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Author Report for: Cashman JR

Contact information:

Cashman John R
Human BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121
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    Title: A Method for Diagnosing Organophosphate Pesticide Exposure in Humans using Liquid Chromatography Coupled Tandem Mass Spectrometry
    Indapurkar AS, Eangoor P, Yeh JS, Vakkalanka M, Cashman JR, Knaack JS
    Ref: J Anal Toxicol, :, 2020 : PubMed


    Title: Use of Hupresin To Capture Red Blood Cell Acetylcholinesterase for Detection of Soman Exposure
    Onder S, Schopfer LM, Cashman JR, Tacal O, Johnson RC, Blake TA, Lockridge O
    Ref: Analytical Chemistry, 90:974, 2018 : PubMed


    Title: Immunopurification of Acetylcholinesterase from Red Blood Cells for Detection of Nerve Agent Exposure
    Dafferner AJ, Schopfer LM, Xiao G, Cashman JR, Yerramalla U, Johnson RC, Blake TA, Lockridge O
    Ref: Chemical Research in Toxicology, 30:1897, 2017 : PubMed


    Title: Novel human butyrylcholinesterase variants: toward organophosphonate detoxication
    Dwyer M, Javor S, Ryan DA, Smith EM, Wang B, Zhang J, Cashman JR
    Ref: Biochemistry, 53:4476, 2014 : PubMed


    Title: Preclinical studies of noncharged oxime reactivators for organophosphate exposure
    Okolotowicz KJ, Dwyer M, Smith E, Cashman JR
    Ref: J Biochem Mol Toxicol, 28:23, 2014 : PubMed


    Title: Mass spectrometry method to identify aging pathways of Sp- and Rp-tabun adducts on human butyrylcholinesterase based on the acid labile P-N bond
    Jiang W, Cashman JR, Nachon F, Masson P, Schopfer LM, Lockridge O
    Ref: Toxicol Sci, 132:390, 2013 : PubMed


    Title: Polyclonal antibody to soman-tyrosine
    Li B, Duysen EG, Froment MT, Masson P, Nachon F, Jiang W, Schopfer LM, Thiele GM, Klassen LW and Lockridge O <2 more author(s)>
    Ref: Chemical Research in Toxicology, 26:584, 2013 : PubMed


    Title: Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran
    Duysen EG, Cashman JR, Schopfer LM, Nachon F, Masson P, Lockridge O
    Ref: Chemico-Biological Interactions, 195:189, 2012 : PubMed


    Title: Nonquaternary reactivators for organophosphate-inhibited cholinesterases
    Kalisiak J, Ralph EC, Cashman JR
    Ref: Journal of Medicinal Chemistry, 55:465, 2012 : PubMed


    Title: Identification of Human Butyrylcholinesterase Organophosphate-Resistant Variants through a Novel Mammalian Enzyme Functional Screen
    Zhang J, Chen S, Ralph EC, Dwyer MA, Cashman JR
    Ref: Journal of Pharmacology & Experimental Therapeutics, 343:673, 2012 : PubMed


    Title: Nerve agent hydrolysis activity designed into a human drug metabolism enzyme
    Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Edwards CC, Tsurkan L, Cadieux CL and Redinbo MR <5 more author(s)>
    Ref: PLoS ONE, 6:e17441, 2011 : PubMed


    Title: Amidine-oximes: reactivators for organophosphate exposure
    Kalisiak J, Ralph EC, Zhang J, Cashman JR
    Ref: Journal of Medicinal Chemistry, 54:3319, 2011 : PubMed


    Title: Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin
    Hemmert AC, Otto TC, Wierdl M, Edwards CC, Fleming CD, MacDonald M, Cashman JR, Potter PM, Cerasoli DM, Redinbo MR
    Ref: Molecular Pharmacology, 77:508, 2010 : PubMed


    Title: Direct detection of the hydrolysis of nerve agent model compounds using a fluorescent probe
    Zheng X, Okolotowicz K, Wang B, MacDonald M, Cashman JR, Zhang J
    Ref: Chemico-Biological Interactions, 187:330, 2010 : PubMed


    Title: Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase
    Barakat NH, Zheng X, Gilley CB, MacDonald M, Okolotowicz K, Cashman JR, Vyas S, Beck JM, Hadad CM, Zhang J
    Ref: Chemical Research in Toxicology, 22:1669, 2009 : PubMed


    Title: Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase
    Gilley C, MacDonald M, Nachon F, Schopfer LM, Zhang J, Cashman JR, Lockridge O
    Ref: Chemical Research in Toxicology, 22:1680, 2009 : PubMed


    Title: Catalytic antibodies that hydrolyze (-)-cocaine obtained by a high-throughput procedure
    Cashman JR, Berkman CE, Underiner GE
    Ref: Journal of Pharmacology & Experimental Therapeutics, 293:952, 2000 : PubMed


    Title: An improved cocaine hydrolase: the A328Y mutant of human butyrylcholinesterase is 4-fold more efficient
    Xie W, Altamirano CV, Bartels CF, Speirs RJ, Cashman JR, Lockridge O
    Ref: Molecular Pharmacology, 55:83, 1999 : PubMed


    Title: Cocaine benzoyl thioester: synthesis, kinetics of base hydrolysis, and application to the assay of cocaine esterases
    Cashman JR, Berkman CE, Underiner G, Kolly CA, Hunter AD
    Ref: Chemical Research in Toxicology, 11:895, 1998 : PubMed


    Title: Stereoselective inhibition of human butyrylcholinesterase by phosphonothiolate analogs of (+)- and (-)-cocaine
    Berkman CE, Underiner GE, Cashman JR
    Ref: Biochemical Pharmacology, 54:1261, 1997 : PubMed


    Title: Human liver carboxylesterase hCE-1: binding specificity for cocaine, heroin, and their metabolites and analogs
    Brzezinski MR, Spink BJ, Dean RA, Berkman CE, Cashman JR, Bosron WF
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 25:1089, 1997 : PubMed


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