Full name : Castro Newton G
First name : Newton G
Mail : Departamento de Farmacologia Basica e Clinica, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ
Zip Code :
City :
Country : Brazil
Email : ngcastro@farmaco.ufrj.br
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| Title : Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer's Disease - de Freitas Silva_2020_Molecules_25_ |
| Author(s) : de Freitas Silva M , Tardelli Lima E , Pruccoli L , Castro NG , Guimares MJR , F MRdS , Fonseca Nadur N , de Azevedo LL , Kummerle AE , Guedes IA , Dardenne LE , Gontijo VS , Tarozzi A , Viegas C |
| Ref : Molecules , 25 : , 2020 |
| Abstract : de Freitas Silva_2020_Molecules_25_ |
| ESTHER : de Freitas Silva_2020_Molecules_25_ |
| PubMedSearch : de Freitas Silva_2020_Molecules_25_ |
| PubMedID: 32664425 |
| Title : Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease - Dias_2017_Eur.J.Med.Chem_130_440 |
| Author(s) : Dias KS , de Paula CT , Dos Santos T , Souza IN , Boni MS , Guimaraes MJ , da Silva FM , Castro NG , Neves GA , Veloso CC , Coelho MM , de Melo IS , Giusti FC , Giusti-Paiva A , da Silva ML , Dardenne LE , Guedes IA , Pruccoli L , Morroni F , Tarozzi A , Viegas C, Jr. |
| Ref : Eur Journal of Medicinal Chemistry , 130 :440 , 2017 |
| Abstract : Dias_2017_Eur.J.Med.Chem_130_440 |
| ESTHER : Dias_2017_Eur.J.Med.Chem_130_440 |
| PubMedSearch : Dias_2017_Eur.J.Med.Chem_130_440 |
| PubMedID: 28282613 |
| Title : Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease - Lemes_2015_Eur.J.Med.Chem_108_687 |
| Author(s) : Lemes LF , de Andrade Ramos G , de Oliveira AS , da Silva FM , de Castro Couto G , da Silva Boni M , Guimaraes MJ , Souza IN , Bartolini M , Andrisano V , do Nascimento Nogueira PC , Silveira ER , Brand GD , Soukup O , Korabecny J , Romeiro NC , Castro NG , Bolognesi ML , Romeiro LA |
| Ref : Eur Journal of Medicinal Chemistry , 108 :687 , 2015 |
| Abstract : Lemes_2015_Eur.J.Med.Chem_108_687 |
| ESTHER : Lemes_2015_Eur.J.Med.Chem_108_687 |
| PubMedSearch : Lemes_2015_Eur.J.Med.Chem_108_687 |
| PubMedID: 26735910 |
| Title : Design, synthesis, and evaluation of guanylhydrazones as potential inhibitors or reactivators of acetylcholinesterase - Petronilho_2015_J.Enzyme.Inhib.Med.Chem__1 |
| Author(s) : Petronilho EC , Renno MD , Castro NG , da Silva FM , Pinto AD , Figueroa-Villar JD |
| Ref : J Enzyme Inhib Med Chem , :1 , 2015 |
| Abstract : Petronilho_2015_J.Enzyme.Inhib.Med.Chem__1 |
| ESTHER : Petronilho_2015_J.Enzyme.Inhib.Med.Chem__1 |
| PubMedSearch : Petronilho_2015_J.Enzyme.Inhib.Med.Chem__1 |
| PubMedID: 26558640 |
| Title : Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling - Diniz_2014_Glia_62_1917 |
| Author(s) : Diniz LP , Tortelli V , Garcia MN , Araujo AP , Melo HM , Seixas da Silva GS , De Felice FG , Alves-Leon SV , de Souza JM , Romao LF , Castro NG , Gomes FC |
| Ref : Glia , 62 :1917 , 2014 |
| Abstract : Diniz_2014_Glia_62_1917 |
| ESTHER : Diniz_2014_Glia_62_1917 |
| PubMedSearch : Diniz_2014_Glia_62_1917 |
| PubMedID: 25042347 |
| Title : LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation - Tributino_2010_Br.J.Pharmacol_159_1716 |
| Author(s) : Tributino JL , Santos ML , Mesquita CM , Lima CK , Silva LL , Maia RC , Duarte CD , Barreiro EJ , Fraga CA , Castro NG , Miranda AL , Guimaraes MZ |
| Ref : British Journal of Pharmacology , 159 :1716 , 2010 |
| Abstract : Tributino_2010_Br.J.Pharmacol_159_1716 |
| ESTHER : Tributino_2010_Br.J.Pharmacol_159_1716 |
| PubMedSearch : Tributino_2010_Br.J.Pharmacol_159_1716 |
| PubMedID: 20401963 |
| Title : New potential AChE inhibitor candidates - de Paula_2009_Eur.J.Med.Chem_44_3754 |
| Author(s) : de Paula AA , Martins JB , dos Santos ML , Nascente Lde C , Romeiro LA , Areas TF , Vieira KS , Gamboa NF , Castro NG , Gargano R |
