Full name : Decker Michael
First name : Michael
Mail : Institut fur Pharmazie und Lebensmittelchemie, Julius-Maximilians-Universitat Wurzburg, Am Hubland, 97074 Wurzburg
Zip Code :
City :
Country : Germany
Email : michael.decker@uni-wuerzburg.de
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Fax :
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Directory :
| Title : Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist\/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model - Spatz_2023_J.Med.Chem__ |
| Author(s) : Spatz P , Steinmuller SAM , Tutov A , Poeta E , Morilleau A , Carles A , Deventer MH , Hofmann J , Stove CP , Monti B , Maurice T , Decker M |
| Ref : Journal of Medicinal Chemistry , : , 2023 |
| Abstract : Spatz_2023_J.Med.Chem__ |
| ESTHER : Spatz_2023_J.Med.Chem__ |
| PubMedSearch : Spatz_2023_J.Med.Chem__ |
| PubMedID: 37127287 |
| Title : Synthesis and Biological Evaluation of Flavonoid-Cinnamic Acid Amide Hybrids with Distinct Activity against Neurodegeneration in Vitro and in Vivo - Hofmann_2022_Chemistry__e202200786 |
| Author(s) : Hofmann J , Spatz P , Walther R , Gutmann M , Maurice T , Decker M |
| Ref : Chemistry , :e202200786 , 2022 |
| Abstract : Hofmann_2022_Chemistry__e202200786 |
| ESTHER : Hofmann_2022_Chemistry__e202200786 |
| PubMedSearch : Hofmann_2022_Chemistry__e202200786 |
| PubMedID: 35621167 |
| Title : Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model - Spatz_2022_RSC.Med.Chem_13_944 |
| Author(s) : Spatz P , Zimmermann T , Steinmuller S , Hofmann J , Maurice T , Decker M |
| Ref : RSC Med Chem , 13 :944 , 2022 |
| Abstract : Spatz_2022_RSC.Med.Chem_13_944 |
| ESTHER : Spatz_2022_RSC.Med.Chem_13_944 |
| PubMedSearch : Spatz_2022_RSC.Med.Chem_13_944 |
| PubMedID: 36092149 |
| Title : Photoswitchable Pseudoirreversible Butyrylcholinesterase Inhibitors Allow Optical Control of Inhibition in Vitro and Enable Restoration of Cognition in an Alzheimer's Disease Mouse Model upon Irradiation - Scheiner_2022_J.Am.Chem.Soc__ |
| Author(s) : Scheiner M , Sink A , Hoffmann M , Vrigneau C , Endres E , Carles A , Sotriffer C , Maurice T , Decker M |
| Ref : Journal of the American Chemical Society , : , 2022 |
| Abstract : Scheiner_2022_J.Am.Chem.Soc__ |
| ESTHER : Scheiner_2022_J.Am.Chem.Soc__ |
| PubMedSearch : Scheiner_2022_J.Am.Chem.Soc__ |
| PubMedID: 35138833 |
| Title : Azobioisosteres of Curcumin with Pronounced Activity against Amyloid Aggregation, Intracellular Oxidative Stress, and Neuroinflammation - Hofmann_2021_Chemistry_27_6015 |
| Author(s) : Hofmann J , Ginex T , Espargaro A , Scheiner M , Gunesch S , Arago M , Stigloher C , Sabate R , Luque FJ , Decker M |
| Ref : Chemistry , 27 :6015 , 2021 |
| Abstract : Hofmann_2021_Chemistry_27_6015 |
| ESTHER : Hofmann_2021_Chemistry_27_6015 |
| PubMedSearch : Hofmann_2021_Chemistry_27_6015 |
| PubMedID: 33666306 |
| Title : Selective Pseudo-irreversible Butyrylcholinesterase Inhibitors Transferring Antioxidant Moieties to the Enzyme Show Pronounced Neuroprotective Efficacy In Vitro and In Vivo in an Alzheimer's Disease Mouse Model - Scheiner_2021_J.Med.Chem_64_9302 |
