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| Title : Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine - Yu_2010_Bioorg.Med.Chem_18_4687 |
| Author(s) : Yu QS , Holloway HW , Luo W , Lahiri DK , Brossi A , Greig NH |
| Ref : Bioorganic & Medicinal Chemistry , 18 :4687 , 2010 |
| Abstract : Yu_2010_Bioorg.Med.Chem_18_4687 |
| ESTHER : Yu_2010_Bioorg.Med.Chem_18_4687 |
| PubMedSearch : Yu_2010_Bioorg.Med.Chem_18_4687 |
| PubMedID: 20627738 |
| Title : Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide - Utsuki_2006_J.Pharmacol.Exp.Ther_318_855 |
| Author(s) : Utsuki T , Yu QS , Davidson D , Chen D , Holloway HW , Brossi A , Sambamurti K , Lahiri DK , Greig NH , Giordano T |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 318 :855 , 2006 |
| Abstract : Utsuki_2006_J.Pharmacol.Exp.Ther_318_855 |
| ESTHER : Utsuki_2006_J.Pharmacol.Exp.Ther_318_855 |
| PubMedSearch : Utsuki_2006_J.Pharmacol.Exp.Ther_318_855 |
| PubMedID: 16690718 |
| Title : Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine - Luo_2006_J.Med.Chem_49_2174 |
| Author(s) : Luo W , Yu QS , Kulkarni SS , Parrish DA , Holloway HW , Tweedie D , Shafferman A , Lahiri DK , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 49 :2174 , 2006 |
| Abstract : Luo_2006_J.Med.Chem_49_2174 |
| ESTHER : Luo_2006_J.Med.Chem_49_2174 |
| PubMedSearch : Luo_2006_J.Med.Chem_49_2174 |
| PubMedID: 16570913 |
| Title : Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent - Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| Author(s) : Greig NH , Utsuki T , Ingram DK , Wang Y , Pepeu G , Scali C , Yu QS , Mamczarz J , Holloway HW , Giordano T , Chen D , Furukawa K , Sambamurti K , Brossi A , Lahiri DK |
| Ref : Proc Natl Acad Sci U S A , 102 :17213 , 2005 |
| Abstract : Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| ESTHER : Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| PubMedSearch : Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| PubMedID: 16275899 |
| Title : Syntheses of tetrahydrofurobenzofurans and dihydromethanobenzodioxepines from 5-hydroxy-3-methyl-3H-benzofuran-2-one. Rearrangement and ring expansion under reductive conditions on treatment with hydrides - Luo_2005_J.Org.Chem_70_6171 |
| Author(s) : Luo W , Yu QS , Holloway HW , Parrish D , Greig NH , Brossi A |
| Ref : J Org Chem , 70 :6171 , 2005 |
| Abstract : Luo_2005_J.Org.Chem_70_6171 |
| ESTHER : Luo_2005_J.Org.Chem_70_6171 |
| PubMedSearch : Luo_2005_J.Org.Chem_70_6171 |
| PubMedID: 16050674 |
| Title : Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine - Luo_2005_J.Med.Chem_48_986 |
| Author(s) : Luo W , Yu QS , Zhan M , Parrish D , Deschamps JR , Kulkarni SS , Holloway HW , Alley GM , Lahiri DK , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 48 :986 , 2005 |
| Abstract : Luo_2005_J.Med.Chem_48_986 |
| ESTHER : Luo_2005_J.Med.Chem_48_986 |
| PubMedSearch : Luo_2005_J.Med.Chem_48_986 |
| PubMedID: 15715468 |
| Title : An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease - Greig_2005_Curr.Alzheimer.Res_2_281 |
| Author(s) : Greig NH , Sambamurti K , Yu QS , Brossi A , Bruinsma GB , Lahiri DK |
| Ref : Curr Alzheimer Res , 2 :281 , 2005 |
| Abstract : Greig_2005_Curr.Alzheimer.Res_2_281 |
