Report for Gordon RK

General

Full name : Gordon Richard K

First name : Richard K

Mail : Walter Reed Army Institute of Research\; Division of Regulated Activities\; Department of Regulated Laboratories\; (Room 2W105)\; 503 Robert Grant Avenue\; Silver Spring\; MD 20910-7500

Zip Code :

City :

Country : USA

Email : Richard.K.Gordon.civ@mail.mil

Phone : 202-782-7293

Fax : 202-782-6327

Website :

Directory :

References (43)

Title : Discovery of non-oxime reactivators using an in silico pharmacophore model of reactivators for DFP-inhibited acetylcholinesterase - Bhattacharjee_2014_Eur.J.Med.Chem_90C_209
Author(s) : Bhattacharjee AK , Marek E , Le HT , Ratcliffe R , DeMar JC , Pervitsky D , Gordon RK
Ref : Eur Journal of Medicinal Chemistry , 90C :209 , 2014
Abstract : Bhattacharjee_2014_Eur.J.Med.Chem_90C_209
ESTHER : Bhattacharjee_2014_Eur.J.Med.Chem_90C_209
PubMedSearch : Bhattacharjee_2014_Eur.J.Med.Chem_90C_209
PubMedID: 25461321

Title : Physiological and neurobehavioral effects of cholinesterase inhibition in healthy adults - Morasch_2014_Physiol.Behav_138C_165
Author(s) : Morasch KC , Aaron CL , Moon JE , Gordon RK
Ref : Physiol Behav , 138C :165 , 2014
Abstract : Morasch_2014_Physiol.Behav_138C_165
ESTHER : Morasch_2014_Physiol.Behav_138C_165
PubMedSearch : Morasch_2014_Physiol.Behav_138C_165
PubMedID: 25455867

Title : Discovery of non-oxime reactivators using an in silico pharmacophore model of oxime reactivators of OP-inhibited acetylcholinesterase - Bhattacharjee_2012_Eur.J.Med.Chem_49_229
Author(s) : Bhattacharjee AK , Marek E , Le HT , Gordon RK
Ref : Eur Journal of Medicinal Chemistry , 49 :229 , 2012
Abstract : Bhattacharjee_2012_Eur.J.Med.Chem_49_229
ESTHER : Bhattacharjee_2012_Eur.J.Med.Chem_49_229
PubMedSearch : Bhattacharjee_2012_Eur.J.Med.Chem_49_229
PubMedID: 22309910

Title : An in silico stereo-electronic comparison of conventional pyridinium oximes and K-oximes for organophosphate (OP) poisoning - Bhattacharjee_2012_Med.Chem_8_230
Author(s) : Bhattacharjee AK , Kuca K , Musilek K , Gordon RK
Ref : Med Chem , 8 :230 , 2012
Abstract : Bhattacharjee_2012_Med.Chem_8_230
ESTHER : Bhattacharjee_2012_Med.Chem_8_230
PubMedSearch : Bhattacharjee_2012_Med.Chem_8_230
PubMedID: 22385173

Title : Oxidative mechanisms for the biotransformation of 1-methyl-1,6-dihydropyridine-2-carbaldoxime to pralidoxime chloride - Khan_2011_Life.Sci_89_911
Author(s) : Khan FA , Campbell AJ , Hoyt B , Herdman C , Ku T , Thangavelu S , Gordon RK
Ref : Life Sciences , 89 :911 , 2011
Abstract : Khan_2011_Life.Sci_89_911
ESTHER : Khan_2011_Life.Sci_89_911
PubMedSearch : Khan_2011_Life.Sci_89_911
PubMedID: 21989207

Title : In silico pharmacophore model for tabun-inhibited acetylcholinesterase reactivators: a study of their stereoelectronic properties - Bhattacharjee_2010_Chem.Res.Toxicol_23_26
Author(s) : Bhattacharjee AK , Kuca K , Musilek K , Gordon RK
Ref : Chemical Research in Toxicology , 23 :26 , 2010
Abstract : Bhattacharjee_2010_Chem.Res.Toxicol_23_26
ESTHER : Bhattacharjee_2010_Chem.Res.Toxicol_23_26
PubMedSearch : Bhattacharjee_2010_Chem.Res.Toxicol_23_26
PubMedID: 20028185

