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Torpedo_number Report for: 537
human-BCHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
A199S/
F227A/
S287G/
A328W/
Y332G/
N535C
sdm
Cocaine hydrolysis
improved catalytic efficiency against-cocaine and increased biological half-life with new cross-subunit SS bonds
Fang_2014_Chem.Biol.Interact_214C_18
torca-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
N533T/
A534T/
C537T/
G539T/
S542T/
S543T/
S544T/
G545R
sdm
Glypiation
All T construct all omega site mutated, catalitically inactive and retained in the cell
Bucht_1992_4th.ChE.Meeting.Eilat__185
,
Bucht_1995_5th.ChE.Meeting.Madras__89
C537S
sdm
Subunit assembly
Monomers on the membrane inactive when solubilized half-life reduced
Bucht_1995_5th.ChE.Meeting.Madras__89
C537S
sdm
Folding
Monomers on the membrane inactive when solubilized half-life reduced
Bucht_1995_5th.ChE.Meeting.Madras__89
C537D
sdm
Subunit assembly
Folding,Monomers on the membrane inactive when solubilized half-life reduced
Bucht_1995_5th.ChE.Meeting.Madras__89
C537D
sdm
Folding
Monomers on the membrane inactive when solubilized half-life reduced
Bucht_1995_5th.ChE.Meeting.Madras__89
C537G
sdm
Subunit assembly
, Folding,Monomers on the membrane inactive when solubilized half-life reduced
Bucht_1995_5th.ChE.Meeting.Madras__89
C537G
sdm
Folding
Monomers on the membrane inactive when solubilized half-life reduced
Bucht_1995_5th.ChE.Meeting.Madras__89
C537T/
D538T/
G539T
sdm
Glypiation
TM537-539T mutant still GPI-anchored and active
Bucht_1995_5th.ChE.Meeting.Madras__89
torma-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
C537S
sdm
Subunit attachment, Folding
Monomers on the membrane, when solubilized half-life reduced
Bucht_1995_5th.ChE.Meeting.Madras__89
C537D
sdm
Subunit assembly
Folding, Monomers on the membrane, when solubilized half-life reduced
Bucht_1995_5th.ChE.Meeting.Madras__89
C537D
sdm
Folding
Monomers on the membrane inactive when solubilized half-life reduced
Bucht_1995_5th.ChE.Meeting.Madras__89
C537G
sdm
Subunit assembly
Folding, Monomers on the membrane, when solubilized half-life reduced
Bucht_1995_5th.ChE.Meeting.Madras__89
C537G
sdm
Folding
Monomers on the membrane inactive when solubilized half-life reduced
Bucht_1995_5th.ChE.Meeting.Madras__89
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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