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Substrate Report for: Iomazenil

Antagonist and partial inverse agonist of benzodiazepine and a potential treatment for alcohol abuse. 123I-iomazenil used in SPECT imaging epileptic seizure foci as an alternative to 18F-fludeoxyglucose PET imaging


General
Type Benzodiazepin, Not A/B H target, Drug
Chemical_Nomenclature ethyl 7-iodo-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
Canonical SMILES CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC=C3I)C
InChI InChI=1S/C15H14IN3O3/c1-3-22-15(21)13-11-7-18(2)14(20)12-9(16)5-4-6-10(12)19(11)8-17-13/h4-6,8H,3,7H2,1-2H3
InChIKey FRIZVHMAECRUBR-UHFFFAOYSA-N
Other name(s) UNII-7DVX185FLQ ; 7DVX185FLQ ; NCGC00181912-01 ; RO-16-0154
________________________________________________________________________________________________
MW|411.19
Formula|C15H14IN3O3
CAS_number|127985-21-1
PubChem|10251042
UniChem|FRIZVHMAECRUBR-UHFFFAOYSA-N
IUPHAR|
Wikipedia|Iomazenil

Target
Families | Iomazenil ligand of proteins in family: Carb_B_Chordata

References:
Search PubMed for references concerning: Iomazenil
    Title: 123I-iomazenil whole-body imaging to detect hepatic carboxylesterase drug-metabolizing enzyme activity
    Mizutani A, Kobayashi M, Fujita KI, Takahashi K, Hokama T, Takasu H, Nishi K, Nishii R, Shikano N and Kawai K <1 more author(s)>
    Ref: Nucl Med Commun, 39:825, 2018 : PubMed