Wilson IB

General

Full name : Wilson Irwin B

First name : Irwin B

Mail : Dept. of Chemistry & Biology, Chemistry Bldg., University of Colorado-Boulder, Boulder, CO 80309

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Country : USA

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Comment
Irwin B Wilson was born on May 8, 1921 and passed away on Sunday, December 22, 2013. Irwin Wilson described features of the active site of acetylcholinesterase in collaboration with Felix Bergmann and David Nachmansohn. Irwin B. Wilson and Richard J. Kitz described the inhibition of acetylcholinesterase in two steps by covalently acting molecules which rapidly and reversibly bind to the active site of the enzyme. Next, the reversible complex undergoes covalent fixation at a characteristic rate. Wilson and Sara Ginsburg synthetized the 2-PAM (pralidoxime) a reactivator of cholinesterase inhibited by organophosphates simultaneously and independently of Green AL. See: Petroianu 2013. Important steps in his carrier are described in the -Irwin Wilson lecture- given by Israel Silman and Joel L Sussman in 1998 at the 6th meeting on cholinesterase in San Diego.

References (68)

Title : Acetylcholinesterase: theory of noncompetitive inhibition - Froede_1986_Arch.Biochem.Biophys_247_420
Author(s) : Froede HC , Wilson IB , Kaufman H
Ref : Archives of Biochemistry & Biophysics , 247 :420 , 1986
Abstract :
PubMedSearch : Froede_1986_Arch.Biochem.Biophys_247_420
PubMedID: 3717952

Title : The slow rate of inhibition of acetylcholinesterase by fluoride - Froede_1985_Mol.Pharmacol_27_630
Author(s) : Froede HC , Wilson IB
Ref : Molecular Pharmacology , 27 :630 , 1985
Abstract :
PubMedSearch : Froede_1985_Mol.Pharmacol_27_630
PubMedID: 4000107

Title : Acetylcholinesterase: inhibition by tetranitromethane and arsenite. Binding of arsenite by tyrosine residues - Page_1985_J.Biol.Chem_260_1475
Author(s) : Page JD , Wilson IB
Ref : Journal of Biological Chemistry , 260 :1475 , 1985
Abstract :
PubMedSearch : Page_1985_J.Biol.Chem_260_1475
PubMedID: 3968080

Title : Butyrylcholinesterase: inhibition by arsenite, fluoride, and other ligands, cooperativity in binding - Page_1985_Mol.Pharmacol_27_437
Author(s) : Page JD , Wilson IB , Silman I
Ref : Molecular Pharmacology , 27 :437 , 1985
Abstract :
PubMedSearch : Page_1985_Mol.Pharmacol_27_437
PubMedID: 3982389

Title : Direct determination of acetyl-enzyme intermediate in the acetylcholinesterase-catalyzed hydrolysis of acetylcholine and acetylthiocholine - Froede_1984_J.Biol.Chem_259_11010
Author(s) : Froede HC , Wilson IB
Ref : Journal of Biological Chemistry , 259 :11010 , 1984
Abstract :
PubMedSearch : Froede_1984_J.Biol.Chem_259_11010
PubMedID: 6469995

Title : The inhibition of acetylcholinesterase by arsenite and fluoride - Page_1983_Arch.Biochem.Biophys_226_492
Author(s) : Page JD , Wilson IB
Ref : Archives of Biochemistry & Biophysics , 226 :492 , 1983
Abstract :
PubMedSearch : Page_1983_Arch.Biochem.Biophys_226_492
PubMedID: 6639069

Title : Polyacrylamide gels which contain a novel mixed disulfide compound can be used to detect enzymes that catalyze thiol-producing reactions - Harris_1983_Anal.Biochem_134_126
Author(s) : Harris RB , Wilson IB
Ref : Analytical Biochemistry , 134 :126 , 1983
Abstract :
PubMedSearch : Harris_1983_Anal.Biochem_134_126
PubMedID: 6362479

Title : On the mechanism of the acceleration of methanesulfonylation of acetylcholinesterase with cationic accelerators - Pavlic_1978_Biochim.Biophys.Acta_523_101
Author(s) : Pavlic MR , Wilson IB
Ref : Biochimica & Biophysica Acta , 523 :101 , 1978
Abstract :
PubMedSearch : Pavlic_1978_Biochim.Biophys.Acta_523_101
PubMedID: 204352

Title : The turnover numbers of acetylcholinesterase forms -
Author(s) : Gordon MA , Carpenter DE , Wilson IB
Ref : Molecular Pharmacology , 14 :266 , 1978
PubMedID: 642928

Title : Determination of the normality of cholinesterase solutions - Gordon_1978_Anal.Biochem_85_519
Author(s) : Gordon MA , Carpenter DE , Barrett HW , Wilson IB
Ref : Analytical Biochemistry , 85 :519 , 1978
Abstract :
PubMedSearch : Gordon_1978_Anal.Biochem_85_519
PubMedID: 646105

