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Author Report for: Lockridge O

Contact information:

Lockridge Oksana
University of Nebraska Medical Center, Eppley Institute, 985950 Nebraska Medical Center, Omaha, NE 68198-5950
68198-6805
Omaha
USA
Phone : 402 559-6032
Fax : 402 559-4651
Send E-Mail to Lockridge Oksana
Visit the web site of Lockridge O at : http://www.unmc.edu/eppley/about/faculty/lockridge.html


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Lockridge Oksana Pezzementi Leo
The 3rd International Meeting on Cholinesterases
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The 3rd International Meeting on Cholinesterases
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The 3rd International Meeting on Cholinesterases
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Reiner Elsa
The 10th International Meeting on Cholinesterases
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The 10th International Meeting on Cholinesterases
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Chatonnet Arnaud Lockridge Oksana
The 10th International Meeting on Cholinesterases
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The 10th International Meeting on Cholinesterases
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Chatonnet Arnaud Bourne Yves Masson Patrick Lenfant Nicolas Marchot Pascale Paul Hrabovska Anna Vidal-Moreno Cecilio J Krejci Eric Nachon Florian Soreq Hermona Sussman Joel L Lockridge Oksana Tsim KW Rosenberry Terrone L Doctor Bhupendra P Kovarik Zrinka
The 11th International Meeting on Cholinesterases
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The 11th International Meeting on Cholinesterases
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Masson Patrick Lockridge Oksana
The 11th International Meeting on Cholinesterases
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The 11th International Meeting on Cholinesterases
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The 11th International Meeting on Cholinesterases
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The 11th International Meeting on Cholinesterases
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The 11th International Meeting on Cholinesterases
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Lockridge Oksana
The 11th International Meeting on Cholinesterases
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The 11th International Meeting on Cholinesterases
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The 7th International Meeting on Cholinesterases
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The 7th International Meeting on Cholinesterases
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The 6th International Meeting on Cholinesterases
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The 12th International Meeting on Cholinesterases
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The 12th International Meeting on Cholinesterases
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The 13th International Meeting on Cholinesterases 7th Conference on Paraoxonase
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The 13th International Meeting on Cholinesterases 7th Conference on Paraoxonase
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The 13th International Meeting on Cholinesterases 7th Conference on Paraoxonase
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The 15th International Symposium on Cholinergic Mechanisms
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The Second symposium on butyrylcholinesterase
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Construction of a retina from stem cells - tribute to former students, colleagues and collaborators of Paul G Layer



    Title: Overview of Adductomics in Toxicology
    Lockridge O
    Ref: Curr Protoc, 3:e672, 2023 : PubMed

            

    Title: Review: Organophosphorus toxicants, in addition to inhibiting acetylcholinesterase activity, make covalent adducts on multiple proteins and promote protein crosslinking into high molecular weight aggregates
    Lockridge O, Schopfer LM
    Ref: Chemico-Biological Interactions, :110460, 2023 : PubMed

            

    Title: Drug and pro-drug substrates and pseudo-substrates of human butyrylcholinesterase
    Masson P, Shaihutdinova Z, Lockridge O
    Ref: Biochemical Pharmacology, 218:115910, 2023 : PubMed

            

    Title: Human butyrylcholinesterase in Cohn fraction IV-4 purified in a single chromatography step on Hupresin
    Schopfer LM, David E, Hinrichs SH, Lockridge O
    Ref: PLoS ONE, 18:e0280380, 2023 : PubMed

            

    Title: Butyrylcholinesterase in SH-SY5Y human neuroblastoma cells
    Onder S, Schopfer LM, Jiang W, Tacal O, Lockridge O
    Ref: Neurotoxicology, :, 2022 : PubMed

            

    Title: Organophosphorus Pesticides Promote Protein Cross-Linking
    Schopfer LM, Onder S, Lockridge O
    Ref: Chemical Research in Toxicology, :, 2022 : PubMed

            

    Title: Rabbit Antidiethoxyphosphotyrosine Antibody, Made by Single B Cell Cloning, Detects Chlorpyrifos Oxon-Modified Proteins in Cultured Cells and Immunopurifies Modified Peptides for Mass Spectrometry
    Onder S, van Grol M, Fidder A, Xiao G, Noort D, Yerramalla U, Tacal O, Schopfer LM, Lockridge O
    Ref: J Proteome Res, :, 2021 : PubMed

            

    Title: Evaluation of mass spectrometry MS/MS spectra for the presence of isopeptide crosslinked peptides
    Schopfer LM, Onder S, Lockridge O
    Ref: PLoS ONE, 16:e0254450, 2021 : PubMed

            

    Title: Chlorpyrifos Oxon-Induced Isopeptide Bond Formation in Human Butyrylcholinesterase
    Biberoglu K, Tacal O, Schopfer LM, Lockridge O
    Ref: Molecules, 25:, 2020 : PubMed

            

    Title: Characteristic fragment ions associated with dansyl cadaverine and biotin cadaverine adducts on glutamine
    Biberoglu K, Schopfer LM, Tacal O, Lockridge O
    Ref: Analytical Biochemistry, :113718, 2020 : PubMed

            

    Title: Signature Ions in MS/MS Spectra for Dansyl-Aminohexyl-QQIV Adducts on Lysine
    Schopfer LM, Lockridge O
    Ref: Molecules, 25:, 2020 : PubMed

            

    Title: Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers
    Toker L, Silman I, Zeev-Ben-Mordehai T, Sussman JL, Schopfer LM, Lockridge O
    Ref: Chemico-Biological Interactions, :109007, 2020 : PubMed

            

    Title: Proline 285 is integral for the reactivation of organophosphate-inhibited human butyrylcholinesterase by 2-PAM
    diTargiani RC, Belinskaya T, Tipparaju P, Lockridge O, Saxena A
    Ref: Chemico-Biological Interactions, :109092, 2020 : PubMed

            

    Title: Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad
    Grigorenko BL, Novichkova DA, Lushchekina SV, Zueva IV, Schopfer LM, Nemukhin AV, Varfolomeev SD, Lockridge O, Masson P
    Ref: Chemico-Biological Interactions, 306:138, 2019 : PubMed

            

    Title: Half-life of chlorpyrifos oxon and other organophosphorus esters in aqueous solution
    Lockridge O, Verdier L, Schopfer LM
    Ref: Chemico-Biological Interactions, :108788, 2019 : PubMed

            

    Title: Purification of human butyrylcholinesterase from frozen Cohn fraction IV-4 by ion exchange and Hupresin affinity chromatography
    Schopfer LM, Lockridge O, David E, Hinrichs SH
    Ref: PLoS ONE, 14:e0209795, 2019 : PubMed

            

    Title: Mass Spectrometry Identifies Isopeptide Cross-Links Promoted by Diethylphosphorylated Lysine in Proteins Treated with Chlorpyrifos Oxon
    Schopfer LM, Lockridge O
    Ref: Chemical Research in Toxicology, 32:762, 2019 : PubMed

            

    Title: Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly
    Leung MR, van Bezouwen LS, Schopfer LM, Sussman JL, Silman I, Lockridge O, Zeev-Ben-Mordehai T
    Ref: Proc Natl Acad Sci U S A, 115:13270, 2018 : PubMed

            

    Title: Purification of recombinant human butyrylcholinesterase on Hupresin(R)
    Lockridge O, David E, Schopfer LM, Masson P, Brazzolotto X, Nachon F
    Ref: Journal of Chromatography B Analyt Technol Biomed Life Sciences, 1102-1103:109, 2018 : PubMed

            

    Title: Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents
    Lushchekina SV, Schopfer LM, Grigorenko BL, Nemukhin AV, Varfolomeev SD, Lockridge O, Masson P
    Ref: Front Pharmacol, 9:211, 2018 : PubMed

            

    Title: Identification of Carboxylesterase, Butyrylcholinesterase, Acetylcholinesterase, Paraoxonase, and Albumin Pseudoesterase in Guinea Pig Plasma through Nondenaturing Gel Electrophoresis
    Napon G, Dafferner AJ, Saxena A, Lockridge O
    Ref: Comp Med, 68:367, 2018 : PubMed

            

    Title: Delipidation of Plasma Has Minimal Effects on Human Butyrylcholinesterase
    Onder S, Tacal O, Lockridge O
    Ref: Front Pharmacol, 9:117, 2018 : PubMed

            

    Title: Use of Hupresin To Capture Red Blood Cell Acetylcholinesterase for Detection of Soman Exposure
    Onder S, Schopfer LM, Cashman JR, Tacal O, Johnson RC, Blake TA, Lockridge O
    Ref: Analytical Chemistry, 90:974, 2018 : PubMed

            

    Title: Tetramer organizing polyproline-rich peptides identified by mass spectrometry after release of the peptides from Hupresin-purified butyrylcholinesterase tetramers isolated from milk of domestic pig (Sus scrofa)
    Saxena A, Belinskaya T, Schopfer LM, Lockridge O
    Ref: Data Brief, 20:1607, 2018 : PubMed

            

    Title: Characterization of butyrylcholinesterase from porcine milk
    Saxena A, Belinskaya T, Schopfer LM, Lockridge O
    Ref: Archives of Biochemistry & Biophysics, 652:38, 2018 : PubMed

            

    Title: Chlorpyrifos oxon promotes tubulin aggregation via isopeptide cross-linking between diethoxyphospho-Lys and Glu or Asp: Implications for neurotoxicity
    Schopfer LM, Lockridge O
    Ref: Journal of Biological Chemistry, 293:13566, 2018 : PubMed

            

    Title: Characterization of butyrylcholinesterase in bovine serum
    Dafferner AJ, Lushchekina SV, Masson P, Xiao G, Schopfer LM, Lockridge O
    Ref: Chemico-Biological Interactions, 266:17, 2017 : PubMed

            

    Title: Immunopurification of Acetylcholinesterase from Red Blood Cells for Detection of Nerve Agent Exposure
    Dafferner AJ, Schopfer LM, Xiao G, Cashman JR, Yerramalla U, Johnson RC, Blake TA, Lockridge O
    Ref: Chemical Research in Toxicology, 30:1897, 2017 : PubMed

