Full name : Akaike Akinori
First name : Akinori
Mail : Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501
Zip Code :
City :
Country : Japan
Email : aakaike@pharm.kyoto-u.ac.jp
Phone :
Fax :
Website :
Directory :
| Title : Donepezil modulates amyloid precursor protein endocytosis and reduction by up-regulation of SNX33 expression in primary cortical neurons - Takada-Takatori_2019_Sci.Rep_9_11922 |
| Author(s) : Takada-Takatori Y , Nakagawa S , Kimata R , Nao Y , Mizukawa Y , Urushidani T , Izumi Y , Akaike A , Tsuchida K , Kume T |
| Ref : Sci Rep , 9 :11922 , 2019 |
| Abstract : Takada-Takatori_2019_Sci.Rep_9_11922 |
| ESTHER : Takada-Takatori_2019_Sci.Rep_9_11922 |
| PubMedSearch : Takada-Takatori_2019_Sci.Rep_9_11922 |
| PubMedID: 31417133 |
| Title : Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes - Makitani_2017_J.Pharmacol.Sci_134_37 |
| Author(s) : Makitani K , Nakagawa S , Izumi Y , Akaike A , Kume T |
| Ref : J Pharmacol Sci , 134 :37 , 2017 |
| Abstract : Makitani_2017_J.Pharmacol.Sci_134_37 |
| ESTHER : Makitani_2017_J.Pharmacol.Sci_134_37 |
| PubMedSearch : Makitani_2017_J.Pharmacol.Sci_134_37 |
| PubMedID: 28499726 |
| Title : Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors - Takahashi_2010_Bioorg.Med.Chem.Lett_20_1718 |
| Author(s) : Takahashi J , Hijikuro I , Kihara T , Murugesh MG , Fuse S , Kunimoto R , Tsumura Y , Akaike A , Niidome T , Okuno Y , Takahashi T , Sugimoto H |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :1718 , 2010 |
| Abstract : Takahashi_2010_Bioorg.Med.Chem.Lett_20_1718 |
| ESTHER : Takahashi_2010_Bioorg.Med.Chem.Lett_20_1718 |
| PubMedSearch : Takahashi_2010_Bioorg.Med.Chem.Lett_20_1718 |
| PubMedID: 20137934 |
| Title : Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors - Shen_2010_Br.J.Pharmacol_161_127 |
| Author(s) : Shen H , Kihara T , Hongo H , Wu X , Kem WR , Shimohama S , Akaike A , Niidome T , Sugimoto H |
| Ref : British Journal of Pharmacology , 161 :127 , 2010 |
| Abstract : Shen_2010_Br.J.Pharmacol_161_127 |
| ESTHER : Shen_2010_Br.J.Pharmacol_161_127 |
| PubMedSearch : Shen_2010_Br.J.Pharmacol_161_127 |
| PubMedID: 20718745 |
| Title : Design, synthesis and evaluation of carbamate-modified (-)-N(1)-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors - Takahashi_2010_Bioorg.Med.Chem.Lett_20_1721 |
| Author(s) : Takahashi J , Hijikuro I , Kihara T , Murugesh MG , Fuse S , Tsumura Y , Akaike A , Niidome T , Takahashi T , Sugimoto H |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :1721 , 2010 |
| Abstract : Takahashi_2010_Bioorg.Med.Chem.Lett_20_1721 |
| ESTHER : Takahashi_2010_Bioorg.Med.Chem.Lett_20_1721 |
| PubMedSearch : Takahashi_2010_Bioorg.Med.Chem.Lett_20_1721 |
| PubMedID: 20137941 |
| Title : Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection - Akaike_2010_J.Mol.Neurosci_40_211 |
| Author(s) : Akaike A , Takada-Takatori Y , Kume T , Izumi Y |
| Ref : Journal of Molecular Neuroscience , 40 :211 , 2010 |
| Abstract : Akaike_2010_J.Mol.Neurosci_40_211 |
| ESTHER : Akaike_2010_J.Mol.Neurosci_40_211 |
| PubMedSearch : Akaike_2010_J.Mol.Neurosci_40_211 |
