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Author Report for: De Simone A

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    Title: Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease
    Fernandes F, Barroso MF, De Simone A, Emrikova E, Dias-Teixeira M, Pereira JP, Chlebek J, Fernandes VC, Rodrigues F and Grosso C <2 more author(s)>
    Ref: J Ethnopharmacol, 290:115107, 2022 : PubMed


    Title: (+/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease
    Ismaili L, Monnin J, Etievant A, Arribas RL, Viejo L, Refouvelet B, Soukup O, Janockova J, Hepnarova V and Haffen E <12 more author(s)>
    Ref: ACS Chem Neurosci, :, 2021 : PubMed


    Title: From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects
    Pont C, Ginex T, Grinan-Ferre C, Scheiner M, Mattellone A, Martinez N, Arce EM, Soriano-Fernandez Y, Naldi M and Munoz-Torrero D <13 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 225:113779, 2021 : PubMed


    Title: Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice
    Viayna E, Coquelle N, Cieslikiewicz-Bouet M, Cisternas P, Oliva CA, Sanchez-Lopez E, Ettcheto M, Bartolini M, De Simone A and Munoz-Torrero D <16 more author(s)>
    Ref: Journal of Medicinal Chemistry, 64:812, 2021 : PubMed


    Title: Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6
    Perez-Areales FJ, Garrido M, Aso E, Bartolini M, De Simone A, Espargaro A, Ginex T, Sabate R, Perez B and Munoz-Torrero D <9 more author(s)>
    Ref: Journal of Medicinal Chemistry, 63:9360, 2020 : PubMed


    Title: Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer's disease
    Perinova R, Maafi N, Korabecny J, Kohelova E, De Simone A, Al Mamun A, Hulcova D, Markova J, Kucera T and Cahlikova L <8 more author(s)>
    Ref: Bioorg Chem, 100:103928, 2020 : PubMed


    Title: Advanced analytical methodologies in Alzheimer's disease drug discovery
    De Simone A, Naldi M, Tedesco D, Bartolini M, Davani L, Andrisano V
    Ref: J Pharm Biomed Anal, 178:112899, 2019 : PubMed


    Title: Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease
    Hulcova D, Marikova J, Korabecny J, Hostalkova A, Jun D, Kunes J, Chlebek J, Opletal L, De Simone A and Cahlikova L <3 more author(s)>
    Ref: Phytochemistry, 165:112055, 2019 : PubMed


    Title: Derivatives of the beta-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer's Disease
    Kohelova E, Perinova R, Maafi N, Korabecny J, Hulcova D, Marikova J, Kucera T, Martinez Gonzalez L, Hrabinova M and Cahlikova L <4 more author(s)>
    Ref: Molecules, 24:, 2019 : PubMed


    Title: A novel class of multitarget anti-Alzheimer benzohomoadamantanechlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors
    Perez-Areales FJ, Turcu AL, Barniol-Xicota M, Pont C, Pivetta D, Espargaro A, Bartolini M, De Simone A, Andrisano V and Munoz-Torrero D <4 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 180:613, 2019 : PubMed


    Title: A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017
    Andrisano V, Naldi M, De Simone A, Bartolini M
    Ref: Expert Opin Ther Pat, 28:455, 2018 : PubMed


    Title: Tacrine-based Multifunctional Agents in Alzheimer's Disease: An Old Story in Continuous Development section sign
    Milelli A, De Simone A, Ticchi N, Chen HH, Betari N, Andrisano V, Tumiatti V
    Ref: Curr Med Chem, 24:3522, 2017 : PubMed


    Title: Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids
    Perez-Areales FJ, Betari N, Viayna A, Pont C, Espargaro A, Bartolini M, De Simone A, Rinaldi Alvarenga JF, Perez B and Munoz-Torrero D <4 more author(s)>
    Ref: Future Med Chem, 9:965, 2017 : PubMed


    Title: Uleine Disrupts Key Enzymatic and Non-Enzymatic Biomarkers that Leads to Alzheimer's Disease
    Seidl C, de Moraes Santos CA, De Simone A, Bartolini M, Weffort-Santos AM, Andrisano V
    Ref: Curr Alzheimer Res, 14:317, 2017 : PubMed


    Title: Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets
    Chlebek J, De Simone A, Hostalkova A, Opletal L, Perez C, Perez DI, Havlikova L, Cahlikova L, Andrisano V
    Ref: Fitoterapia, 109:241, 2016 : PubMed


    Title: Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography
    Zha X, Lamba D, Zhang L, Lou Y, Xu C, Kang D, Chen L, Xu Y, De Simone A and Bartolini M <6 more author(s)>
    Ref: Journal of Medicinal Chemistry, 59:114, 2016 : PubMed


    Title: Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease
    Belluti F, De Simone A, Tarozzi A, Bartolini M, Djemil A, Bisi A, Gobbi S, Montanari S, Cavalli A and Rampa A <2 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 78C:157, 2014 : PubMed


    Title: Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents
    Viayna E, Sola I, Bartolini M, De Simone A, Tapia-Rojas C, Serrano FG, Sabate R, Juarez-Jimenez J, Perez B and Munoz-Torrero D <4 more author(s)>
    Ref: Journal of Medicinal Chemistry, 57:2549, 2014 : PubMed


    Title: Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease
    Prati F, Bartolini M, Simoni E, De Simone A, Pinto A, Andrisano V, Bolognesi ML
    Ref: Bioorganic & Medicinal Chemistry Lett, 23:6254, 2013 : PubMed


    Title: Reversible human serum albumin binding of lipocrine: a circular dichroism study
    Bertucci C, De Simone A, Pistolozzi M, Rosini M
    Ref: Chirality, 23:827, 2011 : PubMed


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