)_115_889 |
| Author(s) : Kamal MA , Qu X , Yu QS , Tweedie D , Holloway HW , Li Y , Tan Y , Greig NH |
| Ref : J Neural Transm (Vienna) , 115 :889 , 2008 |
| Abstract : Kamal_2008_J.Neural.Transm.(Vienna)_115_889 |
| ESTHER : Kamal_2008_J.Neural.Transm.(Vienna)_115_889 |
| PubMedSearch : Kamal_2008_J.Neural.Transm.(Vienna)_115_889 |
| PubMedID: 18235987 |
| Title : Kinetics of human serum butyrylcholinesterase inhibition by a novel experimental Alzheimer therapeutic, dihydrobenzodioxepine cymserine - Kamal_2008_Neurochem.Res_33_745 |
| Author(s) : Kamal MA , Klein P , Luo W , Li Y , Holloway HW , Tweedie D , Greig NH |
| Ref : Neurochem Res , 33 :745 , 2008 |
| Abstract : Kamal_2008_Neurochem.Res_33_745 |
| ESTHER : Kamal_2008_Neurochem.Res_33_745 |
| PubMedSearch : Kamal_2008_Neurochem.Res_33_745 |
| PubMedID: 17985237 |
| Title : Flexibility versus rigidity of the functional architecture of AChE active center - Shafferman_2008_Chem.Biol.Interact_175_166 |
| Author(s) : Shafferman A , Barak D , Stein D , Kronman C , Velan B , Greig NH , Ordentlich A |
| Ref : Chemico-Biological Interactions , 175 :166 , 2008 |
| Abstract : Shafferman_2008_Chem.Biol.Interact_175_166 |
| ESTHER : Shafferman_2008_Chem.Biol.Interact_175_166 |
| PubMedSearch : Shafferman_2008_Chem.Biol.Interact_175_166 |
| PubMedID: 18471807 |
| Title : Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease - Lane_2008_Pharmacogenet.Genomics_18_289 |
| Author(s) : Lane R , Feldman HH , Meyer J , He Y , Ferris SH , Nordberg A , Darreh-Shori T , Soininen H , Pirttila T , Farlow MR , Sfikas N , Ballard C , Greig NH |
| Ref : Pharmacogenet Genomics , 18 :289 , 2008 |
| Abstract : Lane_2008_Pharmacogenet.Genomics_18_289 |
| ESTHER : Lane_2008_Pharmacogenet.Genomics_18_289 |
| PubMedSearch : Lane_2008_Pharmacogenet.Genomics_18_289 |
| PubMedID: 18334913 |
| Title : Preclinical investigation of the topical administration of phenserine: transdermal flux, cholinesterase inhibition, and cognitive efficacy - Utsuki_2007_J.Pharmacol.Exp.Ther_321_353 |
| Author(s) : Utsuki T , Uchimura N , Irikura M , Moriuchi H , Holloway HW , Yu QS , Spangler EL , Mamczarz J , Ingram DK , Irie T , Greig NH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 321 :353 , 2007 |
| Abstract : Utsuki_2007_J.Pharmacol.Exp.Ther_321_353 |
| ESTHER : Utsuki_2007_J.Pharmacol.Exp.Ther_321_353 |
| PubMedSearch : Utsuki_2007_J.Pharmacol.Exp.Ther_321_353 |
| PubMedID: 17255466 |
| Title : Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine - Marutle_2007_Proc.Natl.Acad.Sci.U.S.A_104_12506 |
| Author(s) : Marutle A , Ohmitsu M , Nilbratt M , Greig NH , Nordberg A , Sugaya K |
| Ref : Proc Natl Acad Sci U S A , 104 :12506 , 2007 |
| Abstract : Marutle_2007_Proc.Natl.Acad.Sci.U.S.A_104_12506 |
| ESTHER : Marutle_2007_Proc.Natl.Acad.Sci.U.S.A_104_12506 |
| PubMedSearch : Marutle_2007_Proc.Natl.Acad.Sci.U.S.A_104_12506 |
| PubMedID: 17640880 |
| Title : Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity - Hartmann_2007_J.Neurochem_100_1421 |
| Author(s) : Hartmann J , Kiewert C , Duysen EG , Lockridge O , Greig NH , Klein J |
| Ref : Journal of Neurochemistry , 100 :1421 , 2007 |
| Abstract : Hartmann_2007_J.Neurochem_100_1421 |
| ESTHER : Hartmann_2007_J.Neurochem_100_1421 |
