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| Title : Advances in prodrug design for Alzheimer's disease: the state of the art - Travers-Lesage_2022_Expert.Opin.Drug.Discov_17_325 |
| Author(s) : Travers-Lesage V , Mignani SM , Dallemagne P , Rochais C |
| Ref : Expert Opin Drug Discov , 17 :325 , 2022 |
| Abstract : Travers-Lesage_2022_Expert.Opin.Drug.Discov_17_325 |
| ESTHER : Travers-Lesage_2022_Expert.Opin.Drug.Discov_17_325 |
| PubMedSearch : Travers-Lesage_2022_Expert.Opin.Drug.Discov_17_325 |
| PubMedID: 35089846 |
| Title : Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca(2+) Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation - Malek_2022_Molecules_28_ |
| Author(s) : Malek R , Simakov A , Davis A , Maj M , Bernard PJ , Wnorowski A , Martin H , Marco-Contelles J , Chabchoub F , Dallemagne P , Rochais C , Jozwiak K , Ismaili L |
| Ref : Molecules , 28 : , 2022 |
| Abstract : Malek_2022_Molecules_28_ |
| ESTHER : Malek_2022_Molecules_28_ |
| PubMedSearch : Malek_2022_Molecules_28_ |
| PubMedID: 36615267 |
| Title : Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer's Disease Treatment through Rigidification Strategy - Lecoutey_2021_Molecules_26_ |
| Author(s) : Lecoutey C , Legay R , Davis A , Sopkova-de Oliveira Santos J , Dallemagne P , Rochais C |
| Ref : Molecules , 26 : , 2021 |
| Abstract : Lecoutey_2021_Molecules_26_ |
| ESTHER : Lecoutey_2021_Molecules_26_ |
| PubMedSearch : Lecoutey_2021_Molecules_26_ |
| PubMedID: 33926141 |
| Title : Active Targeted Nanoemulsions for Repurposing of Tegaserod in Alzheimer's Disease Treatment - Seguy_2021_Pharmaceutics_13_ |
| Author(s) : Seguy L , Guyon L , Maurel M , Verdie P , Davis A , Corvaisier S , Lisowski V , Dallemagne P , Groo AC , Malzert-Freon A |
| Ref : Pharmaceutics , 13 : , 2021 |
| Abstract : Seguy_2021_Pharmaceutics_13_ |
| ESTHER : Seguy_2021_Pharmaceutics_13_ |
| PubMedSearch : Seguy_2021_Pharmaceutics_13_ |
| PubMedID: 34683919 |
| Title : Disproportionality analysis in VigiBase as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease - Chretien_2021_Br.J.Clin.Pharmacol_87_2830 |
| Author(s) : Chretien B , Jourdan JP , Davis A , Fedrizzi S , Bureau R , Sassier M , Rochais C , Alexandre J , Lelong-Boulouard V , Dolladille C , Dallemagne P |
| Ref : British Journal of Clinical Pharmacology , 87 :2830 , 2021 |
| Abstract : Chretien_2021_Br.J.Clin.Pharmacol_87_2830 |
| ESTHER : Chretien_2021_Br.J.Clin.Pharmacol_87_2830 |
| PubMedSearch : Chretien_2021_Br.J.Clin.Pharmacol_87_2830 |
| PubMedID: 33274491 |
| Title : Donecopride, a Swiss army knife with potential against Alzheimer's disease - Rochais_2020_Br.J.Pharmacol_177_1988 |
| Author(s) : Rochais C , Lecoutey C , Hamidouche K , Giannoni P , Gaven F , Cem E , Mignani S , Baranger K , Freret T , Bockaert J , Rivera S , Boulouard M , Dallemagne P , Claeysen S |
| Ref : British Journal of Pharmacology , 177 :1988 , 2020 |
