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Author Report for: Gras E

Title: Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts
Guillou C, Mary A, Renko DZ, Gras E, Thal C
Ref: Bioorganic & Medicinal Chemistry Lett, 10:637, 2000 : PubMed
Abstract


ESTHER: Guillou_2000_Bioorg.Med.Chem.Lett_10_637
PubMedSearch: Guillou 2000 Bioorg.Med.Chem.Lett 10 637
PubMedID: 10762042
Inhibitor(s) related to this paper: Galanthamine, Bis-galanthamine

Abstract

The syntheses, the anticholinesterase activities and structure-activity relationships of homodimeric (3a-c) and heterodimeric (6a-c) alkylene linked bis-galanthamine are reported. Compounds 6b-c were found to be more potent than galanthamine and tacrine in inhibiting AChE.