| PubMedSearch : Hartmann_2007_J.Neurochem_100_1421 |
| PubMedID: 17212694 |
| Title : The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice - Lahiri_2007_J.Pharmacol.Exp.Ther_320_386 |
| Author(s) : Lahiri DK , Chen D , Maloney B , Holloway HW , Yu QS , Utsuki T , Giordano T , Sambamurti K , Greig NH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 320 :386 , 2007 |
| Abstract : Lahiri_2007_J.Pharmacol.Exp.Ther_320_386 |
| ESTHER : Lahiri_2007_J.Pharmacol.Exp.Ther_320_386 |
| PubMedSearch : Lahiri_2007_J.Pharmacol.Exp.Ther_320_386 |
| PubMedID: 17003227 |
| Title : Differential effects of two hexahydropyrroloindole carbamate-based anticholinesterase drugs on the amyloid beta protein pathway involved in Alzheimer's disease - Lahiri_2007_Neuromolecular.Med_9_157 |
| Author(s) : Lahiri DK , Alley GM , Tweedie D , Chen D , Greig NH |
| Ref : Neuromolecular Med , 9 :157 , 2007 |
| Abstract : Lahiri_2007_Neuromolecular.Med_9_157 |
| ESTHER : Lahiri_2007_Neuromolecular.Med_9_157 |
| PubMedSearch : Lahiri_2007_Neuromolecular.Med_9_157 |
| PubMedID: 17627035 |
| Title : Kinetic analysis of the inhibition of human butyrylcholinesterase with cymserine - Kamal_2006_Biochim.Biophys.Acta_1760_200 |
| Author(s) : Kamal MA , Al-Jafari AA , Yu QS , Greig NH |
| Ref : Biochimica & Biophysica Acta , 1760 :200 , 2006 |
| Abstract : Kamal_2006_Biochim.Biophys.Acta_1760_200 |
| ESTHER : Kamal_2006_Biochim.Biophys.Acta_1760_200 |
| PubMedSearch : Kamal_2006_Biochim.Biophys.Acta_1760_200 |
| PubMedID: 16309845 |
| Title : Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic, bisnorcymserine - Kamal_2006_J.Alzheimers.Dis_10_43 |
| Author(s) : Kamal MA , Klein P , Yu QS , Tweedie D , Li Y , Holloway HW , Greig NH |
| Ref : J Alzheimers Dis , 10 :43 , 2006 |
| Abstract : Kamal_2006_J.Alzheimers.Dis_10_43 |
| ESTHER : Kamal_2006_J.Alzheimers.Dis_10_43 |
| PubMedSearch : Kamal_2006_J.Alzheimers.Dis_10_43 |
| PubMedID: 16988481 |
| Title : Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide - Utsuki_2006_J.Pharmacol.Exp.Ther_318_855 |
| Author(s) : Utsuki T , Yu QS , Davidson D , Chen D , Holloway HW , Brossi A , Sambamurti K , Lahiri DK , Greig NH , Giordano T |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 318 :855 , 2006 |
| Abstract : Utsuki_2006_J.Pharmacol.Exp.Ther_318_855 |
| ESTHER : Utsuki_2006_J.Pharmacol.Exp.Ther_318_855 |
| PubMedSearch : Utsuki_2006_J.Pharmacol.Exp.Ther_318_855 |
| PubMedID: 16690718 |
| Title : Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine - Luo_2006_J.Med.Chem_49_2174 |
| Author(s) : Luo W , Yu QS , Kulkarni SS , Parrish DA , Holloway HW , Tweedie D , Shafferman A , Lahiri DK , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 49 :2174 , 2006 |
| Abstract : Luo_2006_J.Med.Chem_49_2174 |
| ESTHER : Luo_2006_J.Med.Chem_49_2174 |
| PubMedSearch : Luo_2006_J.Med.Chem_49_2174 |
| PubMedID: 16570913 |
| Title : Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent - Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| Author(s) : Greig NH , Utsuki T , Ingram DK , Wang Y , Pepeu G , Scali C , Yu QS , Mamczarz J , Holloway HW , Giordano T , Chen D , Furukawa K , Sambamurti K , Brossi A , Lahiri DK |
| Ref : Proc Natl Acad Sci U S A , 102 :17213 , 2005 |