Title : Effects of quaternary ligands on the inhibition of acetylcholinesterase by arsenite - Wilson_1977_Biochemistry_16_2701
Author(s) : Wilson IB , Silman I
Ref : Biochemistry , 16 :2701 , 1977
Abstract :
PubMedSearch : Wilson_1977_Biochemistry_16_2701
PubMedID: 19036

Title : Free energy relationships in the inhibition of acetylcholinesterase by diethyl phosphates -
Author(s) : Maglothin JA , Chen WS , Wilson IB
Ref : Molecular Pharmacology , 12 :658 , 1976
PubMedID: 958212

Title : Reactivation and aging of diphenyl phosphoryl acetylcholinesterase - Maglothin_1975_Biochim.Biophys.Acta_403_370
Author(s) : Maglothin JA , Wins P , Wilson IB
Ref : Biochimica & Biophysica Acta , 403 :370 , 1975
Abstract :
PubMedSearch : Maglothin_1975_Biochim.Biophys.Acta_403_370
PubMedID: 241402

Title : Purification of acetylcholinesterase by covalent affinity chromatography -
Author(s) : Voss HF , Ashani Y , Wilson IB
Ref : Advances in Experimental Medicine & Biology , 42 :75 , 1974
PubMedID: 4843798

Title : Equilibrium constants for the phosphorylation of acetylcholinesterase by some diethyl phosphorothiolates and phosphates -
Author(s) : Maglothin JA , Wilson IB
Ref : Biochemistry , 13 :3520 , 1974
PubMedID: 4858711

Title : Multiple forms of acetylcholinesterase from the ciliary body of the human eye -
Author(s) : Lachman C , Wilson IB
Ref : Experimental Eye Research , 19 :195 , 1974
PubMedID: 4442459

Title : A covalent affinity technique for the purification of all forms of acetylcholinesterase -
Author(s) : Voss HF , Ashani Y , Wilson IB
Ref : Methods Enzymol , 34 :581 , 1974
PubMedID: 4476046

Title : Linear free energy relationships in the hydrolysis of some inhibitors of acetylcholinesterase -
Author(s) : Ashani Y , Snyder SL , Wilson IB
Ref : Journal of Medicinal Chemistry , 16 :446 , 1973
PubMedID: 4736963

Title : A covalent affinity column for the purification of acetylcholinesterase - Ashani_1972_Biochim.Biophys.Acta_276_317
Author(s) : Ashani Y , Wilson IB
Ref : Biochimica & Biophysica Acta , 276 :317 , 1972
Abstract :
PubMedSearch : Ashani_1972_Biochim.Biophys.Acta_276_317
PubMedID: 5047710

Title : Inhibition of cholinesterase by 1,3,2-dioxaphosphorinane 2-oxide derivatives -
Author(s) : Ashani Y , Snyder SL , Wilson IB
Ref : Biochemistry , 11 :3518 , 1972
PubMedID: 5066199

Title : The inhibition of cholinesterase by diethyl phosphorochloridate -
Author(s) : Ashani Y , Wins P , Wilson IB
Ref : Biochimica & Biophysica Acta , 284 :427 , 1972
PubMedID: 4673825

Title : The effect of fluoride on the reaction of acetylcholinesterase with carbamates -
Author(s) : Greenspan CM , Wilson IB
Ref : Molecular Pharmacology , 6 :266 , 1970
PubMedID: 5443532

Title : The effect of fluoride on the reactions of methanesulfonates with acetylcholinesterase -
Author(s) : Greenspan CM , Wilson IB
Ref : Molecular Pharmacology , 6 :460 , 1970
PubMedID: 5460001

Title : On the subunit structure of acetylcholinesterase -
Author(s) : Froede HC , Wilson IB
Ref : Israel Journal of Medical Sciences , 6 :179 , 1970
PubMedID: 5506233

Title : The acceleration of the acetylcholinesterase catalyzed hydrolysis of acetyl fluoride -
Author(s) : Metzger HP , Wilson IB
Ref : Biochemical & Biophysical Research Communications , 28 :263 , 1967
PubMedID: 6035501

Title : The reaction of acetylcholinesterase with diethylphosphoryl esters of quaternary and tertiary aminophenols -
Author(s) : Kitz RJ , Ginsburg S , Wilson IB
Ref : Molecular Pharmacology , 3 :225 , 1967
PubMedID: 6037683

Title : The reaction of acetylcholinesterase with O-dimethylcarbamyl esters of quaternary quinolinium compounds -
Author(s) : Kitz RJ , Ginsburg S , Wilson IB
Ref : Biochemical Pharmacology , 16 :2201 , 1967
PubMedID: 6076610

