Full name : Broomfield Clarence A
First name : Clarence A
Mail : U.S. Army Medical Research Institute of Chemical Defense, 1917 Youngston Rd, Jarretsville, MD 21084 Aberdeen Proving Ground, MD 21010-5425
Zip Code :
City :
Country : USA
Email :
Phone :
Fax :
Website :
Directory :
| Title : Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents - Geyer_2010_Proc.Natl.Acad.Sci.U.S.A_107_20251 |
| Author(s) : Geyer BC , Kannan L , Garnaud PE , Broomfield CA , Cadieux CL , Cherni I , Hodgins SM , Kasten SA , Kelley K , Kilbourne J , Oliver ZP , Otto TC , Puffenberger I , Reeves TE , Robbins N, 2nd , Woods RR , Soreq H , Lenz DE , Cerasoli DM , Mor TS |
| Ref : Proc Natl Acad Sci U S A , 107 :20251 , 2010 |
| Abstract : Geyer_2010_Proc.Natl.Acad.Sci.U.S.A_107_20251 |
| ESTHER : Geyer_2010_Proc.Natl.Acad.Sci.U.S.A_107_20251 |
| PubMedSearch : Geyer_2010_Proc.Natl.Acad.Sci.U.S.A_107_20251 |
| PubMedID: 21059932 |
| Title : Comparison of human and guinea pig acetylcholinesterase sequences and rates of oxime-assisted reactivation - Cadieux_2010_Chem.Biol.Interact_187_229 |
| Author(s) : Cadieux CL , Broomfield CA , Kirkpatrick MG , Kazanski ME , Lenz DE , Cerasoli DM |
| Ref : Chemico-Biological Interactions , 187 :229 , 2010 |
| Abstract : Cadieux_2010_Chem.Biol.Interact_187_229 |
| ESTHER : Cadieux_2010_Chem.Biol.Interact_187_229 |
| PubMedSearch : Cadieux_2010_Chem.Biol.Interact_187_229 |
| PubMedID: 20433814 |
| Gene_locus related to this paper: cavpo-d3ye96 |
| Title : A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters - Masson_2008_Chem.Biol.Interact_175_273 |
| Author(s) : Masson P , Nachon F , Broomfield CA , Lenz DE , Verdier L , Schopfer LM , Lockridge O |
| Ref : Chemico-Biological Interactions , 175 :273 , 2008 |
| Abstract : Masson_2008_Chem.Biol.Interact_175_273 |
| ESTHER : Masson_2008_Chem.Biol.Interact_175_273 |
| PubMedSearch : Masson_2008_Chem.Biol.Interact_175_273 |
| PubMedID: 18508040 |
| Title : Mutants of human butyrylcholinesterase with organophosphate hydrolase activity\; evidence that His117 is a general base catalyst for hydrolysis of echothiophate - Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1 |
| Author(s) : Schopfer LM , Boeck AT , Broomfield CA , Lockridge O |
| Ref : Journal of Medicinal Chemistryical Biology Radiol Def , 2 :1 , 2004 |
| Abstract : Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1 |
| ESTHER : Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1 |
| PubMedSearch : Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1 |
| PubMedID: |
| Title : Serum paraoxonase (PON1) isozymes: the quantitative analysis of isozymes affecting individual sensitivity to environmental chemicals - La_2001_Drug.Metab.Dispos_29_566 |
| Author(s) : La Du BN , Billecke S , Hsu C , Haley RW , Broomfield CA |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 29 :566 , 2001 |
| Abstract : La_2001_Drug.Metab.Dispos_29_566 |
| ESTHER : La_2001_Drug.Metab.Dispos_29_566 |
| PubMedSearch : La_2001_Drug.Metab.Dispos_29_566 |
| PubMedID: 11259353 |
| Title : Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to vx lethality - Duysen_2001_J.Pharmacol.Exp.Ther_299_528 |
| Author(s) : Duysen EG , Li B , Xie W , Schopfer LM , Anderson RS , Broomfield CA , Lockridge O |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 299 :528 , 2001 |
