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References (31)

Title : 4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H(3) Receptors and Cholinesterases - Michalska_2024_ACS.Chem.Neurosci__
Author(s) : Michalska B , Dziegielewski M , Godyn J , Werner T , Bajda M , Karcz T , Szczepanska K , Stark H , Wieckowska A , Walczynski K , Staszewski M
Ref : ACS Chem Neurosci , : , 2024
Abstract : Michalska_2024_ACS.Chem.Neurosci__
ESTHER : Michalska_2024_ACS.Chem.Neurosci__
PubMedSearch : Michalska_2024_ACS.Chem.Neurosci__
PubMedID: 38440987

Title : Discovery of new, highly potent and selective inhibitors of BuChE - Design, synthesis, in vitro and in vivo evaluation and crystallography studies - Panek_2023_Eur.J.Med.Chem_249_115135
Author(s) : Panek D , Pasieka A , Latacz G , Zareba P , Szczech M , Godyn J , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Walczak M , Smolik M , Salat K , Hofner G , Wanner K , Wieckowska A , Malawska B
Ref : Eur Journal of Medicinal Chemistry , 249 :115135 , 2023
Abstract : Panek_2023_Eur.J.Med.Chem_249_115135
ESTHER : Panek_2023_Eur.J.Med.Chem_249_115135
PubMedSearch : Panek_2023_Eur.J.Med.Chem_249_115135
PubMedID: 36696766
Gene_locus related to this paper: human-BCHE

Title : Guanidines: Synthesis of Novel Histamine H(3)R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect - Staszewski_2023_Pharmaceuticals.(Basel)_16_
Author(s) : Staszewski M , Iwan M , Werner T , Bajda M , Godyn J , Latacz G , Korga-Plewko A , Kubik J , Szalaj N , Stark H , Malawska B , Wieckowska A , Walczynski K
Ref : Pharmaceuticals (Basel) , 16 : , 2023
Abstract : Staszewski_2023_Pharmaceuticals.(Basel)_16_
ESTHER : Staszewski_2023_Pharmaceuticals.(Basel)_16_
PubMedSearch : Staszewski_2023_Pharmaceuticals.(Basel)_16_
PubMedID: 37242458

Title : Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, beta-secretase, and amyloid beta aggregation as potential treatment of Alzheimer's disease - Zareba_2023_Eur.J.Med.Chem_261_115832
Author(s) : Zareba P , Latka K , Mazur G , Gryzlo B , Pasieka A , Godyn J , Panek D , Skrzypczak-Wiercioch A , Hofner GC , Latacz G , Maj M , Espargaro A , Sabate R , Jozwiak K , Wanner KT , Salat K , Malawska B , Kulig K , Bajda M
Ref : Eur Journal of Medicinal Chemistry , 261 :115832 , 2023
Abstract : Zareba_2023_Eur.J.Med.Chem_261_115832
ESTHER : Zareba_2023_Eur.J.Med.Chem_261_115832
PubMedSearch : Zareba_2023_Eur.J.Med.Chem_261_115832
PubMedID: 37837674

Title : Multitargeting Histamine H(3) Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives - Lazewska_2023_Molecules_28_
Author(s) : Lazewska D , Kaleta M , Zareba P , Godyn J , Dubiel M , Honkisz-Orzechowska E , Doroz-Plonka A , Wieckowska A , Stark H , Kiec-Kononowicz K
Ref : Molecules , 28 : , 2023
Abstract : Lazewska_2023_Molecules_28_
ESTHER : Lazewska_2023_Molecules_28_
PubMedSearch : Lazewska_2023_Molecules_28_
PubMedID: 36903593

Title : Benzophenone Derivatives with Histamine H(3) Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease - Godyn_2022_Molecules_28_
Author(s) : Godyn J , Zareba P , Stary D , Kaleta M , Kuder KJ , Latacz G , Mogilski S , Reiner-Link D , Frank A , Doroz-Plonka A , Olejarz-Maciej A , Sudol-Talaj S , Nolte T , Handzlik J , Stark H , Wieckowska A , Malawska B , Kiec-Kononowicz K , Lazewska D , Bajda M
Ref : Molecules , 28 : , 2022
Abstract : Godyn_2022_Molecules_28_
ESTHER : Godyn_2022_Molecules_28_
PubMedSearch : Godyn_2022_Molecules_28_
PubMedID: 36615435