| PubMedID: 19714494 |
| Title : Mechanisms of chronic nicotine treatment-induced enhancement of the sensitivity of cortical neurons to the neuroprotective effect of donepezil in cortical neurons - Takada-Takatori_2010_J.Pharmacol.Sci_112_265 |
| Author(s) : Takada-Takatori Y , Kume T , Izumi Y , Niidome T , Fujii T , Sugimoto H , Akaike A |
| Ref : J Pharmacol Sci , 112 :265 , 2010 |
| Abstract : Takada-Takatori_2010_J.Pharmacol.Sci_112_265 |
| ESTHER : Takada-Takatori_2010_J.Pharmacol.Sci_112_265 |
| PubMedSearch : Takada-Takatori_2010_J.Pharmacol.Sci_112_265 |
| PubMedID: 20173312 |
| Title : Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models - Takeuchi_2009_J.Neurosci.Res_87_576 |
| Author(s) : Takeuchi H , Yanagida T , Inden M , Takata K , Kitamura Y , Yamakawa K , Sawada H , Izumi Y , Yamamoto N , Kihara T , Uemura K , Inoue H , Taniguchi T , Akaike A , Takahashi R , Shimohama S |
| Ref : Journal of Neuroscience Research , 87 :576 , 2009 |
| Abstract : Takeuchi_2009_J.Neurosci.Res_87_576 |
| ESTHER : Takeuchi_2009_J.Neurosci.Res_87_576 |
| PubMedSearch : Takeuchi_2009_J.Neurosci.Res_87_576 |
| PubMedID: 18803299 |
| Title : Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation - Takada-Takatori_2009_Biol.Pharm.Bull_32_318 |
| Author(s) : Takada-Takatori Y , Kume T , Izumi Y , Ohgi Y , Niidome T , Fujii T , Sugimoto H , Akaike A |
| Ref : Biol Pharm Bull , 32 :318 , 2009 |
| Abstract : Takada-Takatori_2009_Biol.Pharm.Bull_32_318 |
| ESTHER : Takada-Takatori_2009_Biol.Pharm.Bull_32_318 |
| PubMedSearch : Takada-Takatori_2009_Biol.Pharm.Bull_32_318 |
| PubMedID: 19252271 |
| Title : Long-term treatment with nicotine suppresses neurotoxicity of, and microglial activation by, thrombin in cortico-striatal slice cultures - Ohnishi_2009_Eur.J.Pharmacol_602_288 |
| Author(s) : Ohnishi M , Katsuki H , Takagi M , Kume T , Akaike A |
| Ref : European Journal of Pharmacology , 602 :288 , 2009 |
| Abstract : Ohnishi_2009_Eur.J.Pharmacol_602_288 |
| ESTHER : Ohnishi_2009_Eur.J.Pharmacol_602_288 |
| PubMedSearch : Ohnishi_2009_Eur.J.Pharmacol_602_288 |
| PubMedID: 19063881 |
| Title : Donepezil attenuates excitotoxic damage induced by membrane depolarization of cortical neurons exposed to veratridine - Akasofu_2008_Eur.J.Pharmacol_588_189 |
| Author(s) : Akasofu S , Sawada K , Kosasa T , Hihara H , Ogura H , Akaike A |
| Ref : European Journal of Pharmacology , 588 :189 , 2008 |
| Abstract : Akasofu_2008_Eur.J.Pharmacol_588_189 |
| ESTHER : Akasofu_2008_Eur.J.Pharmacol_588_189 |
| PubMedSearch : Akasofu_2008_Eur.J.Pharmacol_588_189 |
| PubMedID: 18508044 |
| Title : Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe\/PS1dE9 mouse model of Alzheimer's disease - Goto_2008_Eur.J.Pharmacol_583_84 |
| Author(s) : Goto Y , Niidome T , Hongo H , Akaike A , Kihara T , Sugimoto H |
| Ref : European Journal of Pharmacology , 583 :84 , 2008 |
| Abstract : Goto_2008_Eur.J.Pharmacol_583_84 |
| ESTHER : Goto_2008_Eur.J.Pharmacol_583_84 |
| PubMedSearch : Goto_2008_Eur.J.Pharmacol_583_84 |
| PubMedID: 18282567 |
