Full name : Wilson Irwin B
First name : Irwin B
Mail : Dept. of Chemistry & Biology, Chemistry Bldg., University of Colorado-Boulder, Boulder, CO 80309
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Country : USA
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Comment
Irwin B Wilson was born on May 8, 1921 and passed away on Sunday, December 22, 2013. Irwin Wilson described features of the active site of acetylcholinesterase in collaboration with Felix Bergmann and David Nachmansohn. Irwin B. Wilson and Richard J. Kitz described the inhibition of acetylcholinesterase in two steps by covalently acting molecules which rapidly and reversibly bind to the active site of the enzyme. Next, the reversible complex undergoes covalent fixation at a characteristic rate. Wilson and Sara Ginsburg synthetized the 2-PAM (pralidoxime) a reactivator of cholinesterase inhibited by organophosphates simultaneously and independently of Green AL. See: Petroianu 2013. Important steps in his carrier are described in the -Irwin Wilson lecture- given by Israel Silman and Joel L Sussman in 1998 at the 6th meeting on cholinesterase in San Diego.
| Title : Acetylcholinesterase: theory of noncompetitive inhibition - Froede_1986_Arch.Biochem.Biophys_247_420 |
| Author(s) : Froede HC , Wilson IB , Kaufman H |
| Ref : Archives of Biochemistry & Biophysics , 247 :420 , 1986 |
| Abstract : |
| PubMedSearch : Froede_1986_Arch.Biochem.Biophys_247_420 |
| PubMedID: 3717952 |
| Title : The slow rate of inhibition of acetylcholinesterase by fluoride - Froede_1985_Mol.Pharmacol_27_630 |
| Author(s) : Froede HC , Wilson IB |
| Ref : Molecular Pharmacology , 27 :630 , 1985 |
| Abstract : |
| PubMedSearch : Froede_1985_Mol.Pharmacol_27_630 |
| PubMedID: 4000107 |
| Title : Butyrylcholinesterase: inhibition by arsenite, fluoride, and other ligands, cooperativity in binding - Page_1985_Mol.Pharmacol_27_437 |
| Author(s) : Page JD , Wilson IB , Silman I |
| Ref : Molecular Pharmacology , 27 :437 , 1985 |
| Abstract : |
| PubMedSearch : Page_1985_Mol.Pharmacol_27_437 |
| PubMedID: 3982389 |
| Title : Acetylcholinesterase: inhibition by tetranitromethane and arsenite. Binding of arsenite by tyrosine residues - Page_1985_J.Biol.Chem_260_1475 |
| Author(s) : Page JD , Wilson IB |
| Ref : Journal of Biological Chemistry , 260 :1475 , 1985 |
| Abstract : |
| PubMedSearch : Page_1985_J.Biol.Chem_260_1475 |
| PubMedID: 3968080 |
| Title : Direct determination of acetyl-enzyme intermediate in the acetylcholinesterase-catalyzed hydrolysis of acetylcholine and acetylthiocholine - Froede_1984_J.Biol.Chem_259_11010 |
| Author(s) : Froede HC , Wilson IB |
| Ref : Journal of Biological Chemistry , 259 :11010 , 1984 |
| Abstract : |
| PubMedSearch : Froede_1984_J.Biol.Chem_259_11010 |
| PubMedID: 6469995 |
| Title : Polyacrylamide gels which contain a novel mixed disulfide compound can be used to detect enzymes that catalyze thiol-producing reactions - Harris_1983_Anal.Biochem_134_126 |
| Author(s) : Harris RB , Wilson IB |
| Ref : Analytical Biochemistry , 134 :126 , 1983 |
| Abstract : |
| PubMedSearch : Harris_1983_Anal.Biochem_134_126 |
| PubMedID: 6362479 |
| Title : The inhibition of acetylcholinesterase by arsenite and fluoride - Page_1983_Arch.Biochem.Biophys_226_492 |
| Author(s) : Page JD , Wilson IB |
| Ref : Archives of Biochemistry & Biophysics , 226 :492 , 1983 |
| Abstract : |
| PubMedSearch : Page_1983_Arch.Biochem.Biophys_226_492 |
| PubMedID: 6639069 |
| Title : On the mechanism of the acceleration of methanesulfonylation of acetylcholinesterase with cationic accelerators - Pavlic_1978_Biochim.Biophys.Acta_523_101 |
