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Type_inhibitor Report for: Carbamate

Derived from carbamic acid (NH2COOH). Carbamates can also inhibits many enzymes whose catalytic active site contains a nucleophilic Serine. This serine can be carbamylated. The first naturally occurring carbamate discovered was physostigmeine( eserine). Many carbamates were developped as insecticides or nerve agents (inhibitors of cholinesterases) but also in medicine. Polymers whose units are joined by divalent carbamate groups NH(C=O)O are an important family of plastics, the polyurethanes.

InhibitorMain targeted enzyme familiesTypeStructure
(-)-phenethylcymserineACHE | BCHE | Carb_B_Chordata Carbamate | Derivative of physostigmine-eserine
123I-PIPBCHE Carbamate | PET probe
2-trimethylsilyl-ethyl-N-butylcarbamateACHE | BCHE Analogue of substrate | Carbamate | Sulfur Compound
3,3-Dimethylbutyl-N-butylcarbamateACHE | BCHE Analogue of substrate | Carbamate
3-Cholesteryl-N-butylcarbamateCholesterol_esterase Carbamate | Lipase inhibitor | Phenanthrene | Steroid
3-Cholesteryl-N-octylcarbamateCholesterol_esterase Carbamate | Lipase inhibitor | Phenanthrene | Steroid
5-deoxo-3-hydroxyevodiamine-heptyl-carbamateBCHE Carbamate | Derivative of Evodiamine | Natural_modified
6AX1-cp3Monoglyceridelipase_lysophospholip Azetidin | Carbamate | Halo ketone | Oxadiazol | Trifluoro
6EUL-BY2BCHE Carbamate | Derivative of Rivastigmine
6H6-Heptyl-CarbamateBCHE Carbamate | Derivative of Tryptamine | Indole
6SAM-cpd13BCHE Carbamate | Inden | Monoamine-oxidase-inhibitor | Multitarget | Piperidine
ABC44Palmitoyl-protein_thioesterase Carbamate | N-hydroxyhydantoin | Piperidine
ABC47CGI-58_ABHD5_ABHD4 | abh_upf0017 Carbamate | N-hydroxyhydantoin | Phenoxyphenyl | Piperidine
ABC51CGI-58_ABHD5_ABHD4 Carbamate | N-hydroxyhydantoin | Phenoxyphenyl | Piperidine
ABC99Pectinacetylesterase-Notum Carbamate | Pyridine
ABD-1970Monoglyceridelipase_lysophospholip Azabicyclo | Carbamate | Piperazine | Trifluoro
ABX-1431Monoglyceridelipase_lysophospholip Carbamate | Piperazine | Pyrrolidine | Trifluoro
AM9928Monoglyceridelipase_lysophospholip Carbamate | Fluoren | Piperazine
AS115Arylacetamide_deacetylase Carbamate
AlanycarbACHE Carbamate | Insecticide | Propionate | Sulfur Compound
AldicarbACHE Carbamate | Insecticide | Sulfur Compound
AldoxycarbACHE Carbamate | Insecticide | Sulfur Compound
Amantadine-M30D-hybrid5eBCHE Adamantyl | Alkyl linked bis-ligand | Carbamate | Monoamine-oxidase-inhibitor | Multitarget
AminocarbACHE Carbamate | Insecticide
Antibact-product-Oxadiazolone-cp36_AlphaBeta_hydrolase Carbamate | Oxadiazol
Antibacterial-agent-1366_AlphaBeta_hydrolase | Hormone-sensitive_lipase_like | Monoglyceridelipase_lysophospholip Carbamate | Oxadiazol
BChE-IN-3BCHE Carbamate | Cycloheptyl | Derivative of Tryptamine | Derivative of Tryptophan | Indole
BambuterolBCHE Carbamate | Drug | Not A/B H target | Pro-Drug | tert-Butyl
BanolACHE Carbamate
BarbanACHE Carbamate | Herbicide
BendiocarbACHE Benzodioxo | Carbamate | Insecticide
