Type Inhibitor

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Type_inhibitor Report for: pNP

Esters of 4-Nitrophenol (also called p-nitrophenol or 4-hydroxynitrobenzene) which is a phenolic compound that has a nitro group at the opposite position of the hydroxyl group on the benzene ring. Amounts of 4-nitrophenol produced by a particular enzyme in the presence of its corresponding substrate can be measured with a spectrophotometer at or around 405 nm and used as a proxy measurement for the amount of the enzyme activity in the sample.

InhibitorMain targeted enzyme familiesTypeStructure
4-methylumbelliferyl-hexylphosphonateCanar_LipB | Hormone-sensitive_lipase_like Coumarin | Organophosphate | pNP
5ALP-QYDEpoxide_hydrolase Carboxamide | Morpholine | Sulfur Compound | Thiomorpholine | pNP
ABP-C6A85-EsteraseD-FGH | ABHD11-Acetyl_transferase | ACPH_Peptidase_S9 | Arylacetamide_deacetylase | BCHE | CGI-58_ABHD5_ABHD4 | Carb_B_Chordata | DPP4N_Peptidase_S9 | Hormone-sensitive_lipase_like | LYsophospholipase_carboxylesterase | Monoglyceridelipase_lysophospholip | PC-sterol_acyltransferase | PPase_methylesterase_euk | Prolylcarboxypeptidase ABPP-Probe | Azido | Organophosphate | pNP
ArM-Rhubidium-cofactor-8Canar_LipB | Cutinase Organophosphate | Pincer-Metal-cofactor | pNP
ArminACHE Chemical Warfare Agent | Organophosphate | pNP
B4-4NHPHormone-sensitive_lipase_like Organophosphate | pNP
BNPPArylacetamide_deacetylase | Carb_B_Chordata Organophosphate | pNP
ButoxyhexylphosphonateHormone-sensitive_lipase_like Organophosphate | pNP
C12-myristoyl-MAG-like-phosphonateCarbLipBact_2 Analogue of substrate | Azido | Lipase inhibitor | Organophosphate | pNP
C14-palmitoyl-MAG-like-phosphonateCarbLipBact_2 Analogue of substrate | Azido | Lipase inhibitor | Organophosphate | pNP
C16-stearoyl-MAG-like-phosphonateCarbLipBact_2 Analogue of substrate | Azido | Lipase inhibitor | Organophosphate | pNP
C18-octadecyl-MAG-like-phosphonateMonoglyceridelipase_lysophospholip Analogue of substrate | Azido | Lipase inhibitor | Organophosphate | pNP
ChlorthionACHE Insecticide | Organophosphate | Sulfur Compound | pNP
DOTA-(amide)4-(EG)n-tetraphosphonateCutinase Organophosphate | Poly-ethylene-glycol | Polymer | pNP
EPNACHE Insecticide | Organophosphate | Organothiophosphate | Sulfur Compound | pNP
EPN-oxonACHE Insecticide | Organophosphate | pNP
EthylchlorthionACHE Insecticide | Organophosphate | Sulfur Compound | pNP
FenitrothionACHE Insecticide | Organophosphate | Organothiophosphate | Sulfur Compound | pNP
H-Lys(4-nitro-Z)-pyrrolidideDPP4N_Peptidase_S9 Carbamate | Peptide | Pyrrolidine | pNP
IMP-pNPACHE | Cholesterol_esterase Derivative of Sarin | Nerve Agent G-series | Organophosphate | Surrogate OP | pNP
IMP-pNP-FACHE Derivative of Sarin | Nerve Agent G-series | Organophosphate | Surrogate OP | pNP
IsochlorthionACHE Insecticide | Organophosphate | Sulfur Compound | pNP
IsoparathionACHE Organophosphate | Organothiophosphate | Sulfur Compound | pNP
JZL184ABHD6-Lip | Carb_B_Chordata | Monoglyceridelipase_lysophospholip Benzodioxo | FAAH inhibitor | Multitarget | Piperidine | pNP
JZL195ABHD6-Lip | Carb_B_Chordata | Monoglyceridelipase_lysophospholip FAAH inhibitor | Multitarget | Phenoxyphenyl | Piperazine | pNP
M4-4NHPHormone-sensitive_lipase_like Organophosphate | pNP
MHHHormone-sensitive_lipase_like Organophosphate | pNP