Title : Pro-2-PAM therapy for central and peripheral cholinesterases - Demar_2010_Chem.Biol.Interact_187_191
Author(s) : DeMar JC , Clarkson ED , Ratcliffe RH , Campbell AJ , Thangavelu SG , Herdman CA , Leader H , Schulz SM , Marek E , Medynets MA , Ku TC , Evans SA , Khan FA , Owens RR , Nambiar MP , Gordon RK
Ref : Chemico-Biological Interactions , 187 :191 , 2010
Abstract : Demar_2010_Chem.Biol.Interact_187_191
ESTHER : Demar_2010_Chem.Biol.Interact_187_191
PubMedSearch : Demar_2010_Chem.Biol.Interact_187_191
PubMedID: 20156430

Title : Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure - Haigh_2010_Chem.Biol.Interact_187_416
Author(s) : Haigh JR , Adler M , Apland JP , Deshpande SS , Barham CB , Desmond P , Koplovitz I , Lenz DE , Gordon RK
Ref : Chemico-Biological Interactions , 187 :416 , 2010
Abstract : Haigh_2010_Chem.Biol.Interact_187_416
ESTHER : Haigh_2010_Chem.Biol.Interact_187_416
PubMedSearch : Haigh_2010_Chem.Biol.Interact_187_416
PubMedID: 20144889

Title : 3D-QSAR studies of 2,2-diphenylpropionates to aid discovery of novel potent muscarinic antagonists - Bhattacharjee_2009_Bioorg.Med.Chem_17_3999
Author(s) : Bhattacharjee AK , Gordon JA , Marek E , Campbell A , Gordon RK
Ref : Bioorganic & Medicinal Chemistry , 17 :3999 , 2009
Abstract : Bhattacharjee_2009_Bioorg.Med.Chem_17_3999
ESTHER : Bhattacharjee_2009_Bioorg.Med.Chem_17_3999
PubMedSearch : Bhattacharjee_2009_Bioorg.Med.Chem_17_3999
PubMedID: 19409797

Title : Blood and bronchoalveolar lavage fluid acetylcholinesterase levels following microinstillation inhalation exposure to sarin in Guinea pigs - Che_2008_Inhal.Toxicol_20_821
Author(s) : Che MM , Conti M , Boylan M , Sciuto AM , Gordon RK , Nambiar MP
Ref : Inhal Toxicol , 20 :821 , 2008
Abstract : Che_2008_Inhal.Toxicol_20_821
ESTHER : Che_2008_Inhal.Toxicol_20_821
PubMedSearch : Che_2008_Inhal.Toxicol_20_821
PubMedID: 18645722

Title : Un-nicked BoNT\/B activity in human SHSY-5Y neuronal cells - Shi_2008_J.Cell.Biochem_105_129
Author(s) : Shi X , Garcia GE , Nambiar MP , Gordon RK
Ref : Journal of Cellular Biochemistry , 105 :129 , 2008
Abstract : Shi_2008_J.Cell.Biochem_105_129
ESTHER : Shi_2008_J.Cell.Biochem_105_129
PubMedSearch : Shi_2008_J.Cell.Biochem_105_129
PubMedID: 18459116

Title : [+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure\/status epilepticus in rats - Coleman_2008_Chem.Biol.Interact_175_387
Author(s) : Coleman BR , Ratcliffe RH , Oguntayo SA , Shi X , Doctor BP , Gordon RK , Nambiar MP
Ref : Chemico-Biological Interactions , 175 :387 , 2008
Abstract : Coleman_2008_Chem.Biol.Interact_175_387
ESTHER : Coleman_2008_Chem.Biol.Interact_175_387
PubMedSearch : Coleman_2008_Chem.Biol.Interact_175_387
PubMedID: 18588864