| ESTHER : Greig_2005_Curr.Alzheimer.Res_2_281 |
| PubMedSearch : Greig_2005_Curr.Alzheimer.Res_2_281 |
| PubMedID: 15974893 |
| Title : Poster (43) BChE inhibition as a treatment strategy for alzheimer's disease. - |
| Author(s) : Greig NH , Ingram DK , Yu QS , Holloway HW , Utsuki T , Brossi A , Sambamurti K , Lahiri DK |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :343 , 2004 |
| PubMedID: |
| Title : Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines - Yu_2002_J.Med.Chem_45_3684 |
| Author(s) : Yu QS , Zhu X , Holloway HW , Whittaker NF , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 45 :3684 , 2002 |
| Abstract : Yu_2002_J.Med.Chem_45_3684 |
| ESTHER : Yu_2002_J.Med.Chem_45_3684 |
| PubMedSearch : Yu_2002_J.Med.Chem_45_3684 |
| PubMedID: 12166941 |
| Title : Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development - Shaw_2001_Proc.Natl.Acad.Sci.U.S.A_98_7605 |
| Author(s) : Shaw KT , Utsuki T , Rogers J , Yu QS , Sambamurti K , Brossi A , Ge YW , Lahiri DK , Greig NH |
| Ref : Proc Natl Acad Sci U S A , 98 :7605 , 2001 |
| Abstract : Shaw_2001_Proc.Natl.Acad.Sci.U.S.A_98_7605 |
| ESTHER : Shaw_2001_Proc.Natl.Acad.Sci.U.S.A_98_7605 |
| PubMedSearch : Shaw_2001_Proc.Natl.Acad.Sci.U.S.A_98_7605 |
| PubMedID: 11404470 |
| Title : Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure\/activity relationships for acetyl- and butyrylcholinesterase inhibitory action - Yu_2001_J.Med.Chem_44_4062 |
| Author(s) : Yu Q , Holloway HW , Flippen-Anderson JL , Hoffman B , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 44 :4062 , 2001 |
| Abstract : Yu_2001_J.Med.Chem_44_4062 |
| ESTHER : Yu_2001_J.Med.Chem_44_4062 |
| PubMedSearch : Yu_2001_J.Med.Chem_44_4062 |
| PubMedID: 11708910 |
| Title : The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics - Greig_2000_Acta.Neurol.Scand.Suppl_176_74 |
| Author(s) : Greig NH , De Micheli E , Holloway HW , Yu QS , Utsuki T , Perry TA , Brossi A , Ingram DK , Deutsch J , Lahiri DK , Soncrant TT |
| Ref : Acta Neurologica Scandinavica Supplementum , 176 :74 , 2000 |
| Abstract : Greig_2000_Acta.Neurol.Scand.Suppl_176_74 |
| ESTHER : Greig_2000_Acta.Neurol.Scand.Suppl_176_74 |
| PubMedSearch : Greig_2000_Acta.Neurol.Scand.Suppl_176_74 |
| PubMedID: 11261809 |
| Title : Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease - Yu_1999_J.Med.Chem_42_1855 |
| Author(s) : Yu Q , Holloway HW , Utsuki T , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 42 :1855 , 1999 |
| Abstract : Yu_1999_J.Med.Chem_42_1855 |
| ESTHER : Yu_1999_J.Med.Chem_42_1855 |
| PubMedSearch : Yu_1999_J.Med.Chem_42_1855 |
| PubMedID: 10346939 |
| Title : Syntheses and anticholinesterase activities of (3aS)-N1, N8- bisnorphenserine, (3aS)-N1,N8-bisnorphysostigmine, their antipodal isomers, and other potential metabolites of phenserine - Yu_1998_J.Med.Chem_41_2371 |
| Author(s) : Yu Q , Greig NH , Holloway HW , Brossi A |
| Ref : Journal of Medicinal Chemistry , 41 :2371 , 1998 |
| Abstract : Yu_1998_J.Med.Chem_41_2371 |
| ESTHER : Yu_1998_J.Med.Chem_41_2371 |
| PubMedSearch : Yu_1998_J.Med.Chem_41_2371 |
| PubMedID: 9632370 |
| Title : Total syntheses and anticholinesterase activities of (3aS)-N(8)- norphysostigmine, (3aS)-N(8)-norphenserine, their antipodal isomers, and other N(8)-substituted analogues - Yu_1997_J.Med.Chem_40_2895 |