| Title : Mechanisms of alpha7-nicotinic receptor up-regulation and sensitization to donepezil induced by chronic donepezil treatment - Takada-Takatori_2008_Eur.J.Pharmacol_590_150 |
| Author(s) : Takada-Takatori Y , Kume T , Ohgi Y , Fujii T , Niidome T , Sugimoto H , Akaike A |
| Ref : European Journal of Pharmacology , 590 :150 , 2008 |
| Abstract : Takada-Takatori_2008_Eur.J.Pharmacol_590_150 |
| ESTHER : Takada-Takatori_2008_Eur.J.Pharmacol_590_150 |
| PubMedSearch : Takada-Takatori_2008_Eur.J.Pharmacol_590_150 |
| PubMedID: 18585378 |
| Title : Mechanism of neuroprotection by donepezil pretreatment in rat cortical neurons chronically treated with donepezil - Takada-Takatori_2008_J.Neurosci.Res_86_3575 |
| Author(s) : Takada-Takatori Y , Kume T , Ohgi Y , Izumi Y , Niidome T , Fujii T , Sugimoto H , Akaike A |
| Ref : Journal of Neuroscience Research , 86 :3575 , 2008 |
| Abstract : Takada-Takatori_2008_J.Neurosci.Res_86_3575 |
| ESTHER : Takada-Takatori_2008_J.Neurosci.Res_86_3575 |
| PubMedSearch : Takada-Takatori_2008_J.Neurosci.Res_86_3575 |
| PubMedID: 18655200 |
| Title : Donepezil potentiates nerve growth factor-induced neurite outgrowth in PC12 cells - Oda_2007_J.Pharmacol.Sci_104_349 |
| Author(s) : Oda T , Kume T , Katsuki H , Niidome T , Sugimoto H , Akaike A |
| Ref : J Pharmacol Sci , 104 :349 , 2007 |
| Abstract : Oda_2007_J.Pharmacol.Sci_104_349 |
| ESTHER : Oda_2007_J.Pharmacol.Sci_104_349 |
| PubMedSearch : Oda_2007_J.Pharmacol.Sci_104_349 |
| PubMedID: 17675796 |
| Title : Preclinical evidence of neuroprotection by cholinesterase inhibitors - Akaike_2006_Alzheimer.Dis.Assoc.Disord_20_S8 |
| Author(s) : Akaike A |
| Ref : Alzheimer Disease & Associated Disorders , 20 :S8 , 2006 |
| Abstract : Akaike_2006_Alzheimer.Dis.Assoc.Disord_20_S8 |
| ESTHER : Akaike_2006_Alzheimer.Dis.Assoc.Disord_20_S8 |
| PubMedSearch : Akaike_2006_Alzheimer.Dis.Assoc.Disord_20_S8 |
| PubMedID: 16772755 |
| Title : Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity - Takada-Takatori_2006_Eur.J.Pharmacol_549_19 |
| Author(s) : Takada-Takatori Y , Kume T , Sugimoto M , Katsuki H , Niidome T , Sugimoto H , Fujii T , Okabe S , Akaike A |
| Ref : European Journal of Pharmacology , 549 :19 , 2006 |
| Abstract : Takada-Takatori_2006_Eur.J.Pharmacol_549_19 |
| ESTHER : Takada-Takatori_2006_Eur.J.Pharmacol_549_19 |
| PubMedSearch : Takada-Takatori_2006_Eur.J.Pharmacol_549_19 |
| PubMedID: 16996497 |
| Title : Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade - Takada-Takatori_2006_Neuropharmacol_51_474 |
| Author(s) : Takada-Takatori Y , Kume T , Sugimoto M , Katsuki H , Sugimoto H , Akaike A |
| Ref : Neuropharmacology , 51 :474 , 2006 |
| Abstract : Takada-Takatori_2006_Neuropharmacol_51_474 |
| ESTHER : Takada-Takatori_2006_Neuropharmacol_51_474 |
| PubMedSearch : Takada-Takatori_2006_Neuropharmacol_51_474 |
| PubMedID: 16762377 |
| Title : Tetraethylammonium exacerbates ischemic neuronal injury in rat cerebrocortical slice cultures - Katsuki_2005_Eur.J.Pharmacol_508_85 |
| Author(s) : Katsuki H , Shinohara A , Fujimoto S , Kume T , Akaike A |
