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Author Report for: Dale HH

Contact information:

Sir Dale Henry Hallett
Department of Biochemistry and Pharmacology at the National Institute for Medical Research London
United Kingdom
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Sir Henry Hallett Dale, (9 June 1875 - 23 July 1968) was an English pharmacologist and physiologist. For his study of acetylcholine as agent in the chemical transmission of nerve impulses (neurotransmission) he shared the 1936 Nobel Prize in Physiology or Medicine with Otto Loewi. He first extracted Acetylcholine from an ergot fungus Claviceps purpurea in 1914. Dale showed that some of the peripheral action of acetylcholine resembled those of muscarine (smooth musle, heart, and gland cells and these actions were sensitive to atropine) others those of nicotine (sympathetic and parasympethetic ganglia, adrenal medulla) He predicted the presence of a cholinesterase in blood. Loewi had shown in 1926 that nerves produce neurotransmitter called then -vagusstoff- (released from the vagus nerve). In 1929 Dale and Dudley extracted ACh from bovine and horse spleen and in 1936 Dale showed that ACh is liberated from motoneurones.

(only selected references for ESTHER. Possibly more references in PubMed. Beware of homonymes. This author worked on 0 Gene_locus.)

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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