| Abstract : Duysen_2001_J.Pharmacol.Exp.Ther_299_528 |
| ESTHER : Duysen_2001_J.Pharmacol.Exp.Ther_299_528 |
| PubMedSearch : Duysen_2001_J.Pharmacol.Exp.Ther_299_528 |
| PubMedID: 11602663 |
| Title : Protective action of the serine protease inhibitor N-tosyl-L-lysine chloromethyl ketone (TLCK) against acute soman poisoning - Cowan_2001_J.Appl.Toxicol_21_293 |
| Author(s) : Cowan FM , Broomfield CA , Lenz DE , Shih TM |
| Ref : J Appl Toxicol , 21 :293 , 2001 |
| Abstract : Cowan_2001_J.Appl.Toxicol_21_293 |
| ESTHER : Cowan_2001_J.Appl.Toxicol_21_293 |
| PubMedSearch : Cowan_2001_J.Appl.Toxicol_21_293 |
| PubMedID: 11481662 |
| Title : Expression of biologically active human butyrylcholinesterase in the cabbage looper (Trichoplusia ni) - Platteborze_2000_Biotechnol.Appl.Biochem_31 ( Pt 3)_225 |
| Author(s) : Platteborze PL , Broomfield CA |
| Ref : Biotechnol Appl Biochem , 31 ( Pt 3) :225 , 2000 |
| Abstract : Platteborze_2000_Biotechnol.Appl.Biochem_31 ( Pt 3)_225 |
| ESTHER : Platteborze_2000_Biotechnol.Appl.Biochem_31 ( Pt 3)_225 |
| PubMedSearch : Platteborze_2000_Biotechnol.Appl.Biochem_31 ( Pt 3)_225 |
| PubMedID: 10814593 |
| Title : Characterization of a soluble mouse liver enzyme capable of hydrolyzing diisopropyl phosphorofluoridate - Billecke_1999_Chem.Biol.Interact_119-120_251 |
| Author(s) : Billecke SS , Primo-Parmo SL , Dunlop CS , Doorn JA , La Du BN , Broomfield CA |
| Ref : Chemico-Biological Interactions , 119-120 :251 , 1999 |
| Abstract : Billecke_1999_Chem.Biol.Interact_119-120_251 |
| ESTHER : Billecke_1999_Chem.Biol.Interact_119-120_251 |
| PubMedSearch : Billecke_1999_Chem.Biol.Interact_119-120_251 |
| PubMedID: 10421459 |
| Title : Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterization - Broomfield_1999_Chem.Biol.Interact_119-120_413 |
| Author(s) : Broomfield CA , Lockridge O , Millard CB |
| Ref : Chemico-Biological Interactions , 119-120 :413 , 1999 |
| Abstract : Broomfield_1999_Chem.Biol.Interact_119-120_413 |
| ESTHER : Broomfield_1999_Chem.Biol.Interact_119-120_413 |
| PubMedSearch : Broomfield_1999_Chem.Biol.Interact_119-120_413 |
| PubMedID: 10421478 |
| Title : Mechanical Aspects of the Phosphotriesterase Activity of Human Butyrylcholinesterase G117H Mutant - |
| Author(s) : Albaret C , Masson P , Broomfield CA , Kaim LE , Fortier PL |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :399 , 1998 |
| PubMedID: |
| Title : Poster: Mechanical Aspects of the Phosphotriesterase Activity of Human Butyrylcholinesterase G117H Mutant - |
| Author(s) : Albaret C , Masson P , Broomfield CA , Kaim LE , Fortier PL |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :434 , 1998 |
| PubMedID: |
| Title : Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase - Millard_1998_Biochemistry_37_237 |
| Author(s) : Millard CB , Lockridge O , Broomfield CA |
| Ref : Biochemistry , 37 :237 , 1998 |
| Abstract : Millard_1998_Biochemistry_37_237 |
| ESTHER : Millard_1998_Biochemistry_37_237 |
| PubMedSearch : Millard_1998_Biochemistry_37_237 |
| PubMedID: 9425044 |
| Gene_locus related to this paper: human-BCHE |
| Title : Expression of Human Butyrylcholinesterase in Trichoplusia ni Insect Larvae - |