Title : Resveratrol induces catalytic bioscavenger paraoxonase 1 expression and protects against chemical warfare nerve agent toxicity in human cell lines - Curtin_2008_J.Cell.Biochem_103_1524
Author(s) : Curtin BF , Seetharam KI , Dhoieam P , Gordon RK , Doctor BP , Nambiar MP
Ref : Journal of Cellular Biochemistry , 103 :1524 , 2008
Abstract : Curtin_2008_J.Cell.Biochem_103_1524
ESTHER : Curtin_2008_J.Cell.Biochem_103_1524
PubMedSearch : Curtin_2008_J.Cell.Biochem_103_1524
PubMedID: 17879943

Title : Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase - Haigh_2008_Chem.Biol.Interact_175_380
Author(s) : Haigh JR , Johnston SR , Peppernay A , Mattern PJ , Garcia GE , Doctor BP , Gordon RK , Aisen PS
Ref : Chemico-Biological Interactions , 175 :380 , 2008
Abstract : Haigh_2008_Chem.Biol.Interact_175_380
ESTHER : Haigh_2008_Chem.Biol.Interact_175_380
PubMedSearch : Haigh_2008_Chem.Biol.Interact_175_380
PubMedID: 18572153

Title : Advantages of the WRAIR whole blood cholinesterase assay: comparative analysis to the micro-Ellman, Test-mate ChE, and Michel (DeltapH) assays - Haigh_2008_Chem.Biol.Interact_175_417
Author(s) : Haigh JR , Lefkowitz LJ , Capacio BR , Doctor BP , Gordon RK
Ref : Chemico-Biological Interactions , 175 :417 , 2008
Abstract : Haigh_2008_Chem.Biol.Interact_175_417
ESTHER : Haigh_2008_Chem.Biol.Interact_175_417
PubMedSearch : Haigh_2008_Chem.Biol.Interact_175_417
PubMedID: 18555983

Title : Abdominal bloating and irritable bowel syndrome like symptoms following microinstillation inhalation exposure to chemical warfare nerve agent VX in guinea pigs - Katos_2007_Toxicol.Ind.Health_23_231
Author(s) : Katos AM , Conti ML , Moran TS , Gordon RK , Doctor BP , Sciuto AM , Nambiar MP
Ref : Toxicol Ind Health , 23 :231 , 2007
Abstract : Katos_2007_Toxicol.Ind.Health_23_231
ESTHER : Katos_2007_Toxicol.Ind.Health_23_231
PubMedSearch : Katos_2007_Toxicol.Ind.Health_23_231
PubMedID: 18429383

Title : Acute toxic effects of nerve agent VX on respiratory dynamics and functions following microinsillation inhalation exposure in guinea pigs - Rezk_2007_Inhal.Toxicol_19_291
Author(s) : Rezk PE , Graham JR , Moran TS , Gordon RK , Sciuto AM , Doctor BP , Nambiar MP
Ref : Inhal Toxicol , 19 :291 , 2007
Abstract : Rezk_2007_Inhal.Toxicol_19_291
ESTHER : Rezk_2007_Inhal.Toxicol_19_291
PubMedSearch : Rezk_2007_Inhal.Toxicol_19_291
PubMedID: 17365032

Title : Butyrylcholinesterase in guinea pig lung lavage: a novel biomarker to assess lung injury following inhalation exposure to nerve agent VX - Graham_2006_Inhal.Toxicol_18_493
Author(s) : Graham JR , Wright BS , Rezk PE , Gordon RK , Sciuto AM , Nambiar MP
Ref : Inhal Toxicol , 18 :493 , 2006
Abstract : Graham_2006_Inhal.Toxicol_18_493
ESTHER : Graham_2006_Inhal.Toxicol_18_493
PubMedSearch : Graham_2006_Inhal.Toxicol_18_493
PubMedID: 16603480