| Abstract : Rochais_2020_Br.J.Pharmacol_177_1988 |
| ESTHER : Rochais_2020_Br.J.Pharmacol_177_1988 |
| PubMedSearch : Rochais_2020_Br.J.Pharmacol_177_1988 |
| PubMedID: 31881553 |
| Title : Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer's Disease Treatment - Adnet_2020_Pharmaceutics_12_ |
| Author(s) : Adnet T , Groo AC , Picard C , Davis A , Corvaisier S , Since M , Bounoure F , Rochais C , Pluart LL , Dallemagne P , Malzert-Freon A |
| Ref : Pharmaceutics , 12 : , 2020 |
| Abstract : Adnet_2020_Pharmaceutics_12_ |
| ESTHER : Adnet_2020_Pharmaceutics_12_ |
| PubMedSearch : Adnet_2020_Pharmaceutics_12_ |
| PubMedID: 32168767 |
| Title : First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer's Disease - Guieu_2020_Molecules_26_ |
| Author(s) : Guieu B , Lecoutey C , Legay R , Davis A , Sopkova de Oliveira Santos J , Altomare CD , Catto M , Rochais C , Dallemagne P |
| Ref : Molecules , 26 : , 2020 |
| Abstract : Guieu_2020_Molecules_26_ |
| ESTHER : Guieu_2020_Molecules_26_ |
| PubMedSearch : Guieu_2020_Molecules_26_ |
| PubMedID: 33375412 |
| Title : Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT(6) receptor antagonist with therapeutic interest in Alzheimer's disease - Toublet_2020_Eur.J.Med.Chem_210_113059 |
| Author(s) : Toublet FX , Lalut J , Hatat B , Lecoutey C , Davis A , Since M , Corvaisier S , Freret T , Sopkova-de Oliveira Santos J , Claeysen S , Boulouard M , Dallemagne P , Rochais C |
| Ref : Eur Journal of Medicinal Chemistry , 210 :113059 , 2020 |
| Abstract : Toublet_2020_Eur.J.Med.Chem_210_113059 |
| ESTHER : Toublet_2020_Eur.J.Med.Chem_210_113059 |
| PubMedSearch : Toublet_2020_Eur.J.Med.Chem_210_113059 |
| PubMedID: 33310288 |
| Title : Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer's disease - Lalut_2020_Sci.Rep_10_3014 |
| Author(s) : Lalut J , Payan H , Davis A , Lecoutey C , Legay R , Sopkova-de Oliveira Santos J , Claeysen S , Dallemagne P , Rochais C |
| Ref : Sci Rep , 10 :3014 , 2020 |
| Abstract : Lalut_2020_Sci.Rep_10_3014 |
| ESTHER : Lalut_2020_Sci.Rep_10_3014 |
| PubMedSearch : Lalut_2020_Sci.Rep_10_3014 |
| PubMedID: 32080261 |
| Title : A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer's Disease - Hatat_2019_Front.Aging.Neurosci_11_148 |
| Author(s) : Hatat B , Yahiaoui S , Lecoutey C , Davis A , Freret T , Boulouard M , Claeysen S , Rochais C , Dallemagne P |
| Ref : Front Aging Neurosci , 11 :148 , 2019 |
| Abstract : Hatat_2019_Front.Aging.Neurosci_11_148 |
| ESTHER : Hatat_2019_Front.Aging.Neurosci_11_148 |
| PubMedSearch : Hatat_2019_Front.Aging.Neurosci_11_148 |
| PubMedID: 31316368 |
| Title : New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease - Sergeant_2019_Neurobiol.Dis_129_217 |
| Author(s) : Sergeant N , Vingtdeux V , Eddarkaoui S , Gay M , Evrard C , Le Fur N , Laurent C , Caillierez R , Obriot H , Larchanche PE , Farce A , Coevoet M , Carato P , Kouach M , Descat A , Dallemagne P , Buee-Scherrer V , Blum D , Hamdane M , Buee L , Melnyk P |