| Author(s) : Scheiner M , Hoffmann M , He F , Poeta E , Chatonnet A , Monti B , Maurice T , Decker M |
| Ref : Journal of Medicinal Chemistry , 64(13): :9302 , 2021 |
| Abstract : Scheiner_2021_J.Med.Chem_64_9302 |
| ESTHER : Scheiner_2021_J.Med.Chem_64_9302 |
| PubMedSearch : Scheiner_2021_J.Med.Chem_64_9302 |
| PubMedID: 34152756 |
| Title : Synthesis and Initial Characterization of a Selective, Pseudo-irreversible Inhibitor of Human Butyrylcholinesterase as PET Tracer - Gentzsch_2021_ChemMedChem__ |
| Author(s) : Gentzsch C , Hoffmann M , Ohshima Y , Nose N , Chen X , Higuchi T , Decker M |
| Ref : ChemMedChem , : , 2021 |
| Abstract : Gentzsch_2021_ChemMedChem__ |
| ESTHER : Gentzsch_2021_ChemMedChem__ |
| PubMedSearch : Gentzsch_2021_ChemMedChem__ |
| PubMedID: 33645891 |
| Title : Synthesis and Initial Characterization of a Reversible, Selective (18)F-Labeled Radiotracer for Human Butyrylcholinesterase - Gentzsch_2021_Mol.Imaging.Biol__ |
| Author(s) : Gentzsch C , Chen X , Spatz P , Kosak U , Knez D , Nose N , Gobec S , Higuchi T , Decker M |
| Ref : Mol Imaging Biol , : , 2021 |
| Abstract : Gentzsch_2021_Mol.Imaging.Biol__ |
| ESTHER : Gentzsch_2021_Mol.Imaging.Biol__ |
| PubMedSearch : Gentzsch_2021_Mol.Imaging.Biol__ |
| PubMedID: 33660167 |
| Title : From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects - Pont_2021_Eur.J.Med.Chem_225_113779 |
| Author(s) : Pont C , Ginex T , Grinan-Ferre C , Scheiner M , Mattellone A , Martinez N , Arce EM , Soriano-Fernandez Y , Naldi M , De Simone A , Barenys M , Gomez-Catalan J , Perez B , Sabate R , Andrisano V , Loza MI , Brea J , Bartolini M , Bolognesi ML , Decker M , Pallas M , Luque FJ , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 225 :113779 , 2021 |
| Abstract : Pont_2021_Eur.J.Med.Chem_225_113779 |
| ESTHER : Pont_2021_Eur.J.Med.Chem_225_113779 |
| PubMedSearch : Pont_2021_Eur.J.Med.Chem_225_113779 |
| PubMedID: 34418785 |
| Title : Photopharmacology on Acetylcholinesterase: Novel Photoswitchable Inhibitors with Improved Pharmacological Profiles - Scheiner_2021_ChemPhotoChem_5_149 |
| Author(s) : Scheiner M , Sink A , Spatz P , Endres E , Decker M |
| Ref : ChemPhotoChem , 5 :149 , 2021 |
| Abstract : Scheiner_2021_ChemPhotoChem_5_149 |
| ESTHER : Scheiner_2021_ChemPhotoChem_5_149 |
| PubMedSearch : Scheiner_2021_ChemPhotoChem_5_149 |
| PubMedID: |
| Title : N-1,2,3-triazole-isatin derivatives for cholinesterase and beta-amyloid aggregation inhibition: A comprehensive bioassay study - Marques_2020_Bioorg.Chem_98_103753 |
| Author(s) : Marques CS , Lopez O , Bagetta D , Carreiro EP , Petralla S , Bartolini M , Hoffmann M , Alcaro S , Monti B , Bolognesi ML , Decker M , Fernandez-Bolanos JG , Burke AJ |
| Ref : Bioorg Chem , 98 :103753 , 2020 |
| Abstract : Marques_2020_Bioorg.Chem_98_103753 |
| ESTHER : Marques_2020_Bioorg.Chem_98_103753 |
| PubMedSearch : Marques_2020_Bioorg.Chem_98_103753 |
| PubMedID: 32200328 |
| Title : Sterubin: Enantioresolution and Configurational Stability, Enantiomeric Purity in Nature, and Neuroprotective Activity in Vitro and in Vivo - Hofmann_2020_Chemistry_26_7299 |
| Author(s) : Hofmann J , Fayez S , Scheiner M , Hoffmann M , Oerter S , Appelt-Menzel A , Maher P , Maurice T , Bringmann G , Decker M |
