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| Title : alpha4beta2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties - Mineur_2011_Behav.Pharmacol_22_291 |
| Author(s) : Mineur YS , Einstein EB , Seymour PA , Coe JW , O'Neill B T , Rollema H , Picciotto MR |
| Ref : Behav Pharmacol , 22 :291 , 2011 |
| Abstract : Mineur_2011_Behav.Pharmacol_22_291 |
| ESTHER : Mineur_2011_Behav.Pharmacol_22_291 |
| PubMedSearch : Mineur_2011_Behav.Pharmacol_22_291 |
| PubMedID: 21566524 |
| Title : Partial agonists of the alpha3beta4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats - Chatterjee_2011_Neuropsychopharmacology_36_603 |
| Author(s) : Chatterjee S , Steensland P , Simms JA , Holgate J , Coe JW , Hurst RS , Shaffer CL , Lowe J , Rollema H , Bartlett SE |
| Ref : Neuropsychopharmacology , 36 :603 , 2011 |
| Abstract : Chatterjee_2011_Neuropsychopharmacology_36_603 |
| ESTHER : Chatterjee_2011_Neuropsychopharmacology_36_603 |
| PubMedSearch : Chatterjee_2011_Neuropsychopharmacology_36_603 |
| PubMedID: 21048701 |
| Title : Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models - O'Donnell_2010_J.Med.Chem_53_1222 |
| Author(s) : O'Donnell CJ , Rogers BN , Bronk BS , Bryce DK , Coe JW , Cook KK , Duplantier AJ , Evrard E , Hajos M , Hoffmann WE , Hurst RS , Maklad N , Mather RJ , McLean S , Nedza FM , O'Neill BT , Peng L , Qian W , Rottas MM , Sands SB , Schmidt AW , Shrikhande AV , Spracklin DK , Wong DF , Zhang A , Zhang L |
| Ref : Journal of Medicinal Chemistry , 53 :1222 , 2010 |
| Abstract : O'Donnell_2010_J.Med.Chem_53_1222 |
| ESTHER : O'Donnell_2010_J.Med.Chem_53_1222 |
| PubMedSearch : O'Donnell_2010_J.Med.Chem_53_1222 |
| PubMedID: 20043678 |
| Title : A novel series of [3.2.1] azabicyclic biaryl ethers as alpha3beta4 and alpha6\/4beta4 nicotinic receptor agonists - Lowe_2010_Bioorg.Med.Chem.Lett_20_4749 |
| Author(s) : Lowe JA, 3rd , DeNinno SL , Coe JW , Zhang L , Mente S , Hurst RS , Mather RJ , Ward KM , Shrikhande A , Rollema H , Johnson DE , Horner W , Gorczyca R , Tingley FD, 3rd , Kozak R , Majchrzak MJ , Tritto T , Sadlier J , Shaffer CL , Ellerbrock B , Osgood SM , MacDougall MC , McDowell LL |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :4749 , 2010 |
| Abstract : Lowe_2010_Bioorg.Med.Chem.Lett_20_4749 |
| ESTHER : Lowe_2010_Bioorg.Med.Chem.Lett_20_4749 |
| PubMedSearch : Lowe_2010_Bioorg.Med.Chem.Lett_20_4749 |
| PubMedID: 20663668 |
| Title : Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence - Rollema_2010_Br.J.Pharmacol_160_334 |
| Author(s) : Rollema H , Shrikhande A , Ward KM , Tingley FD, 3rd , Coe JW , O'Neill BT , Tseng E , Wang EQ , Mather RJ , Hurst RS , Williams KE , De Vries M , Cremers T , Bertrand S , Bertrand D |
| Ref : British Journal of Pharmacology , 160 :334 , 2010 |
| Abstract : Rollema_2010_Br.J.Pharmacol_160_334 |
| ESTHER : Rollema_2010_Br.J.Pharmacol_160_334 |
| PubMedSearch : Rollema_2010_Br.J.Pharmacol_160_334 |
| PubMedID: 20331614 |
| Title : Poster: Preclinical properties of the alpha4\/beta2 nAChR partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence - |
| Author(s) : Rollema H , Shrikhande A , Ward KM , Coe JW , Tseng E , Wang EQ , De Vries M , Cremers THIF , Bertrand S , Bertrand D |
| Ref : Biochemical Pharmacology , 78 :918 , 2009 |
| PubMedID: |
| Title : Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect - Rollema_2009_Eur.J.Pharmacol_605_114 |
| Author(s) : Rollema H , Guanowsky V , Mineur YS , Shrikhande A , Coe JW , Seymour PA , Picciotto MR |
| Ref : European Journal of Pharmacology , 605 :114 , 2009 |
| Abstract : Rollema_2009_Eur.J.Pharmacol_605_114 |
| ESTHER : Rollema_2009_Eur.J.Pharmacol_605_114 |