            

    Title: Hupresin Retains Binding Capacity for Butyrylcholinesterase and Acetylcholinesterase after Sanitation with Sodium Hydroxide
    Onder S, David E, Tacal O, Schopfer LM, Lockridge O
    Ref: Front Pharmacol, 8:713, 2017 : PubMed

            

    Title: Monoclonal Antibody That Recognizes Diethoxyphosphotyrosine-Modified Proteins and Peptides Independent of Surrounding Amino Acids
    Onder S, Dafferner AJ, Schopfer LM, Xiao G, Yerramalla U, Tacal O, Blake TA, Johnson RC, Lockridge O
    Ref: Chemical Research in Toxicology, 30:2218, 2017 : PubMed

            

    Title: The C5 Variant of the Butyrylcholinesterase Tetramer Includes a Noncovalently Bound 60 kDa Lamellipodin Fragment
    Schopfer LM, Delacour H, Masson P, Leroy J, Krejci E, Lockridge O
    Ref: Molecules, 22:, 2017 : PubMed

            

    Title: Heat pretreatment eliminates spurious butyrylcholinesterase enhancement of endotoxin levels in the kinetic chromogenic assay
    Brawner A, Hinrichs SH, Larson MA, Lockridge O
    Ref: Chemico-Biological Interactions, 249:19, 2016 : PubMed

            

    Title: Naturally Occurring Genetic Variants of Human Acetylcholinesterase and Butyrylcholinesterase and Their Potential Impact on the Risk of Toxicity from Cholinesterase Inhibitors
    Lockridge O, Norgren RB, Jr., Johnson RC, Blake TA
    Ref: Chemical Research in Toxicology, 29:1381, 2016 : PubMed

            

    Title: Origin of polyproline-rich peptides in human butyrylcholinesterase tetramers
    Peng H, Schopfer LM, Lockridge O
    Ref: Chemico-Biological Interactions, 259:63, 2016 : PubMed

            

    Title: Monoclonal antibodies to human butyrylcholinesterase reactive with butyrylcholinesterase in animal plasma
    Peng H, Brimijoin S, Hrabovska A, Krejci E, Blake TA, Johnson RC, Masson P, Lockridge O
    Ref: Chemico-Biological Interactions, 243:82, 2016 : PubMed

            

    Title: Monoclonal Antibodies That Recognize Various Folding States of Pure Human Butyrylcholinesterase Can Immunopurify Butyrylcholinesterase from Human Plasma Stored at Elevated Temperatures
    Peng H, Blake TA, Johnson RC, Dafferner AJ, Brimijoin S, Lockridge O
    Ref: ACS Omega, 1:1182, 2016 : PubMed

            

    Title: Tetramer-organizing polyproline-rich peptides differ in CHO cell-expressed and plasma-derived human butyrylcholinesterase tetramers
    Schopfer LM, Lockridge O
    Ref: Biochimica & Biophysica Acta, 1864:706, 2016 : PubMed

            

    Title: Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses
    Lockridge O
    Ref: Pharmacol Ther, 148C:34, 2015 : PubMed

            

    Title: Human butyrylcholinesterase polymorphism: Molecular modeling
    Lushchekina SV, Delacour H, Lockridge O, Masson P
    Ref: Int J Risk Saf Med, 27 Suppl 1:S80, 2015 : PubMed

            

    Title: Comparison of 5 monoclonal antibodies for immunopurification of human butyrylcholinesterase on Dynabeads: K values, binding pairs, and amino acid sequences
    Peng H, Brimijoin S, Hrabovska A, Targosova K, Krejci E, Blake TA, Johnson RC, Masson P, Lockridge O
    Ref: Chemico-Biological Interactions, 240:336, 2015 : PubMed

            

    Title: Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin
    Schopfer LM, Lockridge O, Brimijoin S
    Ref: General & Comparative Endocrinology, 224:61, 2015 : PubMed

            

    Title: Butyrylcholinesterase genotype and enzyme activity in relation to Gulf War illness: preliminary evidence of gene-exposure interaction from a case-control study of 1991 Gulf War veterans
    Steele L, Lockridge O, Gerkovich MM, Cook MR, Sastre A
    Ref: Environ Health, 14:4, 2015 : PubMed

            

    Title: Characterization of a Novel BCHE Silent Allele: Point Mutation (p.Val204Asp) Causes Loss of Activity and Prolonged Apnea with Suxamethonium
    Delacour H, Lushchekina SV, Mabboux I, Bousquet A, Ceppa F, Schopfer LM, Lockridge O, Masson P
    Ref: PLoS ONE, 9:e101552, 2014 : PubMed

            

    Title: Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), silent with mivacurium
    Delacour H, Lushchekina SV, Mabboux I, Ceppa F, Masson P, Schopfer LM, Lockridge O
    Ref: Biochemical Pharmacology, 92:476, 2014 : PubMed

            

    Title: Polyproline promotes tetramerization of recombinant human butyrylcholinesterase
    Larson MA, Lockridge O, Hinrichs SH
    Ref: Biochemical Journal, 462:329, 2014 : PubMed

            

    Title: Detection of cresyl phosphate-modified butyrylcholinesterase in human plasma for chemical exposure associated with aerotoxic syndrome
    Schopfer LM, Masson P, Lamourette P, Simon S, Lockridge O
    Ref: Analytical Biochemistry, 461C:17, 2014 : PubMed

            

    Title: Polyproline tetramer organizing peptides in fetal bovine serum acetylcholinesterase
    Biberoglu K, Schopfer LM, Saxena A, Tacal O, Lockridge O
    Ref: Biochimica & Biophysica Acta, 1834:745, 2013 : PubMed

            

    Title: Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry
    Carletti E, Colletier JP, Schopfer LM, Santoni G, Masson P, Lockridge O, Nachon F, Weik M
    Ref: Chemical Research in Toxicology, 26:280, 2013 : PubMed

            

    Title: Detectable organophosphorus pesticide exposure in the blood of Nebraska and Iowa residents measured by mass spectrometry of butyrylcholinesterase adducts
    Jiang W, Lockridge O
    Ref: Chemico-Biological Interactions, 203:91, 2013 : PubMed

            

    Title: Mass spectrometry method to identify aging pathways of Sp- and Rp-tabun adducts on human butyrylcholinesterase based on the acid labile P-N bond
    Jiang W, Cashman JR, Nachon F, Masson P, Schopfer LM, Lockridge O
    Ref: Toxicol Sci, 132:390, 2013 : PubMed

            

    Title: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of titanium oxide-enriched peptides for detection of aged organophosphorus adducts on human butyrylcholinesterase
    Jiang W, Murashko EA, Dubrovskii YA, Podolskaya EP, Babakov VN, Mikler J, Nachon F, Masson P, Schopfer LM, Lockridge O
    Ref: Analytical Biochemistry, 439:132, 2013 : PubMed

            

    Title: PHOS-Select Iron Affinity Beads Enrich Peptides for the Detection of Organophosphorus Adducts on Albumin
    Jiang W, Dubrovskii YA, Podolskaya EP, Murashko EA, Babakov VN, Nachon F, Masson P, Schopfer LM, Lockridge O
    Ref: Chemical Research in Toxicology, 26:1917, 2013 : PubMed

            

    Title: Application of chromosomal DNA and protein targeting for the identification of Yersinia pestis
    Larson MA, Ding SJ, Slater SR, Hanway A, Bartling AM, Fey PD, Lockridge O, Francesconi SC, Hinrichs SH
    Ref: Proteomics Clin Appl, 7:416, 2013 : PubMed

            

    Title: Polyclonal antibody to soman-tyrosine
    Li B, Duysen EG, Froment MT, Masson P, Nachon F, Jiang W, Schopfer LM, Thiele GM, Klassen LW and Lockridge O <2 more author(s)>
    Ref: Chemical Research in Toxicology, 26:584, 2013 : PubMed

            

    Title: Cresyl saligenin phosphate makes multiple adducts on free histidine, but does not form an adduct on histidine 438 of human butyrylcholinesterase
    Liyasova MS, Schopfer LM, Lockridge O
    Ref: Chemico-Biological Interactions, 203:103, 2013 : PubMed

            

    Title: Newly observed spontaneous activation of ethephon as a butyrylcholinesterase inhibitor
    Liyasova MS, Schopfer LM, Kodani S, Lantz SR, Casida JE, Lockridge O
    Ref: Chemical Research in Toxicology, 26:422, 2013 : PubMed

            

    Title: Effects of viscosity and osmotic stress on the reaction of human butyrylcholinesterase with cresyl saligenin phosphate, a toxicant related to aerotoxic syndrome: kinetic and molecular dynamics studies
    Masson P, Lushchekina SV, Schopfer LM, Lockridge O
    Ref: Biochemical Journal, 454:387, 2013 : PubMed

            

    Title: Resistance of human butyrylcholinesterase to methylene blue-catalyzed photoinactivation; mass spectrometry analysis of oxidation products
    Tacal O, Li B, Lockridge O, Schopfer LM
    Ref: Photochem Photobiol, 89:336, 2013 : PubMed

            

    Title: Human serum albumin-based design of a diflunisal prodrug
    Yang F, Ma ZY, Zhang Y, Li GQ, Li M, Qin JK, Lockridge O, Liang H
    Ref: Eur J Pharm Biopharm, 84:549, 2013 : PubMed

            

    Title: The proline-rich tetramerization peptides in equine serum butyrylcholinesterase
    Biberoglu K, Schopfer LM, Tacal O, Lockridge O
    Ref: Febs J, 279:3844, 2012 : PubMed

            

    Title: Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure
    Brazzolotto X, Wandhammer M, Ronco C, Trovaslet M, Jean L, Lockridge O, Renard PY, Nachon F
    Ref: Febs J, 279:2905, 2012 : PubMed

            