| Ref : Chemistry , 26 :7299 , 2020 |
| Abstract : Hofmann_2020_Chemistry_26_7299 |
| ESTHER : Hofmann_2020_Chemistry_26_7299 |
| PubMedSearch : Hofmann_2020_Chemistry_26_7299 |
| PubMedID: 32358806 |
| Title : 7-O-Esters of taxifolin with pronounced and overadditive effects in neuroprotection, anti-neuroinflammation, and amelioration of short-term memory impairment in vivo - Gunesch_2020_Redox.Biol_29_101378 |
| Author(s) : Gunesch S , Hoffmann M , Kiermeier C , Fischer W , Pinto AFM , Maurice T , Maher P , Decker M |
| Ref : Redox Biol , 29 :101378 , 2020 |
| Abstract : Gunesch_2020_Redox.Biol_29_101378 |
| ESTHER : Gunesch_2020_Redox.Biol_29_101378 |
| PubMedSearch : Gunesch_2020_Redox.Biol_29_101378 |
| PubMedID: 31926632 |
| Title : Functionalized Cannabinoid Subtype 2 Receptor Ligands: Fluorescent, PET, Photochromic and Covalent Molecular Probes - Basagni_2020_ChemMedChem_15_1374 |
| Author(s) : Basagni F , Rosini M , Decker M |
| Ref : ChemMedChem , 15 :1374 , 2020 |
| Abstract : Basagni_2020_ChemMedChem_15_1374 |
| ESTHER : Basagni_2020_ChemMedChem_15_1374 |
| PubMedSearch : Basagni_2020_ChemMedChem_15_1374 |
| PubMedID: 32578963 |
| Title : Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands - Rodriguez-Soacha_2019_Eur.J.Med.Chem_180_690 |
| Author(s) : Rodriguez-Soacha DA , Scheiner M , Decker M |
| Ref : Eur Journal of Medicinal Chemistry , 180 :690 , 2019 |
| Abstract : Rodriguez-Soacha_2019_Eur.J.Med.Chem_180_690 |
| ESTHER : Rodriguez-Soacha_2019_Eur.J.Med.Chem_180_690 |
| PubMedSearch : Rodriguez-Soacha_2019_Eur.J.Med.Chem_180_690 |
| PubMedID: 31401465 |
| Title : Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model - Hoffmann_2019_J.Med.Chem_62_9116 |
| Author(s) : Hoffmann M , Stiller C , Endres E , Scheiner M , Gunesch S , Sotriffer C , Maurice T , Decker M |
| Ref : Journal of Medicinal Chemistry , 62 :9116 , 2019 |
| Abstract : Hoffmann_2019_J.Med.Chem_62_9116 |
| ESTHER : Hoffmann_2019_J.Med.Chem_62_9116 |
| PubMedSearch : Hoffmann_2019_J.Med.Chem_62_9116 |
| PubMedID: 31609115 |
| Title : Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo - Scheiner_2019_J.Med.Chem_62_9078 |
| Author(s) : Scheiner M , Dolles D , Gunesch S , Hoffmann M , Nabissi M , Marinelli O , Naldi M , Bartolini M , Petralla S , Poeta E , Monti B , Falkeis C , Vieth M , Hubner H , Gmeiner P , Maitra R , Maurice T , Decker M |
| Ref : Journal of Medicinal Chemistry , 62 :9078 , 2019 |
| Abstract : Scheiner_2019_J.Med.Chem_62_9078 |
| ESTHER : Scheiner_2019_J.Med.Chem_62_9078 |
| PubMedSearch : Scheiner_2019_J.Med.Chem_62_9078 |
| PubMedID: 31609608 |
| Title : Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles - Dolles_2018_J.Med.Chem_61_1646 |
| Author(s) : Dolles D , Hoffmann M , Gunesch S , Marinelli O , Moller J , Santoni G , Chatonnet A , Lohse MJ , Wittmann HJ , Strasser A , Nabissi M , Maurice T , Decker M |
| Ref : Journal of Medicinal Chemistry , 61 :1646 , 2018 |
| Abstract : Dolles_2018_J.Med.Chem_61_1646 |
| ESTHER : Dolles_2018_J.Med.Chem_61_1646 |
| PubMedSearch : Dolles_2018_J.Med.Chem_61_1646 |
| PubMedID: 29400965 |