BenfuracarbACHE Benzofuran | Carbamate | Insecticide | Propionate | Sulfur Compound
BenomylACHE Benzimidazole | Carbamate | Fungicide | Imidazole
Benzimidazole-Diethylcarbamoyl-isopentyl-dimethylcarbamate-15dBCHE Benzimidazole | Cannabinoid-Receptor-ligand | Carbamate | Carboxamide
Benzimidazole-Ethoxybenzyl-isopentyl-azetidine-carboxylate-21dBCHE Azetidin | Benzimidazole | Cannabinoid-Receptor-ligand | Carbamate | Carboxamide
Benzimidazole-phenyl-azetidine-carboxylate-11dBCHE Azetidin | Benzimidazole | Cannabinoid-Receptor-ligand | Carbamate | Carboxamide
Bis(N-propylcarbamic-acid)ethylene-esterBacterial_lip_FamI.1 Carbamate
BiscarbofuranACHE Benzofuran | Carbamate | Insecticide | Sulfur Compound
BisnorcymserineACHE | BCHE Carbamate | Derivative of physostigmine-eserine | Indole
BufencarbACHE Carbamate | Insecticide
ButocarboximACHE Carbamate | Insecticide | Sulfur Compound
ButoxycarboximACHE Carbamate | Insecticide | Sulfur Compound
CAY10499ABHD6-Lip | Carb_B_Chordata | Hormone-sensitive_lipase_like | Lipase_3 | Monoglyceridelipase_lysophospholip Carbamate | Oxadiazol
CBD-carbamate-C16BCHE Cannabinoid-Receptor-ligand | Carbamate
CHEMBL1784957ACHE Carbamate | Derivative of Rivastigmine | Drug | Pro-Drug
CHEMBL238787ABHD6-Lip | Carb_B_Chordata | Hormone-sensitive_lipase_like Carbamate | Piperidine | Trifluoro
CHEMBL3585776ACHE Carbamate | Sulfonamide | Sulfur Compound
CHEMBL4079247BCHE Carbamate
CHEMBL440526ACHE | BCHE Carbamate | Coumarin | Multitarget
CHEMBL4454960BCHE Carbamate | Isoquinoline | Morpholine | Quinazoline
CHEMBL4454960-PETBCHE Carbamate | PET probe
CHEMBL49895Hormone-sensitive_lipase_like Carbamate | Morpholine | tert-Butyl
CID656508 Carbamate | Derivative of physostigmine-eserine | Indole
CarbacholACHE | BCHE Analogue of substrate | Carbamate | Drug | Not A/B H target | Trimethylammonium
CarbarylACHE Carbamate | Insecticide
CarbofuranACHE Benzofuran | Carbamate | Insecticide
CarbosulfanACHE Benzofuran | Carbamate | Insecticide | Sulfur Compound
ChlorprophamCarb_B_Bacteria Carbamate | Herbicide | Not A/B H target
Compound-47abh_upf0017 Carbamate
CosbanACHE Carbamate | Insecticide
Cpd-6-8AI7BCHE Carbamate | Indole
Cpd35-Rivastigmine-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Carbamate | Derivative of Rivastigmine | Indole | Multitarget | Sulfonamide | Sulfur Compound | anti-Abeta-aggregation
Cpd37-Fluoroindol-carbamateMonoglyceridelipase_lysophospholip Alkyl linked bis-ligand | Carbamate | FAAH inhibitor | Indole | Multitarget
CronetonACHE | BCHE Carbamate | Insecticide | Sulfur Compound
CymserineBCHE Carbamate | Derivative of physostigmine-eserine | Indole
DECFCarb_B_Chordata | Carboxylesterase Carbamate
DO34Lipase_3 Carbamate | Piperazine | Trifluoro | tert-Butyl | tert-Butyloxycarbonyl
Dihydrobenzodioxepine-cymeserineBCHE Carbamate | Derivative of physostigmine-eserine
DimethylhydroxycarbaphenBCHE Carbamate | Multitarget | Muscarinic antagonist | Not A/B H target | Pro-Drug | Propionate
DioxacarbACHE Carbamate | Insecticide
DistigmineBCHE Carbamate | Drug | Pyridine
