Full name : Brazzolotto Xavier
First name : Xavier
Mail : Institut de Recherche Biomedicale des Armees, 91223 Bretigny sur Orge
Zip Code :
City :
Country : France
Email : xavier.brazzolotto@irba.fr
Phone : +33476639738
Fax :
Website :
Directory :
| Title : Detoxification of V-nerve agents assisted by a microperoxidase: new pathway revealed by the use of a relevant VX simulant - Baptista_2024_Chembiochem__e202400137 |
| Author(s) : Baptista da Silva V , Mahy JP , Brazzolotto X , Renard PY , Ricoux R , Legros J |
| Ref : Chembiochem , :e202400137 , 2024 |
| Abstract : Baptista_2024_Chembiochem__e202400137 |
| ESTHER : Baptista_2024_Chembiochem__e202400137 |
| PubMedSearch : Baptista_2024_Chembiochem__e202400137 |
| PubMedID: 38591336 |
| Title : Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation - Pidany_2023_Eur.J.Med.Chem_252_115301 |
| Author(s) : Pidany F , Kroustkova J , Al Mamun A , Suchankova D , Brazzolotto X , Nachon F , Chantegreil F , Dolezal R , Pulkrabkova L , Muckova L , Hrabinova M , Finger V , Kufa M , Soukup O , Jun D , Jenco J , Kunes J , Novakova L , Korabecny J , Cahlikova L |
| Ref : Eur Journal of Medicinal Chemistry , 252 :115301 , 2023 |
| Abstract : Pidany_2023_Eur.J.Med.Chem_252_115301 |
| ESTHER : Pidany_2023_Eur.J.Med.Chem_252_115301 |
| PubMedSearch : Pidany_2023_Eur.J.Med.Chem_252_115301 |
| PubMedID: 36996715 |
| Gene_locus related to this paper: human-BCHE |
| Title : Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies - Jing_2023_Bioorg.Chem_134_106465 |
| Author(s) : Jing L , Wei W , Meng B , Chantegreil F , Nachon F , Martinez A , Wu G , Zhao H , Song Y , Kang D , Brazzolotto X , Zhan P , Liu X |
| Ref : Bioorg Chem , 134 :106465 , 2023 |
| Abstract : Jing_2023_Bioorg.Chem_134_106465 |
| ESTHER : Jing_2023_Bioorg.Chem_134_106465 |
| PubMedSearch : Jing_2023_Bioorg.Chem_134_106465 |
| PubMedID: 36933339 |
| Gene_locus related to this paper: human-BCHE |
| Title : 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases - Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152 |
| Author(s) : Knez D , Diez-Iriepa D , Chioua M , Gottinger A , Denic M , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Meden A , Pislar A , Kos J , Zakelj S , Stojan J , Salat K , Serrano J , Patricia Fernandez AP , Sanchez-Garcia A , Martinez-Murillo R , Binda C , Lopez-Munoz F , Gobec S , Marco-Contelle J |
| Ref : Acta Pharmaceutica Sinica B , 13 :2152 , 2023 |
| Abstract : Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152 |
| ESTHER : Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152 |
| PubMedSearch : Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152 |
| PubMedID: 37250172 |
| Gene_locus related to this paper: human-BCHE |
| Title : Discovery of new, highly potent and selective inhibitors of BuChE - Design, synthesis, in vitro and in vivo evaluation and crystallography studies - Panek_2023_Eur.J.Med.Chem_249_115135 |
| Author(s) : Panek D , Pasieka A , Latacz G , Zareba P , Szczech M , Godyn J , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Walczak M , Smolik M , Salat K , Hofner G , Wanner K , Wieckowska A , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 249 :115135 , 2023 |
| Abstract : Panek_2023_Eur.J.Med.Chem_249_115135 |
| ESTHER : Panek_2023_Eur.J.Med.Chem_249_115135 |
| PubMedSearch : Panek_2023_Eur.J.Med.Chem_249_115135 |
| PubMedID: 36696766 |
| Gene_locus related to this paper: human-BCHE |