| Ref : Neurobiol Dis , 129 :217 , 2019 |
| Abstract : Sergeant_2019_Neurobiol.Dis_129_217 |
| ESTHER : Sergeant_2019_Neurobiol.Dis_129_217 |
| PubMedSearch : Sergeant_2019_Neurobiol.Dis_129_217 |
| PubMedID: 30928644 |
| Title : Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease - Toublet_2019_Molecules_24_ |
| Author(s) : Toublet FX , Lecoutey C , Lalut J , Hatat B , Davis A , Since M , Corvaisier S , Freret T , Sopkova de Oliveira Santos J , Claeysen S , Boulouard M , Dallemagne P , Rochais C |
| Ref : Molecules , 24 : , 2019 |
| Abstract : Toublet_2019_Molecules_24_ |
| ESTHER : Toublet_2019_Molecules_24_ |
| PubMedSearch : Toublet_2019_Molecules_24_ |
| PubMedID: 31370232 |
| Title : Novel multitarget-directed ligands targeting acetylcholinesterase and sigma1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase - Lalut_2019_Eur.J.Med.Chem_162_234 |
| Author(s) : Lalut J , Santoni G , Karila D , Lecoutey C , Davis A , Nachon F , Silman I , Sussman JL , Weik M , Maurice T , Dallemagne P , Rochais C |
| Ref : Eur Journal of Medicinal Chemistry , 162 :234 , 2019 |
| Abstract : Lalut_2019_Eur.J.Med.Chem_162_234 |
| ESTHER : Lalut_2019_Eur.J.Med.Chem_162_234 |
| PubMedSearch : Lalut_2019_Eur.J.Med.Chem_162_234 |
| PubMedID: 30447434 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Synthesis and biological evaluation of pyrano[4,3-b][1]benzopyranone derivatives as monoamine oxidase and cholinesterase inhibitors - Lecoutey_2012_MedChemComm_3_627 |
| Author(s) : Lecoutey C , Rochais C , Genest D , Butt-Gueulle S , Ballandonne C , Corvaisier S , Dulin F , Lepailleur A , Sopkova-de , Dallemagne P |
| Ref : Medchemcomm , 33 :627 , 2018 |
| Abstract : Lecoutey_2012_MedChemComm_3_627 |
| ESTHER : Lecoutey_2012_MedChemComm_3_627 |
| PubMedSearch : Lecoutey_2012_MedChemComm_3_627 |
| PubMedID: |
| Title : Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment - Jourdan_2017_ChemMedChem_12_913 |
| Author(s) : Jourdan JP , Since M , El Kihel L , Lecoutey C , Corvaisier S , Legay R , Sopkova-de Oliveira Santos J , Cresteil T , Malzert-Freon A , Rochais C , Dallemagne P |
| Ref : ChemMedChem , 12 :913 , 2017 |
| Abstract : Jourdan_2017_ChemMedChem_12_913 |
| ESTHER : Jourdan_2017_ChemMedChem_12_913 |
| PubMedSearch : Jourdan_2017_ChemMedChem_12_913 |
| PubMedID: 28342294 |
| Title : Modulating 5-HT4 and 5-HT6 receptors in Alzheimer's disease treatment - Lalut_2017_Future.Med.Chem_9_781 |
| Author(s) : Lalut J , Karila D , Dallemagne P , Rochais C |
| Ref : Future Med Chem , 9 :781 , 2017 |
| Abstract : Lalut_2017_Future.Med.Chem_9_781 |
| ESTHER : Lalut_2017_Future.Med.Chem_9_781 |
| PubMedSearch : Lalut_2017_Future.Med.Chem_9_781 |
| PubMedID: 28504917 |
| Title : Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer's disease - Yahiaoui_2016_Eur.J.Med.Chem_121_283 |
