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| Title : From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease - Brown_2021_Cell_184_5886 |
| Author(s) : Brown AJH , Bradley SJ , Marshall FH , Brown GA , Bennett KA , Brown J , Cansfield JE , Cross DM , de Graaf C , Hudson BD , Dwomoh L , Dias JM , Errey JC , Hurrell E , Liptrot J , Mattedi G , Molloy C , Nathan PJ , Okrasa K , Osborne G , Patel JC , Pickworth M , Robertson N , Shahabi S , Bundgaard C , Phillips K , Broad LM , Goonawardena AV , Morairty SR , Browning M , Perini F , Dawson GR , Deakin JFW , Smith RT , Sexton PM , Warneck J , Vinson M , Tasker T , Tehan BG , Teobald B , Christopoulos A , Langmead CJ , Jazayeri A , Cooke RM , Rucktooa P , Congreve MS , Weir M , Tobin AB |
| Ref : Cell , 184 :5886 , 2021 |
| Abstract : Brown_2021_Cell_184_5886 |
| ESTHER : Brown_2021_Cell_184_5886 |
| PubMedSearch : Brown_2021_Cell_184_5886 |
| PubMedID: 34822784 |
| Title : Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs - Bradley_2020_Nat.Chem.Biol_16_240 |
| Author(s) : Bradley SJ , Molloy C , Valuskova P , Dwomoh L , Scarpa M , Rossi M , Finlayson L , Svensson KA , Chernet E , Barth VN , Gherbi K , Sykes DA , Wilson CA , Mistry R , Sexton PM , Christopoulos A , Mogg AJ , Rosethorne EM , Sakata S , John Challiss RA , Broad LM , Tobin AB |
| Ref : Nat Chemical Biology , 16 :240 , 2020 |
| Abstract : Bradley_2020_Nat.Chem.Biol_16_240 |
| ESTHER : Bradley_2020_Nat.Chem.Biol_16_240 |
| PubMedSearch : Bradley_2020_Nat.Chem.Biol_16_240 |
| PubMedID: 32080630 |
| Title : Acetylcholine modulates gamma frequency oscillations in the hippocampus by activation of muscarinic M1 receptors - Betterton_2017_Eur.J.Neurosci_45_1570 |
| Author(s) : Betterton RT , Broad LM , Tsaneva-Atanasova K , Mellor JR |
| Ref : European Journal of Neuroscience , 45 :1570 , 2017 |
| Abstract : Betterton_2017_Eur.J.Neurosci_45_1570 |
| ESTHER : Betterton_2017_Eur.J.Neurosci_45_1570 |
| PubMedSearch : Betterton_2017_Eur.J.Neurosci_45_1570 |
| PubMedID: 28406538 |
| Title : M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss - Bradley_2017_J.Clin.Invest_127_487 |
| Author(s) : Bradley SJ , Bourgognon JM , Sanger HE , Verity N , Mogg AJ , White DJ , Butcher AJ , Moreno JA , Molloy C , Macedo-Hatch T , Edwards JM , Wess J , Pawlak R , Read DJ , Sexton PM , Broad LM , Steinert JR , Mallucci GR , Christopoulos A , Felder CC , Tobin AB |
| Ref : J Clinical Investigation , 127 :487 , 2017 |
| Abstract : Bradley_2017_J.Clin.Invest_127_487 |
| ESTHER : Bradley_2017_J.Clin.Invest_127_487 |
| PubMedSearch : Bradley_2017_J.Clin.Invest_127_487 |
| PubMedID: 27991860 |
| Title : Sazetidine-A is a potent and selective agonist at native and recombinant alpha 4 beta 2 nicotinic acetylcholine receptors - Zwart_2008_Mol.Pharmacol_73_1838 |
| Author(s) : Zwart R , Carbone AL , Moroni M , Bermudez I , Mogg AJ , Folly EA , Broad LM , Williams AC , Zhang D , Ding C , Heinz BA , Sher E |
| Ref : Molecular Pharmacology , 73 :1838 , 2008 |
| Abstract : Zwart_2008_Mol.Pharmacol_73_1838 |
| ESTHER : Zwart_2008_Mol.Pharmacol_73_1838 |
| PubMedSearch : Zwart_2008_Mol.Pharmacol_73_1838 |
| PubMedID: 18367540 |
| Title : Species selectivity of a nicotinic acetylcholine receptor agonist is conferred by two adjacent extracellular beta4 amino acids that are implicated in the coupling of binding to channel gating - Young_2007_Mol.Pharmacol_71_389 |