| Author(s) : Yu QS , Pei XF , Holloway HW , Greig NH , Brossi A |
| Ref : Journal of Medicinal Chemistry , 40 :2895 , 1997 |
| Abstract : Yu_1997_J.Med.Chem_40_2895 |
| ESTHER : Yu_1997_J.Med.Chem_40_2895 |
| PubMedSearch : Yu_1997_J.Med.Chem_40_2895 |
| PubMedID: 9288171 |
| Title : Maze learning in aged rats is enhanced by phenserine, a novel anticholinesterase - Ikari_1995_Neuroreport_6_481 |
| Author(s) : Ikari H , Spangler EL , Greig NH , Pei XF , Brossi A , Speer D , Patel N , Ingram DK |
| Ref : Neuroreport , 6 :481 , 1995 |
| Abstract : Ikari_1995_Neuroreport_6_481 |
| ESTHER : Ikari_1995_Neuroreport_6_481 |
| PubMedSearch : Ikari_1995_Neuroreport_6_481 |
| PubMedID: 7766848 |
| Title : Phenserine: a physostigmine derivative that is a long-acting inhibitor of cholinesterase and demonstrates a wide dose range for attenuating a scopolamine-induced learning impairment of rats in a 14-unit T-maze - Iijima_1993_Psychopharmacology_112_415 |
| Author(s) : Iijima S , Greig NH , Garofalo P , Spangler EL , Heller B , Brossi A , Ingram DK |
| Ref : Psychopharmacology , 112 :415 , 1993 |
| Abstract : Iijima_1993_Psychopharmacology_112_415 |
| ESTHER : Iijima_1993_Psychopharmacology_112_415 |
| PubMedSearch : Iijima_1993_Psychopharmacology_112_415 |
| PubMedID: 7871051 |
| Title : The long-acting cholinesterase inhibitor heptyl-physostigmine attenuates the scopolamine-induced learning impairment of rats in a 14- unit T-maze - Iijima_1992_Neurosci.Lett_144_79 |
| Author(s) : Iijima S , Greig NH , Garofalo P , Spangler EL , Heller B , Brossi A , Ingram DK |
| Ref : Neuroscience Letters , 144 :79 , 1992 |
| Abstract : Iijima_1992_Neurosci.Lett_144_79 |
| ESTHER : Iijima_1992_Neurosci.Lett_144_79 |
| PubMedSearch : Iijima_1992_Neurosci.Lett_144_79 |
| PubMedID: 1436716 |
| Title : Comparative inhibitory effects of various physostigmine analogs against acetyl- and butyrylcholinesterases - Atack_1989_J.Pharmacol.Exp.Ther_249_194 |
| Author(s) : Atack JR , Yu QS , Soncrant TT , Brossi A , Rapoport SI |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 249 :194 , 1989 |
| Abstract : Atack_1989_J.Pharmacol.Exp.Ther_249_194 |
| ESTHER : Atack_1989_J.Pharmacol.Exp.Ther_249_194 |
| PubMedSearch : Atack_1989_J.Pharmacol.Exp.Ther_249_194 |
| PubMedID: 2709330 |
| Title : Enantiomer (+)physostigmine prevents organophosphate-induced subjunctional damage at the neuromuscular synapse by a mechanism not related to cholinesterase carbamylation - Kawabuchi_1988_Synapse_2_139 |
| Author(s) : Kawabuchi M , Boyne AF , Deshpande SS , Cintra WM , Brossi A , Albuquerque EX |
| Ref : Synapse , 2 :139 , 1988 |
| Abstract : Kawabuchi_1988_Synapse_2_139 |
| ESTHER : Kawabuchi_1988_Synapse_2_139 |
| PubMedSearch : Kawabuchi_1988_Synapse_2_139 |
| PubMedID: 3420535 |
| Title : Carbamate analogues of (-)-physostigmine: in vitro inhibition of acetyl- and butyrylcholinesterase - Yu_1988_FEBS.Lett_234_127 |
| Author(s) : Yu QS , Atack JR , Rapoport SI , Brossi A |
| Ref : FEBS Letters , 234 :127 , 1988 |
| Abstract : Yu_1988_FEBS.Lett_234_127 |
| ESTHER : Yu_1988_FEBS.Lett_234_127 |
| PubMedSearch : Yu_1988_FEBS.Lett_234_127 |