| Title : Inhibition of Human Cholinesterases and In Vitro beta-Amyloid Aggregation by Rationally Designed Peptides - Sanchis_2023_ChemMedChem__e202200691 |
| Author(s) : Sanchis I , Spinelli R , Dias J , Brazzolotto X , Rietmann A , Aimaretti F , Siano AS |
| Ref : ChemMedChem , :e202200691 , 2023 |
| Abstract : Sanchis_2023_ChemMedChem__e202200691 |
| ESTHER : Sanchis_2023_ChemMedChem__e202200691 |
| PubMedSearch : Sanchis_2023_ChemMedChem__e202200691 |
| PubMedID: 36995341 |
| Title : Grid-type Quaternary Metallosupramolecular Compounds Inhibit Human Cholinesterases through Dynamic Multivalent Interactions - Nachon_2022_Chembiochem_23_e202200456 |
| Author(s) : Nachon F , Brazzolotto X , Dias J , Courageux C , Drozdz W , Cao XY , Stefankiewicz AR , Lehn JM |
| Ref : Chembiochem , 23 :e202200456 , 2022 |
| Abstract : Nachon_2022_Chembiochem_23_e202200456 |
| ESTHER : Nachon_2022_Chembiochem_23_e202200456 |
| PubMedSearch : Nachon_2022_Chembiochem_23_e202200456 |
| PubMedID: 36193860 |
| Gene_locus related to this paper: human-BCHE |
| Title : From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series - Meden_2022_Eur.J.Med.Chem_230_114248 |
| Author(s) : Meden A , Knez D , Brazzolotto X , Nachon F , Dias J , Svete J , Stojan J , Groselj U , Gobec S |
| Ref : Eur Journal of Medicinal Chemistry , 230 :114248 , 2022 |
| Abstract : Meden_2022_Eur.J.Med.Chem_230_114248 |
| ESTHER : Meden_2022_Eur.J.Med.Chem_230_114248 |
| PubMedSearch : Meden_2022_Eur.J.Med.Chem_230_114248 |
| PubMedID: 35299116 |
| Gene_locus related to this paper: human-BCHE |
| Title : Pseudo-irreversible butyrylcholinesterase inhibitors: Structure-activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead - Meden_2022_Eur.J.Med.Chem_247_115048 |
| Author(s) : Meden A , Knez D , Brazzolotto X , Modeste F , Perdih A , Pislar A , Zorman M , Zorovic M , Denic M , Pajk S , Zivin M , Nachon F , Gobec S |
| Ref : Eur Journal of Medicinal Chemistry , 247 :115048 , 2022 |
| Abstract : Meden_2022_Eur.J.Med.Chem_247_115048 |
| ESTHER : Meden_2022_Eur.J.Med.Chem_247_115048 |
| PubMedSearch : Meden_2022_Eur.J.Med.Chem_247_115048 |
| PubMedID: 36586299 |
| Gene_locus related to this paper: human-BCHE |
| Title : Pseudo-irreversible butyrylcholinesterase inhibitors: SAR, kinetic, computational, and crystallographic study of the N-dialkyl O-arylcarbamate warhead - Meden_2022_Chemrxiv__ |
| Author(s) : Meden A , Knez D , Brazzolotto X , Modeste F , Perdih A , Pislar A , Zorman M , Denic M , Pajk S , Nachon F , Gobec S |
| Ref : Chemrxiv , : , 2022 |
| Abstract : Meden_2022_Chemrxiv__ |
| ESTHER : Meden_2022_Chemrxiv__ |
| PubMedSearch : Meden_2022_Chemrxiv__ |
| PubMedID: |
| Gene_locus related to this paper: human-BCHE |
| Title : Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT(6) receptor with anti-aggregation properties against amyloid-beta and tau - Wichur_2021_Eur.J.Med.Chem_225_113783 |
| Author(s) : Wichur T , Pasieka A , Godyn J , Panek D , Goral I , Latacz G , Honkisz-Orzechowska E , Bucki A , Siwek A , Gluch-Lutwin M , Knez D , Brazzolotto X , Gobec S , Kolaczkowski M , Sabate R , Malawska B , Wieckowska A |
| Ref : Eur Journal of Medicinal Chemistry , 225 :113783 , 2021 |
| Abstract : Wichur_2021_Eur.J.Med.Chem_225_113783 |
| ESTHER : Wichur_2021_Eur.J.Med.Chem_225_113783 |
| PubMedSearch : Wichur_2021_Eur.J.Med.Chem_225_113783 |
| PubMedID: 34461507 |