| Abstract : Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| ESTHER : Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| PubMedSearch : Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| PubMedID: 16275899 |
| Title : Intravenous butyrylcholinesterase administration and plasma and brain levels of cocaine and metabolites in rats - Carmona_2005_Eur.J.Pharmacol_517_186 |
| Author(s) : Carmona GN , Schindler CW , Greig NH , Holloway HW , Jufer RA , Cone EJ , Gorelick DA |
| Ref : European Journal of Pharmacology , 517 :186 , 2005 |
| Abstract : Carmona_2005_Eur.J.Pharmacol_517_186 |
| ESTHER : Carmona_2005_Eur.J.Pharmacol_517_186 |
| PubMedSearch : Carmona_2005_Eur.J.Pharmacol_517_186 |
| PubMedID: 15967428 |
| Title : Syntheses of tetrahydrofurobenzofurans and dihydromethanobenzodioxepines from 5-hydroxy-3-methyl-3H-benzofuran-2-one. Rearrangement and ring expansion under reductive conditions on treatment with hydrides - Luo_2005_J.Org.Chem_70_6171 |
| Author(s) : Luo W , Yu QS , Holloway HW , Parrish D , Greig NH , Brossi A |
| Ref : J Org Chem , 70 :6171 , 2005 |
| Abstract : Luo_2005_J.Org.Chem_70_6171 |
| ESTHER : Luo_2005_J.Org.Chem_70_6171 |
| PubMedSearch : Luo_2005_J.Org.Chem_70_6171 |
| PubMedID: 16050674 |
| Title : Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine - Luo_2005_J.Med.Chem_48_986 |
| Author(s) : Luo W , Yu QS , Zhan M , Parrish D , Deschamps JR , Kulkarni SS , Holloway HW , Alley GM , Lahiri DK , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 48 :986 , 2005 |
| Abstract : Luo_2005_J.Med.Chem_48_986 |
| ESTHER : Luo_2005_J.Med.Chem_48_986 |
| PubMedSearch : Luo_2005_J.Med.Chem_48_986 |
| PubMedID: 15715468 |
| Title : Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors - Campiani_2005_J.Med.Chem_48_1919 |
| Author(s) : Campiani G , Fattorusso C , Butini S , Gaeta A , Agnusdei M , Gemma S , Persico M , Catalanotti B , Savini L , Nacci V , Novellino E , Holloway HW , Greig NH , Belinskaya T , Fedorko JM , Saxena A |
| Ref : Journal of Medicinal Chemistry , 48 :1919 , 2005 |
| Abstract : Campiani_2005_J.Med.Chem_48_1919 |
| ESTHER : Campiani_2005_J.Med.Chem_48_1919 |
| PubMedSearch : Campiani_2005_J.Med.Chem_48_1919 |
| PubMedID: 15771436 |
| Title : Cholinesterases: roles in the brain during health and disease - Ballard_2005_Curr.Alzheimer.Res_2_307 |
| Author(s) : Ballard CG , Greig NH , Guillozet-Bongaarts AL , Enz A , Darvesh S |
| Ref : Curr Alzheimer Res , 2 :307 , 2005 |
| Abstract : Ballard_2005_Curr.Alzheimer.Res_2_307 |
| ESTHER : Ballard_2005_Curr.Alzheimer.Res_2_307 |
| PubMedSearch : Ballard_2005_Curr.Alzheimer.Res_2_307 |
| PubMedID: 15974896 |
| Title : In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger - Cerasoli_2005_Chem.Biol.Interact_157-158_363 |
| Author(s) : Cerasoli DM , Griffiths EM , Doctor BP , Saxena A , Fedorko JM , Greig NH , Yu QS , Huang Y , Wilgus H , Karatzas CN , Koplovitz I , Lenz DE |
| Ref : Chemico-Biological Interactions , 157-158 :363 , 2005 |
| Abstract : Cerasoli_2005_Chem.Biol.Interact_157-158_363 |
| ESTHER : Cerasoli_2005_Chem.Biol.Interact_157-158_363 |
| PubMedSearch : Cerasoli_2005_Chem.Biol.Interact_157-158_363 |
| PubMedID: 16429486 |
| Title : Amyloid, cholinesterase, melatonin, and metals and their roles in aging and neurodegenerative diseases - Lahiri_2005_Ann.N.Y.Acad.Sci_1056_430 |
