3VJL
Name : Crystal structure of human dipeptidyl peptidase IV (DPP-4) in complex with a prolylthiazolidine inhibitor 2
Revelation date : 24-Oct-2012
Family : DPP4N_Peptidase_S9
Gene_locus : human-DPP4
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Akahoshi, F., Kishida, H., Miyaguchi, I., Yoshida, T., Ishii, S.
Ligand :
References (4)
| Title : Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-y lcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Yoshida_2012_Bioorg.Med.Chem_20_5705 |
| Author(s) : Yoshida T , Akahoshi F , Sakashita H , Kitajima H , Nakamura M , Sonda S , Takeuchi M , Tanaka Y , Ueda N , Sekiguchi S , Ishige T , Shima K , Nabeno M , Abe Y , Anabuki J , Soejima A , Yoshida K , Takashina Y , Ishii S , Kiuchi S , Fukuda S , Tsutsumiuchi R , Kosaka K , Murozono T , Nakamaru Y , Utsumi H , Masutomi N , Kishida H , Miyaguchi I , Hayashi Y |
| Ref : Bioorganic & Medicinal Chemistry , 20 :5705 , 2012 |
| Abstract : Yoshida_2012_Bioorg.Med.Chem_20_5705 |
| ESTHER : Yoshida_2012_Bioorg.Med.Chem_20_5705 |
| PubMedSearch : Yoshida_2012_Bioorg.Med.Chem_20_5705 |
| PubMedID: 22959556 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group - Yoshida_2012_Bioorg.Med.Chem_20_5033 |
| Author(s) : Yoshida T , Akahoshi F , Sakashita H , Sonda S , Takeuchi M , Tanaka Y , Nabeno M , Kishida H , Miyaguchi I , Hayashi Y |
| Ref : Bioorganic & Medicinal Chemistry , 20 :5033 , 2012 |
| Abstract : Yoshida_2012_Bioorg.Med.Chem_20_5033 |
| ESTHER : Yoshida_2012_Bioorg.Med.Chem_20_5033 |
| PubMedSearch : Yoshida_2012_Bioorg.Med.Chem_20_5033 |
| PubMedID: 22824762 |
| Gene_locus related to this paper: human-DPP4 |
| Title : [(S)-gamma-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors - Yoshida_2007_Bioorg.Med.Chem.Lett_17_2618 |
| Author(s) : Yoshida T , Sakashita H , Akahoshi F , Hayashi Y |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :2618 , 2007 |
| Abstract : Yoshida_2007_Bioorg.Med.Chem.Lett_17_2618 |
| ESTHER : Yoshida_2007_Bioorg.Med.Chem.Lett_17_2618 |
| PubMedSearch : Yoshida_2007_Bioorg.Med.Chem.Lett_17_2618 |
| PubMedID: 17317162 |
| Gene_locus related to this paper: human-DPP4 |
| Title : [(S)-gamma-(Arylamino)prolyl]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitors - Sakashita_2006_Bioorg.Med.Chem_14_3662 |
| Author(s) : Sakashita H , Akahoshi F , Kitajima H , Tsutsumiuchi R , Hayashi Y |
| Ref : Bioorganic & Medicinal Chemistry , 14 :3662 , 2006 |
| Abstract : Sakashita_2006_Bioorg.Med.Chem_14_3662 |
| ESTHER : Sakashita_2006_Bioorg.Med.Chem_14_3662 |
| PubMedSearch : Sakashita_2006_Bioorg.Med.Chem_14_3662 |
| PubMedID: 16460948 |
| Gene_locus related to this paper: human-DPP4 |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