| Author(s) : Yahiaoui S , Hamidouche K , Ballandonne C , Davis A , de Oliveira Santos JS , Freret T , Boulouard M , Rochais C , Dallemagne P |
| Ref : Eur Journal of Medicinal Chemistry , 121 :283 , 2016 |
| Abstract : Yahiaoui_2016_Eur.J.Med.Chem_121_283 |
| ESTHER : Yahiaoui_2016_Eur.J.Med.Chem_121_283 |
| PubMedSearch : Yahiaoui_2016_Eur.J.Med.Chem_121_283 |
| PubMedID: 27266998 |
| Title : Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment - Jourdan_2016_Eur.J.Med.Chem_114_365 |
| Author(s) : Jourdan JP , Since M , El Kihel L , Lecoutey C , Corvaisier S , Legay R , Sopkova-de Oliveira Santos J , Cresteil T , Malzert-Freon A , Rochais C , Dallemagne P |
| Ref : Eur Journal of Medicinal Chemistry , 114 :365 , 2016 |
| Abstract : Jourdan_2016_Eur.J.Med.Chem_114_365 |
| ESTHER : Jourdan_2016_Eur.J.Med.Chem_114_365 |
| PubMedSearch : Jourdan_2016_Eur.J.Med.Chem_114_365 |
| PubMedID: 27046230 |
| Title : Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography - Lalut_2016_Eur.J.Med.Chem_116_90 |
| Author(s) : Lalut J , Tournier BB , Cailly T , Lecoutey C , Corvaisier S , Davis A , Ballandonne C , Since M , Millet P , Fabis F , Dallemagne P , Rochais C |
| Ref : Eur Journal of Medicinal Chemistry , 116 :90 , 2016 |
| Abstract : Lalut_2016_Eur.J.Med.Chem_116_90 |
| ESTHER : Lalut_2016_Eur.J.Med.Chem_116_90 |
| PubMedSearch : Lalut_2016_Eur.J.Med.Chem_116_90 |
| PubMedID: 27060761 |
| Title : Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride - Rochais_2015_J.Med.Chem_58_3172 |
| Author(s) : Rochais C , Lecoutey C , Gaven F , Giannoni P , Hamidouche K , Hedou D , Dubost E , Genest D , Yahiaoui S , Freret T , Bouet V , Dauphin F , Sopkova de Oliveira Santos J , Ballandonne C , Corvaisier S , Malzert-Freon A , Legay R , Boulouard M , Claeysen S , Dallemagne P |
| Ref : Journal of Medicinal Chemistry , 58 :3172 , 2015 |
| Abstract : Rochais_2015_J.Med.Chem_58_3172 |
| ESTHER : Rochais_2015_J.Med.Chem_58_3172 |
| PubMedSearch : Rochais_2015_J.Med.Chem_58_3172 |
| PubMedID: 25793650 |
| Title : Therapeutic Potential of 5-HT6 Receptor Agonists - Karila_2015_J.Med.Chem_58_7901 |
| Author(s) : Karila D , Freret T , Bouet V , Boulouard M , Dallemagne P , Rochais C |
| Ref : Journal of Medicinal Chemistry , 58 :7901 , 2015 |
| Abstract : Karila_2015_J.Med.Chem_58_7901 |
| ESTHER : Karila_2015_J.Med.Chem_58_7901 |
| PubMedSearch : Karila_2015_J.Med.Chem_58_7901 |
| PubMedID: 26099069 |
| Title : Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances - Quiedeville_2015_Behav.Brain.Res_293_10 |
| Author(s) : Quiedeville A , Boulouard M , Hamidouche K , Da Silva Costa-Aze V , Nee G , Rochais C , Dallemagne P , Fabis F , Freret T , Bouet V |
| Ref : Behavioural Brain Research , 293 :10 , 2015 |
| Abstract : Quiedeville_2015_Behav.Brain.Res_293_10 |
| ESTHER : Quiedeville_2015_Behav.Brain.Res_293_10 |
