Bottromycin-A2-MKW
General
Type : Antibiotic || Azabicyclo
Chemical_Nomenclature : (4R)-2-[(1R)-2-Carboxy-1-[[(2S)-2-[[(2S)-3-methyl-2-[[(6S,9S,12S)-2,8,11-trioxo-6,9-di(propan-2-yl)-1,4,7,10-tetrazabicyclo[10.3.0]pentadec-4-en-5-yl]amino]butanoyl]amino]-3-phenylpropanoyl]amino]ethyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid
Canonical SMILES : CC(C)C1C(=O)NC(C(=NCC(=O)N2CCCC2C(=O)N1)NC(C(C)C)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC(=O)O)C4=NC(CS4)C(=O)O)C(C)C
InChI : InChI=1S\/C38H54N8O9S\/c1-19(2)29-32(39-17-27(47)46-14-10-13-26(46)34(51)45-31(21(5)6)36(53)44-29)43-30(20(3)4)35(52)40-23(15-22-11-8-7-9-12-22)33(50)41-24(16-28(48)49)37-42-25(18-56-37)38(54)55\/h7-9,11-12,19-21,23-26,29-31H,10,13-18H2,1-6H3,(H,39,43)(H,40,52)(H,41,50)(H,44,53)(H,45,51)(H,48,49)(H,54,55)\/t23-,24+,25-,26-,29-,30-,31-\/m0\/s1
InChIKey : XXAKUWJCGKVNK-JQXGNVTOSA-N
Other name(s) : MQW
MW : 799
Formula : C38H54N8O9S
CAS_number :
PubChem :
UniChem :
Iuphar :
Target
Families : BotH
References (1)
| Title : The bottromycin epimerase BotH defines a group of atypical alpha\/beta-hydrolase-fold enzymes - Sikandar_2020_Nat.Chem.Biol_16_1013 |
| Author(s) : Sikandar A , Franz L , Adam S , Santos-Aberturas J , Horbal L , Luzhetskyy A , Truman AW , Kalinina OV , Koehnke J |
| Ref : Nat Chemical Biology , 16 :1013 , 2020 |
| Abstract : Sikandar_2020_Nat.Chem.Biol_16_1013 |
| ESTHER : Sikandar_2020_Nat.Chem.Biol_16_1013 |
| PubMedSearch : Sikandar_2020_Nat.Chem.Biol_16_1013 |
| PubMedID: 32601484 |
| Gene_locus related to this paper: 9actn-k4mhv9 |