Z-Gly-Pro-AMC
General
Type : Benzyloxycarbonyl || Peptide || Pyrrolidine || 7-amido-4-methylcoumarin || Coumarin
Chemical_Nomenclature : benzyl N-[2-[(2S)-2-[(4-methyl-2-oxochromen-7-yl)carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]carbamate
Canonical SMILES : CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C3CCCN3C(=O)CNC(=O)OCC4=CC=CC=C4
InChI : InChI=1S\/C25H25N3O6\/c1-16-12-23(30)34-21-13-18(9-10-19(16)21)27-24(31)20-8-5-11-28(20)22(29)14-26-25(32)33-15-17-6-3-2-4-7-17\/h2-4,6-7,9-10,12-13,20H,5,8,11,14-15H2,1H3,(H,26,32)(H,27,31)\/t20-\/m0\/s1
InChIKey : YWOXKKRKNGWXEG-FQEVSTJZSA-N
Other name(s) : N-[(benzyloxy)carbonyl]glycyl-n-(4-methyl-2-oxo-2h-chromen-7-yl)-l-prolinamide, Benzyl N-{2-[(2S)-2-[(4-methyl-2-oxochromen-7-yl)carbamoyl]pyrrolidin-1-yl]-2-oxoethyl}carbamate, Z-GP-AMC, Z-Gly-propmecounh, Cbz-Gly-Pro-AMC
Target
Families : S9N_PPCE_Peptidase_S9, DPP4N_Peptidase_S9
References (3)
| Title : The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma - Bracke_2019_Clin.Chim.Acta_495_154 |
| Author(s) : Bracke A , Van Elzen R , Van der Veken P , Augustyns K , De Meester I , Lambeir AM |
| Ref : Clinica Chimica Acta , 495 :154 , 2019 |
| Abstract : Bracke_2019_Clin.Chim.Acta_495_154 |
| ESTHER : Bracke_2019_Clin.Chim.Acta_495_154 |
| PubMedSearch : Bracke_2019_Clin.Chim.Acta_495_154 |
| PubMedID: 30981844 |
| Gene_locus related to this paper: human-FAP , human-PREP |
| Title : Virtual screening and computational optimization for the discovery of covalent prolyl oligopeptidase inhibitors with activity in human cells - De Cesco_2012_J.Med.Chem_55_6306 |
| Author(s) : De Cesco S , Deslandes S , Therrien E , Levan D , Cueto M , Schmidt R , Cantin LD , Mittermaier A , Juillerat-Jeanneret L , Moitessier N |
| Ref : Journal of Medicinal Chemistry , 55 :6306 , 2012 |
| Abstract : De Cesco_2012_J.Med.Chem_55_6306 |
| ESTHER : De Cesco_2012_J.Med.Chem_55_6306 |
| PubMedSearch : De Cesco_2012_J.Med.Chem_55_6306 |
| PubMedID: 22765237 |
| Title : Structures of prolyl oligopeptidase substrate\/inhibitor complexes. Use of inhibitor binding for titration of the catalytic histidine residue - Fulop_2001_J.Biol.Chem_276_1262 |
| Author(s) : Fulop V , Szeltner Z , Renner V , Polgar L |
| Ref : Journal of Biological Chemistry , 276 :1262 , 2001 |
| Abstract : Fulop_2001_J.Biol.Chem_276_1262 |
| ESTHER : Fulop_2001_J.Biol.Chem_276_1262 |
| PubMedSearch : Fulop_2001_J.Biol.Chem_276_1262 |
| PubMedID: 11031266 |
| Gene_locus related to this paper: pig-ppce |