| Author(s) : Young GT , Broad LM , Zwart R , Astles PC , Bodkin M , Sher E , Millar NS |
| Ref : Molecular Pharmacology , 71 :389 , 2007 |
| Abstract : Young_2007_Mol.Pharmacol_71_389 |
| ESTHER : Young_2007_Mol.Pharmacol_71_389 |
| PubMedSearch : Young_2007_Mol.Pharmacol_71_389 |
| PubMedID: 17065235 |
| Title : Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators - Broad_2006_J.Pharmacol.Exp.Ther_318_1108 |
| Author(s) : Broad LM , Zwart R , Pearson KH , Lee M , Wallace L , McPhie GI , Emkey R , Hollinshead SP , Dell CP , Baker SR , Sher E |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 318 :1108 , 2006 |
| Abstract : Broad_2006_J.Pharmacol.Exp.Ther_318_1108 |
| ESTHER : Broad_2006_J.Pharmacol.Exp.Ther_318_1108 |
| PubMedSearch : Broad_2006_J.Pharmacol.Exp.Ther_318_1108 |
| PubMedID: 16738207 |
| Title : 5-I A-85380 and TC-2559 differentially activate heterologously expressed alpha4beta2 nicotinic receptors - Zwart_2006_Eur.J.Pharmacol_539_10 |
| Author(s) : Zwart R , Broad LM , Xi Q , Lee M , Moroni M , Bermudez I , Sher E |
| Ref : European Journal of Pharmacology , 539 :10 , 2006 |
| Abstract : Zwart_2006_Eur.J.Pharmacol_539_10 |
| ESTHER : Zwart_2006_Eur.J.Pharmacol_539_10 |
| PubMedSearch : Zwart_2006_Eur.J.Pharmacol_539_10 |
| PubMedID: 16674940 |
| Title : Stable expression and characterisation of a human alpha 7 nicotinic subunit chimera: a tool for functional high-throughput screening - Craig_2004_Eur.J.Pharmacol_502_31 |
| Author(s) : Craig PJ , Bose S , Zwart R , Beattie RE , Folly EA , Johnson LR , Bell E , Evans NM , Benedetti G , Pearson KH , McPhie GI , Volsen SG , Millar NS , Sher E , Broad LM |
| Ref : European Journal of Pharmacology , 502 :31 , 2004 |
| Abstract : Craig_2004_Eur.J.Pharmacol_502_31 |
| ESTHER : Craig_2004_Eur.J.Pharmacol_502_31 |
| PubMedSearch : Craig_2004_Eur.J.Pharmacol_502_31 |
| PubMedID: 15464087 |
| Title : Common structural and pharmacological properties of serotonin 5-HT3 receptors and alpha7 nicotinic acetylcholine receptors. - |
| Author(s) : Zwart R , Bodkin M , Broad LM , De Filippi G , Craig PJ , Baldwinson T , Benedetti G , Felthouse C , McPhie GI , Pearson KH , Sher E |
| Ref : Cholinergic Mechanisms, CRC Press :309 , 2004 |
| PubMedID: |
| Title : Expression and functional characterisation of a human chimeric nicotinic receptor with alpha6beta4 properties - Evans_2003_Eur.J.Pharmacol_466_31 |
| Author(s) : Evans NM , Bose S , Benedetti G , Zwart R , Pearson KH , McPhie GI , Craig PJ , Benton JP , Volsen SG , Sher E , Broad LM |
| Ref : European Journal of Pharmacology , 466 :31 , 2003 |
| Abstract : Evans_2003_Eur.J.Pharmacol_466_31 |
| ESTHER : Evans_2003_Eur.J.Pharmacol_466_31 |
| PubMedSearch : Evans_2003_Eur.J.Pharmacol_466_31 |
| PubMedID: 12679139 |
| Title : PSAB-OFP, a selective alpha 7 nicotinic receptor agonist, is also a potent agonist of the 5-HT3 receptor - Broad_2002_Eur.J.Pharmacol_452_137 |
| Author(s) : Broad LM , Felthouse C , Zwart R , McPhie GI , Pearson KH , Craig PJ , Wallace L , Broadmore RJ , Boot JR , Keenan M , Baker SR , Sher E |
| Ref : European Journal of Pharmacology , 452 :137 , 2002 |
| Abstract : Broad_2002_Eur.J.Pharmacol_452_137 |
| ESTHER : Broad_2002_Eur.J.Pharmacol_452_137 |
| PubMedSearch : Broad_2002_Eur.J.Pharmacol_452_137 |
| PubMedID: 12354563 |