    Title: Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran
    Duysen EG, Cashman JR, Schopfer LM, Nachon F, Masson P, Lockridge O
    Ref: Chemico-Biological Interactions, 195:189, 2012 : PubMed

            

    Title: Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis
    Hlady RA, Novakova S, Opavska J, Klinkebiel D, Peters SL, Bies J, Hannah J, Iqbal J, Anderson KM and Opavsky R <11 more author(s)>
    Ref: J Clinical Investigation, 122:163, 2012 : PubMed

            

    Title: Mice treated with a nontoxic dose of chlorpyrifos oxon have diethoxyphosphotyrosine labeled proteins in blood up to 4 days post exposure, detected by mass spectrometry
    Jiang W, Duysen EG, Lockridge O
    Ref: Toxicology, 295:15, 2012 : PubMed

            

    Title: Cresyl saligenin phosphate, an organophosphorus toxicant, makes covalent adducts with histidine, lysine, and tyrosine residues of human serum albumin
    Liyasova MS, Schopfer LM, Lockridge O
    Ref: Chemical Research in Toxicology, 25:1752, 2012 : PubMed

            

    Title: Analytical approaches for monitoring exposure to organophosphorus and carbamate agents through analysis of protein adducts
    Schopfer LM, Lockridge O
    Ref: Drug Test Anal, 4:246, 2012 : PubMed

            

    Title: Role of acetylcholinesterase on the structure and function of cholinergic synapses: insights gained from studies on knockout mice
    Adler M, Sweeney RE, Hamilton TA, Lockridge O, Duysen EG, Purcell AL, Deshpande SS
    Ref: Cellular Molecular Neurobiology, 31:909, 2011 : PubMed

            

    Title: Cocrystallization studies of full-length recombinant butyrylcholinesterase (BChE) with cocaine
    Asojo OA, Ngamelue MN, Homma K, Lockridge O
    Ref: Acta Crystallographica Sect F Struct Biol Cryst Commun, 67:434, 2011 : PubMed

            

    Title: The kinetic study of the inhibition of human cholinesterases by demeton-S-methyl shows that cholinesterase-based titration methods are not suitable for this organophosphate
    Bazire A, Gillon E, Lockridge O, Vallet V, Nachon F
    Ref: Toxicol In Vitro, 25:754, 2011 : PubMed

            

    Title: Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis
    Carletti E, Schopfer LM, Colletier JP, Froment MT, Nachon F, Weik M, Lockridge O, Masson P
    Ref: Chemical Research in Toxicology, 24:797, 2011 : PubMed

            

    Title: Adenovirus-mediated human paraoxonase1 gene transfer to provide protection against the toxicity of the organophosphorus pesticide toxicant diazoxon
    Duysen EG, Parikh K, Aleti V, Manne V, Lockridge O, Chilukuri N
    Ref: Gene Therapy, 18:250, 2011 : PubMed

            

    Title: Production of ES1 plasma carboxylesterase knockout mice for toxicity studies
    Duysen EG, Koentgen F, Williams GR, Timperley CM, Schopfer LM, Cerasoli DM, Lockridge O
    Ref: Chemical Research in Toxicology, 24:1891, 2011 : PubMed

            

    Title: Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons
    Duysen EG, Lockridge O
    Ref: Toxicol Appl Pharmacol, 255:214, 2011 : PubMed

            

    Title: Prolonged toxic effects after cocaine challenge in butyrylcholinesterase/plasma carboxylesterase double knockout mice: a model for butyrylcholinesterase-deficient humans
    Duysen EG, Lockridge O
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 39:1321, 2011 : PubMed

            

    Title: Exposure to tri-o-cresyl phosphate detected in jet airplane passengers
    Liyasova M, Li B, Schopfer LM, Nachon F, Masson P, Furlong CE, Lockridge O
    Ref: Toxicol Appl Pharmacol, 256:337, 2011 : PubMed

            

    Title: Transglutaminase-mediated remodeling of the human erythrocyte membrane skeleton: relevance for erythrocyte diseases with shortened cell lifespan
    Lorand L, Murthy SN, Khan AA, Xue W, Lockridge O, Chishti AH
    Ref: Adv Enzymol Relat Areas Mol Biol, 78:385, 2011 : PubMed

            

    Title: Biomarkers of organophosphorus (OP) exposures in humans
    Marsillach J, Richter RJ, Kim JH, Stevens RC, Maccoss MJ, Tomazela D, Suzuki SM, Schopfer LM, Lockridge O, Furlong CE
    Ref: Neurotoxicology, 32:656, 2011 : PubMed

            

    Title: X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger
    Nachon F, Carletti E, Wandhammer M, Nicolet Y, Schopfer LM, Masson P, Lockridge O
    Ref: Biochemical Journal, 434:73, 2011 : PubMed

            

    Title: Gene-Delivered Butyrylcholinesterase Is Prophylactic against the Toxicity of Chemical Warfare Nerve Agents and Organophosphorus Compounds
    Parikh K, Duysen EG, Snow B, Jensen NS, Manne V, Lockridge O, Chilukuri N
    Ref: Journal of Pharmacology & Experimental Therapeutics, 337:92, 2011 : PubMed

            

    Title: Contributions of selective knockout studies to understanding cholinesterase disposition and function
    Camp S, Zhang L, Krejci E, Dobbertin A, Bernard V, Girard E, Duysen EG, Lockridge O, De Jaco A, Taylor P
    Ref: Chemico-Biological Interactions, 187:72, 2010 : PubMed

            

    Title: Visualization of exogenous delivery of nanoformulated butyrylcholinesterase to the central nervous system
    Gaydess A, Duysen E, Li Y, Gilman V, Kabanov A, Lockridge O, Bronich T
    Ref: Chemico-Biological Interactions, 187:295, 2010 : PubMed

            

    Title: Drastic decrease in dopamine receptor levels in the striatum of acetylcholinesterase knock-out mouse
    Hrabovska A, Farar V, Bernard V, Duysen EG, Brabec J, Lockridge O, Myslivecek J
    Ref: Chemico-Biological Interactions, 183:194, 2010 : PubMed

            

    Title: Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents
    Jiang W, Duysen EG, Hansen H, Shlyakhtenko L, Schopfer LM, Lockridge O
    Ref: Toxicol Sci, 115:183, 2010 : PubMed

            

    Title: Dichlorvos, chlorpyrifos oxon and Aldicarb adducts of butyrylcholinesterase, detected by mass spectrometry in human plasma following deliberate overdose
    Li B, Ricordel I, Schopfer LM, Baud F, Megarbane B, Masson P, Lockridge O
    Ref: J Appl Toxicol, 30:559, 2010 : PubMed

            

    Title: Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos
    Li B, Ricordel I, Schopfer LM, Baud F, Megarbane B, Nachon F, Masson P, Lockridge O
    Ref: Toxicol Sci, 116:23, 2010 : PubMed

            

    Title: Reaction of human albumin with aspirin in vitro: mass spectrometric identification of acetylated lysines 199, 402, 519, and 545
    Liyasova MS, Schopfer LM, Lockridge O
    Ref: Biochemical Pharmacology, 79:784, 2010 : PubMed

            

    Title: Review of tyrosine and lysine as new motifs for organophosphate binding to proteins that have no active site serine
    Lockridge O, Schopfer LM
    Ref: Chemico-Biological Interactions, 187:344, 2010 : PubMed

            

    Title: Butyrylcholinesterase for protection from organophosphorus poisons: catalytic complexities and hysteretic behavior
    Masson P, Lockridge O
    Ref: Archives of Biochemistry & Biophysics, 494:107, 2010 : PubMed

            

    Title: Structural approach to the aging of phosphylated cholinesterases
    Masson P, Nachon F, Lockridge O
    Ref: Chemico-Biological Interactions, 187:157, 2010 : PubMed

            

    Title: Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates
    Schopfer LM, Grigoryan H, Li B, Nachon F, Masson P, Lockridge O
    Ref: Journal of Chromatography B Analyt Technol Biomed Life Sciences, 878:1297, 2010 : PubMed

            

    Title: Development of diagnostics in the search for an explanation of aerotoxic syndrome
    Schopfer LM, Furlong CE, Lockridge O
    Ref: Analytical Biochemistry, 404:64, 2010 : PubMed

            

    Title: Methamidophos, dichlorvos, O-methoate and diazinon pesticides used in Turkey make a covalent bond with butyrylcholinesterase detected by mass spectrometry
    Tacal O, Lockridge O
    Ref: J Appl Toxicol, 30:469, 2010 : PubMed

            

    Title: Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents
    Chilukuri N, Duysen EG, Parikh K, diTargiani RC, Doctor BP, Lockridge O, Saxena A
    Ref: Molecular Pharmacology, 76:612, 2009 : PubMed

            

    Title: The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease
    Duysen EG, Li B, Lockridge O
    Ref: Expert Opin Drug Metab Toxicol, 5:523, 2009 : PubMed

            

    Title: Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase
    Gilley C, MacDonald M, Nachon F, Schopfer LM, Zhang J, Cashman JR, Lockridge O
    Ref: Chemical Research in Toxicology, 22:1680, 2009 : PubMed

            

    Title: Mass spectral characterization of organophosphate-labeled lysine in peptides.
    Grigoryan H, Li B, Xue W, Grigoryan M, Schopfer LM, Lockridge O
    Ref: Analytical Biochemistry, 394:92, 2009 : PubMed

            

    Title: Mass spectrometry identifies multiple organophosphorylated sites on tubulin
    Grigoryan H, Schopfer LM, Peeples ES, Duysen EG, Grigoryan M, Thompson CM, Lockridge O
    Ref: Toxicol Appl Pharmacol, 240:149, 2009 : PubMed

            

    Title: Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine
    Grigoryan H, Li B, Anderson EK, Xue W, Nachon F, Lockridge O, Schopfer LM
    Ref: Chemico-Biological Interactions, 180:492, 2009 : PubMed

            

    Title: Nanoimages show disruption of tubulin polymerization by chlorpyrifos oxon: implications for neurotoxicity
    Grigoryan H, Lockridge O
    Ref: Toxicol Appl Pharmacol, 240:143, 2009 : PubMed

