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| Title : Analogues of cannabinoids as multitarget drugs in the treatment of Alzheimer's disease - Sanchez Montero _2021_Eur.J.Pharmacol__173875 |
| Author(s) : Sanchez Montero JM , Agis-Torres A , Solano D , Sollhuber M , Fernandez M , Villaro W , Gomez-Canas M , Garcia-Arencibia M , Fernandez-Ruiz J , Egea J , Martin MI , Giron R |
| Ref : European Journal of Pharmacology , :173875 , 2021 |
| Abstract : Sanchez Montero _2021_Eur.J.Pharmacol__173875 |
| ESTHER : Sanchez Montero _2021_Eur.J.Pharmacol__173875 |
| PubMedSearch : Sanchez Montero _2021_Eur.J.Pharmacol__173875 |
| PubMedID: 33460612 |
| Title : New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition - Malek_2019_J.Med.Chem_62_11416 |
| Author(s) : Malek R , Arribas RL , Palomino-Antolin A , Totoson P , Demougeot C , Kobrlova T , Soukup O , Iriepa I , Moraleda I , Diez-Iriepa D , Godyn J , Panek D , Malawska B , Gluch-Lutwin M , Mordyl B , Siwek A , Chabchoub F , Marco-Contelles J , Kiec-Kononowicz K , Egea J , de los Rios C , Ismaili L |
| Ref : Journal of Medicinal Chemistry , 62 :11416 , 2019 |
| Abstract : Malek_2019_J.Med.Chem_62_11416 |
| ESTHER : Malek_2019_J.Med.Chem_62_11416 |
| PubMedSearch : Malek_2019_J.Med.Chem_62_11416 |
| PubMedID: 31724859 |
| Title : QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy - Ramos_2019_Molecules_24_ |
| Author(s) : Ramos E , Palomino-Antolin A , Bartolini M , Iriepa I , Moraleda I , Diez-Iriepa D , Samadi A , Cortina CV , Chioua M , Egea J , Romero A , Marco-Contelles J |
| Ref : Molecules , 24 : , 2019 |
| Abstract : Ramos_2019_Molecules_24_ |
| ESTHER : Ramos_2019_Molecules_24_ |
| PubMedSearch : Ramos_2019_Molecules_24_ |
| PubMedID: 30999586 |
| Title : Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia - Monjas_2017_Eur.J.Med.Chem_130_60 |
| Author(s) : Monjas L , Arce MP , Leon R , Egea J , Perez C , Villarroya M , Lopez MG , Gil C , Conde S , Rodriguez-Franco MI |
| Ref : Eur Journal of Medicinal Chemistry , 130 :60 , 2017 |
| Abstract : Monjas_2017_Eur.J.Med.Chem_130_60 |
| ESTHER : Monjas_2017_Eur.J.Med.Chem_130_60 |
| PubMedSearch : Monjas_2017_Eur.J.Med.Chem_130_60 |
| PubMedID: 28242552 |
| Title : Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases - Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| Author(s) : Bautista-Aguilera OM , Hagenow S , Palomino-Antolin A , Farre-Alins V , Ismaili L , Joffrin PL , Jimeno ML , Soukup O , Janockova J , Kalinowsky L , Proschak E , Iriepa I , Moraleda I , Schwed JS , Romero Martinez A , Lopez-Munoz F , Chioua M , Egea J , Ramsay RR , Marco-Contelles J , Stark H |
| Ref : Angew Chem Int Ed Engl , 56 :12765 , 2017 |
| Abstract : Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| ESTHER : Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| PubMedSearch : Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| PubMedID: 28861918 |
| Title : Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography - Zha_2016_J.Med.Chem_59_114 |
| Author(s) : Zha X , Lamba D , Zhang L , Lou Y , Xu C , Kang D , Chen L , Xu Y , De Simone A , Samez S , Pesaresi A , Stojan J , Lopez MG , Egea J , Andrisano V , Bartolini M |
| Ref : Journal of Medicinal Chemistry , 59 :114 , 2016 |
| Abstract : Zha_2016_J.Med.Chem_59_114 |
| ESTHER : Zha_2016_J.Med.Chem_59_114 |
| PubMedSearch : Zha_2016_J.Med.Chem_59_114 |
| PubMedID: 26632651 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Subthreshold Concentrations of Melatonin and Galantamine Improves Pathological AD-Hallmarks in Hippocampal Organotypic Cultures - Buendia_2016_Mol.Neurobiol_53_3338 |