| Author(s) : Pavlic MR , Wilson IB |
| Ref : Biochimica & Biophysica Acta , 523 :101 , 1978 |
| Abstract : |
| PubMedSearch : Pavlic_1978_Biochim.Biophys.Acta_523_101 |
| PubMedID: 204352 |
| Title : The turnover numbers of acetylcholinesterase forms - |
| Author(s) : Gordon MA , Carpenter DE , Wilson IB |
| Ref : Molecular Pharmacology , 14 :266 , 1978 |
| PubMedID: 642928 |
| Title : Determination of the normality of cholinesterase solutions - Gordon_1978_Anal.Biochem_85_519 |
| Author(s) : Gordon MA , Carpenter DE , Barrett HW , Wilson IB |
| Ref : Analytical Biochemistry , 85 :519 , 1978 |
| Abstract : |
| PubMedSearch : Gordon_1978_Anal.Biochem_85_519 |
| PubMedID: 646105 |
| Title : Effects of quaternary ligands on the inhibition of acetylcholinesterase by arsenite - Wilson_1977_Biochemistry_16_2701 |
| Author(s) : Wilson IB , Silman I |
| Ref : Biochemistry , 16 :2701 , 1977 |
| Abstract : |
| PubMedSearch : Wilson_1977_Biochemistry_16_2701 |
| PubMedID: 19036 |
| Title : Free energy relationships in the inhibition of acetylcholinesterase by diethyl phosphates - |
| Author(s) : Maglothin JA , Chen WS , Wilson IB |
| Ref : Molecular Pharmacology , 12 :658 , 1976 |
| PubMedID: 958212 |
| Title : Reactivation and aging of diphenyl phosphoryl acetylcholinesterase - Maglothin_1975_Biochim.Biophys.Acta_403_370 |
| Author(s) : Maglothin JA , Wins P , Wilson IB |
| Ref : Biochimica & Biophysica Acta , 403 :370 , 1975 |
| Abstract : |
| PubMedSearch : Maglothin_1975_Biochim.Biophys.Acta_403_370 |
| PubMedID: 241402 |
| Title : Equilibrium constants for the phosphorylation of acetylcholinesterase by some diethyl phosphorothiolates and phosphates - |
| Author(s) : Maglothin JA , Wilson IB |
| Ref : Biochemistry , 13 :3520 , 1974 |
| PubMedID: 4858711 |
| Title : A covalent affinity column for the purification of acetylcholinesterase - Ashani_1972_Biochim.Biophys.Acta_276_317 |
| Author(s) : Ashani Y , Wilson IB |
| Ref : Biochimica & Biophysica Acta , 276 :317 , 1972 |
| Abstract : |
| PubMedSearch : Ashani_1972_Biochim.Biophys.Acta_276_317 |
| PubMedID: 5047710 |
| Title : The effect of fluoride on the reaction of acetylcholinesterase with carbamates - |
| Author(s) : Greenspan CM , Wilson IB |
| Ref : Molecular Pharmacology , 6 :266 , 1970 |
| PubMedID: 5443532 |
| Title : The effect of fluoride on the reactions of methanesulfonates with acetylcholinesterase - |
| Author(s) : Greenspan CM , Wilson IB |
| Ref : Molecular Pharmacology , 6 :460 , 1970 |
| PubMedID: 5460001 |
| Title : The acceleration of the acetylcholinesterase catalyzed hydrolysis of acetyl fluoride - |
| Author(s) : Metzger HP , Wilson IB |
| Ref : Biochemical & Biophysical Research Communications , 28 :263 , 1967 |
| PubMedID: 6035501 |
| Title : The reaction of acetylcholinesterase with diethylphosphoryl esters of quaternary and tertiary aminophenols - |
| Author(s) : Kitz RJ , Ginsburg S , Wilson IB |
| Ref : Molecular Pharmacology , 3 :225 , 1967 |
| PubMedID: 6037683 |
| Title : The reaction of acetylcholinesterase with O-dimethylcarbamyl esters of quaternary quinolinium compounds - |
| Author(s) : Kitz RJ , Ginsburg S , Wilson IB |
| Ref : Biochemical Pharmacology , 16 :2201 , 1967 |
| PubMedID: 6076610 |
| Title : Effect of fluoride on the reaction of acetylcholinesterase with dimethylcarbamylcholine - |
| Author(s) : Greenspan CM , Wilson IB |
| Ref : Federation Proceedings , 26 :448 , 1967 |
| PubMedID: |
| Title : O-diethyl phosphoryl esters of quaternary and tertiary aminophenols - |
| Author(s) : Ginsburg S , Kitz RJ , Wilson IB |
| Ref : Journal of Medicinal Chemistry , 9 :632 , 1966 |
