6G75

Name : Crystal structure of the common ancestor of haloalkane dehalogenases and Renilla luciferase (AncHLD-RLuc)

Revelation date : 24-Apr-2019

Family : Haloalkane_dehalogenase-HLD2

Gene_locus : 9zzzz-AncHLDRLuc

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Chaloupkova, R., Waterman, J., Marek, M., Damborsky, J. || Luciferase from Renilla reniformis (RLuc)<\/A> catalyzes the degradation of coelenterazine in the presence of molecular oxygen, resulting in the product coelenteramide, carbon dioxide, and the desired photon of light (EC 1.13.12.5). This enzyme belongs to the Haloalkane dehalogenase family II with a different catalytic function (EC 3.8.1.5) Reconstruction of an ancestral enzyme shows it has both hydrolase and monooxygenase activities ( Chaloupkova et al.<\/A>)