| Author(s) : Platteborze PL , Lockridge O , Broomfield CA |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :150 , 1998 |
| PubMedID: |
| Title : Reaction of Human Butyrylcholinesterase (BChE) H117 Enzymes with Carbamates - |
| Author(s) : Broomfield CA , Mills KV , Meier BM , Lockridge O , Millard CB |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :223 , 1998 |
| PubMedID: |
| Title : A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase - Lockridge_1997_Biochemistry_36_786 |
| Author(s) : Lockridge O , Blong RM , Masson P , Froment MT , Millard CB , Broomfield CA |
| Ref : Biochemistry , 36 :786 , 1997 |
| Abstract : Lockridge_1997_Biochemistry_36_786 |
| ESTHER : Lockridge_1997_Biochemistry_36_786 |
| PubMedSearch : Lockridge_1997_Biochemistry_36_786 |
| PubMedID: 9020776 |
| Title : Unique push-pull mechanism of dealkylation in soman-inhibited cholinesterases - Viragh_1997_Biochemistry_36_8243 |
| Author(s) : Viragh C , Akhmetshin R , Kovach IM , Broomfield CA |
| Ref : Biochemistry , 36 :8243 , 1997 |
| Abstract : Viragh_1997_Biochemistry_36_8243 |
| ESTHER : Viragh_1997_Biochemistry_36_8243 |
| PubMedSearch : Viragh_1997_Biochemistry_36_8243 |
| PubMedID: 9204869 |
| Title : The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin - Davies_1996_Nat.Genet_14_334 |
| Author(s) : Davies HG , Richter RJ , Keifer M , Broomfield CA , Sowalla J , Furlong CE |
| Ref : Nat Genet , 14 :334 , 1996 |
| Abstract : Davies_1996_Nat.Genet_14_334 |
| ESTHER : Davies_1996_Nat.Genet_14_334 |
| PubMedSearch : Davies_1996_Nat.Genet_14_334 |
| PubMedID: 8896566 |
| Title : Anticholinesterases: medical applications of neurochemical principles. - Millard_1995_J.Neurochem_64_1909 |
| Author(s) : Millard CB , Broomfield CA |
| Ref : Journal of Neurochemistry , 64 :1909 , 1995 |
| Abstract : Millard_1995_J.Neurochem_64_1909 |
| ESTHER : Millard_1995_J.Neurochem_64_1909 |
| PubMedSearch : Millard_1995_J.Neurochem_64_1909 |
| PubMedID: 7722478 |
| Title : Design and expression of organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase - Millard_1995_Biochemistry_34_15925 |
| Author(s) : Millard CB , Lockridge O , Broomfield CA |
| Ref : Biochemistry , 34 :15925 , 1995 |
| Abstract : Millard_1995_Biochemistry_34_15925 |
| ESTHER : Millard_1995_Biochemistry_34_15925 |
| PubMedSearch : Millard_1995_Biochemistry_34_15925 |
| PubMedID: 8519749 |
| Title : Mutation of Human Butyrylcholinesterase Glycine 117 to Histidine Preserves Activity but Confers Resistance to Organophosphorus Inhibitors - |
| Author(s) : Broomfield CA , Millard CB , Lockridge O , Caviston TL |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :169 , 1995 |
| PubMedID: |
| Title : Behavioral decrements persist in rhesus monkeys trained on a serial probe recognition task despite protection against soman lethality by butyrylcholinesterase - Castro_1994_Neurotoxicol.Teratol_16_145 |
| Author(s) : Castro CA , Gresham VC , Finger AV , Maxwell DM , Solana RP , Lenz DE , Broomfield CA |
| Ref : Neurotoxicology & Teratology , 16 :145 , 1994 |
| Abstract : Castro_1994_Neurotoxicol.Teratol_16_145 |
| ESTHER : Castro_1994_Neurotoxicol.Teratol_16_145 |
| PubMedSearch : Castro_1994_Neurotoxicol.Teratol_16_145 |
| PubMedID: 8052188 |