MethylparaoxonACHE | Carboxypeptidase_S10 Derivative of Paraoxon | Insecticide | Organophosphate | pNP
MethylparathionACHE Derivative of Paraoxon | Insecticide | Organophosphate | Organothiophosphate | Sulfur Compound | pNP
NBD-CP ABPP-Probe | Benzoxadiazole | NBD-nitro-benzoxadiazol-fluorescent | Organophosphate | Phenanthrene | pNP
NBD-HE-HPA85-EsteraseD-FGH | ABHD11-Acetyl_transferase | ACPH_Peptidase_S9 | Bacterial_lip_FamI.2 | CGI-58_ABHD5_ABHD4 | Carb_B_Arthropoda | Carb_B_Chordata | Hormone-sensitive_lipase_like | Juvenile_hormone_esterase | LYsophospholipase_carboxylesterase | Lipase_3 | Monoglyceridelipase_lysophospholip | PPase_methylesterase_euk | S9N_PPCE_Peptidase_S9 ABPP-Probe | Benzoxadiazole | NBD-nitro-benzoxadiazol-fluorescent | Organophosphate | pNP
NBD-TGABHD11-Acetyl_transferase | Hormone-sensitive_lipase_like | Monoglyceridelipase_lysophospholip ABPP-Probe | Benzoxadiazole | NBD-nitro-benzoxadiazol-fluorescent | Triacylglycerol | pNP
NCMPACHE Chemical Warfare Agent | Derivative of Sarin | Nerve Agent G-series | Organophosphate | pNP
NEDPAACHE | Cholesterol_esterase Nerve Agent G-series | Organophosphate | Surrogate OP | pNP
NEMPACHE | Cholesterol_esterase Derivative of VX | Nerve Agent V-series | Organophosphate | Surrogate OP | pNP
NEMP-FACHE Derivative of VX | Nerve Agent V-series | Organophosphate | Surrogate OP | pNP
Nitrophenyl-methyl-p-biotinamidophenylmethylphosphonateBCHE Biotin derivative | Organophosphate | Sulfur Compound | pNP
Nitrophenyl-trifluoroethyl-arsenocholineACHE Trifluoro | pNP
PNPMPCACPH_Peptidase_S9 Carbamate | pNP
PNPPCACPH_Peptidase_S9 Carbamate | pNP
Paraoxon5_AlphaBeta_hydrolase | A85-EsteraseD-FGH | A85-Mycolyl-transferase | ACHE | Acetyl-esterase_deacetylase | BCHE | Bacterial_lip_FamI.1 | Bacterial_lip_FamI.3 | CarbLipBact_1 | Cutinase | Dienelactone_hydrolase | Hormone-sensitive_lipase_like | Lipase_2 | Lipase_3 | PAF-Acetylhydrolase | Pancreatic_lipase | Plant_carboxylesterase Derivative of Paraoxon | Insecticide | Organophosphate | pNP
ParathionACHE | BCHE Derivative of Paraoxon | Insecticide | Organophosphate | Organothiophosphate | Sulfur Compound | pNP
Parathion-SACHE Organophosphate | Organothiophosphate | Sulfur Compound | pNP
Rh-pNPCanar_LipB | Cutinase Organophosphate | Pincer-Metal-cofactor | pNP
Ru-NHC-1Cutinase Organophosphate | Pincer-Metal-cofactor | pNP
Ru-NHC-3Cutinase Organophosphate | Pincer-Metal-cofactor | pNP
SXCCutinase Organophosphate | Pincer-Metal-cofactor | Sulfur Compound | pNP
VXSACHE | BCHE Derivative of Paraoxon | Derivative of VX | Organophosphate | PET probe | pNP
WWL153PAF-Acetylhydrolase Piperazine | Quinoline | pNP
WWL222AlphaBeta_hydrolase Carbamate | pNP
WWL229Carb_B_Chordata Carbamate | Piperidine | pNP
di-O-octylglycero-O-(p-nitrophenyl)-n-hexyl-phosphonateBacterial_lip_FamI.2 | Lipase_3 Analogue of substrate | Lipase inhibitor | Organophosphate | Triacylglycerol | pNP
l,2-Dioctylcarbamoylglycero-3-O-p-nitrophenyloctylphosphonateBacterial_lip_FamI.6 | Cutinase Analogue of substrate | Lipase inhibitor | Organophosphate | Triacylglycerol | pNP
p-nitrophenyl-N-butyl-N-methyl-carbamateCholesterol_esterase Carbamate | pNP
p-nitrophenyl-N-butyl-carbamateCholesterol_esterase Carbamate | pNP
p-nitrophenyl-N-octyl-carbamateCholesterol_esterase Carbamate | pNP

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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