            

    Title: Intrathecal delivery of fluorescent labeled butyrylcholinesterase to the brains of butyrylcholinesterase knock-out mice: visualization and quantification of enzyme distribution in the brain
    Johnson ND, Duysen EG, Lockridge O
    Ref: Neurotoxicology, 30:386, 2009 : PubMed

            

    Title: Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serine
    Li B, Schopfer LM, Grigoryan H, Thompson CM, Hinrichs SH, Masson P, Lockridge O
    Ref: Toxicol Sci, 107:144, 2009 : PubMed

            

    Title: Carbofuran poisoning detected by mass spectrometry of butyrylcholinesterase adduct in human serum
    Li H, Ricordel I, Tong L, Schopfer LM, Baud F, Megarbane B, Maury E, Masson P, Lockridge O
    Ref: J Appl Toxicol, 29:149, 2009 : PubMed

            

    Title: Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice
    Naik RS, Hartmann J, Kiewert C, Duysen EG, Lockridge O, Klein J
    Ref: J Pharm Pharm Sci, 12:79, 2009 : PubMed

            

    Title: Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation
    Carletti E, Li H, Li B, Ekstrom F, Nicolet Y, Loiodice M, Gillon E, Froment MT, Lockridge O and Nachon F <2 more author(s)>
    Ref: Journal of the American Chemical Society, 130:16011, 2008 : PubMed

            

    Title: Adenovirus-mediated gene transfer of human butyrylcholinesterase results in persistent high-level transgene expression in vivo
    Chilukuri N, Duysen EG, Parikh K, Sun W, Doctor BP, Lockridge O, Saxena A
    Ref: Chemico-Biological Interactions, 175:327, 2008 : PubMed

            

    Title: Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase
    Darvesh S, Darvesh KV, McDonald RS, Mataija D, Walsh R, Mothana S, Lockridge O, Martin E
    Ref: Journal of Medicinal Chemistry, 51:4200, 2008 : PubMed

            

    Title: Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin
    Ding SJ, Carr J, Carlson JE, Tong L, Xue W, Li Y, Schopfer LM, Li B, Nachon F and Lockridge O <4 more author(s)>
    Ref: Chemical Research in Toxicology, 21:1787, 2008 : PubMed

            

    Title: Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected with near infrared dye labeled butyrylcholinesterase
    Duysen EG, Lockridge O
    Ref: Chemico-Biological Interactions, 175:119, 2008 : PubMed

            

    Title: Increased hepatotoxicity and cardiac fibrosis in cocaine-treated butyrylcholinesterase knockout mice
    Duysen EG, Li B, Carlson M, Li YF, Wieseler S, Hinrichs SH, Lockridge O
    Ref: Basic Clin Pharmacol Toxicol, 103:514, 2008 : PubMed

            

    Title: Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents
    Grigoryan H, Schopfer LM, Thompson CM, Terry AV, Masson P, Lockridge O
    Ref: Chemico-Biological Interactions, 175:180, 2008 : PubMed

            

    Title: Choline availability and acetylcholine synthesis in the hippocampus of acetylcholinesterase-deficient mice
    Hartmann J, Kiewert C, Duysen EG, Lockridge O, Klein J
    Ref: Neurochem Int, 52:972, 2008 : PubMed

            

    Title: Binding and hydrolysis of soman by human serum albumin
    Li B, Nachon F, Froment MT, Verdier L, Debouzy JC, Brasme B, Gillon E, Schopfer LM, Lockridge O, Masson P
    Ref: Chemical Research in Toxicology, 21:421, 2008 : PubMed

            

    Title: The butyrylcholinesterase knockout mouse as a model for human butyrylcholinesterase deficiency
    Li B, Duysen EG, Carlson M, Lockridge O
    Ref: Journal of Pharmacology & Experimental Therapeutics, 324:1146, 2008 : PubMed

            

    Title: The butyrylcholinesterase knockout mouse is obese on a high-fat diet
    Li B, Duysen EG, Lockridge O
    Ref: Chemico-Biological Interactions, 175:88, 2008 : PubMed

            

    Title: Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers
    Li H, Schopfer LM, Masson P, Lockridge O
    Ref: Biochemical Journal, 411:425, 2008 : PubMed

            

    Title: Fast affinity purification coupled with mass spectrometry for identifying organophosphate labeled plasma butyrylcholinesterase
    Li H, Tong L, Schopfer LM, Masson P, Lockridge O
    Ref: Chemico-Biological Interactions, 175:68, 2008 : PubMed

            

    Title: Pseudo-esterase activity of human albumin: slow turnover on tyrosine 411 and stable acetylation of 82 residues including 59 lysines
    Lockridge O, Xue W, Gaydess A, Grigoryan H, Ding SJ, Schopfer LM, Hinrichs SH, Masson P
    Ref: Journal of Biological Chemistry, 283:22582, 2008 : PubMed

            

    Title: A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters
    Masson P, Nachon F, Broomfield CA, Lenz DE, Verdier L, Schopfer LM, Lockridge O
    Ref: Chemico-Biological Interactions, 175:273, 2008 : PubMed

            

    Title: Kinetic analysis of effector modulation of butyrylcholinesterase-catalysed hydrolysis of acetanilides and homologous esters
    Masson P, Froment MT, Gillon E, Nachon F, Lockridge O, Schopfer LM
    Ref: Febs J, 275:2617, 2008 : PubMed

            

    Title: Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population
    Mikami LR, Wieseler S, de Souza RLR, Schopfer LM, Nachon F, Lockridge O, Chautard-Freire-Maia EA
    Ref: Pharmacogenet Genomics, 18:213, 2008 : PubMed

            

    Title: Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission
    Duysen EG, Li B, Darvesh S, Lockridge O
    Ref: Toxicology, 233:60, 2007 : PubMed

            

    Title: Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity
    Hartmann J, Kiewert C, Duysen EG, Lockridge O, Greig NH, Klein J
    Ref: Journal of Neurochemistry, 100:1421, 2007 : PubMed

            

    Title: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411
    Li B, Schopfer LM, Hinrichs SH, Masson P, Lockridge O
    Ref: Analytical Biochemistry, 361:263, 2007 : PubMed

            

    Title: A novel method for purifying recombinant human host defense cathelicidin LL-37 by utilizing its inherent property of aggregation
    Li Y, Li X, Li H, Lockridge O, Wang G
    Ref: Protein Expr Purif, 54:157, 2007 : PubMed

            

    Title: Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry
    Li H, Schopfer LM, Nachon F, Froment MT, Masson P, Lockridge O
    Ref: Toxicol Sci, 100:136, 2007 : PubMed

            

    Title: A medical health report on individuals with silent butyrylcholinesterase in the Vysya community of India
    Manoharan I, Boopathy R, Darvesh S, Lockridge O
    Ref: Clinica Chimica Acta, 378:128, 2007 : PubMed

            

    Title: Comparison of cognitive functions between people with silent and wild-type butyrylcholinesterase
    Manoharan I, Kuznetsova A, Fisk JD, Boopathy R, Lockridge O, Darvesh S
    Ref: J Neural Transm (Vienna), 114:939, 2007 : PubMed

            

    Title: Aryl acylamidase activity of human serum albumin with o-nitrotrifluoroacetanilide as the substrate
    Masson P, Froment MT, Darvesh S, Schopfer LM, Lockridge O
    Ref: J Enzyme Inhib Med Chem, 22:463, 2007 : PubMed

            

    Title: Hydrolysis of oxo- and thio-esters by human butyrylcholinesterase
    Masson P, Froment MT, Gillon E, Nachon F, Lockridge O, Schopfer LM
    Ref: Biochimica & Biophysica Acta, 1774:16, 2007 : PubMed

            

    Title: Expression of three naturally occurring genetic variants (G75R, E90D, I99M) of the BCHE gene of human butyrylcholinesterase
    Mikami LR, Wieseler S, de Souza RLR, Schopfer LM, Lockridge O, Chautard-Freire-Maia EA
    Ref: Pharmacogenet Genomics, 17:681, 2007 : PubMed

            

    Title: Adaptation to excess acetylcholine by downregulation of adrenoceptors and muscarinic receptors in lungs of acetylcholinesterase knockout mice
    Myslivecek J, Duysen EG, Lockridge O
    Ref: Naunyn Schmiedebergs Arch Pharmacol, 376:83, 2007 : PubMed

            

    Title: Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase
    Ngamelue MN, Homma K, Lockridge O, Asojo OA
    Ref: Acta Crystallographica Sect F Struct Biol Cryst Commun, 63:723, 2007 : PubMed

            

    Title: Neuropathological and immunochemical studies of brain parenchyma in acetylcholinesterase knockout mice: implications in Alzheimer's disease
    Rice SG, Nowak L, Duysen EG, Lockridge O, Lahiri DK, Reyes PF
    Ref: J Alzheimers Dis, 11:481, 2007 : PubMed

            

    Title: A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family
    De Jaco A, Comoletti D, Kovarik Z, Gaietta G, Radic Z, Lockridge O, Ellisman MH, Taylor P
    Ref: Journal of Biological Chemistry, 281:9667, 2006 : PubMed

            

    Title: Phenotype comparison of three acetylcholinesterase knockout strains
    Duysen EG, Lockridge O
    Ref: Journal of Molecular Neuroscience, 30:91, 2006 : PubMed

            

    Title: Protection from the toxicity of diisopropylfluorophosphate by adeno-associated virus expressing acetylcholinesterase
    Li B, Duysen EG, Poluektova LY, Murrin LC, Lockridge O
    Ref: Toxicol Appl Pharmacol, 214:152, 2006 : PubMed

            

    Title: Gene transfer of acetylcholinesterase protects the knockout mouse from the toxicity of DFP
    Li B, Duysen EG, Lockridge O
    Ref: Journal of Molecular Neuroscience, 30:79, 2006 : PubMed

            