| Title : A purified recombinant organophosphorus acid anhydrase protects mice against soman - Broomfield_1993_Chem.Biol.Interact_87_279 |
| Author(s) : Broomfield CA |
| Ref : Chemico-Biological Interactions , 87 :279 , 1993 |
| Abstract : Broomfield_1993_Chem.Biol.Interact_87_279 |
| ESTHER : Broomfield_1993_Chem.Biol.Interact_87_279 |
| PubMedSearch : Broomfield_1993_Chem.Biol.Interact_87_279 |
| PubMedID: 8393744 |
| Title : Catalytic antibodies hydrolysing organophosphorus esters - Brimfield_1993_Chem.Biol.Interact_87_95 |
| Author(s) : Brimfield AA , Lenz DE , Maxwell DM , Broomfield CA |
| Ref : Chemico-Biological Interactions , 87 :95 , 1993 |
| Abstract : Brimfield_1993_Chem.Biol.Interact_87_95 |
| ESTHER : Brimfield_1993_Chem.Biol.Interact_87_95 |
| PubMedSearch : Brimfield_1993_Chem.Biol.Interact_87_95 |
| PubMedID: 8344006 |
| Title : A computer model of glycosylated human butyrylcholinesterase - Millard_1992_Biochem.Biophys.Res.Commun_189_1280 |
| Author(s) : Millard CB , Broomfield CA |
| Ref : Biochemical & Biophysical Research Communications , 189 :1280 , 1992 |
| Abstract : Millard_1992_Biochem.Biophys.Res.Commun_189_1280 |
| ESTHER : Millard_1992_Biochem.Biophys.Res.Commun_189_1280 |
| PubMedSearch : Millard_1992_Biochem.Biophys.Res.Commun_189_1280 |
| PubMedID: 1482344 |
| Title : Cholinesterase studies with (R) (+)- and (S)(-)-5-(1,3,3-trimethylindolinyl)-N-(1-phenylethyl)carbamate - Lieske_1992_J.Enzyme.Inhib_6_283 |
| Author(s) : Lieske CN , Gepp RT , Maxwell DM , Clark JH , Broomfield CA , Blumbergs P , Tseng CC |
| Ref : J Enzyme Inhib , 6 :283 , 1992 |
| Abstract : Lieske_1992_J.Enzyme.Inhib_6_283 |
| ESTHER : Lieske_1992_J.Enzyme.Inhib_6_283 |
| PubMedSearch : Lieske_1992_J.Enzyme.Inhib_6_283 |
| PubMedID: 1284965 |
| Title : A novel tertiary pyridostigmine derivative [3-(N,N-dimethylcarbamyloxy)-1-methyl-delta 3-tetrahydropyridine]: anticholinesterase properties and efficacy against soman - Ray_1991_Fundam.Appl.Toxicol_16_267 |
| Author(s) : Ray R , Clark OEd , Ford KW , Knight KR , Harris LW , Broomfield CA |
| Ref : Fundamental & Applied Toxicology , 16 :267 , 1991 |
| Abstract : Ray_1991_Fundam.Appl.Toxicol_16_267 |
| ESTHER : Ray_1991_Fundam.Appl.Toxicol_16_267 |
| PubMedSearch : Ray_1991_Fundam.Appl.Toxicol_16_267 |
| PubMedID: 2055358 |
| Title : Poster: Hydrolysis of nerve agents by plasma enzymes - |
| Author(s) : Broomfield CA , Ford KW |
| Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :307 , 1991 |
| PubMedID: |
| Title : Protection by butyrylcholinesterase against organophosphorus poisoning in nonhuman primates - Broomfield_1991_J.Pharmacol.Exp.Ther_259_633 |
| Author(s) : Broomfield CA , Maxwell DM , Solana RP , Castro CA , Finger AV , Lenz DE |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 259 :633 , 1991 |
| Abstract : Broomfield_1991_J.Pharmacol.Exp.Ther_259_633 |
| ESTHER : Broomfield_1991_J.Pharmacol.Exp.Ther_259_633 |
| PubMedSearch : Broomfield_1991_J.Pharmacol.Exp.Ther_259_633 |
| PubMedID: 1941611 |
| Title : Poster: Protection by butyry1cholinesterase against soman poisoning - |
| Author(s) : Lenz DE , Broomfield CA , Maxwell CA , Solana RP , Finger AV , Woodard CL |
| Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :302 , 1991 |