| Title : Bitopic muscarinic agonists and antagonists and uses thereof: a patent evaluation of US20160136145A1 - Holzgrabe_2017_Expert.Opin.Ther.Pat_27_121 |
| Author(s) : Holzgrabe U , Decker M |
| Ref : Expert Opin Ther Pat , 27 :121 , 2017 |
| Abstract : Holzgrabe_2017_Expert.Opin.Ther.Pat_27_121 |
| ESTHER : Holzgrabe_2017_Expert.Opin.Ther.Pat_27_121 |
| PubMedSearch : Holzgrabe_2017_Expert.Opin.Ther.Pat_27_121 |
| PubMedID: 27967250 |
| Title : Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Abeta1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy - Dgachi_2016_ChemMedChem_11_1318 |
| Author(s) : Dgachi Y , Ismaili L , Knez D , Benchekroun M , Martin H , Szalaj N , Wehle S , Bautista-Aguilera OM , Luzet V , Bonnet A , Malawska B , Gobec S , Chioua M , Decker M , Chabchoub F , Marco-Contelles J |
| Ref : ChemMedChem , 11 :1318 , 2016 |
| Abstract : Dgachi_2016_ChemMedChem_11_1318 |
| ESTHER : Dgachi_2016_ChemMedChem_11_1318 |
| PubMedSearch : Dgachi_2016_ChemMedChem_11_1318 |
| PubMedID: 26804623 |
| Title : Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB2 R Ligands To Combat Neurodegenerative Disorders - Dolles_2016_ChemMedChem_11_1270 |
| Author(s) : Dolles D , Nimczick M , Scheiner M , Ramler J , Stadtmuller P , Sawatzky E , Drakopoulos A , Sotriffer C , Wittmann HJ , Strasser A , Decker M |
| Ref : ChemMedChem , 11 :1270 , 2016 |
| Abstract : Dolles_2016_ChemMedChem_11_1270 |
| ESTHER : Dolles_2016_ChemMedChem_11_1270 |
| PubMedSearch : Dolles_2016_ChemMedChem_11_1270 |
| PubMedID: 26548365 |
| Title : The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats - Sadek_2016_Physiol.Behav_165_383 |
| Author(s) : Sadek B , Khan N , Darras FH , Pockes S , Decker M |
| Ref : Physiol Behav , 165 :383 , 2016 |
| Abstract : Sadek_2016_Physiol.Behav_165_383 |
| ESTHER : Sadek_2016_Physiol.Behav_165_383 |
| PubMedSearch : Sadek_2016_Physiol.Behav_165_383 |
| PubMedID: 27568232 |
| Title : Experimental and theoretical investigations into the stability of cyclic aminals - Sawatzky_2016_Beilstein.J.Org.Chem_12_2280 |
| Author(s) : Sawatzky E , Drakopoulos A , Rolz M , Sotriffer C , Engels B , Decker M |
| Ref : Beilstein J Org Chem , 12 :2280 , 2016 |
| Abstract : Sawatzky_2016_Beilstein.J.Org.Chem_12_2280 |
| ESTHER : Sawatzky_2016_Beilstein.J.Org.Chem_12_2280 |
| PubMedSearch : Sawatzky_2016_Beilstein.J.Org.Chem_12_2280 |
| PubMedID: 28144295 |
| Title : A Novel Way To Radiolabel Human Butyrylcholinesterase for Positron Emission Tomography through Irreversible Transfer of the Radiolabeled Moiety - Sawatzky_2016_ChemMedChem_11_1540 |
| Author(s) : Sawatzky E , Al-Momani E , Kobayashi R , Higuchi T , Samnick S , Decker M |
| Ref : ChemMedChem , 11 :1540 , 2016 |
| Abstract : Sawatzky_2016_ChemMedChem_11_1540 |
| ESTHER : Sawatzky_2016_ChemMedChem_11_1540 |
| PubMedSearch : Sawatzky_2016_ChemMedChem_11_1540 |
| PubMedID: 27348083 |
| Title : Special Issue: Molecules against Alzheimer - Decker_2016_Molecules_21_ |
| Author(s) : Decker M , Munoz-Torrero D |
| Ref : Molecules , 21 : , 2016 |
| Abstract : Decker_2016_Molecules_21_ |
| ESTHER : Decker_2016_Molecules_21_ |
| PubMedSearch : Decker_2016_Molecules_21_ |
| PubMedID: 27999295 |