Title : Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate-induced injury in embryonic rat forebrain neuronal cells - Godkar_2006_Phytomedicine_13_29
Author(s) : Godkar PB , Gordon RK , Ravindran A , Doctor BP
Ref : Phytomedicine , 13 :29 , 2006
Abstract : Godkar_2006_Phytomedicine_13_29
ESTHER : Godkar_2006_Phytomedicine_13_29
PubMedSearch : Godkar_2006_Phytomedicine_13_29
PubMedID: 16360930

Title : Forskolin, an inducer of cAMP, up-regulates acetylcholinesterase expression and protects against organophosphate exposure in neuro 2A cells - Curtin_2006_Mol.Cell.Biochem_290_23
Author(s) : Curtin BF , Pal N , Gordon RK , Nambiar MP
Ref : Molecular & Cellular Biochemistry , 290 :23 , 2006
Abstract : Curtin_2006_Mol.Cell.Biochem_290_23
ESTHER : Curtin_2006_Mol.Cell.Biochem_290_23
PubMedSearch : Curtin_2006_Mol.Cell.Biochem_290_23
PubMedID: 16924422

Title : Inhibition of guinea pig hemi-diaphragm acetylcholinesterase activity by pyridostigmine bromide and protection against soman toxicity -
Author(s) : Haigh JR , Johnston SR , Peters BM , Doctor BP , Gordon RK , Adler M , Gall KJ , Deshpande SS
Ref : Chemico-Biological Interactions , 157-158 :381 , 2005
PubMedID: 16429510

Title : Transcriptional induction of cholinesterase expression and protection against chemical warfare nerve agents - Nambiar_2005_Chem.Biol.Interact_157-158_409
Author(s) : Nambiar MP , Curtin BF , Pal N , Compton JR , Doctor BP , Gordon RK
Ref : Chemico-Biological Interactions , 157-158 :409 , 2005
Abstract : Nambiar_2005_Chem.Biol.Interact_157-158_409
ESTHER : Nambiar_2005_Chem.Biol.Interact_157-158_409
PubMedSearch : Nambiar_2005_Chem.Biol.Interact_157-158_409
PubMedID: 16429504

Title : Histone acetylase inhibitor trichostatin A induces acetylcholinesterase expression and protects against organophosphate exposure - Curtin_2005_J.Cell.Biochem_96_839
Author(s) : Curtin BF , Tetz LM , Compton JR , Doctor BP , Gordon RK , Nambiar MP
Ref : Journal of Cellular Biochemistry , 96 :839 , 2005
Abstract : Curtin_2005_J.Cell.Biochem_96_839
ESTHER : Curtin_2005_J.Cell.Biochem_96_839
PubMedSearch : Curtin_2005_J.Cell.Biochem_96_839
PubMedID: 16149071

Title : Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman - Gordon_2005_Chem.Biol.Interact_157-158_239
Author(s) : Gordon RK , Haigh JR , Garcia GE , Feaster SR , Riel MA , Lenz DE , Aisen PS , Doctor BP
Ref : Chemico-Biological Interactions , 157-158 :239 , 2005
Abstract : Gordon_2005_Chem.Biol.Interact_157-158_239
ESTHER : Gordon_2005_Chem.Biol.Interact_157-158_239
PubMedSearch : Gordon_2005_Chem.Biol.Interact_157-158_239
PubMedID: 16256090

Title : Poster (81) Interaction of beta-amyloid and cholinesterases by fluorescent polarization -
Author(s) : Nigam SV , Doctor BP , Gordon RK
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :363 , 2004
PubMedID:

Title : Interaction of beta-amyloid and cholinesterases by fluorescent polarization -
Author(s) : Nigam SV , Doctor BP , Gordon RK
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :171 , 2004
PubMedID:

Title : Detection and identification of chemical warfare Agents polyurethane immobilized enzymes -
Author(s) : Gordon RK , Gunduz AT , Doctor BP
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :243 , 2004
PubMedID:

Title : Poster (30) Detection and identification of chemical warfare agents polyurethane immobilized enzymes -
Author(s) : Gordon RK , Gunduz AT , Doctor BP
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :336 , 2004
PubMedID:

Title : Polyurethane immobilized enzymes. -
Author(s) : Gordon RK , Gunduz AT , Doctor BP , Cronin T
Ref : Cholinergic Mechanisms, CRC Press :265 , 2004
PubMedID:

Title : Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors - Leader_2002_J.Med.Chem_45_902
Author(s) : Leader H , Wolfe AD , Chiang PK , Gordon RK
Ref : Journal of Medicinal Chemistry , 45 :902 , 2002
Abstract : Leader_2002_J.Med.Chem_45_902
ESTHER : Leader_2002_J.Med.Chem_45_902
PubMedSearch : Leader_2002_J.Med.Chem_45_902
PubMedID: 11831902

Title : The NMDA receptor ion channel: a site for binding of Huperzine A - Gordon_2001_J.Appl.Toxicol_21 Suppl 1_S47
Author(s) : Gordon RK , Nigam SV , Weitz JA , Dave JR , Doctor BP , Ved HS
Ref : J Appl Toxicol , 21 Suppl 1 :S47 , 2001
Abstract : Gordon_2001_J.Appl.Toxicol_21 Suppl 1_S47
ESTHER : Gordon_2001_J.Appl.Toxicol_21 Suppl 1_S47
PubMedSearch : Gordon_2001_J.Appl.Toxicol_21 Suppl 1_S47
PubMedID: 11920920

Title : Improvements in scavenger protection against organophosphorus agents by modification of cholinesterases - Maxwell_1999_Chem.Biol.Interact_119-120_419
Author(s) : Maxwell DM , Saxena A , Gordon RK , Doctor BP
Ref : Chemico-Biological Interactions , 119-120 :419 , 1999
Abstract : Maxwell_1999_Chem.Biol.Interact_119-120_419
ESTHER : Maxwell_1999_Chem.Biol.Interact_119-120_419
PubMedSearch : Maxwell_1999_Chem.Biol.Interact_119-120_419
PubMedID: 10421479

Title : Organophosphate skin decontamination using immobilized enzymes - Gordon_1999_Chem.Biol.Interact_119-120_463
Author(s) : Gordon RK , Feaster SR , Russell AJ , LeJeune KE , Maxwell DM , Lenz DE , Ross M , Doctor BP
Ref : Chemico-Biological Interactions , 119-120 :463 , 1999
Abstract : Gordon_1999_Chem.Biol.Interact_119-120_463
ESTHER : Gordon_1999_Chem.Biol.Interact_119-120_463
PubMedSearch : Gordon_1999_Chem.Biol.Interact_119-120_463
PubMedID: 10421484

Title : Characterization of ChEs Immobilized on Polyurethane Foams -
Author(s) : Gordon RK , Feaster SR , Herron PC II , Lowe ER , LeJeune KE , Russell AJ , Lenz DE , Ross M , Doctor BP
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :307 , 1998
PubMedID:

Title : Synthesis and antimuscarinic activity of 2-[N-(ethyl)-(N-beta- hydroxyethyl)]aminoethyl 2,2-diphenylpropionate, a metabolite of aprophen - Brown_1993_J.Pharm.Sci_82_563
Author(s) : Brown ND , Leader H , Phillips LR , Smejkal RM , Gordon RK , Chiang PK
Ref : J Pharm Sci , 82 :563 , 1993
Abstract : Brown_1993_J.Pharm.Sci_82_563
ESTHER : Brown_1993_J.Pharm.Sci_82_563
PubMedSearch : Brown_1993_J.Pharm.Sci_82_563
PubMedID: 8331525