| Title : Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with beta-amyloid anti-aggregation properties - Wichur_2021_Eur.J.Med.Chem_225_113792 |
| Author(s) : Wichur T , Godyn J , Goral I , Latacz G , Bucki A , Siwek A , Gluch-Lutwin M , Mordyl B , Sniecikowska J , Walczak M , Knez D , Jukic M , Salat K , Gobec S , Kolaczkowski M , Malawska B , Brazzolotto X , Wieckowska A |
| Ref : Eur Journal of Medicinal Chemistry , 225 :113792 , 2021 |
| Abstract : Wichur_2021_Eur.J.Med.Chem_225_113792 |
| ESTHER : Wichur_2021_Eur.J.Med.Chem_225_113792 |
| PubMedSearch : Wichur_2021_Eur.J.Med.Chem_225_113792 |
| PubMedID: 34530376 |
| Gene_locus related to this paper: human-BCHE |
| Title : Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases - Chavarria_2021_Antioxidants.(Basel)_10_329 |
| Author(s) : Chavarria D , Da Silva O , Benfeito S , Barreiro S , Garrido J , Cagide F , Soares P , Remiao F , Brazzolotto X , Nachon F , Oliveira PJ , Dias J , Borges F |
| Ref : Antioxidants (Basel) , 10 :329 , 2021 |
| Abstract : Chavarria_2021_Antioxidants.(Basel)_10_329 |
| ESTHER : Chavarria_2021_Antioxidants.(Basel)_10_329 |
| PubMedSearch : Chavarria_2021_Antioxidants.(Basel)_10_329 |
| PubMedID: 33672269 |
| Gene_locus related to this paper: human-ACHE , human-BCHE |
| Title : A Thermophilic Bacterial Esterase for Scavenging Nerve Agents: A Kinetic, Biophysical and Structural Study - Bzdrenga_2021_Molecules_26_657 |
| Author(s) : Bzdrenga J , Trenet E , Chantegreil F , Bernal K , Nachon F , Brazzolotto X |
| Ref : Molecules , 26 :657 , 2021 |
| Abstract : Bzdrenga_2021_Molecules_26_657 |
| ESTHER : Bzdrenga_2021_Molecules_26_657 |
| PubMedSearch : Bzdrenga_2021_Molecules_26_657 |
| PubMedID: 33513869 |
| Gene_locus related to this paper: 9bact-TtEst2 |
| Title : Discovery of drug-like acetylcholinesterase inhibitors by rapid virtual screening of a 6.9 million compound database - Miles_2021_Chem.Biol.Drug.Des__ |
| Author(s) : Miles JA , Ng JH , Sreenivas BY , Courageux C , Igert A , Dias J , McGeary RP , Brazzolotto X , Ross BP |
| Ref : Chemical Biology Drug Des , : , 2021 |
| Abstract : Miles_2021_Chem.Biol.Drug.Des__ |
| ESTHER : Miles_2021_Chem.Biol.Drug.Des__ |
| PubMedSearch : Miles_2021_Chem.Biol.Drug.Des__ |
| PubMedID: 33455074 |
| Title : Diisopropylfluorophosphate-induced status epilepticus drives complex glial cell phenotypes in adult male mice - Maupu_2021_Neurobiol.Dis__105276 |
| Author(s) : Maupu C , Enderlin J , Igert A , Oger M , Auvin S , Hassan-Abdi R , Soussi-Yanicostas N , Brazzolotto X , Nachon F , Bo GD , Dupuis N |
| Ref : Neurobiol Dis , :105276 , 2021 |
| Abstract : Maupu_2021_Neurobiol.Dis__105276 |
| ESTHER : Maupu_2021_Neurobiol.Dis__105276 |
| PubMedSearch : Maupu_2021_Neurobiol.Dis__105276 |
| PubMedID: 33529768 |
| Title : Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP\/PS1 Mice - Viayna_2021_J.Med.Chem_64_812 |
| Author(s) : Viayna E , Coquelle N , Cieslikiewicz-Bouet M , Cisternas P , Oliva CA , Sanchez-Lopez E , Ettcheto M , Bartolini M , De Simone A , Ricchini M , Rendina M , Pons M , Firuzi O , Perez B , Saso L , Andrisano V , Nachon F , Brazzolotto X , Garcia ML , Camins A , Silman I , Jean L , Inestrosa NC , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 64 :812 , 2021 |
| Abstract : Viayna_2021_J.Med.Chem_64_812 |
| ESTHER : Viayna_2021_J.Med.Chem_64_812 |
| PubMedSearch : Viayna_2021_J.Med.Chem_64_812 |
| PubMedID: 33356266 |
| Gene_locus related to this paper: human-ACHE |