Title : Serotonin 5-HT(6) Receptor Ligands and Butyrylcholinesterase Inhibitors Displaying Antioxidant Activity-Design, Synthesis and Biological Evaluation of Multifunctional Agents against Alzheimer's Disease - Wieckowski_2022_Int.J.Mol.Sci_23_9443
Author(s) : Wieckowski K , Szalaj N , Gryzlo B , Wichur T , Goral I , Slugocka E , Sniecikowska J , Latacz G , Siwek A , Godyn J , Bucki A , Kolaczkowski M , Wieckowska A
Ref : Int J Mol Sci , 23 : , 2022
Abstract : Wieckowski_2022_Int.J.Mol.Sci_23_9443
ESTHER : Wieckowski_2022_Int.J.Mol.Sci_23_9443
PubMedSearch : Wieckowski_2022_Int.J.Mol.Sci_23_9443
PubMedID: 36012707

Title : Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT(6) receptor with anti-aggregation properties against amyloid-beta and tau - Wichur_2021_Eur.J.Med.Chem_225_113783
Author(s) : Wichur T , Pasieka A , Godyn J , Panek D , Goral I , Latacz G , Honkisz-Orzechowska E , Bucki A , Siwek A , Gluch-Lutwin M , Knez D , Brazzolotto X , Gobec S , Kolaczkowski M , Sabate R , Malawska B , Wieckowska A
Ref : Eur Journal of Medicinal Chemistry , 225 :113783 , 2021
Abstract : Wichur_2021_Eur.J.Med.Chem_225_113783
ESTHER : Wichur_2021_Eur.J.Med.Chem_225_113783
PubMedSearch : Wichur_2021_Eur.J.Med.Chem_225_113783
PubMedID: 34461507

Title : Biphenylalkoxyamine Derivatives-Histamine H(3) Receptor Ligands with Butyrylcholinesterase Inhibitory Activity - Lazewska_2021_Molecules_26_
Author(s) : Lazewska D , Zareba P , Godyn J , Doroz-Plonka A , Frank A , Reiner-Link D , Bajda M , Stary D , Mogilski S , Olejarz-Maciej A , Kaleta M , Stark H , Malawska B , Kiec-Kononowicz K
Ref : Molecules , 26 : , 2021
Abstract : Lazewska_2021_Molecules_26_
ESTHER : Lazewska_2021_Molecules_26_
PubMedSearch : Lazewska_2021_Molecules_26_
PubMedID: 34208297

Title : Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with beta-amyloid anti-aggregation properties - Wichur_2021_Eur.J.Med.Chem_225_113792
Author(s) : Wichur T , Godyn J , Goral I , Latacz G , Bucki A , Siwek A , Gluch-Lutwin M , Mordyl B , Sniecikowska J , Walczak M , Knez D , Jukic M , Salat K , Gobec S , Kolaczkowski M , Malawska B , Brazzolotto X , Wieckowska A
Ref : Eur Journal of Medicinal Chemistry , 225 :113792 , 2021
Abstract : Wichur_2021_Eur.J.Med.Chem_225_113792
ESTHER : Wichur_2021_Eur.J.Med.Chem_225_113792
PubMedSearch : Wichur_2021_Eur.J.Med.Chem_225_113792
PubMedID: 34530376
Gene_locus related to this paper: human-BCHE

Title : Cyanobiphenyls: Novel H(3) receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer's disease - Godyn_2021_Bioorg.Chem_114_105129
Author(s) : Godyn J , Zareba P , aewska D , Stary D , Reiner-Link D , Frank A , Latacz G , Mogilski S , Kaleta M , Doroz-Plonka A , Lubelska A , Honkisz-Orzechowska E , Olejarz-Maciej A , Handzlik J , Stark H , Kiec-Kononowicz K , Malawska B , Bajda M
Ref : Bioorg Chem , 114 :105129 , 2021
Abstract : Godyn_2021_Bioorg.Chem_114_105129
ESTHER : Godyn_2021_Bioorg.Chem_114_105129
PubMedSearch : Godyn_2021_Bioorg.Chem_114_105129
PubMedID: 34217977

Title : Discovery of multifunctional anti-Alzheimers agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and gamma-aminobutyric acid transporters - Pasieka_2021_Eur.J.Med.Chem_218_113397
Author(s) : Pasieka A , Panek D , Jonczyk J , Godyn J , Szalaj N , Latacz G , Tabor J , Mezeiova E , Chantegreil F , Dias J , Knez D , Lu J , Pi R , Korabecny J , Brazzolotto X , Gobec S , Hofner G , Wanner K , Wieckowska Q , Malawska B
Ref : Eur Journal of Medicinal Chemistry , 218 :113397 , 2021
Abstract : Pasieka_2021_Eur.J.Med.Chem_218_113397
ESTHER : Pasieka_2021_Eur.J.Med.Chem_218_113397
PubMedSearch : Pasieka_2021_Eur.J.Med.Chem_218_113397
PubMedID: 33838585