| Title : Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode - Sawatzky_2016_J.Med.Chem_59_2067 |
| Author(s) : Sawatzky E , Wehle S , Kling B , Wendrich J , Bringmann G , Sotriffer CA , Heilmann J , Decker M |
| Ref : Journal of Medicinal Chemistry , 59 :2067 , 2016 |
| Abstract : Sawatzky_2016_J.Med.Chem_59_2067 |
| ESTHER : Sawatzky_2016_J.Med.Chem_59_2067 |
| PubMedSearch : Sawatzky_2016_J.Med.Chem_59_2067 |
| PubMedID: 26886849 |
| Title : The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats - Khan_2015_Behav.Brain.Res_297_155 |
| Author(s) : Khan N , Saad A , Nurulain SM , Darras FH , Decker M , Sadek B |
| Ref : Behavioural Brain Research , 297 :155 , 2015 |
| Abstract : Khan_2015_Behav.Brain.Res_297_155 |
| ESTHER : Khan_2015_Behav.Brain.Res_297_155 |
| PubMedSearch : Khan_2015_Behav.Brain.Res_297_155 |
| PubMedID: 26467607 |
| Title : Novel tacrine-grafted ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic Acid hybrids - Benchekroun_2015_ChemMedChem_10_523 |
| Author(s) : Benchekroun M , Bartolini M , Egea J , Romero A , Soriano E , Pudlo M , Luzet V , Andrisano V , Jimeno ML , Lopez MG , Wehle S , Gharbi T , Refouvelet B , de Andres L , Herrera-Arozamena C , Monti B , Bolognesi ML , Rodriguez-Franco MI , Decker M , Marco-Contelles J , Ismaili L |
| Ref : ChemMedChem , 10 :523 , 2015 |
| Abstract : Benchekroun_2015_ChemMedChem_10_523 |
| ESTHER : Benchekroun_2015_ChemMedChem_10_523 |
| PubMedSearch : Benchekroun_2015_ChemMedChem_10_523 |
| PubMedID: 25537267 |
| Title : Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine - Huang_2014_Eur.J.Med.Chem_81C_15 |
| Author(s) : Huang G , Kling B , Darras FH , Heilmann J , Decker M |
| Ref : Eur Journal of Medicinal Chemistry , 81C :15 , 2014 |
| Abstract : Huang_2014_Eur.J.Med.Chem_81C_15 |
| ESTHER : Huang_2014_Eur.J.Med.Chem_81C_15 |
| PubMedSearch : Huang_2014_Eur.J.Med.Chem_81C_15 |
| PubMedID: 24819955 |
| Title : Synthesis, Biological Evaluation, and Computational Studies of Tri- and Tetracyclic Nitrogen-Bridgehead Compounds as Potent Dual-Acting AChE Inhibitors and hH3 Receptor Antagonists - Darras_2014_ACS.Chem.Neurosci_5_225 |
| Author(s) : Darras FH , Pockes S , Huang G , Wehle S , Strasser A , Wittmann HJ , Nimczick M , Sotriffer CA , Decker M |
| Ref : ACS Chem Neurosci , 5 :225 , 2014 |
| Abstract : Darras_2014_ACS.Chem.Neurosci_5_225 |
| ESTHER : Darras_2014_ACS.Chem.Neurosci_5_225 |
| PubMedSearch : Darras_2014_ACS.Chem.Neurosci_5_225 |
| PubMedID: 24422467 |
| Title : Acetylcholinesterase inhibitors with photoswitchable inhibition of beta-amyloid aggregation - Chen_2014_ACS.Chem.Neurosci_5_377 |
| Author(s) : Chen X , Wehle S , Kuzmanovic N , Merget B , Holzgrabe U , Konig B , Sotriffer CA , Decker M |
| Ref : ACS Chem Neurosci , 5 :377 , 2014 |
| Abstract : Chen_2014_ACS.Chem.Neurosci_5_377 |
| ESTHER : Chen_2014_ACS.Chem.Neurosci_5_377 |
| PubMedSearch : Chen_2014_ACS.Chem.Neurosci_5_377 |
| PubMedID: 24628027 |
| Title : Cyclic acyl guanidines bearing carbamate moieties allow potent and dirigible cholinesterase inhibition of either acetyl- or butyrylcholinesterase - Darras_2014_Bioorg.Med.Chem_22_5020 |