| Author(s) : Lahiri DK , Chen DM , Lahiri P , Bondy S , Greig NH |
| Ref : Annals of the New York Academy of Sciences , 1056 :430 , 2005 |
| Abstract : Lahiri_2005_Ann.N.Y.Acad.Sci_1056_430 |
| ESTHER : Lahiri_2005_Ann.N.Y.Acad.Sci_1056_430 |
| PubMedSearch : Lahiri_2005_Ann.N.Y.Acad.Sci_1056_430 |
| PubMedID: 16387707 |
| Title : An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease - Greig_2005_Curr.Alzheimer.Res_2_281 |
| Author(s) : Greig NH , Sambamurti K , Yu QS , Brossi A , Bruinsma GB , Lahiri DK |
| Ref : Curr Alzheimer Res , 2 :281 , 2005 |
| Abstract : Greig_2005_Curr.Alzheimer.Res_2_281 |
| ESTHER : Greig_2005_Curr.Alzheimer.Res_2_281 |
| PubMedSearch : Greig_2005_Curr.Alzheimer.Res_2_281 |
| PubMedID: 15974893 |
| Title : Anticholinesterase and pharmacokinetic profile of phenserine in healthy elderly human subjects - Greig_2005_Curr.Alzheimer.Res_2_483 |
| Author(s) : Greig NH , Ruckle J , Comer P , Brownell L , Holloway HW , Flanagan DR, Jr. , Canfield CJ , Burford RG |
| Ref : Curr Alzheimer Res , 2 :483 , 2005 |
| Abstract : Greig_2005_Curr.Alzheimer.Res_2_483 |
| ESTHER : Greig_2005_Curr.Alzheimer.Res_2_483 |
| PubMedSearch : Greig_2005_Curr.Alzheimer.Res_2_483 |
| PubMedID: 16248851 |
| Title : The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats - Janas_2005_Life.Sci_76_1073 |
| Author(s) : Janas AM , Cunningham SC , Duffy KB , Devan BD , Greig NH , Holloway HW , Yu QS , Markowska AL , Ingram DK , Spangler EL |
| Ref : Life Sciences , 76 :1073 , 2005 |
| Abstract : Janas_2005_Life.Sci_76_1073 |
| ESTHER : Janas_2005_Life.Sci_76_1073 |
| PubMedSearch : Janas_2005_Life.Sci_76_1073 |
| PubMedID: 15620572 |
| Title : Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents - Lahiri_2004_Curr.Pharm.Des_10_3111 |
| Author(s) : Lahiri DK , Rogers JT , Greig NH , Sambamurti K |
| Ref : Curr Pharm Des , 10 :3111 , 2004 |
| Abstract : Lahiri_2004_Curr.Pharm.Des_10_3111 |
| ESTHER : Lahiri_2004_Curr.Pharm.Des_10_3111 |
| PubMedSearch : Lahiri_2004_Curr.Pharm.Des_10_3111 |
| PubMedID: 15544501 |
| Title : Acetylcholinesterase and its inhibition in Alzheimer disease - Lane_2004_Clin.Neuropharmacol_27_141 |
| Author(s) : Lane RM , Kivipelto M , Greig NH |
| Ref : Clinical Neuropharmacology , 27 :141 , 2004 |
| Abstract : Lane_2004_Clin.Neuropharmacol_27_141 |
| ESTHER : Lane_2004_Clin.Neuropharmacol_27_141 |
| PubMedSearch : Lane_2004_Clin.Neuropharmacol_27_141 |
| PubMedID: 15190239 |
| Title : Poster (39) A new generation of cholinesterase inhibitors with amyloid-modifying properties. - |
| Author(s) : Lahiri DK , Ge YW , Sambamurti K , Utsuki T , Ingram DK , Farlow MR , Greig NH |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :341 , 2004 |
| PubMedID: |
| Title : Poster (43) BChE inhibition as a treatment strategy for alzheimer's disease. - |
| Author(s) : Greig NH , Ingram DK , Yu QS , Holloway HW , Utsuki T , Brossi A , Sambamurti K , Lahiri DK |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :343 , 2004 |
| PubMedID: |
| Title : A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease - Lahiri_2003_Curr.Drug.Targets_4_97 |
| Author(s) : Lahiri DK , Farlow MR , Sambamurti K , Greig NH , Giacobini E , Schneider LS |
