Phenytoin

General

Type : Not A\/B H target

Chemical_Nomenclature :

Canonical SMILES :

InChI :

InChIKey :

Other name(s) : 5,5-Diphenylhydantoin,     Diphenylhydantoin,     Dilantin


MW : 252.27

Formula : C15H12N2O2

CAS_number : 57-41-0

PubChem :

UniChem :

Iuphar :

Target

Families : No family

References (10)

Title : Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine - Yip_2021_Br.J.Clin.Pharmacol_87_2572
Author(s) : Yip VLM , Pertinez H , Meng X , Maggs JL , Carr DF , Park BK , Marson AG , Pirmohamed M
Ref : British Journal of Clinical Pharmacology , 87 :2572 , 2021
Abstract : Yip_2021_Br.J.Clin.Pharmacol_87_2572
ESTHER : Yip_2021_Br.J.Clin.Pharmacol_87_2572
PubMedSearch : Yip_2021_Br.J.Clin.Pharmacol_87_2572
PubMedID: 33217013

Title : Role of CYP2C9, CYP2C19 and EPHX Polymorphism in the Pharmacokinetic of Phenytoin: A Study on Uruguayan Caucasian Subjects - Guevara_2017_Pharmaceuticals.(Basel)_10_
Author(s) : Guevara N , Maldonado C , Uria M , Gonzalez R , Ibarra M , Alvariza S , Carozzi A , Azambuja C , Fagiolino P , Vazquez M
Ref : Pharmaceuticals (Basel) , 10 : , 2017
Abstract : Guevara_2017_Pharmaceuticals.(Basel)_10_
ESTHER : Guevara_2017_Pharmaceuticals.(Basel)_10_
PubMedSearch : Guevara_2017_Pharmaceuticals.(Basel)_10_
PubMedID: 28820457

Title : Phenytoin embryopathy: effect of epoxide hydrolase inhibitor on phenytoin exposure in utero in C57BL\/6J mice - Hartsfield_1995_Biochem.Mol.Med_56_131
Author(s) : Hartsfield JK, Jr. , Holmes LB , Morel JG
Ref : Biochemical & Molecular Medicine , 56 :131 , 1995
Abstract : Hartsfield_1995_Biochem.Mol.Med_56_131
ESTHER : Hartsfield_1995_Biochem.Mol.Med_56_131
PubMedSearch : Hartsfield_1995_Biochem.Mol.Med_56_131
PubMedID: 8825076

Title : Differences in phenytoin biotransformation and susceptibility to congenital malformations: a review - Van Dyke_1991_DICP_25_987
Author(s) : Van Dyke DC , Berg MJ , Olson CH
Ref : DICP , 25 :987 , 1991
Abstract : Van Dyke_1991_DICP_25_987
ESTHER : Van Dyke_1991_DICP_25_987
PubMedSearch : Van Dyke_1991_DICP_25_987
PubMedID: 1683079

Title : Inheritance of poor phenytoin parahydroxylation capacity in a Dutch family - Vermeij_1988_Clin.Pharmacol.Ther_44_588
Author(s) : Vermeij P , Ferrari MD , Buruma OJ , Veenema H , de Wolff FA
Ref : Clinical Pharmacology & Therapeutics , 44 :588 , 1988
Abstract : Vermeij_1988_Clin.Pharmacol.Ther_44_588
ESTHER : Vermeij_1988_Clin.Pharmacol.Ther_44_588
PubMedSearch : Vermeij_1988_Clin.Pharmacol.Ther_44_588
PubMedID: 3180640

Title : Correlations between embryotoxic and genotoxic effects of phenytoin in mice - Barcellona_1987_Teratog.Carcinog.Mutagen_7_159
Author(s) : Barcellona PS , Barale R , Campana A , Zucconi D , Rossi V , Caranti S
Ref : Teratog Carcinog Mutagen , 7 :159 , 1987
Abstract : Barcellona_1987_Teratog.Carcinog.Mutagen_7_159
ESTHER : Barcellona_1987_Teratog.Carcinog.Mutagen_7_159
PubMedSearch : Barcellona_1987_Teratog.Carcinog.Mutagen_7_159
PubMedID: 2885938

Title : Genetic predisposition to phenytoin-induced birth defects - Strickler_1985_Lancet_2_746
Author(s) : Strickler SM , Dansky LV , Miller MA , Seni MH , Andermann E , Spielberg SP
Ref : Lancet , 2 :746 , 1985
Abstract : Strickler_1985_Lancet_2_746
ESTHER : Strickler_1985_Lancet_2_746
PubMedSearch : Strickler_1985_Lancet_2_746
PubMedID: 2864485

Title : Predisposition to phenytoin hepatotoxicity assessed in vitro - Spielberg_1981_N.Engl.J.Med_305_722
Author(s) : Spielberg SP , Gordon GB , Blake DA , Goldstein DA , Herlong HF
Ref : N Engl J Med , 305 :722 , 1981
Abstract : Spielberg_1981_N.Engl.J.Med_305_722
ESTHER : Spielberg_1981_N.Engl.J.Med_305_722
PubMedSearch : Spielberg_1981_N.Engl.J.Med_305_722
PubMedID: 6790991

Title : Inheritance of phenytoin hypometabolism: a kinetic study of one family -
Author(s) : Vasko MR , Bell RD , Daly DD , Pippenger CE
Ref : Clinical Pharmacology & Therapeutics , 27 :96 , 1980
PubMedID: 7351122

Title : Phenytoin teratogenesis: correlation between embryopathic effect and covalent binding of putative arene oxide metabolite in gestational tissue - Martz_1977_J.Pharmacol.Exp.Ther_203_231
Author(s) : Martz F , Failinger C, 3rd , Blake DA
Ref : Journal of Pharmacology & Experimental Therapeutics , 203 :231 , 1977
Abstract : Martz_1977_J.Pharmacol.Exp.Ther_203_231
ESTHER : Martz_1977_J.Pharmacol.Exp.Ther_203_231
PubMedSearch : Martz_1977_J.Pharmacol.Exp.Ther_203_231
PubMedID: 909055