    Title: Production of the butyrylcholinesterase knockout mouse
    Li B, Duysen EG, Saunders TL, Lockridge O
    Ref: Journal of Molecular Neuroscience, 30:193, 2006 : PubMed

            

    Title: Naturally occurring mutation Leu307Pro of human butyrylcholinesterase in the Vysya community of India
    Manoharan I, Wieseler S, Layer PG, Lockridge O, Boopathy R
    Ref: Pharmacogenet Genomics, 16:461, 2006 : PubMed

            

    Title: Mutant of Bungarus fasciatus acetylcholinesterase with low affinity and low hydrolase activity toward organophosphorus esters
    Poyot T, Nachon F, Froment MT, Loiodice M, Wieseler S, Schopfer LM, Lockridge O, Masson P
    Ref: Biochimica & Biophysica Acta, 1764:1470, 2006 : PubMed

            

    Title: Markers of organophosphate exposure in human serum
    Wieseler S, Schopfer LM, Lockridge O
    Ref: Journal of Molecular Neuroscience, 30:93, 2006 : PubMed

            

    Title: Delivery of human acetylcholinesterase by adeno-associated virus to the acetylcholinesterase knockout mouse
    Hrabovska A, Duysen EG, Sanders JD, Murrin LC, Lockridge O
    Ref: Chemico-Biological Interactions, 157-158:71, 2005 : PubMed

            

    Title: Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma
    Li B, Sedlacek M, Manoharan I, Boopathy R, Duysen EG, Masson P, Lockridge O
    Ref: Biochemical Pharmacology, 70:1673, 2005 : PubMed

            

    Title: Identification of organophosphate-reactive proteins by tandem mass spectrometry
    Li H, Schopfer LM, Spaulding R, Thompson CM, Lockridge O
    Ref: Chemico-Biological Interactions, 157-158:383, 2005 : PubMed

            

    Title: Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice
    Lockridge O, Duysen EG, Voelker T, Thompson CM, Schopfer LM
    Ref: Environ Toxicol Pharmacol, 19:463, 2005 : PubMed

            

    Title: Large scale purification of butyrylcholinesterase from human plasma suitable for injection into monkeys; A potential new therapeutic for protection against cocaine end nerve agent toxicity
    Lockridge O, Schopfer LM, Winger G, Woods JH
    Ref: Journal of Medicinal Chemistryical Biology Radiol Def, 3:nihms5095, 2005 : PubMed

            

    Title: Hysteresis of butyrylcholinesterase in the approach to steady-state kinetics
    Masson P, Schopfer LM, Froment MT, Debouzy JC, Nachon F, Gillon E, Lockridge O, Hrabovska A, Goldstein BN
    Ref: Chemico-Biological Interactions, 157-158:143, 2005 : PubMed

            

    Title: Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging
    Nachon F, Asojo OA, Borgstahl GE, Masson P, Lockridge O
    Ref: Biochemistry, 44:1154, 2005 : PubMed

            

    Title: Structural data on the aging of diethylphosphoryl-butyrylcholinesterase
    Nachon F, Asojo OA, Borgstahl GE, Masson P, Lockridge O
    Ref: Chemico-Biological Interactions, 157-158:408, 2005 : PubMed

            

    Title: Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry
    Peeples ES, Schopfer LM, Duysen EG, Spaulding R, Voelker T, Thompson CM, Lockridge O
    Ref: Toxicol Sci, 83:303, 2005 : PubMed

            

    Title: Intraperitoneal administration of 340 kDa human plasma butyrylcholinesterase increases the level of the enzyme in the cerebrospinal fluid of rats
    Saez-Valero J, de Gracia JA, Lockridge O
    Ref: Neuroscience Letters, 383:93, 2005 : PubMed

            

    Title: Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410)
    Schopfer LM, Champion MM, Tamblyn N, Thompson CM, Lockridge O
    Ref: Analytical Biochemistry, 345:122, 2005 : PubMed

            

    Title: Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase
    Schopfer LM, Voelker T, Bartels CF, Thompson CM, Lockridge O
    Ref: Chemical Research in Toxicology, 18:747, 2005 : PubMed

            

    Title: Reduced acetylcholine receptor density, morphological remodeling, and butyrylcholinesterase activity can sustain muscle function in acetylcholinesterase knockout mice
    Adler M, Manley HA, Purcell AL, Deshpande SS, Hamilton TA, Kan RK, Oyler G, Lockridge O, Duysen EG, Sheridan RE
    Ref: Muscle & Nerve, 30:317, 2004 : PubMed

            

    Title: Dramatic depletion of cell surface muscarinic receptor due to limited delivery from intracytoplasmic stores in neurons of acetylcholinesterase-deficient mice.
    Bernard V, Brana C, Liste I, Lockridge O, Bloch B
    Ref: Cholinergic Mechanisms, CRC Press, :477, 2004 : PubMed

            

    Title: Poster (59) Complete postnatal degeneration of the photoreceptor layer in an AChE knockout mouse
    Bytyqi AH, Duysen EG, Lockridge O, Layer PG
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:352, 2004 : PubMed

            

    Title: Poster (60) Early distortion of network formation in the inner retina of an AChE knockout mouse
    Bytyqi AH, Paraoanu LE, Duysen EG, Lockridge O, Layer PG
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:353, 2004 : PubMed

            

    Title: Impaired formation of the inner retina in an AChE knockout mouse results in degeneration of all photoreceptors
    Bytyqi AH, Lockridge O, Duysen E, Wang Y, Wolfrum U, Layer PG
    Ref: European Journal of Neuroscience, 20:2953, 2004 : PubMed

            

    Title: Phenotype of the adult acetylcholinesterase-deficient mouse.
    Duysen EG, Stribley JA, Fry DL, Hinrichs SH, Lockridge O
    Ref: Cholinergic Mechanisms, CRC Press, :559, 2004 : PubMed

            

    Title: Helicobacter hepaticus infection in acetylcholinesterase knockout mice results in severe intestinal distension
    Duysen EG, Kolar CH, Lockridge O
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:301 , 2004 : PubMed

            

    Title: Poster (78) H. hepaticus infection in acetylcholinesterase knockout mice results in severe intestinal distension.
    Duysen EG, Kolar CH, Lockridge O
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:362, 2004 : PubMed

            

    Title: Acetylcholinesterase knockout mice have increased sensitivity to scopolamine and atropine.
    Hrabovska A, Duysen EG, Lockridge O
    Ref: Cholinergic Mechanisms, CRC Press, :593, 2004 : PubMed

            

    Title: Acetylcholinesterase wild-type and knockout mice show different locomotor activity after scopolamine injection
    Hrabovska A, Lockridge O
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:315 , 2004 : PubMed

            

    Title: Poster (82) Acetylcholinesterase wild-type and knock-out mice show different locomotor activity after scopolamine injection
    Hrabovska A, Lockridge O
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:364, 2004 : PubMed

            

    Title: Muscarinic acetylcholine receptors are down-regulated in acetylcholinesterase knockout mice.
    Li B, Duysen EG, Lockridge O
    Ref: Cholinergic Mechanisms, CRC Press, :619, 2004 : PubMed

            

    Title: Poster (90) Acetylcholinesterase knockout mice are resistant oxotremorine-induced hypothermia and pilocarpine-induced seizures
    Li B, Duysen EG, Lockridge O
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:368, 2004 : PubMed

            

    Title: Poster (55) Life without acetylcholinesterase
    Lockridge O, Duysen EG, Li B, Hrabovska A
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:350, 2004 : PubMed

            

    Title: Damped oscillatory hysteretic behaviour of butyrylcholinesterase with benzoylcholine as substrate
    Masson P, Goldstein BN, Debouzy JC, Froment MT, Lockridge O, Schopfer LM
    Ref: European Journal of Biochemistry, 271:220, 2004 : PubMed

            

    Title: Hysteretic behavior of butyrylcholinesterase: Kinetic curiosity or catalytically and physiologicaly significant?
    Masson P, Froment MT, Nachon F, Lockridge O, Schopfer LM
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:191 , 2004 : PubMed

            

    Title: Rate-determining step of butyrylcholinesterase-catalyzed hydrolysis of benzoylcholine and benzoylthiocholine. Volumetric study of wild-type and D70G mutant behavior
    Masson P, Bec N, Froment MT, Nachon F, Balny C, Lockridge O, Schopfer LM
    Ref: European Journal of Biochemistry, 271:1980, 2004 : PubMed

            

    Title: Poster (20) Hysteretic behavior of butyrylcholinesterase : kinetic curiosity or catalytically and physiologically significant?
    Masson P, Froment MT, Nachon F, Lockridge O, Schopfer LM
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:331, 2004 : PubMed

            

    Title: X-Ray structures of native and soman-aged human butyrylcholinesterase.
    Nachon F, Nicolet Y, Masson P, Lockridge O, Fontecilla-Camps JC
    Ref: Cholinergic Mechanisms, CRC Press, :165, 2004 : PubMed

            

    Title: Poster (93) How do the crystal structures of human butyrylcholinesterase compare to torpedo californica acetylcholinesterases structures?
    Nachon F, Nicolet Y, Masson P, Lockridge O, Fontecilla-Camps JC
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:369, 2004 : PubMed

            

    Title: Poster (49) Crystallographic basis for substrate/product exchange in cholinesterases.
    Nicolet Y, Lockridge O, Masson P, Fontecilla-Camps JC, Nachon F
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:347, 2004 : PubMed

            

    Title: Mutants of human butyrylcholinesterase with organophosphate hydrolase activity; evidence that His117 is a general base catalyst for hydrolysis of echothiophate
    Schopfer LM, Boeck AT, Broomfield CA, Lockridge O
    Ref: Journal of Medicinal Chemistryical Biology Radiol Def, 2:1, 2004 : PubMed

            

    Title: Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase
    Wang Y, Boeck AT, Duysen EG, Van Keuren M, Saunders TL, Lockridge O
    Ref: Toxicol Appl Pharmacol, 196:356, 2004 : PubMed

            

    Title: Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants
    Wang Y, Schopfer LM, Duysen EG, Nachon F, Masson P, Lockridge O
    Ref: Analytical Biochemistry, 329:131, 2004 : PubMed