| Ref : Curr Drug Targets , 4 :97 , 2003 |
| Abstract : Lahiri_2003_Curr.Drug.Targets_4_97 |
| ESTHER : Lahiri_2003_Curr.Drug.Targets_4_97 |
| PubMedSearch : Lahiri_2003_Curr.Drug.Targets_4_97 |
| PubMedID: 12558063 |
| Title : Butyrylcholinesterase: an important new target in Alzheimer's disease therapy - Greig_2002_Int.Psychogeriatr_14_77 |
| Author(s) : Greig NH , Lahiri DK , Sambamurti K |
| Ref : Int Psychogeriatr , 14 :77 , 2002 |
| Abstract : Greig_2002_Int.Psychogeriatr_14_77 |
| ESTHER : Greig_2002_Int.Psychogeriatr_14_77 |
| PubMedSearch : Greig_2002_Int.Psychogeriatr_14_77 |
| PubMedID: 12636181 |
| Title : Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines - Yu_2002_J.Med.Chem_45_3684 |
| Author(s) : Yu QS , Zhu X , Holloway HW , Whittaker NF , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 45 :3684 , 2002 |
| Abstract : Yu_2002_J.Med.Chem_45_3684 |
| ESTHER : Yu_2002_J.Med.Chem_45_3684 |
| PubMedSearch : Yu_2002_J.Med.Chem_45_3684 |
| PubMedID: 12166941 |
| Title : Nicotine reduces the secretion of Alzheimer's beta-amyloid precursor protein containing beta-amyloid peptide in the rat without altering synaptic proteins - Lahiri_2002_Ann.N.Y.Acad.Sci_965_364 |
| Author(s) : Lahiri DK , Utsuki T , Chen D , Farlow MR , Shoaib M , Ingram DK , Greig NH |
| Ref : Annals of the New York Academy of Sciences , 965 :364 , 2002 |
| Abstract : Lahiri_2002_Ann.N.Y.Acad.Sci_965_364 |
| ESTHER : Lahiri_2002_Ann.N.Y.Acad.Sci_965_364 |
| PubMedSearch : Lahiri_2002_Ann.N.Y.Acad.Sci_965_364 |
| PubMedID: 12105112 |
| Title : Worsening of motor function and mood in a patient with Parkinson's disease after pharmacologic challenge with oral rivastigmine - Richard_2002_Clin.Neuropharmacol_25_296 |
| Author(s) : Richard IH , Justus AW , Greig NH , Marshall F , Kurlan R |
| Ref : Clinical Neuropharmacology , 25 :296 , 2002 |
| Abstract : Richard_2002_Clin.Neuropharmacol_25_296 |
| ESTHER : Richard_2002_Clin.Neuropharmacol_25_296 |
| PubMedSearch : Richard_2002_Clin.Neuropharmacol_25_296 |
| PubMedID: 12469000 |
| Title : A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase - Greig_2001_Curr.Med.Res.Opin_17_159 |
| Author(s) : Greig NH , Utsuki T , Yu Q , Zhu X , Holloway HW , Perry T , Lee B , Ingram DK , Lahiri DK |
| Ref : Curr Med Res Opin , 17 :159 , 2001 |
| Abstract : Greig_2001_Curr.Med.Res.Opin_17_159 |
| ESTHER : Greig_2001_Curr.Med.Res.Opin_17_159 |
| PubMedSearch : Greig_2001_Curr.Med.Res.Opin_17_159 |
| PubMedID: 11900310 |
| Title : Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development - Shaw_2001_Proc.Natl.Acad.Sci.U.S.A_98_7605 |
| Author(s) : Shaw KT , Utsuki T , Rogers J , Yu QS , Sambamurti K , Brossi A , Ge YW , Lahiri DK , Greig NH |
| Ref : Proc Natl Acad Sci U S A , 98 :7605 , 2001 |
| Abstract : Shaw_2001_Proc.Natl.Acad.Sci.U.S.A_98_7605 |
| ESTHER : Shaw_2001_Proc.Natl.Acad.Sci.U.S.A_98_7605 |
| PubMedSearch : Shaw_2001_Proc.Natl.Acad.Sci.U.S.A_98_7605 |
| PubMedID: 11404470 |
| Title : Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure\/activity relationships for acetyl- and butyrylcholinesterase inhibitory action - Yu_2001_J.Med.Chem_44_4062 |
| Author(s) : Yu Q , Holloway HW , Flippen-Anderson JL , Hoffman B , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 44 :4062 , 2001 |