| Author(s) : Darras FH , Kling B , Sawatzky E , Heilmann J , Decker M |
| Ref : Bioorganic & Medicinal Chemistry , 22 :5020 , 2014 |
| Abstract : Darras_2014_Bioorg.Med.Chem_22_5020 |
| ESTHER : Darras_2014_Bioorg.Med.Chem_22_5020 |
| PubMedSearch : Darras_2014_Bioorg.Med.Chem_22_5020 |
| PubMedID: 25059502 |
| Title : Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with 'inverted' binding mode - Darras_2014_Bioorg.Med.Chem_22_4867 |
| Author(s) : Darras FH , Wehle S , Huang G , Sotriffer CA , Decker M |
| Ref : Bioorganic & Medicinal Chemistry , 22 :4867 , 2014 |
| Abstract : Darras_2014_Bioorg.Med.Chem_22_4867 |
| ESTHER : Darras_2014_Bioorg.Med.Chem_22_4867 |
| PubMedSearch : Darras_2014_Bioorg.Med.Chem_22_4867 |
| PubMedID: 25047936 |
| Title : Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer - Darras_2012_ACS.Med.Chem.Lett_3_914 |
| Author(s) : Darras FH , Kling B , Heilmann J , Decker M |
| Ref : ACS Med Chem Lett , 3 :914 , 2012 |
| Abstract : Darras_2012_ACS.Med.Chem.Lett_3_914 |
| ESTHER : Darras_2012_ACS.Med.Chem.Lett_3_914 |
| PubMedSearch : Darras_2012_ACS.Med.Chem.Lett_3_914 |
| PubMedID: 24900407 |
| Title : EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides - Decker_2012_J.Lipid.Res_53_2038 |
| Author(s) : Decker M , Adamska M , Cronin A , Di Giallonardo F , Burgener J , Marowsky A , Falck JR , Morisseau C , Hammock BD , Gruzdev A , Zeldin DC , Arand M |
| Ref : J Lipid Res , 53 :2038 , 2012 |
| Abstract : Decker_2012_J.Lipid.Res_53_2038 |
| ESTHER : Decker_2012_J.Lipid.Res_53_2038 |
| PubMedSearch : Decker_2012_J.Lipid.Res_53_2038 |
| PubMedID: 22798687 |
| Gene_locus related to this paper: human-EPHX3 , human-EPHX4 |
| Title : Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo - Chen_2012_J.Med.Chem_55_5231 |
| Author(s) : Chen X , Zenger K , Lupp A , Kling B , Heilmann J , Fleck C , Kraus B , Decker M |
| Ref : Journal of Medicinal Chemistry , 55 :5231 , 2012 |
| Abstract : Chen_2012_J.Med.Chem_55_5231 |
| ESTHER : Chen_2012_J.Med.Chem_55_5231 |
| PubMedSearch : Chen_2012_J.Med.Chem_55_5231 |
| PubMedID: 22624880 |
| Title : Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors - Chen_2011_Bioorg.Med.Chem_19_1222 |
| Author(s) : Chen X , Tikhonova IG , Decker M |
| Ref : Bioorganic & Medicinal Chemistry , 19 :1222 , 2011 |
| Abstract : Chen_2011_Bioorg.Med.Chem_19_1222 |
| ESTHER : Chen_2011_Bioorg.Med.Chem_19_1222 |
| PubMedSearch : Chen_2011_Bioorg.Med.Chem_19_1222 |
| PubMedID: 21232964 |
| Title : Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase - Cronin_2011_J.Lipid.Res_52_712 |
| Author(s) : Cronin A , Decker M , Arand M |
| Ref : J Lipid Res , 52 :712 , 2011 |
| Abstract : Cronin_2011_J.Lipid.Res_52_712 |
| ESTHER : Cronin_2011_J.Lipid.Res_52_712 |
| PubMedSearch : Cronin_2011_J.Lipid.Res_52_712 |
| PubMedID: 21217101 |
| Title : Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa - Macabeo_2011_Eur.J.Med.Chem_46_3118 |
| Author(s) : Macabeo AP , Vidar WS , Chen X , Decker M , Heilmann J , Wan B , Franzblau SG , Galvez EV , Aguinaldo MA , Cordell GA |
| Ref : Eur Journal of Medicinal Chemistry , 46 :3118 , 2011 |
| Abstract : Macabeo_2011_Eur.J.Med.Chem_46_3118 |