| Title : Characterization of four BCHE mutations associated with prolonged effect of suxamethonium - Brazzolotto_2021_Pharmacogenomics.J_21_165 |
| Author(s) : Brazzolotto X , Courcelle S , Sauvanet C , Guillon V , Igert A , Kononchik J , Nachon F , Ceppa F , Delacour H |
| Ref : Pharmacogenomics J , 21(2):165-173 : , 2021 |
| Abstract : Brazzolotto_2021_Pharmacogenomics.J_21_165 |
| ESTHER : Brazzolotto_2021_Pharmacogenomics.J_21_165 |
| PubMedSearch : Brazzolotto_2021_Pharmacogenomics.J_21_165 |
| PubMedID: 33024248 |
| Title : Discovery of multifunctional anti-Alzheimers agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and gamma-aminobutyric acid transporters - Pasieka_2021_Eur.J.Med.Chem_218_113397 |
| Author(s) : Pasieka A , Panek D , Jonczyk J , Godyn J , Szalaj N , Latacz G , Tabor J , Mezeiova E , Chantegreil F , Dias J , Knez D , Lu J , Pi R , Korabecny J , Brazzolotto X , Gobec S , Hofner G , Wanner K , Wieckowska Q , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 218 :113397 , 2021 |
| Abstract : Pasieka_2021_Eur.J.Med.Chem_218_113397 |
| ESTHER : Pasieka_2021_Eur.J.Med.Chem_218_113397 |
| PubMedSearch : Pasieka_2021_Eur.J.Med.Chem_218_113397 |
| PubMedID: 33838585 |
| Title : Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime - Calas_2020_Biomolecules_10_ |
| Author(s) : Calas AG , Hanak AS , Jaffre N , Nervo A , Dias J , Rousseau C , Courageux C , Brazzolotto X , Villa P , Obrecht A , Goossens JF , Landry C , Hachani J , Gosselet F , Dehouck MP , Yerri J , Kliachyna M , Baati R , Nachon F |
| Ref : Biomolecules , 10 : , 2020 |
| Abstract : Calas_2020_Biomolecules_10_ |
| ESTHER : Calas_2020_Biomolecules_10_ |
| PubMedSearch : Calas_2020_Biomolecules_10_ |
| PubMedID: 32512884 |
| Title : Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors - Meden_2020_Eur.J.Med.Chem_208_112766 |
| Author(s) : Meden A , Knez D , Malikowska-Racia N , Brazzolotto X , Nachon F , Svete J , Salat K , Groselj U , Gobec S |
| Ref : Eur Journal of Medicinal Chemistry , 208 :112766 , 2020 |
| Abstract : Meden_2020_Eur.J.Med.Chem_208_112766 |
| ESTHER : Meden_2020_Eur.J.Med.Chem_208_112766 |
| PubMedSearch : Meden_2020_Eur.J.Med.Chem_208_112766 |
| PubMedID: 32919297 |
| Gene_locus related to this paper: human-BCHE |
| Title : N-alkylpiperidine carbamates as potential anti-Alzheimer's agents - Kosak_2020_Eur.J.Med.Chem_197_112282 |
| Author(s) : Kosak U , Strasek N , Knez N , Jukic M , Zakelj S , Zahirovic A , Pislar A , Brazzolotto X , Nachon F , Kos J , Gobec S , Knez D |
| Ref : Eur Journal of Medicinal Chemistry , 197 :112282 , 2020 |
| Abstract : Kosak_2020_Eur.J.Med.Chem_197_112282 |
| ESTHER : Kosak_2020_Eur.J.Med.Chem_197_112282 |
| PubMedSearch : Kosak_2020_Eur.J.Med.Chem_197_112282 |
| PubMedID: 32380361 |
| Gene_locus related to this paper: human-BCHE |
| Title : Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes - Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498 |
| Author(s) : Pajk S , Knez D , Kosak U , Zorovic M , Brazzolotto X , Coquelle N , Nachon F , Colletier JP , Zivin M , Stojan J , Gobec S |
| Ref : J Enzyme Inhib Med Chem , 35 :498 , 2020 |
| Abstract : Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498 |
| ESTHER : Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498 |
| PubMedSearch : Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498 |
| PubMedID: 31914836 |
| Gene_locus related to this paper: human-BCHE |
