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Author Report for: Cheng X

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    Title: Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering
    Gerlits O, Fajer M, Cheng X, Blumenthal DK, Radic Z, Kovalevsky A
    Ref: Structure, :, 2022 : PubMed


    Title: Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects
    Blumenthal DK, Cheng X, Fajer M, Ho KY, Rohrer J, Gerlits O, Taylor P, Juneja P, Kovalevsky A, Radic Z
    Ref: Journal of Biological Chemistry, :101007, 2021 : PubMed


    Title: Dynamic changes in chemical compositions and anti-acetylcholinesterase activity associated with steaming process of stem-leaf saponins of Panax notoginseng
    Ma C, Guan H, Lin Q, Liu C, Ju Z, Xue Y, Cheng X, Wang C
    Ref: Biomedical Chromatography, :e5077, 2021 : PubMed


    Title: Combined effects of polyethylene and organic contaminant on zebrafish (Danio rerio): Accumulation of 9-Nitroanthracene, biomarkers and intestinal microbiota
    Zhang J, Meng H, Kong X, Cheng X, Ma T, He H, Du W, Yang S, Li S, Zhang L
    Ref: Environ Pollut, 277:116767, 2021 : PubMed


    Title: Potential of esterase DmtH in transforming plastic additive dimethyl terephthalate to less toxic mono-methyl terephthalate
    Cheng X, Dong S, Chen D, Rui Q, Guo J, Dayong W, Jiang J
    Ref: Ecotoxicology & Environmental Safety, 187:109848, 2020 : PubMed


    Title: Rational design, synthesis and evaluation of uncharged, smart bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase
    Gorecki L, Gerlits O, Kong X, Cheng X, Blumenthal DK, Taylor P, Ballatore C, Kovalevsky A, Radic Z
    Ref: Journal of Biological Chemistry, 295:4079, 2020 : PubMed


    Title: No significant association between dipeptidyl peptidase-4 inhibitors and adverse outcomes of COVID-19
    Zhou JH, Wu B, Wang WX, Lei F, Cheng X, Qin JJ, Cai JJ, Zhang XJ, Zhou F and Li HL <6 more author(s)>
    Ref: World J Clin Cases, 8:5576, 2020 : PubMed


    Title: Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease
    Bai P, Wang K, Zhang P, Shi J, Cheng X, Zhang Q, Zheng C, Cheng Y, Yang J and Sang Z <1 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 183:111737, 2019 : PubMed


    Title: In vivo and in vitro metabolism and pharmacokinetics of cholinesterase inhibitor deoxyvasicine from aerial parts of Peganum harmala Linn in rats via UPLC-ESI-QTOF-MS and UPLC-ESI-MS/MS
    Deng G, Liu W, Ma C, Rong X, Zhang Y, Wang Y, Wu C, Cao N, Ding W and Wang C <2 more author(s)>
    Ref: J Ethnopharmacol, 236:288, 2019 : PubMed


    Title: Ameliorative effect of deoxyvasicine on scopolamine-induced cognitive dysfunction by restoration of cholinergic function in mice
    Deng G, Wu C, Rong X, Li S, Ju Z, Wang Y, Ma C, Ding W, Guan H and Wang C <2 more author(s)>
    Ref: Phytomedicine, 63:153007, 2019 : PubMed


    Title: A new crystal form of human acetylcholinesterase for exploratory room-temperature crystallography studies
    Gerlits O, Ho KY, Cheng X, Blumenthal D, Taylor P, Kovalevsky A, Radic Z
    Ref: Chemico-Biological Interactions, :, 2019 : PubMed


    Title: Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase
    Gerlits O, Kong X, Cheng X, Wymore T, Blumenthal DK, Taylor P, Radic Z, Kovalevsky A
    Ref: Journal of Biological Chemistry, 294:10607, 2019 : PubMed


    Title: Mechanism-based pharmacokinetics-pharmacodynamics studies of harmine and harmaline on neurotransmitters regulatory effects in healthy rats: Challenge on monoamine oxidase and acetylcholinesterase inhibition
    Jiang B, Meng L, Zou N, Wang H, Li S, Huang L, Cheng X, Wang Z, Chen W, Wang C
    Ref: Phytomedicine, 62:152967, 2019 : PubMed


    Title: Genome sequence of Isaria javanica and comparative genome analysis insights into family S53 peptidase evolution in fungal entomopathogens
    Lin R, Zhang X, Xin B, Zou M, Gao Y, Qin F, Hu Q, Xie B, Cheng X
    Ref: Applied Microbiology & Biotechnology, 103:7111, 2019 : PubMed


    Title: Potential Pharmacokinetic Drug(-)Drug Interaction Between Harmine, a Cholinesterase Inhibitor, and Memantine, a Non-Competitive N-Methyl-d-Aspartate Receptor Antagonist
    Zhang Y, Li S, Wang Y, Deng G, Cao N, Wu C, Ding W, Cheng X, Wang C
    Ref: Molecules, 24:, 2019 : PubMed


    Title: Implications of Successful Symptomatic Treatment in Parkinson's Disease for Therapeutic Strategies of Alzheimer's Disease
    Zhao L, Cheng X, Zhong C
    Ref: ACS Chem Neurosci, 10:922, 2019 : PubMed


    Title: Discovery of Selective Butyrylcholinesterase (BChE) Inhibitors through a Combination of Computational Studies and Biological Evaluations
    Zhou Y, Lu X, Yang H, Chen Y, Wang F, Li J, Tang Z, Cheng X, Yang Y and Xia Q <1 more author(s)>
    Ref: Molecules, 24:, 2019 : PubMed


    Title: Structural investigation of the enantioselectivity and thermostability mechanisms of esterase RhEst1
    Chen Q, Yu HL, Cheng X, Xu JH
    Ref: J Mol Graph Model, 85:182, 2018 : PubMed


    Title: The tomato MAX1 homolog, SlMAX1, is involved in the biosynthesis of tomato strigolactones from carlactone
    Zhang Y, Cheng X, Wang Y, Diez-Simon C, Flokova K, Bimbo A, Bouwmeester HJ, Ruyter-Spira C
    Ref: New Phytol, 219:297, 2018 : PubMed


    Title: Stereoselective glucuronidation metabolism, pharmacokinetics, anti-amnesic pharmacodynamics, and toxic properties of vasicine enantiomers in vitro and in vivo
    Zhu Y, Liu W, Qi S, Wang H, Wang Y, Deng G, Zhang Y, Li S, Ma C and Wang C <1 more author(s)>
    Ref: Eur J Pharm Sci, 123:459, 2018 : PubMed


    Title: Oral administration of grape seed polyphenol extract restores memory deficits in chronic cerebral hypoperfusion rats
    Chen C, Zheng Y, Wu T, Wu C, Cheng X
    Ref: Behav Pharmacol, 28:207, 2017 : PubMed


    Title: A review on traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the genus Peganum
    Li S, Cheng X, Wang C
    Ref: J Ethnopharmacol, 203:127, 2017 : PubMed


    Title: Anti-amnesic effect of extract and alkaloid fraction from aerial parts of Peganum harmala on scopolamine-induced memory deficits in mice
    Liu W, Zhu Y, Wang Y, Qi S, Ma C, Li S, Jiang B, Cheng X, Wang Z and Wang C <1 more author(s)>
    Ref: J Ethnopharmacol, 204:95, 2017 : PubMed


    Title: Rational Design of a Red-Emissive Fluorophore with AIE and ESIPT Characteristics and Its Application in Light-Up Sensing of Esterase
    Peng L, Xu S, Zheng X, Cheng X, Zhang R, Liu J, Liu B, Tong A
    Ref: Analytical Chemistry, 89:3162, 2017 : PubMed


    Title: Limitations in current acetylcholinesterase structure-based design of oxime antidotes for organophosphate poisoning
    Kovalevsky A, Blumenthal DK, Cheng X, Taylor P, Radic Z
    Ref: Annals of the New York Academy of Sciences, 1378:41, 2016 : PubMed


    Title: Five new Lycopodium alkaloids from the aerial parts of Phlegmariurus henryi
    Liu YC, Su J, Wu XD, Zhang ZJ, Fan M, Zhu QF, He J, Li XN, Peng LY and Zhao QS <1 more author(s)>
    Ref: Fitoterapia, 115:148, 2016 : PubMed