            

    Title: Dramatic depletion of cell surface m2 muscarinic receptor due to limited delivery from intracytoplasmic stores in neurons of acetylcholinesterase-deficient mice
    Bernard V, Brana C, Liste I, Lockridge O, Bloch B
    Ref: Molecular & Cellular Neurosciences, 23:121, 2003 : PubMed

            

    Title: Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice
    Li B, Duysen EG, Volpicelli-Daley LA, Levey AI, Lockridge O
    Ref: Pharmacol Biochem Behav, 74:977, 2003 : PubMed

            

    Title: High activity of human butyrylcholinesterase at low pH in the presence of excess butyrylthiocholine
    Masson P, Nachon F, Bartels CF, Froment MT, Ribes F, Matthews C, Lockridge O
    Ref: European Journal of Biochemistry, 270:315, 2003 : PubMed

            

    Title: Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products
    Nicolet Y, Lockridge O, Masson P, Fontecilla-Camps JC, Nachon F
    Ref: Journal of Biological Chemistry, 278:41141, 2003 : PubMed

            

    Title: Application of directed evolution technology to optimize the cocaine hydrolase activity of human butyrylcholinesterase
    Pancook JD, Pecht G, Ader M, Mosko M, Lockridge O, Watkins JD
    Ref: FASEB Journal, 17:A565, 2003 : PubMed

            

    Title: Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases
    Saxena A, Fedorko JM, Vinayaka CR, Medhekar R, Radic Z, Taylor P, Lockridge O, Doctor BP
    Ref: European Journal of Biochemistry, 270:4447, 2003 : PubMed

            

    Title: Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice
    Volpicelli-Daley LA, Hrabovska A, Duysen EG, Ferguson SM, Blakely RD, Lockridge O, Levey AI
    Ref: Molecular Pharmacology, 64:1309, 2003 : PubMed

            

    Title: Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice
    Volpicelli-Daley LA, Duysen EG, Lockridge O, Levey AI
    Ref: Annals of Neurology, 53:788, 2003 : PubMed

            

    Title: DNA sequence of butyrylcholinesterase from the rat: expression of the protein and characterization of the properties of rat butyrylcholinesterase
    Boeck AT, Schopfer LM, Lockridge O
    Ref: Biochemical Pharmacology, 63:2101, 2002 : PubMed

            

    Title: Naturally occurring mutation, Asp70his, in human butyrylcholinesterase
    Boeck AT, Fry DL, Sastre A, Lockridge O
    Ref: Annals of Clinical Biochemistry, 39:154, 2002 : PubMed

            

    Title: Wild-type and A328W mutant human butyrylcholinesterase tetramers expressed in Chinese hamster ovary cells have a 16-hour half-life in the circulation and protect mice from cocaine toxicity
    Duysen EG, Bartels CF, Lockridge O
    Ref: Journal of Pharmacology & Experimental Therapeutics, 302:751, 2002 : PubMed

            

    Title: Early weaning and culling eradicated Helicobacter hepaticus from an acetylcholinesterase knockout 129S6/SvEvTac mouse colony
    Duysen EG, Fry DL, Lockridge O
    Ref: Comp Med, 52:461, 2002 : PubMed

            

    Title: Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse
    Duysen EG, Stribley JA, Fry DL, Hinrichs SH, Lockridge O
    Ref: Brain Research Developmental Brain Research, 137:43, 2002 : PubMed

            

    Title: Specificity of ethephon as a butyrylcholinesterase inhibitor and phosphorylating agent
    Haux JE, Lockridge O, Casida JE
    Ref: Chemical Research in Toxicology, 15:1527, 2002 : PubMed

            

    Title: Substrate activation in acetylcholinesterase induced by low pH or mutation in the pi-cation subsite
    Masson P, Schopfer LM, Bartels CF, Froment MT, Ribes F, Nachon F, Lockridge O
    Ref: Biochimica & Biophysica Acta, 1594:313, 2002 : PubMed

            

    Title: Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine
    Mesulam MM, Guillozet A, Shaw P, Levey AI, Duysen EG, Lockridge O, Levey A
    Ref: Neuroscience, 110:627, 2002 : PubMed

            

    Title: Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization
    Nachon F, Nicolet Y, Viguie N, Masson P, Fontecilla-Camps JC, Lockridge O
    Ref: European Journal of Biochemistry, 269:630, 2002 : PubMed

            

    Title: Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase
    Sun H, Shen ML, Pang YP, Lockridge O, Brimijoin S
    Ref: Journal of Pharmacology & Experimental Therapeutics, 302:710, 2002 : PubMed

            

    Title: Re-engineering butyrylcholinesterase as a cocaine hydrolase
    Sun H, Pang YP, Lockridge O, Brimijoin S
    Ref: Molecular Pharmacology, 62:220, 2002 : PubMed

            

    Title: Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to vx lethality
    Duysen EG, Li B, Xie W, Schopfer LM, Anderson RS, Broomfield CA, Lockridge O
    Ref: Journal of Pharmacology & Experimental Therapeutics, 299:528, 2001 : PubMed

            

    Title: The active site of human paraoxonase (PON1)
    Josse D, Lockridge O, Xie W, Bartels CF, Schopfer LM, Masson P
    Ref: J Appl Toxicol, 21 Suppl 1:S7, 2001 : PubMed

            

    Title: Effects of mutations of active site residues and amino acids interacting with the Omega loop on substrate activation of butyrylcholinesterase
    Masson P, Xie W, Froment MT, Lockridge O
    Ref: Biochimica & Biophysica Acta, 1544:166, 2001 : PubMed

            

    Title: Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication.
    Sun H, El Yazal J, Lockridge O, Schopfer LM, Brimijoin S, Pang YP
    Ref: Journal of Biological Chemistry, 276:9330, 2001 : PubMed

            

    Title: The butyrylcholinesterase K-variant shows similar cellular protein turnover and quaternary interaction to the wild-type enzyme
    Altamirano CV, Bartels CF, Lockridge O
    Ref: Journal of Neurochemistry, 74:869, 2000 : PubMed

            

    Title: Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma
    Bartels CF, Xie W, Miller-Lindholm AK, Schopfer LM, Lockridge O
    Ref: Biochemical Pharmacology, 60:479, 2000 : PubMed

            

    Title: Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse
    Li B, Stribley JA, Ticu A, Xie W, Schopfer LM, Hammond P, Brimijoin S, Hinrichs SH, Lockridge O
    Ref: Journal of Neurochemistry, 75:1320, 2000 : PubMed

            

    Title: Pesticides and susceptible populations: people with butyrylcholinesterase genetic variants may be at risk
    Lockridge O, Masson P
    Ref: Neurotoxicology, 21:113, 2000 : PubMed

            

    Title: Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase
    Xie W, Stribley JA, Chatonnet A, Wilder PJ, Rizzino A, McComb RD, Taylor P, Hinrichs SH, Lockridge O
    Ref: Journal of Pharmacology & Experimental Therapeutics, 293:896, 2000 : PubMed

            

    Title: Conserved aromatic residues of the C-terminus of human butyrylcholinesterase mediate the association of tetramers
    Altamirano CV, Lockridge O
    Ref: Biochemistry, 38:13414, 1999 : PubMed

            

    Title: Association of tetramers of human butyrylcholinesterase is mediated by conserved aromatic residues of the carboxy terminus
    Altamirano CV, Lockridge O
    Ref: Chemico-Biological Interactions, 119-120:53, 1999 : PubMed

            

    Title: Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterization
    Broomfield CA, Lockridge O, Millard CB
    Ref: Chemico-Biological Interactions, 119-120:413, 1999 : PubMed

            

    Title: Identification of residues essential for human paraoxonase (PON1) arylesterase/organophosphatase activities
    Josse D, Xie W, Renault F, Rochu D, Schopfer LM, Masson P, Lockridge O
    Ref: Biochemistry, 38:2816, 1999 : PubMed

            

    Title: Human serum paraoxonase (PON1): identification of essential amino acid residues by group-selective labelling and site-directed mutagenesis
    Josse D, Xie W, Masson P, Lockridge O
    Ref: Chemico-Biological Interactions, 119-120:71, 1999 : PubMed

            

    Title: Tryptophan residue(s) as major components of the human serum paraoxonase active site
    Josse D, Xie W, Masson P, Schopfer LM, Lockridge O
    Ref: Chemico-Biological Interactions, 119-120:79, 1999 : PubMed

            

    Title: Polyol-induced activation by excess substrate of the D70G butyrylcholinesterase mutant
    Levitsky V, Xie W, Froment MT, Lockridge O, Masson P
    Ref: Biochimica & Biophysica Acta, 1429:422, 1999 : PubMed

            

    Title: Structural and hydration changes in the active site gorge of phosporhylated butyrylcholinesterase accompanying the aging process
    Masson P, Fortier PL, Albaret C, Clery C, Guerra P, Lockridge O
    Ref: Chemico-Biological Interactions, 119-120:17, 1999 : PubMed

            

    Title: Interaction between the peripheral site residues of human butyrylcholinesterase, D70 and Y332, in binding and hydrolysis of substrates
    Masson P, Xie W, Froment MT, Levitsky V, Fortier PL, Albaret C, Lockridge O
    Ref: Biochimica & Biophysica Acta, 1433:281, 1999 : PubMed

            

    Title: Differences in active-site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase
    Saxena A, Redman AM, Jiang X, Lockridge O, Doctor BP
    Ref: Chemico-Biological Interactions, 119-120:61, 1999 : PubMed

            

    Title: An improved cocaine hydrolase: the A328Y mutant of human butyrylcholinesterase is 4-fold more efficient
    Xie W, Altamirano CV, Bartels CF, Speirs RJ, Cashman JR, Lockridge O
    Ref: Molecular Pharmacology, 55:83, 1999 : PubMed

            