Title : Dual Action of Dipyridothiazine and Quinobenzothiazine Derivatives-Anticancer and Cholinesterase-Inhibiting Activity - Jonczyk_2020_Molecules_25_
Author(s) : Jonczyk J , Godyn J , Stawarska E , Morak-Mlodawska B , Jelen M , Pluta K , Malawska B
Ref : Molecules , 25 : , 2020
Abstract : Jonczyk_2020_Molecules_25_
ESTHER : Jonczyk_2020_Molecules_25_
PubMedSearch : Jonczyk_2020_Molecules_25_
PubMedID: 32503288

Title : Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease - Szalaj_2020_J.Enzyme.Inhib.Med.Chem_35_1944
Author(s) : Szalaj N , Godyn J , Jonczyk J , Pasieka A , Panek D , Wichur T , Wieckowski K , Zareba P , Bajda M , Pislar A , Malawska B , Sabate R , Wieckowska A
Ref : J Enzyme Inhib Med Chem , 35 :1944 , 2020
Abstract : Szalaj_2020_J.Enzyme.Inhib.Med.Chem_35_1944
ESTHER : Szalaj_2020_J.Enzyme.Inhib.Med.Chem_35_1944
PubMedSearch : Szalaj_2020_J.Enzyme.Inhib.Med.Chem_35_1944
PubMedID: 33092411

Title : Rational design of new multitarget histamine H(3) receptor ligands as potential candidates for treatment of Alzheimer's disease - Lazewska_2020_Eur.J.Med.Chem_207_112743
Author(s) : Lazewska D , Bajda M , Kaleta M , Zareba P , Doroz-Plonka A , Siwek A , Alachkar A , Mogilski S , Saad A , Kuder K , Olejarz-Maciej A , Godyn J , Stary D , Sudol S , Wiecek M , Latacz G , Walczak M , Handzlik J , Sadek B , Malawska B , Kiec-Kononowicz K
Ref : Eur Journal of Medicinal Chemistry , 207 :112743 , 2020
Abstract : Lazewska_2020_Eur.J.Med.Chem_207_112743
ESTHER : Lazewska_2020_Eur.J.Med.Chem_207_112743
PubMedSearch : Lazewska_2020_Eur.J.Med.Chem_207_112743
PubMedID: 32882609

Title : New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition - Malek_2019_J.Med.Chem_62_11416
Author(s) : Malek R , Arribas RL , Palomino-Antolin A , Totoson P , Demougeot C , Kobrlova T , Soukup O , Iriepa I , Moraleda I , Diez-Iriepa D , Godyn J , Panek D , Malawska B , Gluch-Lutwin M , Mordyl B , Siwek A , Chabchoub F , Marco-Contelles J , Kiec-Kononowicz K , Egea J , de los Rios C , Ismaili L
Ref : Journal of Medicinal Chemistry , 62 :11416 , 2019
Abstract : Malek_2019_J.Med.Chem_62_11416
ESTHER : Malek_2019_J.Med.Chem_62_11416
PubMedSearch : Malek_2019_J.Med.Chem_62_11416
PubMedID: 31724859

Title : 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease - Wichur_2019_Eur.J.Med.Chem_187_111916
Author(s) : Wichur T , Wieckowska A , Wieckowski K , Godyn J , Jonczyk J , Valdivieso ADR , Panek D , Pasieka A , Sabate R , Knez D , Gobec S , Malawska B
Ref : Eur Journal of Medicinal Chemistry , 187 :111916 , 2019
Abstract : Wichur_2019_Eur.J.Med.Chem_187_111916
ESTHER : Wichur_2019_Eur.J.Med.Chem_187_111916
PubMedSearch : Wichur_2019_Eur.J.Med.Chem_187_111916
PubMedID: 31812794