| PubMedSearch : Rollema_2009_Eur.J.Pharmacol_605_114 |
| PubMedID: 19168054 |
| Title : Poster: Low efficacy partial agonists of the alpha4\/beta2 nicotinic acetylcholine receptor (nAChR). Does functional efficacy govern in vivo response? - |
| Author(s) : Coe JW , Brooks PR , Wirtz MC , Vetelino MG , Arnold EP , Sands SB , Davis TI , Lebel LA , Fox CB , Shrikhande A , Mansbach RS , Chambers LK , Rovetti CC , Schulz DW , Tingley Iii FD , ONeill BT , Rollema H |
| Ref : Biochemical Pharmacology , 78 :919 , 2009 |
| PubMedID: |
| Title : Varenicline: new treatment with efficacy in smoking cessation - Reus_2007_Drugs.Today.(Barc)_43_65 |
| Author(s) : Reus VI , Obach RS , Coe JW , Faessel H , Rollema H , Watsky E , Reeves K |
| Ref : Drugs Today (Barc) , 43 :65 , 2007 |
| Abstract : Reus_2007_Drugs.Today.(Barc)_43_65 |
| ESTHER : Reus_2007_Drugs.Today.(Barc)_43_65 |
| PubMedSearch : Reus_2007_Drugs.Today.(Barc)_43_65 |
| PubMedID: 17353944 |
| Title : Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid - Rollema_2007_Neuropharmacol_52_985 |
| Author(s) : Rollema H , Chambers LK , Coe JW , Glowa J , Hurst RS , Lebel LA , Lu Y , Mansbach RS , Mather RJ , Rovetti CC , Sands SB , Schaeffer E , Schulz DW , Tingley FD, 3rd , Williams KE |
| Ref : Neuropharmacology , 52 :985 , 2007 |
| Abstract : Rollema_2007_Neuropharmacol_52_985 |
| ESTHER : Rollema_2007_Neuropharmacol_52_985 |
| PubMedSearch : Rollema_2007_Neuropharmacol_52_985 |
| PubMedID: 17157884 |
| Title : Rationale, pharmacology and clinical efficacy of partial agonists of alpha4beta2 nACh receptors for smoking cessation - Rollema_2007_Trends.Pharmacol.Sci_28_316 |
| Author(s) : Rollema H , Coe JW , Chambers LK , Hurst RS , Stahl SM , Williams KE |
| Ref : Trends in Pharmacological Sciences , 28 :316 , 2007 |
| Abstract : Rollema_2007_Trends.Pharmacol.Sci_28_316 |
| ESTHER : Rollema_2007_Trends.Pharmacol.Sci_28_316 |
| PubMedSearch : Rollema_2007_Trends.Pharmacol.Sci_28_316 |
| PubMedID: 17573127 |
| Title : 3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation - Coe_2005_Bioorg.Med.Chem.Lett_15_4889 |
| Author(s) : Coe JW , Brooks PR , Wirtz MC , Bashore CG , Bianco KE , Vetelino MG , Arnold EP , Lebel LA , Fox CB , Tingley FD, 3rd , Schulz DW , Davis TI , Sands SB , Mansbach RS , Rollema H , O'Neill BT |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :4889 , 2005 |
| Abstract : Coe_2005_Bioorg.Med.Chem.Lett_15_4889 |
| ESTHER : Coe_2005_Bioorg.Med.Chem.Lett_15_4889 |
| PubMedSearch : Coe_2005_Bioorg.Med.Chem.Lett_15_4889 |
| PubMedID: 16171993 |
| Title : In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine - Coe_2005_Bioorg.Med.Chem.Lett_15_2974 |
| Author(s) : Coe JW , Vetelino MG , Bashore CG , Wirtz MC , Brooks PR , Arnold EP , Lebel LA , Fox CB , Sands SB , Davis TI , Schulz DW , Rollema H , Tingley FD, 3rd , O'Neill BT |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :2974 , 2005 |
| Abstract : Coe_2005_Bioorg.Med.Chem.Lett_15_2974 |
| ESTHER : Coe_2005_Bioorg.Med.Chem.Lett_15_2974 |
| PubMedSearch : Coe_2005_Bioorg.Med.Chem.Lett_15_2974 |
| PubMedID: 15908213 |
| Title : Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation - Coe_2005_J.Med.Chem_48_3474 |
| Author(s) : Coe JW , Brooks PR , Vetelino MG , Wirtz MC , Arnold EP , Huang J , Sands SB , Davis TI , Lebel LA , Fox CB , Shrikhande A , Heym JH , Schaeffer E , Rollema H , Lu Y , Mansbach RS , Chambers LK , Rovetti CC , Schulz DW , Tingley FD, 3rd , O'Neill BT |
| Ref : Journal of Medicinal Chemistry , 48 :3474 , 2005 |
| Abstract : Coe_2005_J.Med.Chem_48_3474 |
| ESTHER : Coe_2005_J.Med.Chem_48_3474 |
| PubMedSearch : Coe_2005_J.Med.Chem_48_3474 |
| PubMedID: 15887955 |