| Ref : European Journal of Pharmacology , 508 :85 , 2005 |
| Abstract : Katsuki_2005_Eur.J.Pharmacol_508_85 |
| ESTHER : Katsuki_2005_Eur.J.Pharmacol_508_85 |
| PubMedSearch : Katsuki_2005_Eur.J.Pharmacol_508_85 |
| PubMedID: 15680257 |
| Title : Stimulation of nicotinic acetylcholine receptors protects motor neurons - Nakamizo_2005_Biochem.Biophys.Res.Commun_330_1285 |
| Author(s) : Nakamizo T , Kawamata J , Yamashita H , Kanki R , Kihara T , Sawada H , Akaike A , Shimohama S |
| Ref : Biochemical & Biophysical Research Communications , 330 :1285 , 2005 |
| Abstract : Nakamizo_2005_Biochem.Biophys.Res.Commun_330_1285 |
| ESTHER : Nakamizo_2005_Biochem.Biophys.Res.Commun_330_1285 |
| PubMedSearch : Nakamizo_2005_Biochem.Biophys.Res.Commun_330_1285 |
| PubMedID: 15823582 |
| Title : Up-regulation of nicotinic acetylcholine receptors by central-type acetylcholinesterase inhibitors in rat cortical neurons - Kume_2005_Eur.J.Pharmacol_527_77 |
| Author(s) : Kume T , Sugimoto M , Takada Y , Yamaguchi T , Yonezawa A , Katsuki H , Sugimoto H , Akaike A |
| Ref : European Journal of Pharmacology , 527 :77 , 2005 |
| Abstract : Kume_2005_Eur.J.Pharmacol_527_77 |
| ESTHER : Kume_2005_Eur.J.Pharmacol_527_77 |
| PubMedSearch : Kume_2005_Eur.J.Pharmacol_527_77 |
| PubMedID: 16313899 |
| Title : Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons - Takada_2003_J.Pharmacol.Exp.Ther_306_772 |
| Author(s) : Takada Y , Yonezawa A , Kume T , Katsuki H , Kaneko S , Sugimoto H , Akaike A |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 306 :772 , 2003 |
| Abstract : Takada_2003_J.Pharmacol.Exp.Ther_306_772 |
| ESTHER : Takada_2003_J.Pharmacol.Exp.Ther_306_772 |
| PubMedSearch : Takada_2003_J.Pharmacol.Exp.Ther_306_772 |
| PubMedID: 12734391 |
| Title : alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity - Kihara_2001_J.Biol.Chem_276_13541 |
| Author(s) : Kihara T , Shimohama S , Sawada H , Honda K , Nakamizo T , Shibasaki H , Kume T , Akaike A |
| Ref : Journal of Biological Chemistry , 276 :13541 , 2001 |
| Abstract : Kihara_2001_J.Biol.Chem_276_13541 |
| ESTHER : Kihara_2001_J.Biol.Chem_276_13541 |
| PubMedSearch : Kihara_2001_J.Biol.Chem_276_13541 |
| PubMedID: 11278378 |
| Title : Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity - Kihara_1998_Brain.Res_792_331 |
| Author(s) : Kihara T , Shimohama S , Urushitani M , Sawada H , Kimura J , Kume T , Maeda T , Akaike A |
| Ref : Brain Research , 792 :331 , 1998 |
| Abstract : Kihara_1998_Brain.Res_792_331 |
| ESTHER : Kihara_1998_Brain.Res_792_331 |
| PubMedSearch : Kihara_1998_Brain.Res_792_331 |
| PubMedID: 9593977 |
| Title : Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via alpha7-neuronal receptors and neuronal CNS receptors - Kaneko_1997_Brain.Res_765_135 |
| Author(s) : Kaneko S , Maeda T , Kume T , Kochiyama H , Akaike A , Shimohama S , Kimura J |
| Ref : Brain Research , 765 :135 , 1997 |
| Abstract : Kaneko_1997_Brain.Res_765_135 |
| ESTHER : Kaneko_1997_Brain.Res_765_135 |
| PubMedSearch : Kaneko_1997_Brain.Res_765_135 |
| PubMedID: 9310404 |
