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Substrate Report for: Homatropine

Homatropine (Equipin, Isopto Homatropine) is an antagonist at muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic (to temporarily paralyze accommodation), and as a mydriatic (to dilate the pupil). Homatropine is less potent than atropine and has a shorter duration of action. Homatropine is also given as an atropine substitute given to reverse the muscarinic and CNS effects associated with AChE inhibitors


General
Type Not A/B H target, Drug, Azabicyclo
Chemical_Nomenclature (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate
Canonical SMILES CN1C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O
InChI InChI=1S/C16H21NO3/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11/h2-6,12-15,18H,7-10H2,1H3
InChIKey ZTVIKZXZYLEVOL-UHFFFAOYSA-N
Other name(s) Mandelyltropeine ; Homotropine ; DL-Homatropine hydrobromide ; NSC60600 ; Homatropin ; HTQ ; DB02161 ; DB11181
________________________________________________________________________________________________
MW|275.34
Formula|C16H21NO3
CAS_number|
PubChem|3623, 447234
UniChem|ZTVIKZXZYLEVOL-UHFFFAOYSA-N
IUPHAR|
Wikipedia|Homatropine

Target
Families | Homatropine ligand of proteins in family: Carb_B_Chordata, A85-Mycolyl-transferase
Stucture | 2 structures: 2DQZ, 1MX5
Protein | human-CES1

References:
Search PubMed for references concerning: Homatropine
    Title: Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1
    Bencharit S, Edwards CC, Morton CL, Howard-Williams EL, Kuhn P, Potter PM, Redinbo MR
    Ref: Journal of Molecular Biology, 363:201, 2006 : PubMed

            

    Title: Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme
    Bencharit S, Morton CL, Xue Y, Potter PM, Redinbo MR
    Ref: Nat Struct Biol, 10:349, 2003 : PubMed