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Torpedo_number Report for: 537

human-BCHE
MutationKin.TypeEvaluation systemEffectReference
A199S/
F227A/
S287G/
A328W/
Y332G/
N535C
 sdmCocaine hydrolysisimproved catalytic efficiency against-cocaine and increased biological half-life with new cross-subunit SS bondsFang_2014_Chem.Biol.Interact_214C_18

torca-ACHE
MutationKin.TypeEvaluation systemEffectReference
N533T/
A534T/
C537T/
G539T/
S542T/
S543T/
S544T/
G545R
 sdmGlypiationAll T construct all omega site mutated, catalitically inactive and retained in the cellBucht_1992_4th.ChE.Meeting.Eilat__185,
Bucht_1995_5th.ChE.Meeting.Madras__89
C537S sdmSubunit assemblyMonomers on the membrane inactive when solubilized half-life reducedBucht_1995_5th.ChE.Meeting.Madras__89
C537S sdmFoldingMonomers on the membrane inactive when solubilized half-life reducedBucht_1995_5th.ChE.Meeting.Madras__89
C537D sdmSubunit assembly Folding,Monomers on the membrane inactive when solubilized half-life reducedBucht_1995_5th.ChE.Meeting.Madras__89
C537D sdmFoldingMonomers on the membrane inactive when solubilized half-life reducedBucht_1995_5th.ChE.Meeting.Madras__89
C537G sdmSubunit assembly, Folding,Monomers on the membrane inactive when solubilized half-life reducedBucht_1995_5th.ChE.Meeting.Madras__89
C537G sdmFoldingMonomers on the membrane inactive when solubilized half-life reducedBucht_1995_5th.ChE.Meeting.Madras__89
C537T/
D538T/
G539T
 sdmGlypiationTM537-539T mutant still GPI-anchored and activeBucht_1995_5th.ChE.Meeting.Madras__89

torma-ACHE
MutationKin.TypeEvaluation systemEffectReference
C537S sdmSubunit attachment, FoldingMonomers on the membrane, when solubilized half-life reducedBucht_1995_5th.ChE.Meeting.Madras__89
C537D sdmSubunit assembly Folding, Monomers on the membrane, when solubilized half-life reducedBucht_1995_5th.ChE.Meeting.Madras__89
C537D sdmFoldingMonomers on the membrane inactive when solubilized half-life reducedBucht_1995_5th.ChE.Meeting.Madras__89
C537G sdmSubunit assembly Folding, Monomers on the membrane, when solubilized half-life reducedBucht_1995_5th.ChE.Meeting.Madras__89
C537G sdmFoldingMonomers on the membrane inactive when solubilized half-life reducedBucht_1995_5th.ChE.Meeting.Madras__89

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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