| PubMedID: 5968040 |
| Title : Activity-structure relationships in the reactivation of diethylphosphoryl acetylcholinesterase by phenyl-1-methyl pyridinium ketoximes - |
| Author(s) : Kitz RJ , Ginsburg S , Wilson IB |
| Ref : Biochemical Pharmacology , 14 :1471 , 1965 |
| PubMedID: 5865872 |
| Title : Evidence for an electrophilic mechanism in catalysis by hydrolytic enzymes - Metzger_1964_Biochemistry_3_926 |
| Author(s) : Metzger HP , Wilson IB |
| Ref : Biochemistry , 3 :926 , 1964 |
| Abstract : |
| PubMedSearch : Metzger_1964_Biochemistry_3_926 |
| PubMedID: 14214081 |
| Title : A partial characterization of acetylcholinesterase - |
| Author(s) : Kremzner LT , Wilson IB |
| Ref : Biochemistry , 3 :1902 , 1964 |
| PubMedID: |
| Title : A chromatographic procedure for the purification of acetylcholinesterase - |
| Author(s) : Kremzner LT , Wilson IB |
| Ref : Journal of Biological Chemistry , 238 :1714 , 1963 |
| PubMedID: |
| Title : Carbamyl derivatives of acetylcholinesterase - |
| Author(s) : Wilson IB , Harpison MA , Ginsburg S |
| Ref : Journal of Biological Chemistry , 236 :1498 , 1961 |
| PubMedID: |
| Title : Turnover number of acetylcholinesterase - |
| Author(s) : Wilson IB , Harrison MA |
| Ref : Journal of Biological Chemistry , 236 :2292 , 1961 |
| PubMedID: |
| Title : Carbamylation of acetylcholinesterase - |
| Author(s) : Wilson IB , Hatch MA , Ginsburg S |
| Ref : Journal of Biological Chemistry , 235 :2312 , 1960 |
| PubMedID: |
| Title : Molecular complementarity and antidotes for alkylphosphate poisoning - |
| Author(s) : Wilson IB |
| Ref : Federation Proceedings , 18 :752 , 1959 |
| PubMedID: |
| Title : Molecular complementariness as basis for reactivation of alkyl phosphate-inhibited enzyme - |
| Author(s) : Wilson IB , Ginsburg S , Quan C |
| Ref : Archives of Biochemistry & Biophysics , 77 :286 , 1958 |
| PubMedID: |
| Title : Reactivation of alkyl phosphate-inhibited acetyl- cholinesterase by bis-quaternary derivatives of 2-PAM and 4-PAM - |
| Author(s) : Wilson IB , Ginsburg S |
| Ref : Biochemical Pharmacology , 1 :200 , 1958 |
| PubMedID: |
| Title : Action of lipid-soluble quaternary ammonium ions on conducting membranes - |
| Author(s) : Dettbarn WD , Wilson IB , Nachmansohn D |
| Ref : Science , 128 :1275 , 1958 |
| PubMedID: 13602791 |
| Title : Overshoot and block of conduction by lipid-soluble acetylcholine analogues - |
| Author(s) : Schoffeniels E , Wilson IB , Nachmansohn D |
| Ref : Biochimica & Biophysica Acta , 27 :629 , 1958 |
| PubMedID: 13535650 |
| Title : A specific antidote against lethal alkyl phosphate intoxication. II. Antidotal properties - |
| Author(s) : Kewitz H , Nachmansohn D , Wilson IB |
| Ref : Archives of Biochemistry & Biophysics , 64 :456 , 1956 |
| PubMedID: 13363452 |
| Title : Reactivation of human serum esterase inhibited by alkyl phosphates - |
| Author(s) : Wilson IB |
| Ref : Journal of the American Chemical Society , 77 :2383 , 1955 |
| PubMedID: |
| Title : Reactivation of acetylcholinesterase inhibited by alkyl phosphates - |
| Author(s) : Wilson IB , Ginsburg S |
| Ref : Archives of Biochemistry & Biophysics , 54 :569 , 1955 |
| PubMedID: |
| Title : Acetylcholinesterase - |
| Author(s) : Nachmansohn D , Wilson IB |
| Ref : Methods Enzymol , 1 :642 , 1955 |
| PubMedID: |
| Title : A powerful reactivator of alkylphosphate-inhibited acetylcholinesterase - |
| Author(s) : Wilson IB , Ginsburg S |
| Ref : Biochimica & Biophysica Acta , 18 :168 , 1955 |
| PubMedID: |
| Title : Promotion of acetylcholinesterase activity by the anionic site - |
| Author(s) : Wilson IB |