    Title: Transcriptome differences between fiber-type and seed-type Cannabis sativa variety exposed to salinity
    Liu J, Qiao Q, Cheng X, Du G, Deng G, Zhao M, Liu F
    Ref: Physiol Mol Biol Plants, 22:429, 2016 : PubMed


    Title: Conifer flavonoid compounds inhibit detoxification enzymes and synergize insecticides
    Wang Z, Zhao Z, Cheng X, Liu S, Wei Q, Scott IM
    Ref: Pestic Biochem Physiol, 127:1, 2016 : PubMed


    Title: Molecular dynamics investigation of the substrate binding mechanism in carboxylesterase
    Chen Q, Luan ZJ, Cheng X, Xu JH
    Ref: Biochemistry, 54:1841, 2015 : PubMed


    Title: Rational design of a carboxylic esterase RhEst1 based on computational analysis of substrate binding
    Chen Q, Luan ZJ, Yu HL, Cheng X, Xu JH
    Ref: J Mol Graph Model, 62:319, 2015 : PubMed


    Title: Geissoschizine methyl ether N-oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla
    Jiang WW, Su J, Wu XD, He J, Peng LY, Cheng X, Zhao QS
    Ref: Nat Prod Res, 29:842, 2015 : PubMed


    Title: Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum
    Jiang WW, Liu YC, Zhang ZJ, He J, Su J, Cheng X, Peng LY, Shao LD, Wu XD and Zhao QS <1 more author(s)>
    Ref: Fitoterapia, 109:155, 2015 : PubMed


    Title: In vitro and in vivo metabolism and inhibitory activities of vasicine, a potent acetylcholinesterase and butyrylcholinesterase inhibitor
    Liu W, Shi X, Yang Y, Cheng X, Liu Q, Han H, Yang B, He C, Wang Y and Wang C <2 more author(s)>
    Ref: PLoS ONE, 10:e0122366, 2015 : PubMed


    Title: Four new fawcettimine-related alkaloids from Phlegmariurus squarrosus
    Liu YC, Fan M, Jiang WW, Liu F, Wu XD, He J, Cheng X, Peng LY, Su J and Zhao QS <1 more author(s)>
    Ref: J Asian Nat Prod Res, 17:967, 2015 : PubMed


    Title: Potent AChE and BChE inhibitors isolated from seeds of Peganum harmala Linn by a bioassay-guided fractionation
    Yang Y, Cheng X, Liu W, Chou G, Wang Z, Wang C
    Ref: J Ethnopharmacol, 168:279, 2015 : PubMed


    Title: Comparative genomics and metabolic profiling of the genus Lysobacter
    de Bruijn I, Cheng X, de Jager V, Exposito RG, Watrous J, Patel N, Postma J, Dorrestein PC, Kobayashi D, Raaijmakers JM
    Ref: BMC Genomics, 16:991, 2015 : PubMed


    Title: Amino acid substitutions of acetylcholinesterase associated with carbofuran resistance in Chilo suppressalis
    Chang C, Cheng X, Huang XY, Dai SM
    Ref: Pest Manag Sci, 70:1930, 2014 : PubMed


    Title: The role of synaptic activity in the regulation of amyloid beta levels in Alzheimer's disease
    Cheng X, Wu J, Geng M, Xiong J
    Ref: Neurobiology of Aging, 35:1217, 2014 : PubMed


    Title: Molecular Cloning and Characterization of a Novel Cold-Adapted Family VIII Esterase from a Biogas Slurry Metagenomic Library
    Cheng X, Wang X, Qiu T, Yuan M, Sun J, Gao J
    Ref: J Microbiol Biotechnol, 24:1484, 2014 : PubMed


    Title: Beyond autonomic neuromodulation: Acetylcholinesterase inhibitor against peripheral artery disease
    Hao CN, Shi YQ, Cheng ZE, Cheng X
    Ref: Int J Cardiol, 178C:253, 2014 : PubMed


    Title: Huperserines A-E, Lycopodium alkaloids from Huperzia serrata
    Jiang WW, Liu F, Gao X, He J, Cheng X, Peng LY, Wu XD, Zhao QS
    Ref: Fitoterapia, 99C:72, 2014 : PubMed


    Title: Rapid and sensitive detection of the inhibitive activities of acetyl- and butyryl-cholinesterases inhibitors by UPLC-ESI-MS/MS
    Liu W, Yang Y, Cheng X, Gong C, Li S, He D, Yang L, Wang Z, Wang C
    Ref: J Pharm Biomed Anal, 94:215, 2014 : PubMed


    Title: Carinatines A and B, Alkaloids from
    Liu F, Liu YC, Jiang WW, He J, Wu XD, Peng LY, Su J, Cheng X, Zhao QS
    Ref: Nat Prod Bioprospect, 4:221, 2014 : PubMed


    Title: Targeting Lipid Esterases in Mycobacteria Grown Under Different Physiological Conditions Using Activity-based Profiling with Tetrahydrolipstatin (THL)
    Ravindran MS, Rao SP, Cheng X, Shukla A, Cazenave-Gassiot A, Yao SQ, Wenk MR
    Ref: Mol Cell Proteomics, 13:435, 2014 : PubMed


    Title: Intramembrane proton binding site linked to activation of bacterial pentameric ion channel
    Wang HL, Cheng X, Sine SM
    Ref: Journal of Biological Chemistry, 287:6482, 2012 : PubMed


    Title: Synthesis and acetylcholinesterase and butyrylcholinesterase inhibitory activities of 7-alkoxyl substituted indolizinoquinoline-5,12-dione derivatives
    Wu ZP, Wu XW, Shen T, Li YP, Cheng X, Gu LQ, Huang ZS, An LK
    Ref: Arch Pharm (Weinheim), 345:175, 2012 : PubMed


    Title: Transcription factor-mediated regulation of carboxylesterase enzymes in livers of mice
    Zhang Y, Cheng X, Aleksunes L, Klaassen CD
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 40:1191, 2012 : PubMed


    Title: Molecular-dynamics simulations of ELIC-a prokaryotic homologue of the nicotinic acetylcholine receptor
    Cheng X, Ivanov I, Wang H, Sine SM, McCammon JA
    Ref: Biophysical Journal, 96:4502, 2009 : PubMed


    Title: Structural redesign of lipase B from Candida antarctica by circular permutation and incremental truncation
    Qian Z, Horton JR, Cheng X, Lutz S
    Ref: Journal of Molecular Biology, 393:191, 2009 : PubMed


    Title: Control of cation permeation through the nicotinic receptor channel
    Wang HL, Cheng X, Taylor P, McCammon JA, Sine SM
    Ref: PLoS Comput Biol, 4:e41, 2008 : PubMed


    Title: Nanosecond-timescale conformational dynamics of the human alpha7 nicotinic acetylcholine receptor
    Cheng X, Ivanov I, Wang H, Sine SM, McCammon JA
    Ref: Biophysical Journal, 93:2622, 2007 : PubMed


    Title: Estradiol replacement increases the low-density lipoprotein receptor related protein (LRP) in the mouse brain
    Cheng X, McAsey ME, Li M, Randall S, Cady C, Nathan BP, Struble RG
    Ref: Neuroscience Letters, 417:50, 2007 : PubMed


    Title: Acetylcholinesterase: mechanisms of covalent inhibition of wild-type and H447I mutant determined by computational analyses
    Cheng Y, Cheng X, Radic Z, McCammon JA
    Ref: Journal of the American Chemical Society, 129:6562, 2007 : PubMed


    Title: Barriers to ion translocation in cationic and anionic receptors from the Cys-loop family
    Ivanov I, Cheng X, Sine SM, McCammon JA
    Ref: J Am Chem Soc, 129:8217, 2007 : PubMed


    Title: Estradiol regulation of astroglia and apolipoprotein E: an important role in neuronal regeneration
    Struble RG, Nathan BP, Cady C, Cheng X, McAsey M
    Ref: Experimental Gerontology, 42:54, 2007 : PubMed


    Title: Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors
    Cheng X, Wang H, Grant B, Sine SM, McCammon JA
    Ref: PLoS Comput Biol, 2:e134, 2006 : PubMed


    Title: Order N algorithm for computation of electrostatic interactions in biomolecular systems
    Lu B, Cheng X, Huang J, McCammon JA
    Ref: Proc Natl Acad Sci U S A, 103:19314, 2006 : PubMed


    Title: The sorption behavior of complex pollution system composed of aldicarb and surfactant--SDBS
    Dai S, Liu G, Qian Y, Cheng X
    Ref: Water Res, 35:2286, 2001 : PubMed


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