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| Title : Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors - Holladay_1998_J.Med.Chem_41_407 |
| Author(s) : Holladay MW , Wasicak JT , Lin NH , He Y , Ryther KB , Bannon AW , Buckley MJ , Kim DJ , Decker MW , Anderson DJ , Campbell JE , Kuntzweiler TA , Donnelly-Roberts D , Piattoni-Kaplan M , Briggs CA , Williams M , Arneric SP |
| Ref : Journal of Medicinal Chemistry , 41 :407 , 1998 |
| Abstract : Holladay_1998_J.Med.Chem_41_407 |
| ESTHER : Holladay_1998_J.Med.Chem_41_407 |
| PubMedSearch : Holladay_1998_J.Med.Chem_41_407 |
| PubMedID: 9484491 |
| Title : Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors - Bannon_1998_Science_279_77 |
| Author(s) : Bannon AW , Decker MW , Holladay MW , Curzon P , Donnelly-Roberts D , Puttfarcken PS , Bitner RS , Diaz A , Dickenson AH , Porsolt RD , Williams M , Arneric SP |
| Ref : Science , 279 :77 , 1998 |
| Abstract : Bannon_1998_Science_279_77 |
| ESTHER : Bannon_1998_Science_279_77 |
| PubMedSearch : Bannon_1998_Science_279_77 |
| PubMedID: 9417028 |
| Title : The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594 - Decker_1998_J.Physiol.Paris_92_221 |
| Author(s) : Decker MW , Curzon P , Holladay MW , Nikkel AL , Bitner RS , Bannon AW , Donnelly-Roberts D , Puttfarcken PS , Kuntzweiler TA , Briggs CA , Williams M , Arneric SP |
| Ref : Journal de Physiologie (Paris) , 92 :221 , 1998 |
| Abstract : Decker_1998_J.Physiol.Paris_92_221 |
| ESTHER : Decker_1998_J.Physiol.Paris_92_221 |
| PubMedSearch : Decker_1998_J.Physiol.Paris_92_221 |
| PubMedID: 9789812 |
| Title : ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization - Bannon_1998_J.Pharmacol.Exp.Ther_285_787 |
| Author(s) : Bannon AW , Decker MW , Curzon P , Buckley MJ , Kim DJ , Radek RJ , Lynch JK , Wasicak JT , Lin NH , Arnold WH , Holladay MW , Williams M , Arneric SP |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 285 :787 , 1998 |
| Abstract : Bannon_1998_J.Pharmacol.Exp.Ther_285_787 |
| ESTHER : Bannon_1998_J.Pharmacol.Exp.Ther_285_787 |
| PubMedSearch : Bannon_1998_J.Pharmacol.Exp.Ther_285_787 |
| PubMedID: 9580627 |
| Title : Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice - Decker_1998_Eur.J.Pharmacol_346_23 |
| Author(s) : Decker MW , Bannon AW , Buckley MJ , Kim DJ , Holladay MW , Ryther KB , Lin NH , Wasicak JT , Williams M , Arneric SP |
| Ref : European Journal of Pharmacology , 346 :23 , 1998 |
| Abstract : Decker_1998_Eur.J.Pharmacol_346_23 |
| ESTHER : Decker_1998_Eur.J.Pharmacol_346_23 |
| PubMedSearch : Decker_1998_Eur.J.Pharmacol_346_23 |
| PubMedID: 9617748 |
| Title : Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice - Holladay_1998_Bioorg.Med.Chem.Lett_8_2797 |
| Author(s) : Holladay MW , Bai H , Li Y , Lin NH , Daanen JF , Ryther KB , Wasicak JT , Kincaid JF , He Y , Hettinger AM , Huang P , Anderson DJ , Bannon AW , Buckley MJ , Campbell JE , Donnelly-Roberts D , Gunther KL , Kim DJ , Kuntzweiler TA , Sullivan JP , Decker MW , Arneric SP |
| Ref : Bioorganic & Medicinal Chemistry Lett , 8 :2797 , 1998 |
| Abstract : Holladay_1998_Bioorg.Med.Chem.Lett_8_2797 |
| ESTHER : Holladay_1998_Bioorg.Med.Chem.Lett_8_2797 |
| PubMedSearch : Holladay_1998_Bioorg.Med.Chem.Lett_8_2797 |
| PubMedID: 9873625 |
| Title : ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys - Decker_1997_J.Pharmacol.Exp.Ther_283_247 |
| Author(s) : Decker MW , Bannon AW , Curzon P , Gunther KL , Brioni JD , Holladay MW , Lin NH , Li Y , Daanen JF , Buccafusco JJ , Prendergast MA , Jackson WJ , Arneric SP |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 283 :247 , 1997 |
| Abstract : Decker_1997_J.Pharmacol.Exp.Ther_283_247 |
| ESTHER : Decker_1997_J.Pharmacol.Exp.Ther_283_247 |
| PubMedSearch : Decker_1997_J.Pharmacol.Exp.Ther_283_247 |
| PubMedID: 9336330 |
| Title : Cholinergic channel activators: novel opportunities for the treatment of CNS disorders - Sullivan_1995_Proc.West.Pharmacol.Soc_38_127 |
| Author(s) : Sullivan JP , Decker MW , Donnelly-Roberts D , Brioni JD , Bannon AW , Holladay MW , Anderson DJ , Briggs CA , Williams M , Arneric SP |
| Ref : Proc West Pharmacol Soc , 38 :127 , 1995 |
| Abstract : Sullivan_1995_Proc.West.Pharmacol.Soc_38_127 |
| ESTHER : Sullivan_1995_Proc.West.Pharmacol.Soc_38_127 |
| PubMedSearch : Sullivan_1995_Proc.West.Pharmacol.Soc_38_127 |
| PubMedID: 7480004 |
| Title : Potential treatment of Alzheimer disease using cholinergic channel activators (ChCAs) with cognitive enhancement, anxiolytic-like, and cytoprotective properties - Arneric_1995_Alzheimer.Dis.Assoc.Disord_9 Suppl 2_50 |
| Author(s) : Arneric SP , Sullivan JP , Decker MW , Brioni JD , Bannon AW , Briggs CA , Donnelly-Roberts D , Radek RJ , Marsh KC , Kyncl J , Williams M , Buccafusco JJ |
| Ref : Alzheimer Disease & Associated Disorders , 9 Suppl 2 :50 , 1995 |
| Abstract : Arneric_1995_Alzheimer.Dis.Assoc.Disord_9 Suppl 2_50 |
| ESTHER : Arneric_1995_Alzheimer.Dis.Assoc.Disord_9 Suppl 2_50 |
| PubMedSearch : Arneric_1995_Alzheimer.Dis.Assoc.Disord_9 Suppl 2_50 |
| PubMedID: 8534424 |
| Title : (+\/-)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors - Sullivan_1994_J.Pharmacol.Exp.Ther_271_624 |
| Author(s) : Sullivan JP , Decker MW , Brioni JD , Donnelly-Roberts D , Anderson DJ , Bannon AW , Kang CH , Adams P , Piattoni-Kaplan M , Buckley MJ |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 271 :624 , 1994 |
| Abstract : Sullivan_1994_J.Pharmacol.Exp.Ther_271_624 |
| ESTHER : Sullivan_1994_J.Pharmacol.Exp.Ther_271_624 |
| PubMedSearch : Sullivan_1994_J.Pharmacol.Exp.Ther_271_624 |
| PubMedID: 7965777 |