| ESTHER : Macabeo_2011_Eur.J.Med.Chem_46_3118 |
| PubMedSearch : Macabeo_2011_Eur.J.Med.Chem_46_3118 |
| PubMedID: 21546135 |
| Title : Bivalent 5,8,9,13b-tetrahydro-6H-isoquino[1,2-a]isoquinolines and -isoquinolinium salts: novel heterocyclic templates for butyrylcholinesterase inhibitors - Schulze_2010_Bioorg.Med.Chem.Lett_20_2946 |
| Author(s) : Schulze M , Siol O , Decker M , Lehmann J |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :2946 , 2010 |
| Abstract : Schulze_2010_Bioorg.Med.Chem.Lett_20_2946 |
| ESTHER : Schulze_2010_Bioorg.Med.Chem.Lett_20_2946 |
| PubMedSearch : Schulze_2010_Bioorg.Med.Chem.Lett_20_2946 |
| PubMedID: 20350808 |
| Title : Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors - Fang_2010_J.Med.Chem_53_2094 |
| Author(s) : Fang L , Jumpertz S , Zhang Y , Appenroth D , Fleck C , Mohr K , Trankle C , Decker M |
| Ref : Journal of Medicinal Chemistry , 53 :2094 , 2010 |
| Abstract : Fang_2010_J.Med.Chem_53_2094 |
| ESTHER : Fang_2010_J.Med.Chem_53_2094 |
| PubMedSearch : Fang_2010_J.Med.Chem_53_2094 |
| PubMedID: 20158205 |
| Title : Mammalian epoxide hydrolases in xenobiotic metabolism and signalling - Decker_2009_Arch.Toxicol_83_297 |
| Author(s) : Decker M , Arand M , Cronin A |
| Ref : Archives of Toxicology , 83 :297 , 2009 |
| Abstract : Decker_2009_Arch.Toxicol_83_297 |
| ESTHER : Decker_2009_Arch.Toxicol_83_297 |
| PubMedSearch : Decker_2009_Arch.Toxicol_83_297 |
| PubMedID: 19340413 |
| Title : Decremental response to high-frequency trains of acetylcholine pulses but unaltered fractional Ca2+ currents in a panel of slow-channel syndrome nicotinic receptor mutants - Elenes_2009_J.Gen.Physiol_133_151 |
| Author(s) : Elenes S , Decker M , Cymes GD , Grosman C |
| Ref : Journal of General Physiology , 133 :151 , 2009 |
| Abstract : Elenes_2009_J.Gen.Physiol_133_151 |
| ESTHER : Elenes_2009_J.Gen.Physiol_133_151 |
| PubMedSearch : Elenes_2009_J.Gen.Physiol_133_151 |
| PubMedID: 19171769 |
| Title : Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties - Decker_2008_Bioorg.Med.Chem_16_4252 |
| Author(s) : Decker M , Kraus B , Heilmann J |
| Ref : Bioorganic & Medicinal Chemistry , 16 :4252 , 2008 |
| Abstract : Decker_2008_Bioorg.Med.Chem_16_4252 |
| ESTHER : Decker_2008_Bioorg.Med.Chem_16_4252 |
| PubMedSearch : Decker_2008_Bioorg.Med.Chem_16_4252 |
| PubMedID: 18343673 |
| Title : NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity - Fang_2008_J.Med.Chem_51_7666 |
| Author(s) : Fang L , Appenroth D , Decker M , Kiehntopf M , Lupp A , Peng S , Fleck C , Zhang Y , Lehmann J |
| Ref : Journal of Medicinal Chemistry , 51 :7666 , 2008 |
| Abstract : Fang_2008_J.Med.Chem_51_7666 |
| ESTHER : Fang_2008_J.Med.Chem_51_7666 |
| PubMedSearch : Fang_2008_J.Med.Chem_51_7666 |
| PubMedID: 19053746 |
| Title : Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates - Fang_2008_J.Med.Chem_51_713 |
| Author(s) : Fang L , Appenroth D , Decker M , Kiehntopf M , Roegler C , Deufel T , Fleck C , Peng S , Zhang Y , Lehmann J |
| Ref : Journal of Medicinal Chemistry , 51 :713 , 2008 |
| Abstract : Fang_2008_J.Med.Chem_51_713 |
| ESTHER : Fang_2008_J.Med.Chem_51_713 |
| PubMedSearch : Fang_2008_J.Med.Chem_51_713 |
| PubMedID: 18232655 |
| Title : Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates - Fang_2008_Bioorg.Med.Chem.Lett_18_2905 |
| Author(s) : Fang L , Kraus B , Lehmann J , Heilmann J , Zhang Y , Decker M |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :2905 , 2008 |
| Abstract : Fang_2008_Bioorg.Med.Chem.Lett_18_2905 |
| ESTHER : Fang_2008_Bioorg.Med.Chem.Lett_18_2905 |
| PubMedSearch : Fang_2008_Bioorg.Med.Chem.Lett_18_2905 |
| PubMedID: 18406135 |
| Title : A new way of data interpretation for cognition tests in rats used to characterise six choline esterase inhibitors with heterocyclic nitrogen bridgehead structure. Application in Alzheimer therapy - Fleck_2008_Arzneimittelforschung_58_543 |
| Author(s) : Fleck C , Appenroth D , Decker M , Lehmann J |
| Ref : Arzneimittelforschung , 58 :543 , 2008 |
| Abstract : Fleck_2008_Arzneimittelforschung_58_543 |
| ESTHER : Fleck_2008_Arzneimittelforschung_58_543 |
| PubMedSearch : Fleck_2008_Arzneimittelforschung_58_543 |
| PubMedID: 19137904 |
| Title : Recent advances in the development of hybrid molecules\/designed multiple compounds with antiamnesic properties - Decker_2007_Mini.Rev.Med.Chem_7_221 |
| Author(s) : Decker M |
| Ref : Mini Rev Med Chem , 7 :221 , 2007 |
| Abstract : Decker_2007_Mini.Rev.Med.Chem_7_221 |
| ESTHER : Decker_2007_Mini.Rev.Med.Chem_7_221 |
| PubMedSearch : Decker_2007_Mini.Rev.Med.Chem_7_221 |
| PubMedID: 17346215 |
| Title : 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors - Schott_2006_Bioorg.Med.Chem.Lett_16_5840 |
| Author(s) : Schott Y , Decker M , Rommelspacher H , Lehmann J |
| Ref : Bioorganic & Medicinal Chemistry Lett , 16 :5840 , 2006 |
| Abstract : Schott_2006_Bioorg.Med.Chem.Lett_16_5840 |
| ESTHER : Schott_2006_Bioorg.Med.Chem.Lett_16_5840 |
| PubMedSearch : Schott_2006_Bioorg.Med.Chem.Lett_16_5840 |
| PubMedID: 16945529 |
| Title : Homobivalent quinazolinimines as novel nanomolar inhibitors of cholinesterases with dirigible selectivity toward butyrylcholinesterase - Decker_2006_J.Med.Chem_49_5411 |
| Author(s) : Decker M |
| Ref : Journal of Medicinal Chemistry , 49 :5411 , 2006 |
| Abstract : Decker_2006_J.Med.Chem_49_5411 |
| ESTHER : Decker_2006_J.Med.Chem_49_5411 |
| PubMedSearch : Decker_2006_J.Med.Chem_49_5411 |
| PubMedID: 16942014 |
| Title : Novel tricyclic quinazolinimines and related tetracyclic nitrogen bridgehead compounds as cholinesterase inhibitors with selectivity towards butyrylcholinesterase - Decker_2006_Bioorg.Med.Chem_14_1966 |
| Author(s) : Decker M , Krauth F , Lehmann J |
| Ref : Bioorganic & Medicinal Chemistry , 14 :1966 , 2006 |
| Abstract : Decker_2006_Bioorg.Med.Chem_14_1966 |
| ESTHER : Decker_2006_Bioorg.Med.Chem_14_1966 |
| PubMedSearch : Decker_2006_Bioorg.Med.Chem_14_1966 |
| PubMedID: 16289855 |
| Title : Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpine - Decker_2005_Eur.J.Med.Chem_40_305 |
| Author(s) : Decker M |
| Ref : Eur Journal of Medicinal Chemistry , 40 :305 , 2005 |
| Abstract : Decker_2005_Eur.J.Med.Chem_40_305 |
| ESTHER : Decker_2005_Eur.J.Med.Chem_40_305 |
| PubMedSearch : Decker_2005_Eur.J.Med.Chem_40_305 |
| PubMedID: 15725500 |