| Ref : Discussions of the Faraday Society , 20 :119 , 1955 |
| PubMedID: |
| Title : The reactivation of acetylcholinesterase inhibited by tetraethyl pyrophosphate and diiso-propylfluorophosphate - |
| Author(s) : Wilson IB , Ginsburg S , Meislich EK |
| Ref : Journal of the American Chemical Society , 77 :4286 , 1955 |
| PubMedID: |
| Title : Reactivation of acetylcholinesterase inhibited by alkylphosphates - |
| Author(s) : Wilson IB , Meislich EK |
| Ref : Journal of the American Chemical Society , 75 :4628 , 1953 |
| PubMedID: |
| Title : Choline acetylase specificity in relation to biological function - |
| Author(s) : Berman R , Wilson IB , Nachmansohn D |
| Ref : Biochimica & Biophysica Acta , 12 :315 , 1953 |
| PubMedID: 13115440 |
| Title : Reactivation of acetylcholinesterase inhibited by alkylphosphates - |
| Author(s) : Wilson IB , Meislich EK |
| Ref : Journal of the American Chemical Society , 75 :462 , 1953 |
| PubMedID: |
| Title : Choline acetylase. VI. Substitution of adenosinetriphosphate acetate by thiolacetate - |
| Author(s) : Nachmansohn D , Wilson IB , Korey SR , Berman R |
| Ref : Journal of Biological Chemistry , 195 :25 , 1952 |
| PubMedID: 14938351 |
| Title : Acetylcholinesterase. XII. Further studies of binding forces - |
| Author(s) : Wilson IB |
| Ref : Journal of Biological Chemistry , 197 :215 , 1952 |
| PubMedID: |
| Title : Acetylcholinesterase. XIII. Reactivation of alkyl phosphate-inhibited enzyme - |
| Author(s) : Wilson IB |
| Ref : Journal of Biological Chemistry , 199 :113 , 1952 |
| PubMedID: |
| Title : The enzymic hydrolysis and synthesis of acetylcholine - |
| Author(s) : Nachmansohn D , Wilson IB |
| Ref : Adv Enzymol Relat Areas Mol Biol , 12 :259 , 1951 |
| PubMedID: 14885021 |
| Title : Mechanism of enzymic hydrolysis. I. Role of the acid group in the esteratic site of acetylcholinesterase - |
| Author(s) : Wilson IB |
| Ref : Biochimica & Biophysica Acta , 7 :466 , 1951 |
| PubMedID: |
| Title : Mechanism of hydrolysis. II. New evidence for an acylated enzyme as intermediate - |
| Author(s) : Wilson IB |
| Ref : Biochimica & Biophysica Acta , 7 :520 , 1951 |
| PubMedID: |
| Title : Acetylcholinesterase. XI. Reversibility of tetraethyl pyrophosphate (TEPP) inhibition - |
| Author(s) : Wilson IB |
| Ref : Journal of Biological Chemistry , 190 :111 , 1951 |
| PubMedID: |
| Title : Studies on cholinesterase. VII. The active surface of acetylcholine esterase derived from effects of pH on inhibitors - |
| Author(s) : Wilson IB , Bergmann F |
| Ref : Journal of Biological Chemistry , 185 :479 , 1950 |
| PubMedID: 14774389 |
| Title : Acetylcholinesterase. VIII. Dissociation constants of the active groups - |
| Author(s) : Wilson IB , Bergmann F |
| Ref : Journal of Biological Chemistry , 186 :683 , 1950 |
| PubMedID: |
| Title : Acetylcholinesterase. IX. Structural features determining the inhibition by amino acids and related compounds - |
| Author(s) : Bergmann F , Wilson IB , Nachmansohn D |
| Ref : Journal of Biological Chemistry , 186 :693 , 1950 |
| PubMedID: 14794664 |
| Title : The inhibitory effect of stilbamidine, curare and related compounds and its relationship to the active groups of acetylcholine esterase\; action of stilbamidine upon nerve impulse conduction - |
| Author(s) : Bergmann F , Wilson IB , Nachmansohn D |
| Ref : Biochimica & Biophysica Acta , 6 :217 , 1950 |
| PubMedID: 14791412 |
| Title : Acetylcholinesterase. X. Mechanism of the catalysis of acylation reactions - |
| Author(s) : Wilson IB , Bergmann F , Nachmansohn D |
| Ref : Journal of Biological Chemistry , 186 :781 , 1950 |
| PubMedID: 14794673 |