    Title: Knockout of one acetylcholinesterase allele in the mouse
    Xie W, Wilder PJ, Stribley J, Chatonnet A, Rizzino A, Taylor P, Hinrichs SH, Lockridge O
    Ref: Chemico-Biological Interactions, 119-120:289, 1999 : PubMed

            

    Title: Association of Tetramers of Human Butyrylcholinesterase is Mediated by Conserved Aromatic Residues of the Carboxy Terminus
    Altamirano CV, Lockridge O
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:440, 1998 : PubMed

            

    Title: Acetylcholinesterase and Butyrylcholinesterase of Cat
    Bartels CF, Xie W, Miller-Lindholm AK, Lockridge O
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:147, 1998 : PubMed

            

    Title: Reaction of Human Butyrylcholinesterase (BChE) H117 Enzymes with Carbamates
    Broomfield CA, Mills KV, Meier BM, Lockridge O, Millard CB
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:223, 1998 : PubMed

            

    Title: Resistance of butyrylcholinesterase to inactivation by ultrasound: effects of ultrasound on catalytic activity and subunit association
    Froment MT, Lockridge O, Masson P
    Ref: Biochimica & Biophysica Acta, 1387:53, 1998 : PubMed

            

    Title: A Comparison of Blood Cholinesterase Activities, Pyridostigmine Inhibition of Red Cell Acetylcholinesterase, and Butyrylcholinesterase Phenotypes in Gulf War Veterans and Normal Controls
    Gentry MK, Powell S, Bitsko N, Bartels CF, Bartko J, Chung R, Lockridge O, Ribas J, Roy M and Doctor BP <1 more author(s)>
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:300, 1998 : PubMed

            

    Title: Bert La Du ASPET Plenary Lecture: Bert N. La Du, a Summary of His Career to 1998
    Lockridge O
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:1, 1998 : PubMed

            

    Title: ACHE Knockout Mouse; Cat AChE and Cat BChE Sequences; Tetramers of BChE
    Lockridge O, Xie W, Chatonnet A, Taylor P, Bartels CF
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:41, 1998 : PubMed

            

    Title: Butyrylcholinesterase-catalysed hydrolysis of aspirin, a negatively charged ester, and aspirin-related neutral esters
    Masson P, Froment MT, Fortier PL, Visicchio JE, Bartels CF, Lockridge O
    Ref: Biochimica & Biophysica Acta, 1387:41, 1998 : PubMed

            

    Title: Structural Changes in the Active Site Gorge of Phosphylated Cholinesterase Accompanying the Aging Process
    Masson P, Clery C, Guerra P, Fortier PL, Albaret C, Lockridge O
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:419, 1998 : PubMed

            

    Title: Enzymes hydrolyzing organophosphates as potential catalytic scavengers against organophosphate poisoning
    Masson P, Josse D, Lockridge O, Viguie N, Taupin C, Buhler C
    Ref: Journal de Physiologie (Paris), 92:357, 1998 : PubMed

            

    Title: Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase
    Millard CB, Lockridge O, Broomfield CA
    Ref: Biochemistry, 37:237, 1998 : PubMed

            

    Title: Expression of Human Butyrylcholinesterase in Trichoplusia ni Insect Larvae
    Platteborze PL, Lockridge O, Broomfield CA
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:150, 1998 : PubMed

            

    Title: The pH Dependence of Dealkylation in Soman-Inhibited Cholinesterases and Their Mutants: Further Evidence for a Push-Pull Mechanism
    Saxena A, Viragh C, Frazier DS, Kovach IM, Maxwell DM, Lockridge O, Doctor BP
    Ref: Biochemistry, 37:15086, 1998 : PubMed

            

    Title: Prolonged paralysis after a test dose of mivacurium in a patient with atypical serum cholinesterase
    Vanlinthout LE, Bartels CF, Lockridge O, Callens K, Booij LH
    Ref: Anesthesia & Analgesia, 87:1199, 1998 : PubMed

            

    Title: pH Dependence of Dealkylation in Soman-Inhibited Cholinesterases and Their Mutants
    Viragh C, Saxena A, Frazier DS, Kovach IM, Lockridge O, Doctor BP
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:247, 1998 : PubMed

            

    Title: Tetramerization domain of human butyrylcholinesterase is at the C- terminus
    Blong RM, Bedows E, Lockridge O
    Ref: Biochemical Journal, 327:747, 1997 : PubMed

            

    Title: A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase
    Lockridge O, Blong RM, Masson P, Froment MT, Millard CB, Broomfield CA
    Ref: Biochemistry, 36:786, 1997 : PubMed

            

    Title: Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase
    Masson P, Legrand P, Bartels CF, Froment MT, Schopfer LM, Lockridge O
    Ref: Biochemistry, 36:2266, 1997 : PubMed

            

    Title: Aging of di-isopropyl-phosphorylated human butyrylcholinesterase
    Masson P, Fortier PL, Albaret C, Froment MT, Bartels CF, Lockridge O
    Ref: Biochemical Journal, 327 ( Pt 2):601, 1997 : PubMed

            

    Title: Importance of aspartate-70 in organophosphate inhibition, oxime re-activation and aging of human butyrylcholinesterase
    Masson P, Froment MT, Bartels CF, Lockridge O
    Ref: Biochemical Journal, 325:53, 1997 : PubMed

            

    Title: Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase
    Saxena A, Redman AM, Jiang X, Lockridge O, Doctor BP
    Ref: Biochemistry, 36:14642, 1997 : PubMed

            

    Title: Asp7O in the peripheral anionic site of human butyrylcholinesterase
    Masson P, Froment MT, Bartels CF, Lockridge O
    Ref: European Journal of Biochemistry, 235:36, 1996 : PubMed

            

    Title: Acetylcholinesterase Gene Sequence and Copy Number are Normal in Alzheimer's Disease Patients Treated with the Organophosphate Metrifonate
    Bartels CF, Moriearty PL, Becker RE, Mountjoy CP, Lockridge O
    Ref: In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases, (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.:479, 1995 : PubMed

            

    Title: Subunit Association and Stabilization of Butyrylcholinesterase (BChE)
    Blong RM, Masson P, Lockridge O
    Ref: In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases, (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.:129, 1995 : PubMed

            

    Title: Mutation of Human Butyrylcholinesterase Glycine 117 to Histidine Preserves Activity but Confers Resistance to Organophosphorus Inhibitors
    Broomfield CA, Millard CB, Lockridge O, Caviston TL
    Ref: In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases, (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.:169, 1995 : PubMed

            

    Title: Butyrylcholinesterase Transcription Start Site and Promoter
    Jbilo O, Toutant JP, Chatonnet A, Lockridge O
    Ref: In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases, (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.:23, 1995 : PubMed

            

    Title: Peripheral Anionic Site of Wild-Type and Mutant Human Butyrylcholinesterase
    Masson P, Froment MT, Bartels CF, Lockridge O
    Ref: In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases, (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.:230, 1995 : PubMed

            

    Title: Design and expression of organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase
    Millard CB, Lockridge O, Broomfield CA
    Ref: Biochemistry, 34:15925, 1995 : PubMed

            

    Title: Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase
    Sorenson RC, Primo-Parmo SL, Kuo CL, Adkins S, Lockridge O, La Du BN
    Ref: Proc Natl Acad Sci U S A, 92:7187, 1995 : PubMed

            

    Title: Bacterial expression and in vitro folding of the beta-subunit of human chorionic gonadotropin (hCG beta) and functional assembly of recombinant hCG beta with hCG alpha
    Huth JR, Norton SE, Lockridge O, Shikone T, Hsueh AJ, Ruddon RW
    Ref: Endocrinology, 135:911, 1994 : PubMed

            

    Title: Promoter and transcription start site of human and rabbit butyrylcholinesterase genes
    Jbilo O, Toutant JP, Vatsis KP, Chatonnet A, Lockridge O
    Ref: Journal of Biological Chemistry, 269:20829, 1994 : PubMed

            

    Title: Tissue distribution of human acetylcholinesterase and butyrylcholinesterase messenger RNA
    Jbilo O, Bartels CF, Chatonnet A, Toutant JP, Lockridge O
    Ref: Toxicon, 32:1445, 1994 : PubMed

            

    Title: Endogenous butyrylcholinesterase in SV40 transformed cell lines: COS-1, COS-7, MRC-5 SV40, and WI-38 VA13
    Kris M, Jbilo O, Bartels CF, Masson P, Rhode S, Lockridge O
    Ref: In Vitro Cellular & Developmental Biology Animal, 10:680, 1994 : PubMed

            

    Title: Mutation His322Asn in human acetylcholinesterase does not alter electrophoretic and catalytic properties of the erythrocyte enzyme
    Masson P, Froment MT, Sorenson RC, Bartels CF, Lockridge O
    Ref: Blood, 83:3003, 1994 : PubMed

            

    Title: Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism
    Bartels CF, Zelinski T, Lockridge O
    Ref: American Journal of Human Genetics, 52:928, 1993 : PubMed

            

    Title: Protein folding and assembly in vitro parallel intracellular folding and assembly. Catalysis of folding and assembly of the human chorionic gonadotropin alpha beta dimer by protein disulfide isomerase
    Huth JR, Perini F, Lockridge O, Bedows E, Ruddon RW
    Ref: Journal of Biological Chemistry, 268:16472, 1993 : PubMed

            

    Title: Recombinant human butyrylcholinesterase G390V, the fluoride-2 variant, expressed in Chinese hamster ovary cells, is a low affinity variant
    Masson P, Adkins S, Gouet P, Lockridge O
    Ref: Journal of Biological Chemistry, 268:14329, 1993 : PubMed

            

    Title: DNA mutation associated with the human butyrylcholinesterase K-variant and its linkage to the atypical variant mutation and other polymorphic sites
    Bartels CF, Jensen FS, Lockridge O, van der Spek AF, Rubinstein HM, Lubrano T, La Du BN
    Ref: American Journal of Human Genetics, 50:1086, 1992 : PubMed

            