| Abstract : Yu_2001_J.Med.Chem_44_4062 |
| ESTHER : Yu_2001_J.Med.Chem_44_4062 |
| PubMedSearch : Yu_2001_J.Med.Chem_44_4062 |
| PubMedID: 11708910 |
| Title : Cholinesterase inhibitors, beta-amyloid precursor protein and amyloid beta-peptides in Alzheimer's disease - Lahiri_2000_Acta.Neurol.Scand.Suppl_176_60 |
| Author(s) : Lahiri DK , Farlow MR , Hintz N , Utsuki T , Greig NH |
| Ref : Acta Neurologica Scandinavica Supplementum , 176 :60 , 2000 |
| Abstract : Lahiri_2000_Acta.Neurol.Scand.Suppl_176_60 |
| ESTHER : Lahiri_2000_Acta.Neurol.Scand.Suppl_176_60 |
| PubMedSearch : Lahiri_2000_Acta.Neurol.Scand.Suppl_176_60 |
| PubMedID: 11273593 |
| Title : Butyrylcholinesterase accelerates cocaine metabolism: in vitro and in vivo effects in nonhuman primates and humans - Carmona_2000_Drug.Metab.Dispos_28_367 |
| Author(s) : Carmona GN , Jufer RA , Goldberg SR , Gorelick DA , Greig NH , Yu QS , Cone EJ , Schindler CW |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 28 :367 , 2000 |
| Abstract : Carmona_2000_Drug.Metab.Dispos_28_367 |
| ESTHER : Carmona_2000_Drug.Metab.Dispos_28_367 |
| PubMedSearch : Carmona_2000_Drug.Metab.Dispos_28_367 |
| PubMedID: 10681384 |
| Title : Kinetics of human acetylcholinesterase inhibition by the novel experimental Alzheimer therapeutic agent, tolserine - Kamal_2000_Biochem.Pharmacol_60_561 |
| Author(s) : Kamal MA , Greig NH , Alhomida AS , Al-Jafari AA |
| Ref : Biochemical Pharmacology , 60 :561 , 2000 |
| Abstract : Kamal_2000_Biochem.Pharmacol_60_561 |
| ESTHER : Kamal_2000_Biochem.Pharmacol_60_561 |
| PubMedSearch : Kamal_2000_Biochem.Pharmacol_60_561 |
| PubMedID: 10874131 |
| Title : Time course of pharmacodynamic and pharmacokinetic effects of physostigmine assessed by functional brain imaging in humans - Furey_2000_Pharmacol.Biochem.Behav_66_475 |
| Author(s) : Furey ML , Pietrini P , Alexander GE , Mentis MJ , Szczepanik J , Shetty U , Greig NH , Holloway HW , Schapiro MB , Freo U |
| Ref : Pharmacol Biochem Behav , 66 :475 , 2000 |
| Abstract : Furey_2000_Pharmacol.Biochem.Behav_66_475 |
| ESTHER : Furey_2000_Pharmacol.Biochem.Behav_66_475 |
| PubMedSearch : Furey_2000_Pharmacol.Biochem.Behav_66_475 |
| PubMedID: 10899358 |
| Title : The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics - Greig_2000_Acta.Neurol.Scand.Suppl_176_74 |
| Author(s) : Greig NH , De Micheli E , Holloway HW , Yu QS , Utsuki T , Perry TA , Brossi A , Ingram DK , Deutsch J , Lahiri DK , Soncrant TT |
| Ref : Acta Neurologica Scandinavica Supplementum , 176 :74 , 2000 |
| Abstract : Greig_2000_Acta.Neurol.Scand.Suppl_176_74 |
| ESTHER : Greig_2000_Acta.Neurol.Scand.Suppl_176_74 |
| PubMedSearch : Greig_2000_Acta.Neurol.Scand.Suppl_176_74 |
| PubMedID: 11261809 |
| Title : Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease - Yu_1999_J.Med.Chem_42_1855 |
| Author(s) : Yu Q , Holloway HW , Utsuki T , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 42 :1855 , 1999 |
| Abstract : Yu_1999_J.Med.Chem_42_1855 |
| ESTHER : Yu_1999_J.Med.Chem_42_1855 |
| PubMedSearch : Yu_1999_J.Med.Chem_42_1855 |
| PubMedID: 10346939 |
| Title : Neuroendocrine responses to intravenous infusion of physostigmine in patients with Alzheimer disease - Asthana_1999_Alzheimer.Dis.Assoc.Disord_13_102 |
| Author(s) : Asthana S , Raffaele KC , Greig NH , Schapiro MB , Blackman MR , Soncrant TT |
| Ref : Alzheimer Disease & Associated Disorders , 13 :102 , 1999 |
| Abstract : Asthana_1999_Alzheimer.Dis.Assoc.Disord_13_102 |
| ESTHER : Asthana_1999_Alzheimer.Dis.Assoc.Disord_13_102 |
| PubMedSearch : Asthana_1999_Alzheimer.Dis.Assoc.Disord_13_102 |
| PubMedID: 10372954 |
| Title : Attenuation of cocaine-induced locomotor activity by butyrylcholinesterase - Carmona_1998_Exp.Clin.Psychopharmacol_6_274 |
| Author(s) : Carmona GN , Schindler CW , Shoaib M , Jufer R , Cone EJ , Goldberg SR , Greig NH , Yu QS , Gorelick DA |
| Ref : Experimental & Clinical Psychopharmacology , 6 :274 , 1998 |
| Abstract : Carmona_1998_Exp.Clin.Psychopharmacol_6_274 |
| ESTHER : Carmona_1998_Exp.Clin.Psychopharmacol_6_274 |
| PubMedSearch : Carmona_1998_Exp.Clin.Psychopharmacol_6_274 |
| PubMedID: 9725111 |
| Title : Phenserine, a novel acetylcholinesterase inhibitor, attenuates impaired learning of rats in a 14-unit T-maze induced by blockade of the N- methyl-D-aspartate receptor - Patel_1998_Neuroreport_9_171 |
| Author(s) : Patel N , Spangler EL , Greig NH , Yu QS , Ingram DK , Meyer RC |
| Ref : Neuroreport , 9 :171 , 1998 |
| Abstract : Patel_1998_Neuroreport_9_171 |
| ESTHER : Patel_1998_Neuroreport_9_171 |
| PubMedSearch : Patel_1998_Neuroreport_9_171 |
| PubMedID: 9592071 |
| Title : Kinetics of human erythrocyte acetylcholinesterase inhibition by a novel derivative of physostigmine: phenserine - al-Jafari_1998_Biochem.Biophys.Res.Commun_248_180 |
| Author(s) : Al-Jafari AA , Kamal MA , Greig NH , Alhomida AS , Perry ER |
| Ref : Biochemical & Biophysical Research Communications , 248 :180 , 1998 |
| Abstract : al-Jafari_1998_Biochem.Biophys.Res.Commun_248_180 |
| ESTHER : al-Jafari_1998_Biochem.Biophys.Res.Commun_248_180 |
| PubMedSearch : al-Jafari_1998_Biochem.Biophys.Res.Commun_248_180 |
| PubMedID: 9675107 |
| Title : Sensitivity of bovine retinal acetylcholinesterase to phenserine: A derivative of physostigmine - |
| Author(s) : Al-Jafari AA , Kamal MA , Greig NH |
| Ref : Journal de Physiologie (Paris) , 92 :402 , 1998 |
| PubMedID: |
| Title : Syntheses and anticholinesterase activities of (3aS)-N1, N8- bisnorphenserine, (3aS)-N1,N8-bisnorphysostigmine, their antipodal isomers, and other potential metabolites of phenserine - Yu_1998_J.Med.Chem_41_2371 |
| Author(s) : Yu Q , Greig NH , Holloway HW , Brossi A |
| Ref : Journal of Medicinal Chemistry , 41 :2371 , 1998 |
| Abstract : Yu_1998_J.Med.Chem_41_2371 |
| ESTHER : Yu_1998_J.Med.Chem_41_2371 |
| PubMedSearch : Yu_1998_J.Med.Chem_41_2371 |
| PubMedID: 9632370 |
| Title : Pseudophrynaminol: a potent noncompetitive blocker of nicotinic receptor-channels - Badio_1997_Biochem.Pharmacol_53_671 |
| Author(s) : Badio B , Garraffo HM , Padgett WL , Greig NH , Daly JW |
| Ref : Biochemical Pharmacology , 53 :671 , 1997 |
| Abstract : Badio_1997_Biochem.Pharmacol_53_671 |
| ESTHER : Badio_1997_Biochem.Pharmacol_53_671 |
| PubMedSearch : Badio_1997_Biochem.Pharmacol_53_671 |
| PubMedID: 9113086 |
| Title : Total syntheses and anticholinesterase activities of (3aS)-N(8)- norphysostigmine, (3aS)-N(8)-norphenserine, their antipodal isomers, and other N(8)-substituted analogues - Yu_1997_J.Med.Chem_40_2895 |