| PubMedID: 3391264 |
| Title : Structure-activity relationship of reversible cholinesterase inhibitors: activation, channel blockade and stereospecificity of the nicotinic acetylcholine receptor-ion channel complex - Albuquerque_1988_Braz.J.Med.Biol.Res_21_1173 |
| Author(s) : Albuquerque EX , Aracava Y , Cintra WM , Brossi A , Schonenberger B , Deshpande SS |
| Ref : Brazilian Journal of Medical & Biological Research , 21 :1173 , 1988 |
| Abstract : Albuquerque_1988_Braz.J.Med.Biol.Res_21_1173 |
| ESTHER : Albuquerque_1988_Braz.J.Med.Biol.Res_21_1173 |
| PubMedSearch : Albuquerque_1988_Braz.J.Med.Biol.Res_21_1173 |
| PubMedID: 3074841 |
| Title : The molecular basis of anticholinesterase actions on nicotinic and glutamatergic synapses - |
| Author(s) : Aracava Y , Deshpande SS , Rickett DL , Brossi A , Schonenberger B , Albuquerque EX |
| Ref : Annals of the New York Academy of Sciences , 505 :226 , 1987 |
| PubMedID: 2446549 |
| Title : Interaction of analogs of histrionicotoxin with the acetylcholine receptor ionic channel complex and membrane excitability - Maleque_1984_J.Pharmacol.Exp.Ther_229_72 |
| Author(s) : Maleque MA , Brossi A , Witkop B , Godleski SA , Albuquerque EX |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 229 :72 , 1984 |
| Abstract : Maleque_1984_J.Pharmacol.Exp.Ther_229_72 |
| ESTHER : Maleque_1984_J.Pharmacol.Exp.Ther_229_72 |
| PubMedSearch : Maleque_1984_J.Pharmacol.Exp.Ther_229_72 |
| PubMedID: 6323691 |
| Title : A study of the novel synthetic analog (+\/-)-depentylperhydrohistrionicotoxin on the nicotinic receptor-ion channel complex - Maleque_1984_J.Pharmacol.Exp.Ther_230_619 |
| Author(s) : Maleque MA , Takahashi K , Witkop B , Brossi A , Albuquerque EX |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 230 :619 , 1984 |
| Abstract : Maleque_1984_J.Pharmacol.Exp.Ther_230_619 |
| ESTHER : Maleque_1984_J.Pharmacol.Exp.Ther_230_619 |
| PubMedSearch : Maleque_1984_J.Pharmacol.Exp.Ther_230_619 |
| PubMedID: 6088758 |
| Title : The ionic channel of the nicotinic acetylcholine receptor is unable to differentiate between the optical antipodes of perhydrohistrionicotoxin - Spivak_1983_FEBS.Lett_163_189 |
| Author(s) : Spivak CE , Maleque MA , Takahashi K , Brossi A , Albuquerque EX |
| Ref : FEBS Letters , 163 :189 , 1983 |
| Abstract : Spivak_1983_FEBS.Lett_163_189 |
| ESTHER : Spivak_1983_FEBS.Lett_163_189 |
| PubMedSearch : Spivak_1983_FEBS.Lett_163_189 |
| PubMedID: 6315487 |
| Title : (+\/-)-2-Depentylperhydrohistrionicotoxin: a new probe for a regulatory site on the nicotinic acetylcholine receptor-channel - Takahashi_1982_J.Med.Chem_25_919 |
| Author(s) : Takahashi K , Jacobson AE , Mak CP , Witkop B , Brossi A , Albuquerque EX , Warnick JE , Maleque MA , Bavoso A , Silverton JV |
| Ref : Journal of Medicinal Chemistry , 25 :919 , 1982 |
| Abstract : Takahashi_1982_J.Med.Chem_25_919 |
| ESTHER : Takahashi_1982_J.Med.Chem_25_919 |
| PubMedSearch : Takahashi_1982_J.Med.Chem_25_919 |
| PubMedID: 6288946 |
| Title : Metabolic studies of tetrabenazine, a psychotropic drug in animals and man - |
| Author(s) : Schwartz DE , Bruderer H , Rieder J , Brossi A |
| Ref : Biochemical Pharmacology , 15 :645 , 1966 |
| PubMedID: 5961439 |