Title : Relationship of three-dimensional structure of muscarinic antagonists to antimuscarinic activity: structure of thiodeacylaprophen hydrochloride - Karle_1992_Acta.Crystallogr.B_48_208
Author(s) : Karle JM , Karle IL , Gordon RK , Chiang PK
Ref : Acta Crystallographica B , 48 :208 , 1992
Abstract : Karle_1992_Acta.Crystallogr.B_48_208
ESTHER : Karle_1992_Acta.Crystallogr.B_48_208
PubMedSearch : Karle_1992_Acta.Crystallogr.B_48_208
PubMedID: 1515109

Title : Muscarinic receptor subtype specificity of (N,N-dialkylamino)alkyl 2- cyclohexyl-2-phenylpropionates: cylexphenes (cyclohexyl-substituted aprophen analogues) - Leader_1992_J.Med.Chem_35_1290
Author(s) : Leader H , Gordon RK , Baumgold J , Boyd VL , Newman AH , Smejkal RM , Chiang PK
Ref : Journal of Medicinal Chemistry , 35 :1290 , 1992
Abstract : Leader_1992_J.Med.Chem_35_1290
ESTHER : Leader_1992_J.Med.Chem_35_1290
PubMedSearch : Leader_1992_J.Med.Chem_35_1290
PubMedID: 1560441

Title : Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates - Leader_1989_J.Med.Chem_32_1522
Author(s) : Leader H , Smejkal RM , Payne CS , Padilla FN , Doctor BP , Gordon RK , Chiang PK
Ref : Journal of Medicinal Chemistry , 32 :1522 , 1989
Abstract : Leader_1989_J.Med.Chem_32_1522
ESTHER : Leader_1989_J.Med.Chem_32_1522
PubMedSearch : Leader_1989_J.Med.Chem_32_1522
PubMedID: 2738887

Title : Comparison of in vitro actions with behavioral effects of antimuscarinic agents - Witkin_1987_J.Pharmacol.Exp.Ther_242_796
Author(s) : Witkin JM , Gordon RK , Chiang PK
Ref : Journal of Pharmacology & Experimental Therapeutics , 242 :796 , 1987
Abstract : Witkin_1987_J.Pharmacol.Exp.Ther_242_796
ESTHER : Witkin_1987_J.Pharmacol.Exp.Ther_242_796
PubMedSearch : Witkin_1987_J.Pharmacol.Exp.Ther_242_796
PubMedID: 3498817

Title : Enzymatic synthesis of a false cholinergic neurotransmitter: diethylaminoethyl acetate as a muscarinic agonist analog of acetylcholine - Miura_1986_Gen.Pharmacol_17_477
Author(s) : Miura GA , Chiang PK , Gordon RK , Doctor BP , Twine CE , Philip A , Kepler JA , Carroll FI
Ref : General Pharmacology , 17 :477 , 1986
Abstract : Miura_1986_Gen.Pharmacol_17_477
ESTHER : Miura_1986_Gen.Pharmacol_17_477
PubMedSearch : Miura_1986_Gen.Pharmacol_17_477
PubMedID: 2875921

Title : Disposition of aprophen in rats - Aarbakke_1986_J.Pharm.Pharmacol_38_928
Author(s) : Aarbakke J , Miura GA , Brown ND , Gray RR , Gordon RK , Doctor BP , Chiang PK
Ref : J Pharm Pharmacol , 38 :928 , 1986
Abstract : Aarbakke_1986_J.Pharm.Pharmacol_38_928
ESTHER : Aarbakke_1986_J.Pharm.Pharmacol_38_928
PubMedSearch : Aarbakke_1986_J.Pharm.Pharmacol_38_928
PubMedID: 2880971

Title : Antimuscarinic activity of aprophen -
Author(s) : Gordon RK , Padilla FN , Moore E , Doctor BP , Chiang PK
Ref : Biochemical Pharmacology , 32 :2979 , 1983
PubMedID: 6626268

Title : A radioactive assay for acetylcholinesterase using anion-exchange disk -
Author(s) : Gordon RK , Doctor BP , Chiang PK
Ref : Analytical Biochemistry , 124 :333 , 1982
PubMedID: 6756205