| Title : Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases - Marakovic_2020_Biochem.J_477_2771 |
| Author(s) : Marakovic N , Knezevic A , Roncevic I , Brazzolotto X , Kovarik Z , Sinko G |
| Ref : Biochemical Journal , 477 :2771 , 2020 |
| Abstract : Marakovic_2020_Biochem.J_477_2771 |
| ESTHER : Marakovic_2020_Biochem.J_477_2771 |
| PubMedSearch : Marakovic_2020_Biochem.J_477_2771 |
| PubMedID: 32639532 |
| Gene_locus related to this paper: human-BCHE |
| Title : Rapid discovery of a selective butyrylcholinesterase inhibitor using structure-based virtual screening - Miles_2020_Bioorg.Med.Chem.Lett__127609 |
| Author(s) : Miles JA , Kapure JS , Singh Deora G , Courageux C , Igert A , Dias J , McGeary RP , Brazzolotto X , Ross BP |
| Ref : Bioorganic & Medicinal Chemistry Lett , :127609 , 2020 |
| Abstract : Miles_2020_Bioorg.Med.Chem.Lett__127609 |
| ESTHER : Miles_2020_Bioorg.Med.Chem.Lett__127609 |
| PubMedSearch : Miles_2020_Bioorg.Med.Chem.Lett__127609 |
| PubMedID: 33039562 |
| Title : An evolutionary perspective on the first disulfide bond in members of the cholinesterase-carboxylesterase (COesterase) family: Possible outcomes for cholinesterase expression in prokaryotes - Chatonnet_2019_Chem.Biol.Interact_13ChEPon_308_179 |
| Author(s) : Chatonnet A , Brazzolotto X , Hotelier T , Lenfant N , Marchot P , Bourne Y |
| Ref : Chemico-Biological Interactions , 308 :179 , 2019 |
| Abstract : Chatonnet_2019_Chem.Biol.Interact_13ChEPon_308_179 |
| ESTHER : Chatonnet_2019_Chem.Biol.Interact_13ChEPon_308_179 |
| PubMedSearch : Chatonnet_2019_Chem.Biol.Interact_13ChEPon_308_179 |
| PubMedID: 31100280 |
| Title : Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model. - Dighe_2019_Commun.Chem_2_35 |
| Author(s) : Dighe SN , De la Mora E , Chan S , Kantham S , McColl G , Miles JA , Veliyath SK , Sreenivas BY , Nassar ZD , Silman I , Sussman JL , Weik M , McGeary RP , Parat MO , Brazzolotto X , Ross BP |
| Ref : Communications chemistry , 2 :35 , 2019 |
| Abstract : Dighe_2019_Commun.Chem_2_35 |
| ESTHER : Dighe_2019_Commun.Chem_2_35 |
| PubMedSearch : Dighe_2019_Commun.Chem_2_35 |
| PubMedID: |
| Gene_locus related to this paper: human-BCHE , torca-ACHE |
| Title : Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer's disease - Meden_2019_Chem.Commun.(Camb)_55_3765 |
| Author(s) : Meden A , Knez D , Jukic M , Brazzolotto X , Grsic M , Pislar A , Zahirovic A , Kos J , Nachon F , Svete J , Gobec S , Groselj U |
| Ref : Chem Commun (Camb) , 55 :3765 , 2019 |
| Abstract : Meden_2019_Chem.Commun.(Camb)_55_3765 |
| ESTHER : Meden_2019_Chem.Commun.(Camb)_55_3765 |
| PubMedSearch : Meden_2019_Chem.Commun.(Camb)_55_3765 |
| PubMedID: 30864579 |
| Gene_locus related to this paper: human-BCHE |
| Title : X-ray structures of human bile-salt activated lipase conjugated to nerve agents surrogates - Touvrey_2019_Toxicology_411_15 |
| Author(s) : Touvrey C , Courageux C , Guillon V , Terreux R , Nachon F , Brazzolotto X |
| Ref : Toxicology , 411 :15 , 2019 |
| Abstract : Touvrey_2019_Toxicology_411_15 |
| ESTHER : Touvrey_2019_Toxicology_411_15 |
| PubMedSearch : Touvrey_2019_Toxicology_411_15 |
| PubMedID: 30359675 |
| Gene_locus related to this paper: human-CEL |
| Title : Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease - Chalupova_2019_Eur.J.Med.Chem_168_491 |