| PubMedID: |
| Title : pH effects in the spontaneous reactivation of phosphinylated acetylcholinesterase - Lieske_1990_Life.Sci_46_1189 |
| Author(s) : Lieske CN , Gessner CE , Gepp RT , Clark JH , Meyer HG , Broomfield CA |
| Ref : Life Sciences , 46 :1189 , 1990 |
| Abstract : Lieske_1990_Life.Sci_46_1189 |
| ESTHER : Lieske_1990_Life.Sci_46_1189 |
| PubMedSearch : Lieske_1990_Life.Sci_46_1189 |
| PubMedID: 2338884 |
| Title : Binding of soman antidotes to acetylcholine receptors - Broomfield_1987_Biochem.Pharmacol_36_1017 |
| Author(s) : Broomfield CA , Dembure IJ , Cuculis J |
| Ref : Biochemical Pharmacology , 36 :1017 , 1987 |
| Abstract : Broomfield_1987_Biochem.Pharmacol_36_1017 |
| ESTHER : Broomfield_1987_Biochem.Pharmacol_36_1017 |
| PubMedSearch : Broomfield_1987_Biochem.Pharmacol_36_1017 |
| PubMedID: 3566797 |
| Title : Poster: Use of methyl-quinuclidinyl benzilate for the assay of muscarinic cholinergic binding sites - |
| Author(s) : Filbert MG , Broomfield CA , Dembure IJ , Baskin SI |
| Ref : Trends in Pharmacological Sciences , Suppl :79 , 1986 |
| PubMedID: |
| Title : Poster: The binding of soman antidotes to muscarinic acetylcholine receptors - |
| Author(s) : Broomfield CA , Dembure IJ , Cuculis J |
| Ref : Trends in Pharmacological Sciences , Suppl :81 , 1986 |
| PubMedID: |
| Title : The effects of atropine-oxime therapy on cholinesterase activity and survival of animals intoxicated with p-nitrophenyl di-n-butylphosphinate - |
| Author(s) : Harris LW , Stitcher DL , Heyl WC , Lieske CN , Lowe JR , Clark JH , Broomfield CA |
| Ref : Toxicology & Applied Pharmacology , 49 :23 , 1979 |
| PubMedID: 473199 |
| Title : Effects of 1,1'-oxydimethylene bis-(4-tert-butylpyridinium chloride) (SAD-128) and decamethonium on reactivation of soman- and sarin-inhibited cholinesterase by oximes - |
| Author(s) : Harris LW , Heyl WC , Stitcher DL , Broomfield CA |
| Ref : Biochemical Pharmacology , 27 :757 , 1978 |
| PubMedID: 656114 |
| Title : Spontaneous reactivation of acetylcholinesterase following organophosphate inhibition. I. An analysis of anomalous reactivation kinetics - Hovanec_1977_Biochim.Biophys.Acta_483_312 |
| Author(s) : Hovanec JW , Broomfield CA , Steinberg GM , Lanks KW , Lieske CN |
| Ref : Biochimica & Biophysica Acta , 483 :312 , 1977 |
| Abstract : Hovanec_1977_Biochim.Biophys.Acta_483_312 |
| ESTHER : Hovanec_1977_Biochim.Biophys.Acta_483_312 |
| PubMedSearch : Hovanec_1977_Biochim.Biophys.Acta_483_312 |
| PubMedID: 19068 |
| Title : Guinea pig brain acetylcholinesterase: partial purification by affinity chromatography - |
| Author(s) : Yamamura HI , Reichard DW , Gardner TL , Morrisett JD , Broomfield CA |
| Ref : Biochimica & Biophysica Acta , 302 :305 , 1973 |
| PubMedID: 4699242 |
| Title : A comparative study of spin-labeled serine enzymes: acetylcholinesterase, trypsin, -chymotrypsin, elastase, and subtilisin - |
| Author(s) : Morrisett JD , Broomfield CA |
| Ref : Journal of Biological Chemistry , 247 :7224 , 1972 |
| PubMedID: 4344643 |
| Title : A new spin label specific for the active site of serine enzymes - |
| Author(s) : Morrisett JD , Broomfield CA , Hackley BE, Jr. |
| Ref : Journal of Biological Chemistry , 244 :5758 , 1969 |
| PubMedID: 4310606 |