EA-3990ACHE Bisquaternary | Carbamate | Chemical Warfare Agent | Nerve Agent Carbamate | Trimethylammonium
EA-4056ACHE Bisquaternary | Carbamate | Chemical Warfare Agent | Nerve Agent Carbamate | Trimethylammonium
ENA-713~RivastigmineACHE Carbamate | Derivative of Rivastigmine | Drug
EPTCACHE Carbamate | Herbicide | Sulfur Compound
EthienocarbACHE Carbamate | Cyanide | Insecticide
FenobucarbACHE Carbamate | Insecticide
FenoxycarbACHE Carbamate | Insecticide
FormetanateACHE Carbamate | Insecticide
Fragment-588Pectinacetylesterase-Notum Benzyloxycarbonyl | Carbamate | Fragment inhibitor of Notum
FurathiocarbACHE Benzofuran | Carbamate | Insecticide | Sulfur Compound
GanstigmineACHE Carbamate | Derivative of physostigmine-eserine | Indole
GeneserineACHE | BCHE Carbamate | Derivative of physostigmine-eserine | Indole | Natural
H-Lys(4-nitro-Z)-pyrrolidideDPP4N_Peptidase_S9 Carbamate | Peptide | Pyrrolidine | pNP
H327BCHE Carbamate | Derivative of Tryptamine | Indole
HeptylphysostigmineACHE Carbamate | Derivative of physostigmine-eserine | Indole
Idalopirdine-rivastigmineBCHE 5-HT-receptor-ligand | Carbamate | Derivative of Rivastigmine | Drug | Multitarget | Pro-Drug
Indol-adamantyl-carbamate-Cpd42DPP4N_Peptidase_S9 Adamantyl | Carbamate | Gliptin | Indole
IrinotecanCarb_B_Bacteria | Carb_B_Chordata | Carboxylesterase Carbamate | Derivative of Irinotecan | Drug | Not A/B H target
IsoprocarbACHE Carbamate | Insecticide
Isosorbide-2-benzylcarbamate-5-benzoateBCHE Benzoate | Carbamate | Isosorbide
Isosorbide-2-benzylcarbamate-5-benzyl-etherBCHE Carbamate | Isosorbide
Isosorbide-2-benzylcarbamate-5-salicylateBCHE Benzoate | Carbamate | Isosorbide | Salicylic
Isosorbide-2-butylcarbamate-5-lipoic-acid-esterBCHE Antioxidant | Carbamate | Isosorbide | Multitarget
JCP-265ABHD6-Lip Carbamate
JCP678A85-EsteraseD-FGH Carbamate | Sulfonyl | Sulfur Compound
JJH221 Carbamate | N-hydroxyhydantoin | Piperidine | tert-Butyl | tert-Butyloxycarbonyl
JJH251 Carbamate | N-hydroxyhydantoin | Piperidine
JW480Arylacetamide_deacetylase Carbamate | Naphthalen
JW651Monoglyceridelipase_lysophospholip | Plasmodium_subtelomeric_PST-A Carbamate | Halo ketone | Piperazine | Trifluoro
JZP-430ABHD6-Lip Carbamate | Morpholine | Sulfur Compound | Thiadiazol
JZP-MA-11ABHD6-Lip Carbamate | PET probe | Piperidine | Sulfur Compound | Thiadiazol
KML29Monoglyceridelipase_lysophospholip | Plasmodium_subtelomeric_PST-A Benzodioxo | Carbamate | Halo ketone | Piperidine | Trifluoro
LadostigilACHE | BCHE Carbamate | Drug | Inden | Monoamine-oxidase-inhibitor | Multitarget
M30DACHE Carbamate | Monoamine-oxidase-inhibitor | Multitarget | Quinoline
MF217ACHE Carbamate | Derivative of physostigmine-eserine | Indole | Morpholine
MF268ACHE Carbamate | Derivative of physostigmine-eserine | Indole | Morpholine
MJN110Monoglyceridelipase_lysophospholip | Plasmodium_subtelomeric_PST-A Carbamate | Piperazine | Pyrrolidine
MJN193ABHD6-Lip Carbamate | Imidazole | Piperazine
MT-031ACHE | BCHE Carbamate | Monoamine-oxidase-inhibitor | Multitarget