| Author(s) : Chalupova K , Korabecny J , Bartolini M , Monti B , Lamba D , Caliandro R , Pesaresi A , Brazzolotto X , Gastellier AJ , Nachon F , Pejchal J , Jarosova M , Hepnarova V , Jun D , Hrabinova M , Dolezal R , Karasova JZ , Mzik M , Kristofikova Z , Misik J , Muckova L , Jost P , Soukup O , Benkova M , Setnicka V , Habartova L , Chvojkova M , Kleteckova L , Vales K , Mezeiova E , Uliassi E , Valis M , Nepovimova E , Bolognesi ML , Kuca K |
| Ref : Eur Journal of Medicinal Chemistry , 168 :491 , 2019 |
| Abstract : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| ESTHER : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| PubMedSearch : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| PubMedID: 30851693 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities - Knez_2018_Eur.J.Med.Chem_156_598 |
| Author(s) : Knez D , Coquelle N , Pislar A , Zakelj S , Jukic M , Sova M , Mravljak J , Nachon F , Brazzolotto X , Kos J , Colletier JP , Gobec S |
| Ref : Eur Journal of Medicinal Chemistry , 156 :598 , 2018 |
| Abstract : Knez_2018_Eur.J.Med.Chem_156_598 |
| ESTHER : Knez_2018_Eur.J.Med.Chem_156_598 |
| PubMedSearch : Knez_2018_Eur.J.Med.Chem_156_598 |
| PubMedID: 30031971 |
| Gene_locus related to this paper: human-BCHE |
| Title : The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity - Kosak_2018_J.Med.Chem_61_119 |
| Author(s) : Kosak U , Brus B , Knez D , Zakelj S , Trontelj J , Pislar A , Sink R , Jukic M , Zivin M , Podkowa A , Nachon F , Brazzolotto X , Stojan J , Kos J , Coquelle N , Salat K , Colletier JP , Gobec S |
| Ref : Journal of Medicinal Chemistry , 61 :119 , 2018 |
| Abstract : Kosak_2018_J.Med.Chem_61_119 |
| ESTHER : Kosak_2018_J.Med.Chem_61_119 |
| PubMedSearch : Kosak_2018_J.Med.Chem_61_119 |
| PubMedID: 29227101 |
| Gene_locus related to this paper: human-BCHE |
| Title : Purification of recombinant human butyrylcholinesterase on Hupresin(R) - Lockridge_2018_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1102-1103_109 |
| Author(s) : Lockridge O , David E , Schopfer LM , Masson P , Brazzolotto X , Nachon F |
| Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 1102-1103 :109 , 2018 |
| Abstract : Lockridge_2018_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1102-1103_109 |
| ESTHER : Lockridge_2018_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1102-1103_109 |
| PubMedSearch : Lockridge_2018_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1102-1103_109 |
| PubMedID: 30384187 |
| Title : Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study - Rosenberry_2017_Molecules_22_ |
| Author(s) : Rosenberry TL , Brazzolotto X , Macdonald IR , Wandhammer M , Trovaslet-Leroy M , Darvesh S , Nachon F |
| Ref : Molecules , 22 : , 2017 |
| Abstract : Rosenberry_2017_Molecules_22_ |
| ESTHER : Rosenberry_2017_Molecules_22_ |
| PubMedSearch : Rosenberry_2017_Molecules_22_ |
| PubMedID: 29186056 |
| Gene_locus related to this paper: human-BCHE |
| Title : N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents - Kosak_2017_Bioorg.Med.Chem_25_633 |
| Author(s) : Kosak U , Knez D , Coquelle N , Brus B , Pislar A , Nachon F , Brazzolotto X , Kos J , Colletier JP , Gobec S |
| Ref : Bioorganic & Medicinal Chemistry , 25 :633 , 2017 |
| Abstract : Kosak_2017_Bioorg.Med.Chem_25_633 |
| ESTHER : Kosak_2017_Bioorg.Med.Chem_25_633 |
| PubMedSearch : Kosak_2017_Bioorg.Med.Chem_25_633 |
| PubMedID: 27908752 |
| Gene_locus related to this paper: human-BCHE |
| Title : Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development - Brazzolotto_2017_Molecules_22_ |