Title : Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives - Jonczyk_2019_Bioorg.Chem_90_103084
Author(s) : Jonczyk J , Lodarski K , Staszewski M , Godyn J , Zareba P , Soukup O , Janockova J , Korabecny J , Salat K , Malikowska-Racia N , Hebda M , Szalaj N , Filipek B , Walczynski K , Malawska B , Bajda M
Ref : Bioorg Chem , 90 :103084 , 2019
Abstract : Jonczyk_2019_Bioorg.Chem_90_103084
ESTHER : Jonczyk_2019_Bioorg.Chem_90_103084
PubMedSearch : Jonczyk_2019_Bioorg.Chem_90_103084
PubMedID: 31271942

Title : Search for new multi-target compounds against Alzheimer's disease among histamine H3 receptor ligands - Bajda_2019_Eur.J.Med.Chem_185_111785
Author(s) : Bajda M , Lazewska D , Godyn J , Zareba P , Kuder K , Hagenow S , Latka K , Stawarska E , Stark H , Kiec-Kononowicz K , Malawska B
Ref : Eur Journal of Medicinal Chemistry , 185 :111785 , 2019
Abstract : Bajda_2019_Eur.J.Med.Chem_185_111785
ESTHER : Bajda_2019_Eur.J.Med.Chem_185_111785
PubMedSearch : Bajda_2019_Eur.J.Med.Chem_185_111785
PubMedID: 31669851

Title : Anti-Alzheimer's multitarget-directed ligands with serotonin 5-HT6 antagonist, butyrylcholinesterase inhibitory, and antioxidant activity - Marcinkowska_2019_Arch.Pharm.(Weinheim)__e1900041
Author(s) : Marcinkowska M , Bucki A , Panek D , Siwek A , Fajkis N , Bednarski M , Zygmunt M , Godyn J , Del Rio Valdivieso A , Kotanska M , Kolaczkowski M , Wieckowska A
Ref : Arch Pharm (Weinheim) , :e1900041 , 2019
Abstract : Marcinkowska_2019_Arch.Pharm.(Weinheim)__e1900041
ESTHER : Marcinkowska_2019_Arch.Pharm.(Weinheim)__e1900041
PubMedSearch : Marcinkowska_2019_Arch.Pharm.(Weinheim)__e1900041
PubMedID: 31162703

Title : Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer's Disease - Wieckowska_2018_ACS.Chem.Neurosci_9_1195
Author(s) : Wieckowska A , Wichur T , Godyn J , Bucki A , Marcinkowska M , Siwek A , Wieckowski K , Zareba P , Knez D , Gluch-Lutwin M , Kazek G , Latacz G , Mika K , Kolaczkowski M , Korabecny J , Soukup O , Benkova M , Kiec-Kononowicz K , Gobec S , Malawska B
Ref : ACS Chem Neurosci , 9 :1195 , 2018
Abstract : Wieckowska_2018_ACS.Chem.Neurosci_9_1195
ESTHER : Wieckowska_2018_ACS.Chem.Neurosci_9_1195
PubMedSearch : Wieckowska_2018_ACS.Chem.Neurosci_9_1195
PubMedID: 29384656

Title : Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents - Panek_2018_Molecules_23_
Author(s) : Panek D , Wieckowska A , Pasieka A , Godyn J , Jonczyk J , Bajda M , Knez D , Gobec S , Malawska B
Ref : Molecules , 23 : , 2018
Abstract : Panek_2018_Molecules_23_
ESTHER : Panek_2018_Molecules_23_
PubMedSearch : Panek_2018_Molecules_23_
PubMedID: 29414887

Title : Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents - Panek_2018_ACS.Chem.Neurosci_9_1074
Author(s) : Panek D , Wieckowska A , Jonczyk J , Godyn J , Bajda M , Wichur T , Pasieka A , Knez D , Pislar A , Korabecny J , Soukup O , Sepsova V , Sabate R , Kos J , Gobec S , Malawska B
Ref : ACS Chem Neurosci , 9 :1074 , 2018
Abstract : Panek_2018_ACS.Chem.Neurosci_9_1074
ESTHER : Panek_2018_ACS.Chem.Neurosci_9_1074
PubMedSearch : Panek_2018_ACS.Chem.Neurosci_9_1074
PubMedID: 29345897

Title : Lipophilic properties of anti-Alzheimer's agents determined by micellar electrokinetic chromatography and reversed-phase thin-layer chromatography - Godyn_2017_Electrophoresis_38_1268
Author(s) : Godyn J , Hebda M , Wieckowska A , Wieckowski K , Malawska B , Bajda M
Ref : Electrophoresis , 38 :1268 , 2017
Abstract : Godyn_2017_Electrophoresis_38_1268
ESTHER : Godyn_2017_Electrophoresis_38_1268
PubMedSearch : Godyn_2017_Electrophoresis_38_1268
PubMedID: 28169440