| Ref : Eur Journal of Medicinal Chemistry , 44 :3754 , 2009 |
| Abstract : de Paula_2009_Eur.J.Med.Chem_44_3754 |
| ESTHER : de Paula_2009_Eur.J.Med.Chem_44_3754 |
| PubMedSearch : de Paula_2009_Eur.J.Med.Chem_44_3754 |
| PubMedID: 19446931 |
| Title : Geissospermum vellosii stembark: anticholinesterase activity and improvement of scopolamine-induced memory deficits - Lima_2009_Pharmacol.Biochem.Behav_92_508 |
| Author(s) : Lima JA , Costa RS , Epifanio RA , Castro NG , Rocha MS , Pinto AC |
| Ref : Pharmacol Biochem Behav , 92 :508 , 2009 |
| Abstract : Lima_2009_Pharmacol.Biochem.Behav_92_508 |
| ESTHER : Lima_2009_Pharmacol.Biochem.Behav_92_508 |
| PubMedSearch : Lima_2009_Pharmacol.Biochem.Behav_92_508 |
| PubMedID: 19463267 |
| Title : CNS-selective noncompetitive cholinesterase inhibitors derived from the natural piperidine alkaloid (-)-spectaline - Castro_2008_Eur.J.Pharmacol_580_339 |
| Author(s) : Castro NG , Costa RS , Pimentel LS , Danuello A , Romeiro NC , Viegas C, Jr. , Barreiro EJ , Fraga CA , Bolzani VS , Rocha MS |
| Ref : European Journal of Pharmacology , 580 :339 , 2008 |
| Abstract : Castro_2008_Eur.J.Pharmacol_580_339 |
| ESTHER : Castro_2008_Eur.J.Pharmacol_580_339 |
| PubMedSearch : Castro_2008_Eur.J.Pharmacol_580_339 |
| PubMedID: 18096154 |
| Title : The magnitude of alpha7 nicotinic receptor currents in rat hippocampal neurons is dependent upon GABAergic activity and depolarization - Santos_2006_J.Pharmacol.Exp.Ther_319_376 |
| Author(s) : Santos HR , Ribeiro HS , Setti-Perdigao P , Albuquerque EX , Castro NG |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 319 :376 , 2006 |
| Abstract : Santos_2006_J.Pharmacol.Exp.Ther_319_376 |
| ESTHER : Santos_2006_J.Pharmacol.Exp.Ther_319_376 |
| PubMedSearch : Santos_2006_J.Pharmacol.Exp.Ther_319_376 |
| PubMedID: 16837558 |
| Title : New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids - Viegas_2005_Bioorg.Med.Chem_13_4184 |
| Author(s) : Viegas C, Jr. , Bolzani VS , Pimentel LS , Castro NG , Cabral RF , Costa RS , Floyd C , Rocha MS , Young MC , Barreiro EJ , Fraga CA |
| Ref : Bioorganic & Medicinal Chemistry , 13 :4184 , 2005 |
| Abstract : Viegas_2005_Bioorg.Med.Chem_13_4184 |
| ESTHER : Viegas_2005_Bioorg.Med.Chem_13_4184 |
| PubMedSearch : Viegas_2005_Bioorg.Med.Chem_13_4184 |
| PubMedID: 15878668 |
| Title : Binding of [3H]MK-801 in subcellular fractions of Schistosoma mansoni: evidence for interaction with nicotinic receptors - Pessoa_2005_Biochem.Pharmacol_69_1509 |
| Author(s) : Pessoa RF , Castro NG , Noel F |
| Ref : Biochemical Pharmacology , 69 :1509 , 2005 |
| Abstract : Pessoa_2005_Biochem.Pharmacol_69_1509 |
| ESTHER : Pessoa_2005_Biochem.Pharmacol_69_1509 |
| PubMedSearch : Pessoa_2005_Biochem.Pharmacol_69_1509 |
| PubMedID: 15857615 |
| Title : Spine density and dendritic branching pattern of hippocampal CA1 pyramidal neurons in neonatal rats chronically exposed to the organophosphate paraoxon - Santos_2004_Neurotoxicol_25_481 |
| Author(s) : Santos HR , Cintra WM , Aracava Y , Maciel CM , Castro NG , Albuquerque EX |
| Ref : Neurotoxicology , 25 :481 , 2004 |
| Abstract : Santos_2004_Neurotoxicol_25_481 |
| ESTHER : Santos_2004_Neurotoxicol_25_481 |
| PubMedSearch : Santos_2004_Neurotoxicol_25_481 |
| PubMedID: 15019311 |
| Title : Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors - Barreiro_2003_J.Med.Chem_46_1144 |
| Author(s) : Barreiro EJ , Camara CA , Verli H , Brazil-Mas L , Castro NG , Cintra WM , Aracava Y , Rodrigues CR , Fraga CA |
| Ref : Journal of Medicinal Chemistry , 46 :1144 , 2003 |
| Abstract : Barreiro_2003_J.Med.Chem_46_1144 |
| ESTHER : Barreiro_2003_J.Med.Chem_46_1144 |
| PubMedSearch : Barreiro_2003_J.Med.Chem_46_1144 |
| PubMedID: 12646025 |
| Title : Low concentrations of pyridostigmine prevent soman-induced inhibition of GABAergic transmission in the central nervous system: involvement of muscarinic receptors - Santos_2003_J.Pharmacol.Exp.Ther_304_254 |
| Author(s) : Santos MD , Pereira EF , Aracava Y , Castro NG , Fawcett WP , Randall WR , Albuquerque EX |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 304 :254 , 2003 |
| Abstract : Santos_2003_J.Pharmacol.Exp.Ther_304_254 |
| ESTHER : Santos_2003_J.Pharmacol.Exp.Ther_304_254 |
| PubMedSearch : Santos_2003_J.Pharmacol.Exp.Ther_304_254 |
| PubMedID: 12490599 |
| Title : A novel thienylhydrazone, (2-thienylidene)3,4-methylenedioxybenzoylhydrazine, increases inotropism and decreases fatigue of skeletal muscle - Gonzalez-Serratos_2001_J.Pharmacol.Exp.Ther_299_558 |
| Author(s) : Gonzalez-Serratos H , Chang R , Pereira EF , Castro NG , Aracava Y , Melo PA , Lima PC , Fraga CA , Barreiro EJ , Albuquerque EX |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 299 :558 , 2001 |
| Abstract : Gonzalez-Serratos_2001_J.Pharmacol.Exp.Ther_299_558 |
| ESTHER : Gonzalez-Serratos_2001_J.Pharmacol.Exp.Ther_299_558 |
| PubMedSearch : Gonzalez-Serratos_2001_J.Pharmacol.Exp.Ther_299_558 |
| PubMedID: 11602667 |
| Title : Choline and acetylcholine have similar kinetic properties of activation and desensitization on the alpha7 nicotinic receptors in rat hippocampal neurons - Mike_2000_Brain.Res_882_155 |
| Author(s) : Mike A , Castro NG , Albuquerque EX |
| Ref : Brain Research , 882 :155 , 2000 |
| Abstract : Mike_2000_Brain.Res_882_155 |
| ESTHER : Mike_2000_Brain.Res_882_155 |
| PubMedSearch : Mike_2000_Brain.Res_882_155 |
| PubMedID: 11056195 |
| Title : Properties of neuronal nicotinic acetylcholine receptors: pharmacological characterization and modulation of synaptic function - |
| Author(s) : Albuquerque EX , Alkondon M , Pereira EF , Castro NG , Schrattenholz A , Barbosa CT , Bonfante-Cabarcas R , Aracava Y , Eisenberg HM , Maelicke A |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 280 :1117 , 1997 |
| PubMedID: 9067295 |
| Title : Nicotinic receptor function in the mammalian central nervous system - Albuquerque_1995_Ann.N.Y.Acad.Sci_757_48 |
| Author(s) : Albuquerque EX , Pereira EF , Castro NG , Alkondon M , Reinhardt S , Schroder H , Maelicke A |
| Ref : Annals of the New York Academy of Sciences , 757 :48 , 1995 |
| Abstract : Albuquerque_1995_Ann.N.Y.Acad.Sci_757_48 |
| ESTHER : Albuquerque_1995_Ann.N.Y.Acad.Sci_757_48 |
| PubMedSearch : Albuquerque_1995_Ann.N.Y.Acad.Sci_757_48 |
| PubMedID: 7611705 |
| Title : alpha-Bungarotoxin-sensitive hippocampal nicotinic receptor channel has a high calcium permeability - Castro_1995_Biophys.J_68_516 |
| Author(s) : Castro NG , Albuquerque EX |
| Ref : Biophysical Journal , 68 :516 , 1995 |
| Abstract : Castro_1995_Biophys.J_68_516 |
| ESTHER : Castro_1995_Biophys.J_68_516 |
| PubMedSearch : Castro_1995_Biophys.J_68_516 |
| PubMedID: 7696505 |
| Title : Brief-lifetime, fast-inactivating ion channels account for the alpha-bungarotoxin-sensitive nicotinic response in hippocampal neurons - Castro_1993_Neurosci.Lett_164_137 |
| Author(s) : Castro NG , Albuquerque EX |
| Ref : Neuroscience Letters , 164 :137 , 1993 |
| Abstract : Castro_1993_Neurosci.Lett_164_137 |
| ESTHER : Castro_1993_Neurosci.Lett_164_137 |
| PubMedSearch : Castro_1993_Neurosci.Lett_164_137 |
| PubMedID: 7512242 |
| Title : A novel agonist binding site on nicotinic acetylcholine receptors - Pereira_1993_J.Recept.Res_13_413 |
| Author(s) : Pereira EF , Alkondon M , Tano T , Castro NG , Froes-Ferrao MM , Rozental R , Aronstam RS , Schrattenholz A , Maelicke A , Albuquerque EX |
| Ref : J Recept Res , 13 :413 , 1993 |
| Abstract : Pereira_1993_J.Recept.Res_13_413 |
| ESTHER : Pereira_1993_J.Recept.Res_13_413 |
| PubMedSearch : Pereira_1993_J.Recept.Res_13_413 |
| PubMedID: 8450498 |