    Title: Part 1: Genetic Variant of Human Acetylcholinesterase Part 2: SV-40 Transformed Cell Lines, for Example COS-1, but Not Parental Untransformed Cell Lines, Express Butyrylcholinesterase (BChE)
    Lockridge O, Bartels CF
    Ref: In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases, (Shafferman, A. and Velan, B., Eds) Plenum Press, New York:53, 1992 : PubMed

            

    Title: Identification of two different point mutations associated with the fluoride-resistant phenotype for human butyrylcholinesterase
    Nogueira CP, Bartels CF, McGuire MC, Adkins S, Lubrano T, Rubinstein HM, Lightstone H, van der Spek AF, Lockridge O, La Du BN
    Ref: American Journal of Human Genetics, 51:821, 1992 : PubMed

            

    Title: Poster: Expression of the fluoride variant of human butyrylcholinesterase in chinese hamster ovary cells
    Adkins S, Vaughan TA, Bartels CF, La Du BN, Lockridge O
    Ref: In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology, (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC:196, 1991 : PubMed

            

    Title: The cloned butyrylcholinesterase (BCHE) gene maps to a single chromosome site, 3q26
    Allderdice PW, Gardner HA, Galutira D, Lockridge O, La Du BN, McAlpine PJ
    Ref: Genomics, 11:452, 1991 : PubMed

            

    Title: Use of the polymerase chain reaction for homology probing of butyrylcholinesterase from several vertebrates
    Arpagaus M, Chatonnet A, Masson P, Newton M, Vaughan TA, Bartels CF, Nogueira CP, La Du BN, Lockridge O
    Ref: Journal of Biological Chemistry, 266:6966, 1991 : PubMed

            

    Title: Poster: Use of the polymerase chain reaction for homology probing of butyrylchoIinesterase (BCHE) in several animal species
    Arpagaus M, Vaughan TA, La Du BN, Lockridge O, Masson P, Chatonnet A, Newton M, Taylor P
    Ref: In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology, (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC:194, 1991 : PubMed

            

    Title: Poster: DNA Coding for the K polymorphism in linkage disequilibrium with atypical human butyrylcholinesterase complicates phenotyping
    Bartels CF, Lockridge O, La Du BN, van der Spek AF, Rubinstein HM, Lubrano T
    Ref: In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology, (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC:191, 1991 : PubMed

            

    Title: Poster: Identification of two different mutations associated with human butyrylcholinesterase fluoride resistance in serum
    Bartels CF, Nogueira CP, McGuire MC, Adkins S, Lockridge O, La Du BN, Rubinstein HM, Lubrano T, van der Spek AF, Lightstone H
    Ref: In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology, (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC:190, 1991 : PubMed

            

    Title: Poster: Search for alternative splicing of butyrylcholinesterase transcripts
    Jbilo O, Chatonnet A, Arpagaus M, Lockridge O
    Ref: In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology, (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC:187, 1991 : PubMed

            

    Title: Poster: Practical consequences of having more than one mutation within the same butyrylcholinesterase gene
    La Du BN, Bartels CF, Lockridge O
    Ref: In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology, (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC:192, 1991 : PubMed

            

    Title: Proposed nomenclature for human butyrylcholinesterase genetic variants identified by DNA sequencing
    La Du BN, Bartels CF, Nogueira CP, Arpagaus M, Lockridge O
    Ref: Cellular Molecular Neurobiology, 11:79, 1991 : PubMed

            

    Title: Structure of Human Butyrylcholinesterase Gene and Expression in Mammalian Cells
    Lockridge O
    Ref: In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology, (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC:168, 1991 : PubMed

            

    Title: Poster: Nomenclature for human butyrylcholinesterase genetic variants identified by DNA sequencing
    Lockridge O, Bartels CF, Nogueira CP, Arpagaus M, Adkins S, La Du BN
    Ref: In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology, (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC:193, 1991 : PubMed

            

    Title: The butyrylcholinesterase gene (BCHE) at 3q26.2 shows two RFLPs
    McAlpine PJ, Dixon M, Allderdice PW, Lockridge O, La Du BN
    Ref: Nucleic Acids Research, 19:5088, 1991 : PubMed

            

    Title: The cloning and expression of a gene encoding Old Yellow Enzyme from Saccharomyces carlsbergensis
    Saito K, Thiele DJ, Davio M, Lockridge O, Massey V
    Ref: Journal of Biological Chemistry, 266:20720, 1991 : PubMed

            

    Title: Structure of the gene for human butyrylcholinesterase. Evidence for a single copy
    Arpagaus M, Kott M, Vatsis KP, Bartels CF, La Du BN, Lockridge O
    Ref: Biochemistry, 29:124, 1990 : PubMed

            

    Title: Phenotypic and molecular biological analysis of human butyrylcholinesterase variants
    La Du BN, Bartels CF, Nogueira CP, Hajra A, Lightstone H, van der Spek AF, Lockridge O
    Ref: Clinical Biochemistry, 23:423, 1990 : PubMed

            

    Title: Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine.
    Lockridge O
    Ref: Pharmacol Ther, 47:35, 1990 : PubMed

            

    Title: Evidence for a single butyrylcholinesterase gene in individuals carrying the C5 plasma cholinesterase variant (CHE2)
    Masson P, Chatonnet A, Lockridge O
    Ref: FEBS Letters, 262:115, 1990 : PubMed

            

    Title: Identification of a frameshift mutation responsible for the silent phenotype of human serum cholinesterase, Gly 117 (GGT----GGAG)
    Nogueira CP, McGuire MC, Graeser C, Bartels CF, Arpagaus M, van der Spek AF, Lightstone H, Lockridge O, La Du BN
    Ref: American Journal of Human Genetics, 46:934, 1990 : PubMed

            

    Title: Comparison of butyrylcholinesterase and acetylcholinesterase.
    Chatonnet A, Lockridge O
    Ref: Biochemical Journal, 260:625, 1989 : PubMed

            

    Title: Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase
    McGuire MC, Nogueira CP, Bartels CF, Lightstone H, Hajra A, van der Spek AF, Lockridge O, La Du BN
    Ref: Proc Natl Acad Sci U S A, 86:953, 1989 : PubMed

            

    Title: Identification of a frameshift mutation (gly 117, GGT-to-GGAG) responsible for a silent phenotype of human serum cholinesterase. (Abstract)
    Nogueira CP, McGuire MC, Bartels CF, van der Spek AF, Lightstone H, Lockridge O, La Du BN
    Ref: American Journal of Human Genetics, 45 (suppl.):A210, 1989 : PubMed

            

    Title: Structure of human serum cholinesterase.
    Lockridge O
    Ref: Bioessays, 9:125, 1988 : PubMed

            

    Title: Complete amino acid sequence of human serum cholinesterase
    Lockridge O, Bartels CF, Vaughan TA, Wong CK, Norton SE, Johnson LL
    Ref: Journal of Biological Chemistry, 262:549, 1987 : PubMed

            

    Title: Location of disulfide bonds within the sequence of human serum cholinesterase
    Lockridge O, Adkins S, La Du BN
    Ref: Journal of Biological Chemistry, 262:12945, 1987 : PubMed

            

    Title: Brain cDNA clone for human cholinesterase
    McTiernan C, Adkins S, Chatonnet A, Vaughan TA, Bartels CF, Kott M, Rosenberry TL, La Du BN, Lockridge O
    Ref: Proceedings of the National Academy of Sciences of the United States of America, 84:6682, 1987 : PubMed

            

    Title: Molecular biology of human serum cholinesterase.
    La Du BN, Lockridge O
    Ref: Federation Proceedings, 45:2965, 1986 : PubMed

            

    Title: Amino acid sequence of the active site of human serum cholinesterase from usual, atypical, and atypical-silent genotypes
    Lockridge O, La Du BN
    Ref: Biochemical Genetics, 24:485, 1986 : PubMed

            

    Title: Amino acid composition and sequence of human serum cholinesterase: A progress report
    Lockridge O
    Ref: In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases, (Brzin M, Barnard EA, Sket D, Eds) De Gruyter:5, 1984 : PubMed

            

    Title: Immunological comparison of the usual and atypical human serum cholinesterase phenotypes
    Eckerson HW, Oseroff A, Lockridge O, La Du BN
    Ref: Biochemical Genetics, 21:93, 1983 : PubMed

            

    Title: Substance P hydrolysis by human serum cholinesterase
    Lockridge O
    Ref: Journal of Neurochemistry, 39:106, 1982 : PubMed

            

    Title: Loss of the interchain disulfide peptide and dissociation of the tetramer following limited proteolysis of native human serum cholinesterase
    Lockridge O, La Du BN
    Ref: Journal of Biological Chemistry, 257:12012, 1982 : PubMed

            

    Title: Hydrolysis of methylprednisolone acetate by human serum cholinesterase
    Myers C, Lockridge O, La Du BN
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 10:279, 1982 : PubMed

            

    Title: Prediction of drug sensitivity in individuals with atypical serum cholinesterase based on in vitro biochemical studies
    Valentino RJ, Lockridge O, Eckerson HW, La Du BN
    Ref: Biochemical Pharmacology, 30:1643, 1981 : PubMed

            

    Title: Hydrolysis of diacetylmorphine (heroin) by human serum cholinesterase
    Lockridge O, Mottershaw-Jackson N, Eckerson HW, La Du BN
    Ref: Journal of Pharmacology & Experimental Therapeutics, 215:1, 1980 : PubMed

            

    Title: Interchain disulfide bonds and subunit organization in human serum cholinesterase
    Lockridge O, Eckerson HW, La Du BN
    Ref: Journal of Biological Chemistry, 254:8324, 1979 : PubMed

            

    Title: Prolonged apnea following trimethaphan and succinylcholine
    Poulton TJ, James FMd, Lockridge O
    Ref: Anesthesiology, 50:54, 1979 : PubMed

            

    Title: Comparison of atypical and usual human serum cholinesterase. Purification, number of active sites, substrate affinity, and turnover number
    Lockridge O, La Du BN
    Ref: Journal of Biological Chemistry, 253:361, 1978 : PubMed

            


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