Title : Advances toward multifunctional cholinesterase and beta-amyloid aggregation inhibitors - Panek_2017_Future.Med.Chem_9_1835
Author(s) : Panek D , Wichur T , Godyn J , Pasieka A , Malawska B
Ref : Future Med Chem , 9 :1835 , 2017
Abstract : Panek_2017_Future.Med.Chem_9_1835
ESTHER : Panek_2017_Future.Med.Chem_9_1835
PubMedSearch : Panek_2017_Future.Med.Chem_9_1835
PubMedID: 28925729

Title : Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation - Panek_2016_Eur.J.Med.Chem_125_676
Author(s) : Panek D , Wieckowska A , Wichur T , Bajda M , Godyn J , Jonczyk J , Mika K , Janockova J , Soukup O , Knez D , Korabecny J , Gobec S , Malawska B
Ref : Eur Journal of Medicinal Chemistry , 125 :676 , 2016
Abstract : Panek_2016_Eur.J.Med.Chem_125_676
ESTHER : Panek_2016_Eur.J.Med.Chem_125_676
PubMedSearch : Panek_2016_Eur.J.Med.Chem_125_676
PubMedID: 27721153

Title : Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy - Dgachi_2016_Eur.J.Med.Chem_126_576
Author(s) : Dgachi Y , Sokolov O , Luzet V , Godyn J , Panek D , Bonet A , Martin H , Iriepa I , Moraleda I , Garcia-Iriepa C , Janockova J , Richert L , Soukup O , Malawska B , Chabchoub F , Marco-Contelles J , Ismaili L
Ref : Eur Journal of Medicinal Chemistry , 126 :576 , 2016
Abstract : Dgachi_2016_Eur.J.Med.Chem_126_576
ESTHER : Dgachi_2016_Eur.J.Med.Chem_126_576
PubMedSearch : Dgachi_2016_Eur.J.Med.Chem_126_576
PubMedID: 27918993

Title : Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation - Wieckowska_2016_Eur.J.Med.Chem_124_63
Author(s) : Wieckowska A , Kolaczkowski M , Bucki A , Godyn J , Marcinkowska M , Wieckowski K , Zareba P , Siwek A , Kazek G , Gluch-Lutwin M , Mierzejewski P , Bienkowski P , Sienkiewicz-Jarosz H , Knez D , Wichur T , Gobec S , Malawska B
Ref : Eur Journal of Medicinal Chemistry , 124 :63 , 2016
Abstract : Wieckowska_2016_Eur.J.Med.Chem_124_63
ESTHER : Wieckowska_2016_Eur.J.Med.Chem_124_63
PubMedSearch : Wieckowska_2016_Eur.J.Med.Chem_124_63
PubMedID: 27560283

Title : Therapeutic strategies for Alzheimer's disease in clinical trials - Godyn_2016_Pharmacol.Rep_68_127
Author(s) : Godyn J , Jonczyk J , Panek D , Malawska B
Ref : Pharmacol Rep , 68 :127 , 2016
Abstract : Godyn_2016_Pharmacol.Rep_68_127
ESTHER : Godyn_2016_Pharmacol.Rep_68_127
PubMedSearch : Godyn_2016_Pharmacol.Rep_68_127
PubMedID: 26721364

Title : Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta - Hebda_2016_Molecules_21_
Author(s) : Hebda M , Bajda M , Wieckowska A , Szalaj N , Pasieka A , Panek D , Godyn J , Wichur T , Knez D , Gobec S , Malawska B
Ref : Molecules , 21 : , 2016
Abstract : Hebda_2016_Molecules_21_
ESTHER : Hebda_2016_Molecules_21_
PubMedSearch : Hebda_2016_Molecules_21_
PubMedID: 27023510

Title : Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease - Dgachi_2016_Molecules_21_
Author(s) : Dgachi Y , Bautista-Aguilera OM , Benchekroun M , Martin H , Bonet A , Knez D , Godyn J , Malawska B , Gobec S , Chioua M , Janockova J , Soukup O , Chabchoub F , Marco-Contelles J , Ismaili L
Ref : Molecules , 21 : , 2016
Abstract : Dgachi_2016_Molecules_21_
ESTHER : Dgachi_2016_Molecules_21_
PubMedSearch : Dgachi_2016_Molecules_21_
PubMedID: 27187348