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Substrate Report for: Mca-RPPGFSAFK(Dnp)-OH

peptide derivative of bradykinine: substrate for angiotensine converting enzymz (ACE), and active Cathepsin A and X/Z/P, endothelin-converting enzyme-1 (ECE-1) and neprilysin. Mca fluorescence is quenched by the Dnp group until cleavage separates them.


General
Type Peptide, FRET-Peptide, Fluorescent Probe, Coumarin
Chemical_Nomenclature
Canonical SMILES
InChI
InChIKey
Other name(s) 7-methoxycoumarin-4-yl)acetyl-RPPGFSAFK(2,4-dinitrophenyl)-OH ; Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH
________________________________________________________________________________________________
MW|1388.5
Formula|C66H81N15O19
CAS_number|323577-36-2
PubChem|
UniChem|
IUPHAR|
Wikipedia|

Target
Families | Mca-RPPGFSAFK(Dnp)-OH ligand of proteins in family: Carboxypeptidase_S10
Protein | human-CTSA

References:
Search PubMed for references concerning: Mca-RPPGFSAFK(Dnp)-OH
    Title: Structural and Kinetic Evidence of Aging after Organophosphate Inhibition of Human Cathepsin A
    Bouknight KD, Jurkouich KM, Compton JR, Khavrutskii IV, Guelta MA, Harvey SP, Legler PM
    Ref: Biochemical Pharmacology, :113980, 2020 : PubMed