MecarbamACHE Carbamate | Insecticide | Organophosphate | Sulfur Compound
MeropenemACPH_Peptidase_S9 Antibiotic | Carbamate | Pyrrolidine | Sulfur Compound
MethiocarbACHE | BCHE | Carb_B_Arthropoda Carbamate | Insecticide | Sulfur Compound
MethomylACHE Carbamate | Insecticide | Sulfur Compound
MetolcarbACHE Carbamate | Insecticide
MiotineACHE Carbamate | Derivative of Rivastigmine
Molinate Azepane | Carbamate | Herbicide | Not A/B H target | Sulfur Compound
N-10-Phenothiazine-1-Naphtyl-carbamateBCHE Carbamate | Phenothiazine | Sulfur Compound
N-10-Phenothiazine-2-Pyrrlidinylethyl-carbamateBCHE Carbamate | Phenothiazine | Sulfur Compound
N-10-Phenothiazine-3-(dimethylamino)phenyl-carbamateBCHE Carbamate | Phenothiazine | Sulfur Compound
N-10-Phenothiazine-isopropyl-carbamateACHE | BCHE Carbamate | Phenothiazine | Sulfur Compound
N-Methyl-7-dimethylcarbamoxyquinoliniumACHE | BCHE Carbamate | Quinoline
N-acyl-prolylpyrrolidine-inhibitor-2S9N_PPCE_Peptidase_S9 Carbamate | Pyrrolidine | Triazol | tert-Butyl | tert-Butyloxycarbonyl
N-methyl-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxamidePectinacetylesterase-Notum Carbamate | Carboxamide | Fragment inhibitor of Notum | Sulfur Compound
N1-PhenethylnorcymserineBCHE Carbamate | Derivative of physostigmine-eserine | Indole
Neostigmine~ProstigmineACHE | BCHE Carbamate | Trimethylammonium
Nu-1197ACHE Carbamate | Trimethylammonium
Nu-1250ACHE Carbamate | Trimethylammonium
OxamylACHE | BCHE Carbamate | Sulfur Compound
P-10358ACHE | BCHE Carbamate | Indole | Pyridine
PF-06795071Monoglyceridelipase_lysophospholip Azabicyclo | Carbamate | PET probe | Pyrazole | Trifluoro
PNPMPCACPH_Peptidase_S9 Carbamate | pNP
PNPPCACPH_Peptidase_S9 Carbamate | pNP
PhenmediphamACHE | BCHE Carbamate | FAAH inhibitor | Herbicide | Not A/B H target
PhenserineACHE Carbamate | Derivative of physostigmine-eserine | Drug | Indole
Phenyl-benzyl-carbamate Carbamate | NTE inhibitor | Not A/B H target
Physostigmine-methiodideACHE Carbamate | Derivative of physostigmine-eserine | Indole | Natural_modified
Physostigmine~EserineACHE | Arylacetamide_deacetylase | BCHE Carbamate | Derivative of physostigmine-eserine | Drug | Indole | Natural
PhysovenineACHE Carbamate | Derivative of physostigmine-eserine | Indole | Natural
PirimicarbACHE Carbamate | Insecticide | Pyrimidine
PosiphenACHE Carbamate | Derivative of physostigmine-eserine | Drug | Indole
PromecarbACHE Carbamate | Insecticide
PropoxurACHE | BCHE Carbamate | Insecticide
Pyranone-carbamate-cpd7pBCHE Antioxidant | Carbamate | Piperidine
Pyridophen-10ACHE Carbamate | Multitarget | Muscarinic antagonist | Not A/B H target | PET probe | Pro-Drug | Propionate
PyridostigmineACHE | BCHE Carbamate | Drug | Pyridine
QuilostigmineACHE Carbamate | Derivative of physostigmine-eserine | Indole | Isoquinoline
Quinazolin-carbamate-2pBCHE Carbamate | Quinazoline | Sulfur Compound
RIV-BIMb-5d Benzimidazole | Carbamate | Derivative of Rivastigmine
Rhc80267ABHD6-Lip | Carb_B_Chordata | Hormone-sensitive_lipase_like | Lipase_3 | Monoglyceridelipase_lysophospholip Carbamate