| Title : Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity - Kihara_1997_Ann.Neurol_42_159 |
| Author(s) : Kihara T , Shimohama S , Sawada H , Kimura J , Kume T , Kochiyama H , Maeda T , Akaike A |
| Ref : Annals of Neurology , 42 :159 , 1997 |
| Abstract : Kihara_1997_Ann.Neurol_42_159 |
| ESTHER : Kihara_1997_Ann.Neurol_42_159 |
| PubMedSearch : Kihara_1997_Ann.Neurol_42_159 |
| PubMedID: 9266724 |
| Title : Activation and Inhibition of the Nicotinic Receptor: Actions of Physostigmine, Pyridostigmine and Meproadifen - |
| Author(s) : Albuquerque EX , Allen CN , Aracava Y , Akaike A , Shaw KP , Rickett DL |
| Ref : Advances in Behavioral Biology , 30 :677 , 1986 |
| PubMedID: |
| Title : The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex - Shaw_1985_Mol.Pharmacol_28_527 |
| Author(s) : Shaw KP , Aracava Y , Akaike A , Daly JW , Rickett DL , Albuquerque EX |
| Ref : Molecular Pharmacology , 28 :527 , 1985 |
| Abstract : Shaw_1985_Mol.Pharmacol_28_527 |
| ESTHER : Shaw_1985_Mol.Pharmacol_28_527 |
| PubMedSearch : Shaw_1985_Mol.Pharmacol_28_527 |
| PubMedID: 2417099 |
| Title : The nature of the interactions of pyridostigmine with the nicotinic acetylcholine receptor-ionic channel complex. II. Patch clamp studies - Akaike_1984_Mol.Pharmacol_25_102 |
| Author(s) : Akaike A , Ikeda SR , Brookes N , Pascuzzo GJ , Rickett DL , Albuquerque EX |
| Ref : Molecular Pharmacology , 25 :102 , 1984 |
| Abstract : Akaike_1984_Mol.Pharmacol_25_102 |
| ESTHER : Akaike_1984_Mol.Pharmacol_25_102 |
| PubMedSearch : Akaike_1984_Mol.Pharmacol_25_102 |
| PubMedID: 6323946 |
| Title : The nature of the interactions of pyridostigmine with the nicotinic acetylcholine receptor-ionic channel complex. I. Agonist, desensitizing, and binding properties - Pascuzzo_1984_Mol.Pharmacol_25_92 |
| Author(s) : Pascuzzo GJ , Akaike A , Maleque MA , Shaw KP , Aronstam RS , Rickett DL , Albuquerque EX |
| Ref : Molecular Pharmacology , 25 :92 , 1984 |
| Abstract : Pascuzzo_1984_Mol.Pharmacol_25_92 |
| ESTHER : Pascuzzo_1984_Mol.Pharmacol_25_92 |
| PubMedSearch : Pascuzzo_1984_Mol.Pharmacol_25_92 |
| PubMedID: 6323955 |
| Title : The frog interosseal muscle fiber as a new model for patch clamp studies of chemosensitive- and voltage-sensitive ion channels: actions of acetylcholine and batrachotoxin - Allen_1984_J.Physiol.(Paris)_79_338 |
| Author(s) : Allen CN , Akaike A , Albuquerque EX |
| Ref : Journal de Physiologie (Paris) , 79 :338 , 1984 |
| Abstract : Allen_1984_J.Physiol.(Paris)_79_338 |
| ESTHER : Allen_1984_J.Physiol.(Paris)_79_338 |
| PubMedSearch : Allen_1984_J.Physiol.(Paris)_79_338 |
| PubMedID: 6099417 |
| Title : The interaction of anticholinesterase agents with the acetylcholine receptor-ionic channel complex - Albuquerque_1984_Fundam.Appl.Toxicol_4_S27 |
| Author(s) : Albuquerque EX , Akaike A , Shaw KP , Rickett DL |
| Ref : Fundamental & Applied Toxicology , 4 :S27 , 1984 |
| Abstract : Albuquerque_1984_Fundam.Appl.Toxicol_4_S27 |
| ESTHER : Albuquerque_1984_Fundam.Appl.Toxicol_4_S27 |
| PubMedSearch : Albuquerque_1984_Fundam.Appl.Toxicol_4_S27 |
| PubMedID: 6327444 |