| Author(s) : Buendia I , Parada E , Navarro E , Leon R , Negredo P , Egea J , Lopez MG |
| Ref : Molecular Neurobiology , 53 :3338 , 2016 |
| Abstract : Buendia_2016_Mol.Neurobiol_53_3338 |
| ESTHER : Buendia_2016_Mol.Neurobiol_53_3338 |
| PubMedSearch : Buendia_2016_Mol.Neurobiol_53_3338 |
| PubMedID: 26081146 |
| Title : The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators - Benchekroun_2016_J.Med.Chem_59_9967 |
| Author(s) : Benchekroun M , Romero A , Egea J , Leon R , Michalska P , Buendia I , Jimeno ML , Jun D , Janockova J , Sepsova V , Soukup O , Bautista-Aguilera OM , Refouvelet B , Ouari O , Marco-Contelles J , Ismaili L |
| Ref : Journal of Medicinal Chemistry , 59 :9967 , 2016 |
| Abstract : Benchekroun_2016_J.Med.Chem_59_9967 |
| ESTHER : Benchekroun_2016_J.Med.Chem_59_9967 |
| PubMedSearch : Benchekroun_2016_J.Med.Chem_59_9967 |
| PubMedID: 27736061 |
| Title : Novel tacrine-grafted ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic Acid hybrids - Benchekroun_2015_ChemMedChem_10_523 |
| Author(s) : Benchekroun M , Bartolini M , Egea J , Romero A , Soriano E , Pudlo M , Luzet V , Andrisano V , Jimeno ML , Lopez MG , Wehle S , Gharbi T , Refouvelet B , de Andres L , Herrera-Arozamena C , Monti B , Bolognesi ML , Rodriguez-Franco MI , Decker M , Marco-Contelles J , Ismaili L |
| Ref : ChemMedChem , 10 :523 , 2015 |
| Abstract : Benchekroun_2015_ChemMedChem_10_523 |
| ESTHER : Benchekroun_2015_ChemMedChem_10_523 |
| PubMedSearch : Benchekroun_2015_ChemMedChem_10_523 |
| PubMedID: 25537267 |
| Title : Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection - Egea_2015_Biochem.Pharmacol_97(4)_463 |
| Author(s) : Egea J , Buendia I , Parada E , Navarro E , Leon R , Lopez MG |
| Ref : Biochemical Pharmacology , 97 :463 , 2015 |
| Abstract : Egea_2015_Biochem.Pharmacol_97(4)_463 |
| ESTHER : Egea_2015_Biochem.Pharmacol_97(4)_463 |
| PubMedSearch : Egea_2015_Biochem.Pharmacol_97(4)_463 |
| PubMedID: 26232730 |
| Title : Alpha7 nicotinic receptor activation protects against oxidative stress via heme-oxygenase I induction - Navarro_2015_Biochem.Pharmacol_97(4)_473 |
| Author(s) : Navarro E , Buendia I , Parada E , Leon R , Jansen-Duerr P , Pircher H , Egea J , Lopez MG |
| Ref : Biochemical Pharmacology , 97 :473 , 2015 |
| Abstract : Navarro_2015_Biochem.Pharmacol_97(4)_473 |
| ESTHER : Navarro_2015_Biochem.Pharmacol_97(4)_473 |
| PubMedSearch : Navarro_2015_Biochem.Pharmacol_97(4)_473 |
| PubMedID: 26212551 |
| Title : 1,8-Naphthyridine derivatives as cholinesterases inhibitors and cell Ca2+ regulators, a multitarget strategy for Alzheimer's disease - Egea_2011_Curr.Top.Med.Chem_11_2807 |
| Author(s) : Egea J , de los Rios C |
| Ref : Curr Top Med Chem , 11 :2807 , 2011 |
| Abstract : Egea_2011_Curr.Top.Med.Chem_11_2807 |
| ESTHER : Egea_2011_Curr.Top.Med.Chem_11_2807 |
| PubMedSearch : Egea_2011_Curr.Top.Med.Chem_11_2807 |
| PubMedID: 22039881 |
| Title : Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by alpha7 and beta2* nicotinic stimulation - Del Barrio_2011_Toxicol.Sci_123_193 |
| Author(s) : Del Barrio L , Martin-de-Saavedra MD , Romero A , Parada E , Egea J , Avila J , McIntosh JM , Wonnacott S , Lopez MG |
| Ref : Toxicol Sci , 123 :193 , 2011 |
| Abstract : Del Barrio_2011_Toxicol.Sci_123_193 |
| ESTHER : Del Barrio_2011_Toxicol.Sci_123_193 |
| PubMedSearch : Del Barrio_2011_Toxicol.Sci_123_193 |
| PubMedID: 21715663 |
| Title : Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues - Martins_2011_Eur.J.Med.Chem_46_6119 |