Rivastigmine-Donepezil-COR783 Adamantyl | Cannabinoid-Receptor-ligand | Carbamate | Derivative of Donepezil | Derivative of Rivastigmine | Multitarget | Sulfur Compound
Ro-2-0683BCHE Carbamate | Trimethylammonium
SA-57Monoglyceridelipase_lysophospholip Carbamate | Piperidine
SB31184-49R-4Y2UEpoxide_hydrolase Carbamate | Quinoline | tert-Butyl | tert-Butyloxycarbonyl
SCHEMBL19582562ABHD6-Lip Azaspiro | Carbamate | Morpholine | Triflouro
SCHEMBL20516363ABHD6-Lip | PAF-Acetylhydrolase Carbamate | Imidazole | Morpholine | Piperazine
SPB01403Monoglyceridelipase_lysophospholip Carbamate | FAAH inhibitor | Multitarget | Sulfur Compound
T-1123ACHE Carbamate | Chemical Warfare Agent | Nerve Agent Carbamate | Trimethylammonium
Tacrine-Sibiriline-Cpd7ACHE | BCHE Acridine | Alkyl linked bis-ligand | Carbamate | Derivative of Tacrine | Multitarget | Pyridine | Pyrrolidine
TerbamACHE Carbamate | Insecticide | tert-Butyl
Tetracyclic-carbamate-UW-MD-95BCHE Carbamate | Derivative of Evodiamine | Isoquinoline | Natural_modified | Quinazoline
Tetracyclic-carbamate-cp8BCHE Carbamate | Derivative of Evodiamine | Isoquinoline | Natural_modified | PET probe | Quinazoline
Tetracyclic-carbamate-ferulicacid-4aBCHE Alkyl linked bis-ligand | Antioxidant | Carbamate | Derivative of Evodiamine | Feruloyl | Isoquinoline | Natural_modified | Quinazoline
Tetracyclic-carbamate-melatonine-3c Alkyl linked bis-ligand | Carbamate | Derivative of Evodiamine | Derivative of Tryptamine | Indole | Isoquinoline | Natural_modified | Quinazoline
Tetrahydrofurobenzofuran-cymserine Carbamate | Derivative of physostigmine-eserine
Thiobencarb Carbamate | Herbicide | Sulfur Compound
TolserineACHE | BCHE Carbamate | Derivative of physostigmine-eserine | Indole | NTE inhibitor | Not A/B H target
Triallate Carbamate | Herbicide | Not A/B H target | Sulfur Compound
URB597Monoglyceridelipase_lysophospholip Biphenyl | Carbamate | FAAH inhibitor | Multitarget
URB602Monoglyceridelipase_lysophospholip Biphenyl | Carbamate
WAY-121898Cholesterol_esterase Carbamate | Phenoxyphenyl | Piperidine
WWL113ABHD6-Lip | Carb_B_Chordata Benzoate | Carbamate
WWL123ABHD6-Lip Biphenyl | Carbamate
WWL222AlphaBeta_hydrolase Carbamate | pNP
WWL229Carb_B_Chordata Carbamate | Piperidine | pNP
WWL50Carb_B_Chordata Carbamate
WWL70ABHD6-Lip | Carb_B_Chordata Biphenyl | Carbamate
Xanthostigmine Carbamate | Xanthene
Z-Gly-Gly-Phe-chloromethyl-ketoneACPH_Peptidase_S9 Benzyloxycarbonyl | Carbamate | Carboxamide | Ketone | Peptide
Z-Pro-ProlinalS9N_PPCE_Peptidase_S9 Benzyloxycarbonyl | Carbamate | Peptide | Pyrrolidine
Z-Pro-Prolinal-derivedS9N_PPCE_Peptidase_S9 Benzyloxycarbonyl | Carbamate | Carboxamide | Peptide | Piperidine | Pyrrolidine
ZectranACHE Carbamate | Insecticide
p-nitrophenyl-N-butyl-N-methyl-carbamateCholesterol_esterase Carbamate | pNP
p-nitrophenyl-N-butyl-carbamateCholesterol_esterase Carbamate | pNP
p-nitrophenyl-N-octyl-carbamateCholesterol_esterase Carbamate | pNP

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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