| Author(s) : Brazzolotto X , Igert A , Guillon V , Santoni G , Nachon F |
| Ref : Molecules , 22 : , 2017 |
| Abstract : Brazzolotto_2017_Molecules_22_ |
| ESTHER : Brazzolotto_2017_Molecules_22_ |
| PubMedSearch : Brazzolotto_2017_Molecules_22_ |
| PubMedID: 29077024 |
| Gene_locus related to this paper: human-BCHE |
| Title : Development of an in-vivo active reversible butyrylcholinesterase inhibitor - Kosak_2016_Sci.Rep_6_39495 |
| Author(s) : Kosak U , Brus B , Knez D , Sink R , Zakelj S , Trontelj J , Pislar A , Slenc J , Gobec M , Zivin M , Tratnjek L , Perse M , Salat K , Podkowa A , Filipek B , Nachon F , Brazzolotto X , Wieckowska A , Malawska B , Stojan J , Rascan IM , Kos J , Coquelle N , Colletier JP , Gobec S |
| Ref : Sci Rep , 6 :39495 , 2016 |
| Abstract : Kosak_2016_Sci.Rep_6_39495 |
| ESTHER : Kosak_2016_Sci.Rep_6_39495 |
| PubMedSearch : Kosak_2016_Sci.Rep_6_39495 |
| PubMedID: 28000737 |
| Gene_locus related to this paper: human-BCHE |
| Title : Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening - Dighe_2016_J.Med.Chem_59_7683 |
| Author(s) : Dighe SN , Deora GS , De la Mora E , Nachon F , Chan S , Parat MO , Brazzolotto X , Ross BP |
| Ref : Journal of Medicinal Chemistry , 59 :7683 , 2016 |
| Abstract : Dighe_2016_J.Med.Chem_59_7683 |
| ESTHER : Dighe_2016_J.Med.Chem_59_7683 |
| PubMedSearch : Dighe_2016_J.Med.Chem_59_7683 |
| PubMedID: 27405689 |
| Gene_locus related to this paper: human-BCHE |
| Title : Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents - Knez_2015_Bioorg.Med.Chem_23_4442 |
| Author(s) : Knez D , Brus B , Coquelle N , Sosic I , Sink R , Brazzolotto X , Mravljak J , Colletier JP , Gobec S |
| Ref : Bioorganic & Medicinal Chemistry , 23 :4442 , 2015 |
| Abstract : Knez_2015_Bioorg.Med.Chem_23_4442 |
| ESTHER : Knez_2015_Bioorg.Med.Chem_23_4442 |
| PubMedSearch : Knez_2015_Bioorg.Med.Chem_23_4442 |
| PubMedID: 26116179 |
| Gene_locus related to this paper: human-BCHE |
| Title : Progress in the development of enzyme-based nerve agent bioscavengers - Nachon_2013_Chem.Biol.Interact_206_536 |
| Author(s) : Nachon F , Brazzolotto X , Trovaslet M , Masson P |
| Ref : Chemico-Biological Interactions , 206 :536 , 2013 |
| Abstract : Nachon_2013_Chem.Biol.Interact_206_536 |
| ESTHER : Nachon_2013_Chem.Biol.Interact_206_536 |
| PubMedSearch : Nachon_2013_Chem.Biol.Interact_206_536 |
| PubMedID: 23811386 |
| Title : Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure - Brazzolotto_2012_Febs.J_279_2905 |
| Author(s) : Brazzolotto X , Wandhammer M , Ronco C , Trovaslet M , Jean L , Lockridge O , Renard PY , Nachon F |
| Ref : Febs J , 279 :2905 , 2012 |
| Abstract : Brazzolotto_2012_Febs.J_279_2905 |
| ESTHER : Brazzolotto_2012_Febs.J_279_2905 |
| PubMedSearch : Brazzolotto_2012_Febs.J_279_2905 |
| PubMedID: 22726956 |
| Gene_locus related to this paper: human-BCHE |
| Title : Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents - Trovaslet-Leroy_2011_Toxicol.Lett_206_14 |
| Author(s) : Trovaslet-Leroy M , Musilova L , Renault F , Brazzolotto X , Misik J , Novotny L , Froment MT , Gillon E , Loiodice M , Verdier L , Masson P , Rochu D , Jun D , Nachon F |
| Ref : Toxicol Lett , 206 :14 , 2011 |
| Abstract : Trovaslet-Leroy_2011_Toxicol.Lett_206_14 |
| ESTHER : Trovaslet-Leroy_2011_Toxicol.Lett_206_14 |
| PubMedSearch : Trovaslet-Leroy_2011_Toxicol.Lett_206_14 |
| PubMedID: 21683774 |