| PubMedSearch : Quiedeville_2015_Behav.Brain.Res_293_10 |
| PubMedID: 26187692 |
| Title : Design of donecopride, a dual serotonin subtype 4 receptor agonist\/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment - Lecoutey_2014_Proc.Natl.Acad.Sci.U.S.A_111_E3825 |
| Author(s) : Lecoutey C , Hedou D , Freret T , Giannoni P , Gaven F , Since M , Bouet V , Ballandonne C , Corvaisier S , Malzert Freon A , Mignani S , Cresteil T , Boulouard M , Claeysen S , Rochais C , Dallemagne P |
| Ref : Proc Natl Acad Sci U S A , 111 :E3825 , 2014 |
| Abstract : Lecoutey_2014_Proc.Natl.Acad.Sci.U.S.A_111_E3825 |
| ESTHER : Lecoutey_2014_Proc.Natl.Acad.Sci.U.S.A_111_E3825 |
| PubMedSearch : Lecoutey_2014_Proc.Natl.Acad.Sci.U.S.A_111_E3825 |
| PubMedID: 25157130 |
| Title : Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice - Freret_2012_Behav.Brain.Res_230_304 |
| Author(s) : Freret T , Bouet V , Quiedeville A , Nee G , Dallemagne P , Rochais C , Boulouard M |
| Ref : Behavioural Brain Research , 230 :304 , 2012 |
| Abstract : Freret_2012_Behav.Brain.Res_230_304 |
| ESTHER : Freret_2012_Behav.Brain.Res_230_304 |
| PubMedSearch : Freret_2012_Behav.Brain.Res_230_304 |
| PubMedID: 22348892 |
| Title : Virtual screening discovery of new acetylcholinesterase inhibitors issued from CERMN chemical library - Sopkova-de_2010_J.Chem.Inf.Model_50_422 |
| Author(s) : Sopkova-de Oliveira Santos J , Lesnard A , Agondanou JH , Dupont N , Godard AM , Stiebing S , Rochais C , Fabis F , Dallemagne P , Bureau R , Rault S |
| Ref : J Chem Inf Model , 50 :422 , 2010 |
| Abstract : Sopkova-de_2010_J.Chem.Inf.Model_50_422 |
| ESTHER : Sopkova-de_2010_J.Chem.Inf.Model_50_422 |
| PubMedSearch : Sopkova-de_2010_J.Chem.Inf.Model_50_422 |
| PubMedID: 20196555 |
| Title : Synthesis and preliminary in vivo evaluation of new 2-Aryl-6-methyl-1,2-dihydro-1H-pyridin-4-ones and 2-Aryl-6-methylpiperidin-4-ols, as potential anti-amnesiant agents - Leflemme_2005_J.Enzyme.Inhib.Med.Chem_20_551 |
| Author(s) : Leflemme N , Freret T , Boulouard M , Dallemagne P , Rault S |
| Ref : J Enzyme Inhib Med Chem , 20 :551 , 2005 |
| Abstract : Leflemme_2005_J.Enzyme.Inhib.Med.Chem_20_551 |
| ESTHER : Leflemme_2005_J.Enzyme.Inhib.Med.Chem_20_551 |
| PubMedSearch : Leflemme_2005_J.Enzyme.Inhib.Med.Chem_20_551 |
| PubMedID: 16408790 |
| Title : Synthesis and biological evaluation as AChE inhibitors of new indanones and thiaindanones related to donepezil - Omran_2005_Eur.J.Med.Chem_40_1222 |
| Author(s) : Omran Z , Cailly T , Lescot E , Santos JS , Agondanou JH , Lisowski V , Fabis F , Godard AM , Stiebing S , Le Flem G , Boulouard M , Dauphin F , Dallemagne P , Rault S |
| Ref : Eur Journal of Medicinal Chemistry , 40 :1222 , 2005 |
| Abstract : Omran_2005_Eur.J.Med.Chem_40_1222 |
| ESTHER : Omran_2005_Eur.J.Med.Chem_40_1222 |
| PubMedSearch : Omran_2005_Eur.J.Med.Chem_40_1222 |
| PubMedID: 16137794 |