Title : Conformation changes in acetylcholinesterase -
Author(s) : Wilson IB
Ref : Annals of the New York Academy of Sciences , 144 :664 , 1967
PubMedID: 5237269

Title : Effect of fluoride on the reaction of acetylcholinesterase with dimethylcarbamylcholine -
Author(s) : Greenspan CM , Wilson IB
Ref : Federation Proceedings , 26 :448 , 1967
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Title : O-diethyl phosphoryl esters of quaternary and tertiary aminophenols -
Author(s) : Ginsburg S , Kitz RJ , Wilson IB
Ref : Journal of Medicinal Chemistry , 9 :632 , 1966
PubMedID: 5968040

Title : The free energy of hydrolysis of diethylphosphoryl acetylcholinesterase -
Author(s) : Wilson IB , Rio RA
Ref : Molecular Pharmacology , 1 :60 , 1965
PubMedID: 5835079

Title : Activity-structure relationships in the reactivation of diethylphosphoryl acetylcholinesterase by phenyl-1-methyl pyridinium ketoximes -
Author(s) : Kitz RJ , Ginsburg S , Wilson IB
Ref : Biochemical Pharmacology , 14 :1471 , 1965
PubMedID: 5865872

Title : A partial characterization of acetylcholinesterase -
Author(s) : Kremzner LT , Wilson IB
Ref : Biochemistry , 3 :1902 , 1964
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Title : Evidence for an electrophilic mechanism in catalysis by hydrolytic enzymes - Metzger_1964_Biochemistry_3_926
Author(s) : Metzger HP , Wilson IB
Ref : Biochemistry , 3 :926 , 1964
Abstract :
PubMedSearch : Metzger_1964_Biochemistry_3_926
PubMedID: 14214081

Title : A chromatographic procedure for the purification of acetylcholinesterase -
Author(s) : Kremzner LT , Wilson IB
Ref : Journal of Biological Chemistry , 238 :1714 , 1963
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Title : Esters of methanesulfonic acid as irreversible inhibitors of acetylcholinesterase -
Author(s) : Kitz RJ , Wilson IB
Ref : Journal of Biological Chemistry , 237 :3245 , 1962
PubMedID: 14033211

Title : Carbamyl derivatives of acetylcholinesterase -
Author(s) : Wilson IB , Harpison MA , Ginsburg S
Ref : Journal of Biological Chemistry , 236 :1498 , 1961
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Title : Turnover number of acetylcholinesterase -
Author(s) : Wilson IB , Harrison MA
Ref : Journal of Biological Chemistry , 236 :2292 , 1961
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Title : Carbamylation of acetylcholinesterase -
Author(s) : Wilson IB , Hatch MA , Ginsburg S
Ref : Journal of Biological Chemistry , 235 :2312 , 1960
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Title : Molecular complementarity and antidotes for alkylphosphate poisoning -
Author(s) : Wilson IB
Ref : Federation Proceedings , 18 :752 , 1959
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Title : Reactivation of alkyl phosphate-inhibited acetyl- cholinesterase by bis-quaternary derivatives of 2-PAM and 4-PAM -
Author(s) : Wilson IB , Ginsburg S
Ref : Biochemical Pharmacology , 1 :200 , 1958
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Title : Designing of a new drug with antidotal properties against the nerve gas sarin -
Author(s) : Wilson IB
Ref : Biochimica & Biophysica Acta , 27 :196 , 1958
PubMedID: 13510268

Title : Action of lipid-soluble quaternary ammonium ions on conducting membranes -
Author(s) : Dettbarn WD , Wilson IB , Nachmansohn D
Ref : Science , 128 :1275 , 1958
PubMedID: 13602791

Title : Overshoot and block of conduction by lipid-soluble acetylcholine analogues -
Author(s) : Schoffeniels E , Wilson IB , Nachmansohn D
Ref : Biochimica & Biophysica Acta , 27 :629 , 1958
PubMedID: 13535650

Title : Molecular complementariness as basis for reactivation of alkyl phosphate-inhibited enzyme -
Author(s) : Wilson IB , Ginsburg S , Quan C
Ref : Archives of Biochemistry & Biophysics , 77 :286 , 1958
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Title : A specific antidote against lethal alkyl phosphate intoxication. II. Antidotal properties -
Author(s) : Kewitz H , Nachmansohn D , Wilson IB
Ref : Archives of Biochemistry & Biophysics , 64 :456 , 1956
PubMedID: 13363452