| Author(s) : Martins C , Carreiras MC , Leon R , de los Rios C , Bartolini M , Andrisano V , Iriepa I , Moraleda I , Galvez E , Garcia M , Egea J , Samadi A , Chioua M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 46 :6119 , 2011 |
| Abstract : Martins_2011_Eur.J.Med.Chem_46_6119 |
| ESTHER : Martins_2011_Eur.J.Med.Chem_46_6119 |
| PubMedSearch : Martins_2011_Eur.J.Med.Chem_46_6119 |
| PubMedID: 22000936 |
| Title : N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease - Gonzalez-Munoz_2011_Eur.J.Med.Chem_46_2224 |
| Author(s) : Gonzalez-Munoz GC , Arce MP , Lopez B , Perez C , Romero A , Del Barrio L , Martin-de-Saavedra MD , Egea J , Leon R , Villarroya M , Lopez MG , Garcia AG , Conde S , Rodriguez-Franco MI |
| Ref : Eur Journal of Medicinal Chemistry , 46 :2224 , 2011 |
| Abstract : Gonzalez-Munoz_2011_Eur.J.Med.Chem_46_2224 |
| ESTHER : Gonzalez-Munoz_2011_Eur.J.Med.Chem_46_2224 |
| PubMedSearch : Gonzalez-Munoz_2011_Eur.J.Med.Chem_46_2224 |
| PubMedID: 21420206 |
| Title : Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives - de Los Rios_2010_J.Med.Chem_53_5129 |
| Author(s) : de los Rios C , Egea J , Marco-Contelles J , Leon R , Samadi A , Iriepa I , Moraleda I , Galvez E , Garcia AG , Lopez MG , Villarroya M , Romero A |
| Ref : Journal of Medicinal Chemistry , 53 :5129 , 2010 |
| Abstract : de Los Rios_2010_J.Med.Chem_53_5129 |
| ESTHER : de Los Rios_2010_J.Med.Chem_53_5129 |
| PubMedSearch : de Los Rios_2010_J.Med.Chem_53_5129 |
| PubMedID: 20575555 |
| Title : Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells - Romero_2010_J.Pineal.Res_49_141 |
| Author(s) : Romero A , Egea J , Garcia AG , Lopez MG |
| Ref : J Pineal Res , 49 :141 , 2010 |
| Abstract : Romero_2010_J.Pineal.Res_49_141 |
| ESTHER : Romero_2010_J.Pineal.Res_49_141 |
| PubMedSearch : Romero_2010_J.Pineal.Res_49_141 |
| PubMedID: 20536682 |
| Title : Desensitized nicotinic receptors that, however, afford cytoprotection in bovine chromaffin cells - Egea_2006_J.Mol.Neurosci_30_59 |
| Author(s) : Egea J , Hernandez-Guijo JM , Olivares R , Lopez MG , Garcia AG |
| Ref : Journal of Molecular Neuroscience , 30 :59 , 2006 |
| Abstract : Egea_2006_J.Mol.Neurosci_30_59 |
| ESTHER : Egea_2006_J.Mol.Neurosci_30_59 |
| PubMedSearch : Egea_2006_J.Mol.Neurosci_30_59 |
| PubMedID: 17192627 |
| Title : Neuroprotection by nicotine in hippocampal slices subjected to oxygen-glucose deprivation: involvement of the alpha7 nAChR subtype - Rosa_2006_J.Mol.Neurosci_30_61 |
| Author(s) : Rosa AO , Egea J , Gandia L , Lopez MG , Garcia AG |
| Ref : Journal of Molecular Neuroscience , 30 :61 , 2006 |
| Abstract : Rosa_2006_J.Mol.Neurosci_30_61 |
| ESTHER : Rosa_2006_J.Mol.Neurosci_30_61 |
| PubMedSearch : Rosa_2006_J.Mol.Neurosci_30_61 |
| PubMedID: 17192628 |
| Title : Enhancement of secretion by threshold nicotinic stimulation in bovine chromaffin cells - Tapia_2006_J.Mol.Neurosci_30_81 |
| Author(s) : Tapia L , Eguiagaray JG , Egea J , Garcia AG , Gandia L |
| Ref : Journal of Molecular Neuroscience , 30 :81 , 2006 |
| Abstract : Tapia_2006_J.Mol.Neurosci_30_81 |
| ESTHER : Tapia_2006_J.Mol.Neurosci_30_81 |
| PubMedSearch : Tapia_2006_J.Mol.Neurosci_30_81 |
| PubMedID: 17192638 |
| Title : Galantamine and memantine produce different degrees of neuroprotection in rat hippocampal slices subjected to oxygen-glucose deprivation - Sobrado_2004_Neurosci.Lett_365_132 |
| Author(s) : Sobrado M , Roda JM , Lopez MG , Egea J , Garcia AG |
| Ref : Neuroscience Letters , 365 :132 , 2004 |
| Abstract : Sobrado_2004_Neurosci.Lett_365_132 |
| ESTHER : Sobrado_2004_Neurosci.Lett_365_132 |
| PubMedSearch : Sobrado_2004_Neurosci.Lett_365_132 |
| PubMedID: 15245794 |