| Author(s) : Yu QS , Pei XF , Holloway HW , Greig NH , Brossi A |
| Ref : Journal of Medicinal Chemistry , 40 :2895 , 1997 |
| Abstract : Yu_1997_J.Med.Chem_40_2895 |
| ESTHER : Yu_1997_J.Med.Chem_40_2895 |
| PubMedSearch : Yu_1997_J.Med.Chem_40_2895 |
| PubMedID: 9288171 |
| Title : Effects of cholinesterase inhibitors on the secretion of beta-amyloid precursor protein in cell cultures - Lahiri_1997_Ann.N.Y.Acad.Sci_826_416 |
| Author(s) : Lahiri DK , Farlow MR , Nurnberger JI, Jr. , Greig NH |
| Ref : Annals of the New York Academy of Sciences , 826 :416 , 1997 |
| Abstract : Lahiri_1997_Ann.N.Y.Acad.Sci_826_416 |
| ESTHER : Lahiri_1997_Ann.N.Y.Acad.Sci_826_416 |
| PubMedSearch : Lahiri_1997_Ann.N.Y.Acad.Sci_826_416 |
| PubMedID: 9329715 |
| Title : Clinical pharmacokinetics of physostigmine in patients with Alzheimer's disease - Asthana_1995_Clin.Pharmacol.Ther_58_299 |
| Author(s) : Asthana S , Greig NH , Hegedus L , Holloway HH , Raffaele KC , Schapiro MB , Soncrant TT |
| Ref : Clinical Pharmacology & Therapeutics , 58 :299 , 1995 |
| Abstract : Asthana_1995_Clin.Pharmacol.Ther_58_299 |
| ESTHER : Asthana_1995_Clin.Pharmacol.Ther_58_299 |
| PubMedSearch : Asthana_1995_Clin.Pharmacol.Ther_58_299 |
| PubMedID: 7554703 |
| Title : Maze learning in aged rats is enhanced by phenserine, a novel anticholinesterase - Ikari_1995_Neuroreport_6_481 |
| Author(s) : Ikari H , Spangler EL , Greig NH , Pei XF , Brossi A , Speer D , Patel N , Ingram DK |
| Ref : Neuroreport , 6 :481 , 1995 |
| Abstract : Ikari_1995_Neuroreport_6_481 |
| ESTHER : Ikari_1995_Neuroreport_6_481 |
| PubMedSearch : Ikari_1995_Neuroreport_6_481 |
| PubMedID: 7766848 |
| Title : Rodent models of memory dysfunction in Alzheimer's disease and normal aging: moving beyond the cholinergic hypothesis - Ingram_1994_Life.Sci_55_2037 |
| Author(s) : Ingram DK , Spangler EL , Iijima S , Ikari H , Kuo H , Greig NH , London ED |
| Ref : Life Sciences , 55 :2037 , 1994 |
| Abstract : Ingram_1994_Life.Sci_55_2037 |
| ESTHER : Ingram_1994_Life.Sci_55_2037 |
| PubMedSearch : Ingram_1994_Life.Sci_55_2037 |
| PubMedID: 7997063 |
| Title : Phenserine: a physostigmine derivative that is a long-acting inhibitor of cholinesterase and demonstrates a wide dose range for attenuating a scopolamine-induced learning impairment of rats in a 14-unit T-maze - Iijima_1993_Psychopharmacology_112_415 |
| Author(s) : Iijima S , Greig NH , Garofalo P , Spangler EL , Heller B , Brossi A , Ingram DK |
| Ref : Psychopharmacology , 112 :415 , 1993 |
| Abstract : Iijima_1993_Psychopharmacology_112_415 |
| ESTHER : Iijima_1993_Psychopharmacology_112_415 |
| PubMedSearch : Iijima_1993_Psychopharmacology_112_415 |
| PubMedID: 7871051 |
| Title : The long-acting cholinesterase inhibitor heptyl-physostigmine attenuates the scopolamine-induced learning impairment of rats in a 14- unit T-maze - Iijima_1992_Neurosci.Lett_144_79 |
| Author(s) : Iijima S , Greig NH , Garofalo P , Spangler EL , Heller B , Brossi A , Ingram DK |
| Ref : Neuroscience Letters , 144 :79 , 1992 |
| Abstract : Iijima_1992_Neurosci.Lett_144_79 |
| ESTHER : Iijima_1992_Neurosci.Lett_144_79 |
| PubMedSearch : Iijima_1992_Neurosci.Lett_144_79 |
| PubMedID: 1436716 |