CurDD
General
Type : Drug || Pro-Drug || Natural_modified
Chemical_Nomenclature : 4,4'-((1E,6E)-3,5-Dioxohepta-1,6-diene-1,7-diyl)bis(2-methoxy-1,4-phenylene)diethyl disuccinate
Canonical SMILES : CCOC(CCC(OC1=CC=C(C=C1OC)C=CC(=CC(C=CC2=CC(=C(C=C2)OC(CCC(OCC)=O)=O)OC)=O)O)=O)=O
InChI : InChI=1S\/C33H36O12\/c1-5-42-30(36)15-17-32(38)44-26-13-9-22(19-28(26)40-3)7-11-24(34)21-25(35)12-8-23-10-14-27(29(20-23)41-4)45-33(39)18-16-31(37)43-6-2\/h7-14,19-21,34H,5-6,15-18H2,1-4H3
InChIKey : SKDNHNPKRBWDGR-UHFFFAOYSA-N
Other name(s) : Curcumin diethyl disuccinate
MW : 624.64
Formula : C33H36O12
CAS_number :
PubChem :
UniChem :
Iuphar :
Target
Families : BCHE, CMBL, Carb_B_Chordata
References (6)
| Title : In Vitro Hepatic Metabolism of Curcumin Diethyl Disuccinate by Liver S9 from Different Animal Species - Jithavech_2020_Front.Pharmacol_11_577998 |
| Author(s) : Jithavech P , Ratnatilaka Na Bhuket P , Supasena W , Qiu G , Ye S , Wu J , Wong TW , Rojsitthisak P |
| Ref : Front Pharmacol , 11 :577998 , 2020 |
| Abstract : Jithavech_2020_Front.Pharmacol_11_577998 |
| ESTHER : Jithavech_2020_Front.Pharmacol_11_577998 |
| PubMedSearch : Jithavech_2020_Front.Pharmacol_11_577998 |
| PubMedID: 33312126 |
| Title : Protective Effects of Curcumin Ester Prodrug, Curcumin Diethyl Disuccinate against H(2)O(2)-Induced Oxidative Stress in Human Retinal Pigment Epithelial Cells: Potential Therapeutic Avenues for Age-Related Macular Degeneration - Muangnoi_2019_Int.J.Mol.Sci_20_ |
| Author(s) : Muangnoi C , Sharif U , Ratnatilaka Na Bhuket P , Rojsitthisak P , Paraoan L |
| Ref : Int J Mol Sci , 20 : , 2019 |
| Abstract : Muangnoi_2019_Int.J.Mol.Sci_20_ |
| ESTHER : Muangnoi_2019_Int.J.Mol.Sci_20_ |
| PubMedSearch : Muangnoi_2019_Int.J.Mol.Sci_20_ |
| PubMedID: 31323999 |
| Title : Curcumin diethyl disuccinate, a prodrug of curcumin, enhances anti-proliferative effect of curcumin against HepG2 cells via apoptosis induction - Muangnoi_2019_Sci.Rep_9_11718 |
| Author(s) : Muangnoi C , Ratnatilaka Na Bhuket P , Jithavech P , Supasena W , Paraoan L , Patumraj S , Rojsitthisak P |
| Ref : Sci Rep , 9 :11718 , 2019 |
| Abstract : Muangnoi_2019_Sci.Rep_9_11718 |
| ESTHER : Muangnoi_2019_Sci.Rep_9_11718 |
| PubMedSearch : Muangnoi_2019_Sci.Rep_9_11718 |
| PubMedID: 31406217 |
| Title : Pharmacokinetics of Curcumin Diethyl Disuccinate, a Prodrug of Curcumin, in Wistar Rats - Bangphumi_2016_Eur.J.Drug.Metab.Pharmacokinet_41_777 |
| Author(s) : Bangphumi K , Kittiviriyakul C , Towiwat P , Rojsitthisak P , Khemawoot P |
| Ref : Eur J Drug Metab Pharmacokinet , 41 :777 , 2016 |
| Abstract : Bangphumi_2016_Eur.J.Drug.Metab.Pharmacokinet_41_777 |
| ESTHER : Bangphumi_2016_Eur.J.Drug.Metab.Pharmacokinet_41_777 |
| PubMedSearch : Bangphumi_2016_Eur.J.Drug.Metab.Pharmacokinet_41_777 |
| PubMedID: 26563392 |
| Title : Simultaneous determination of curcumin diethyl disuccinate and its active metabolite curcumin in rat plasma by LC-MS\/MS: Application of esterase inhibitors in the stabilization of an ester-containing prodrug - Ratnatilaka Na Bhuket_2016_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1033-1034_301 |
| Author(s) : Ratnatilaka Na Bhuket P , Niwattisaiwong N , Limpikirati P , Khemawoot P , Towiwat P , Ongpipattanakul B , Rojsitthisak P |
| Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 1033-1034 :301 , 2016 |
| Abstract : Ratnatilaka Na Bhuket_2016_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1033-1034_301 |
| ESTHER : Ratnatilaka Na Bhuket_2016_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1033-1034_301 |
| PubMedSearch : Ratnatilaka Na Bhuket_2016_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1033-1034_301 |
| PubMedID: 27595650 |
| Title : Synthesis, characterization and biological evaluation of succinate prodrugs of curcuminoids for colon cancer treatment - Wichitnithad_2011_Molecules_16_1888 |
| Author(s) : Wichitnithad W , Nimmannit U , Wacharasindhu S , Rojsitthisak P |
| Ref : Molecules , 16 :1888 , 2011 |
| Abstract : Wichitnithad_2011_Molecules_16_1888 |
| ESTHER : Wichitnithad_2011_Molecules_16_1888 |
| PubMedSearch : Wichitnithad_2011_Molecules_16_1888 |
| PubMedID: 21343891 |