Title : Acetylcholinesterase: enthalpies and entropies of activation -
Author(s) : Wilson IB , Cabib E
Ref : Journal of the American Chemical Society , 78 :202 , 1956
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Title : Acetylcholinesterase -
Author(s) : Nachmansohn D , Wilson IB
Ref : Methods Enzymol , 1 :642 , 1955
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Title : A powerful reactivator of alkylphosphate-inhibited acetylcholinesterase -
Author(s) : Wilson IB , Ginsburg S
Ref : Biochimica & Biophysica Acta , 18 :168 , 1955
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Title : Promotion of acetylcholinesterase activity by the anionic site -
Author(s) : Wilson IB
Ref : Discussions of the Faraday Society , 20 :119 , 1955
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Title : The reactivation of acetylcholinesterase inhibited by tetraethyl pyrophosphate and diiso-propylfluorophosphate -
Author(s) : Wilson IB , Ginsburg S , Meislich EK
Ref : Journal of the American Chemical Society , 77 :4286 , 1955
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Title : Reactivation of acetylcholinesterase inhibited by alkyl phosphates -
Author(s) : Wilson IB , Ginsburg S
Ref : Archives of Biochemistry & Biophysics , 54 :569 , 1955
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Title : Reactivation of human serum esterase inhibited by alkyl phosphates -
Author(s) : Wilson IB
Ref : Journal of the American Chemical Society , 77 :2383 , 1955
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Title : Reactivation of acetylcholinesterase inhibited by alkylphosphates -
Author(s) : Wilson IB , Meislich EK
Ref : Journal of the American Chemical Society , 75 :462 , 1953
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Title : Choline acetylase specificity in relation to biological function -
Author(s) : Berman R , Wilson IB , Nachmansohn D
Ref : Biochimica & Biophysica Acta , 12 :315 , 1953
PubMedID: 13115440

Title : Reactivation of acetylcholinesterase inhibited by alkylphosphates -
Author(s) : Wilson IB , Meislich EK
Ref : Journal of the American Chemical Society , 75 :4628 , 1953
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Title : Choline acetylase. VI. Substitution of adenosinetriphosphate acetate by thiolacetate -
Author(s) : Nachmansohn D , Wilson IB , Korey SR , Berman R
Ref : Journal of Biological Chemistry , 195 :25 , 1952
PubMedID: 14938351

Title : Acetylcholinesterase. XIII. Reactivation of alkyl phosphate-inhibited enzyme -
Author(s) : Wilson IB
Ref : Journal of Biological Chemistry , 199 :113 , 1952
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Title : Acetylcholinesterase. XII. Further studies of binding forces -
Author(s) : Wilson IB
Ref : Journal of Biological Chemistry , 197 :215 , 1952
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Title : The enzymic hydrolysis and synthesis of acetylcholine -
Author(s) : Nachmansohn D , Wilson IB
Ref : Adv Enzymol Relat Areas Mol Biol , 12 :259 , 1951
PubMedID: 14885021

Title : Acetylcholinesterase. XI. Reversibility of tetraethyl pyrophosphate (TEPP) inhibition -
Author(s) : Wilson IB
Ref : Journal of Biological Chemistry , 190 :111 , 1951
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Title : Mechanism of enzymic hydrolysis. I. Role of the acid group in the esteratic site of acetylcholinesterase -
Author(s) : Wilson IB
Ref : Biochimica & Biophysica Acta , 7 :466 , 1951
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Title : Mechanism of hydrolysis. II. New evidence for an acylated enzyme as intermediate -
Author(s) : Wilson IB
Ref : Biochimica & Biophysica Acta , 7 :520 , 1951
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Title : Acetylcholinesterase. IX. Structural features determining the inhibition by amino acids and related compounds -
Author(s) : Bergmann F , Wilson IB , Nachmansohn D
Ref : Journal of Biological Chemistry , 186 :693 , 1950
PubMedID: 14794664

Title : The inhibitory effect of stilbamidine, curare and related compounds and its relationship to the active groups of acetylcholine esterase\; action of stilbamidine upon nerve impulse conduction -
Author(s) : Bergmann F , Wilson IB , Nachmansohn D
Ref : Biochimica & Biophysica Acta , 6 :217 , 1950
PubMedID: 14791412

Title : Acetylcholinesterase. X. Mechanism of the catalysis of acylation reactions -
Author(s) : Wilson IB , Bergmann F , Nachmansohn D
Ref : Journal of Biological Chemistry , 186 :781 , 1950
PubMedID: 14794673

Title : Studies on cholinesterase. VII. The active surface of acetylcholine esterase derived from effects of pH on inhibitors -
Author(s) : Wilson IB , Bergmann F
Ref : Journal of Biological Chemistry , 185 :479 , 1950
PubMedID: 14774389

Title : Acetylcholinesterase. VIII. Dissociation constants of the active groups -
Author(s) : Wilson IB , Bergmann F
Ref : Journal of Biological Chemistry , 186 :683 , 1950
PubMedID: